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1. 发明申请

US20080248022A1 Therapeutic Strategy for Treating Autoimmune and Degenerative Diseases 审中-公开
标题翻译：治疗自身免疫性和退行性疾病的治疗策略
公开(公告)号：US20080248022A1
公开(公告)日：2008-10-09
申请号：US11574911
申请日：2005-09-08
申请人： Martin Leonard Ashdown , Maria Luisa Ashdown
发明人： Martin Leonard Ashdown , Maria Luisa Ashdown
IPC分类号： A61K39/395 , C12Q1/02 , A61K39/00 , A61P25/28 , A61P25/16 , A61K31/7052
CPC分类号： A61K39/0005 , A61K31/00 , A61K31/337 , A61K31/437 , A61K31/4745 , A61K39/0007 , A61K2039/505 , A61K2039/515 , A61K2039/58 , C07D305/14 , C07D471/18 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2875 , C07K2317/75 , C12N15/1136 , G01N33/5005 , G01N33/564 , G01N33/56972 , G01N33/6869 , G01N33/6893 , G01N2333/5428 , G01N2800/24 , G01N2800/245
摘要： Numerous diseases have been linked to the production of effector cells. The present invention relates to the realization that effector cells are cycling in these diseases. In addition, the present invention relates to the determination that regulator cells are cycling in degenerative diseases. Based on these realizations, the present invention provides methods for treating conditions such as autoimmune diseases, degenerative diseases, and graft-versus-host disease. The present invention also relates to methods of determining when therapy should be administered to a patient.
摘要翻译：许多疾病与效应细胞的产生有关。本发明涉及在这些疾病中效应细胞循环的认识。此外，本发明涉及调节细胞在退行性疾病中循环的测定。基于这些实现，本发明提供了治疗诸如自身免疫疾病，退行性疾病和移植物抗宿主病之类疾病的方法。本发明还涉及确定何时应当向患者施用治疗的方法。

2. 发明申请

US20120220640A1 METHODS OF TREATING DISEASES 有权
标题翻译：治疗疾病的方法
公开(公告)号：US20120220640A1
公开(公告)日：2012-08-30
申请号：US13322357
申请日：2010-05-27
申请人： Martin Leonard Ashdown , Andrew Robinson
发明人： Martin Leonard Ashdown , Andrew Robinson
IPC分类号： A61K31/4188 , G06F19/00 , A61B5/145 , A61P35/00
CPC分类号： G06F19/12 , A61B5/41 , A61B5/413 , A61B5/4836 , A61B5/7267 , A61K31/495 , G01N33/564 , G01N33/57407 , G01N33/68 , G01N2333/4737 , G01N2800/042 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/28 , G01N2800/2821 , G01N2800/2828 , G01N2800/52 , G01N2800/60 , G06F19/00 , G06F19/24 , G06F19/34 , G16H50/50
摘要： The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.
摘要翻译：本发明涉及用于分析在受试者中循环的生物标志物的计算机实现的方法和系统。在一些其它方面，本发明涉及分析生物标志物，其在治疗疾病之后至少最初增加或减少受试者的量。在其它方面，本发明涉及用于确定施用治疗以治疗受试者的疾病的优选时间的计算机实现的方法和系统。本发明还涉及实现该方法的计算机程序产品。此外，本发明涉及确定在免疫系统循环的受试者中治疗疾病的时机的方法。

3. 发明授权

US09122778B2 Methods of treating diseases 有权
标题翻译：治疗疾病的方法
公开(公告)号：US09122778B2
公开(公告)日：2015-09-01
申请号：US13322357
申请日：2010-05-27
申请人： Martin Leonard Ashdown , Andrew Robinson
发明人： Martin Leonard Ashdown , Andrew Robinson
IPC分类号： G01N33/48 , G06F19/00 , G01N33/564 , G01N33/574 , A61B5/00 , G06F19/24 , G06F19/12
CPC分类号： G06F19/12 , A61B5/41 , A61B5/413 , A61B5/4836 , A61B5/7267 , A61K31/495 , G01N33/564 , G01N33/57407 , G01N33/68 , G01N2333/4737 , G01N2800/042 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/28 , G01N2800/2821 , G01N2800/2828 , G01N2800/52 , G01N2800/60 , G06F19/00 , G06F19/24 , G06F19/34 , G16H50/50
摘要： The present invention relates to computer-implemented methods and system for analyzing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analyzing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.
摘要翻译：本发明涉及用于分析在受试者中循环的生物标志物的计算机实现的方法和系统。在一些其它方面，本发明涉及分析生物标志物，其在治疗疾病之后至少最初增加或减少受试者的量。在其它方面，本发明涉及用于确定施用治疗以治疗受试者的疾病的优选时间的计算机实现的方法和系统。本发明还涉及实现该方法的计算机程序产品。此外，本发明涉及确定在免疫系统循环的受试者中治疗疾病的时机的方法。

4. 发明授权

US08524651B2 Method of therapy 有权
标题翻译：治疗方法
公开(公告)号：US08524651B2
公开(公告)日：2013-09-03
申请号：US13396254
申请日：2012-02-14
申请人： Martin Leonard Ashdown
发明人： Martin Leonard Ashdown
IPC分类号： A01N61/00
CPC分类号： G01N33/56972 , A61K31/282 , A61K31/513 , G01N33/543 , G01N33/56988 , G01N33/574 , G01N33/57407 , G01N33/57446 , G01N33/57449 , G01N33/57484 , G01N2333/4737 , G06F19/00
摘要： Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases. Based on these observations, the present invention provides methods for treating diseases such as cancer and a HIV infection. The present invention also relates to methods of determining when a therapy to treat a disease characterized by the production of regulator cells should be administered to a patient.
摘要翻译：许多疾病与调节细胞的产生有关。本发明涉及免疫系统在这些疾病中循环的观察。基于这些观察，本发明提供了治疗诸如癌症和HIV感染之类疾病的方法。本发明还涉及确定何时将治疗以治疗细胞产生为特征的疾病的治疗施用于患者的方法。

5. 发明授权

US06642012B1 Spectroscopic determination of characteristic of biological material 失效
标题翻译：生物材料特性的光谱测定
公开(公告)号：US06642012B1
公开(公告)日：2003-11-04
申请号：US09125837
申请日：1998-08-26
申请人： Martin Leonard Ashdown
发明人： Martin Leonard Ashdown
IPC分类号： G12Q102
CPC分类号： G01N21/35 , Y10S436/805
摘要： Method for determining a cellular function or change in cellular function by contacting a sample of cells or a component of cells with an activating agent, directing a beam of infrared light at the sample of cells or a component of the cells, analyzing the infrared spectrum of the sample at at least one range of frequencies and ascertaining whether at least one change in the spectral characteristics has occurred due to activation of the cells or a change in the cellular component, that can be correlated to the cellular function or the change in cellular function by the activating agent and determining the cellular function therefrom.
摘要翻译：通过使细胞样品或细胞成分与活化剂接触来确定细胞功能或细胞功能变化的方法，在细胞样品或细胞成分上引导红外光束，分析红细胞光谱的红外光谱在至少一个频率范围内的样本，并且确定由于细胞的激活或细胞成分的变化是否已经发生了光谱特性的至少一个变化，其可以与细胞功能或细胞功能的变化相关并通过活化剂测定细胞功能。

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