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1. 发明申请

US20090227006A1 Apparatus for Performing Nucleic Acid Analysis 审中-公开
标题翻译：用于进行核酸分析的装置
公开(公告)号：US20090227006A1
公开(公告)日：2009-09-10
申请号：US12373276
申请日：2007-07-05
申请人： Martin Kopp , Hans-Peter Wahl , Emad Sarofim , Oliver Elsenhans , Goran Savatic , Roland Christof Hutter
发明人： Martin Kopp , Hans-Peter Wahl , Emad Sarofim , Oliver Elsenhans , Goran Savatic , Roland Christof Hutter
IPC分类号： C12M1/00
CPC分类号： B01L3/502715 , G01N35/0099 , G01N2035/00346
摘要： The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55) comprises workstations (17, 40) for receiving, holding and processing such integrated disposable devices (1), a reagents station (56) for reagents (25), transfer means (36) for performing movements of an actuator, fluid actuation means for processing the sample (32) and reagents in said disposable devices (1), temperature control means (37) for heating or cooling, detection means for measuring a property of the processed samples (32), and control means for controlling the sample (32) preparation, the handling of the disposable devices (1) and the sample analysis performed by the apparatus (55).
摘要翻译：本发明的实施例涉及一种自动装置（55），其被设计用于执行核酸分析，任选地包括样品制备，具有集成的一次性样品保持和处理装置（1），所述装置（1）包括样品用装置（55）进行分析。装置（55）包括用于接收，保持和处理这种集成的一次性装置（1），用于试剂（25）的试剂台（56），用于执行致动器的运动的传送装置（36）用于处理所述一次性装置（1）中的样品（32）和试剂的流体致动装置，用于加热或冷却的温度控制装置（37），用于测量经处理样品（32）的性质的检测装置，以及用于控制样品（32）制备，一次性装置（1）的处理和由装置（55）进行的样品分析。

2. 发明授权

US08642293B2 Disposable device for analyzing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus 有权
标题翻译：用于使用核酸扩增装置分析含有核酸的液体样品的一次性装置
公开(公告)号：US08642293B2
公开(公告)日：2014-02-04
申请号：US12373517
申请日：2007-07-05
申请人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
发明人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
IPC分类号： C12P19/34 , C12M1/00 , C12Q1/68
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/10 , B01L2300/0809
摘要： The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44). The device (1) comprises a rigid body (42) and at least one channel (44), the binding chamber (15) and the amplification chamber (16) are situated on side-surfaces (50) of the body (42), each of those side-surfaces (50), on which a channel (44), the binding chamber (15) or the amplification chamber (16) is situated, is covered by at least one wall (41) and these side-surfaces (50) are substantially vertical planes when the device (1) is operated in the nucleic acid amplification apparatus.
摘要翻译：本发明涉及一种一次性样品保持和处理装置（1），其尺寸适于在用于通过核酸扩增技术分析含有核酸的液体样品的核酸扩增装置中操作。设备（1）包括设计成执行在装置（1）内捕获，扩增和检测核酸以及任选还有裂解室（3）的步骤的室（15,16）和通道（44）。装订室（15）包含用于固定待分析样品的组分的固相（14），并且扩散室（16）通过流体通道（44）连接到装订室（15）。装置（1）包括刚体（42）和至少一个通道（44），装订室（15）和放大室（16）位于主体（42）的侧表面（50）上，其中通道（44），装订室（15）或放大室（16）所在的那些侧表面（50）中的每一个被至少一个壁（41）和这些侧表面 50）在装置（1）在核酸扩增装置中操作时是基本垂直的平面。

3. 发明申请

US20100003683A1 Disposable Device for Analyzing a Liquid Sample Containing a Nucleic Acid With a Nucleic Acid Amplification Apparatus 有权
标题翻译：用于分析含核酸扩增装置的含有核酸的液体样品的一次性装置
公开(公告)号：US20100003683A1
公开(公告)日：2010-01-07
申请号：US12373517
申请日：2007-07-05
申请人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
发明人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/10 , B01L2300/0809
摘要： The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44). The device (1) comprises a rigid body (42) and at least one channel (44), the binding chamber (15) and the amplification chamber (16) are situated on side-surfaces (50) of the body (42), each of those side-surfaces (50), on which a channel (44), the binding chamber (15) or the amplification chamber (16) is situated, is covered by at least one wall (41) and these side-surfaces (50) are substantially vertical planes when the device (1) is operated in the nucleic acid amplification apparatus.
摘要翻译：本发明涉及一种一次性样品保持和处理装置（1），其尺寸适于在用于通过核酸扩增技术分析含有核酸的液体样品的核酸扩增装置中操作。设备（1）包括设计成执行在装置（1）内捕获，扩增和检测核酸以及任选还有裂解室（3）的步骤的室（15,16）和通道（44）。装订室（15）包含用于固定待分析样品的组分的固相（14），并且扩散室（16）通过流体通道（44）连接到装订室（15）。装置（1）包括刚体（42）和至少一个通道（44），装订室（15）和放大室（16）位于主体（42）的侧表面（50）上，其中通道（44），装订室（15）或放大室（16）所在的那些侧表面（50）中的每一个被至少一个壁（41）和这些侧表面 50）在装置（1）在核酸扩增装置中操作时是基本垂直的平面。

4. 发明授权

US09316656B2 Lid separation device and methods 有权
标题翻译：盖分离装置及方法
公开(公告)号：US09316656B2
公开(公告)日：2016-04-19
申请号：US12617611
申请日：2009-11-12
申请人： Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
发明人： Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
IPC分类号： B01L3/00 , G01N35/04 , G01N21/03 , G01N21/07 , G01N21/25
CPC分类号： G01N35/04 , B01L3/5025 , B01L2200/026 , B01L2300/048 , B01L2300/069 , B01L2300/0829 , B01L2300/0858 , B01L2400/0409 , G01N21/03 , G01N21/07 , G01N21/253 , G01N2021/0328 , G01N2035/0449
摘要： The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.
摘要翻译：本发明包括一种包括盖和容器的装置，其形成允许将废物从净化室转移到废物室的界面和用于净化分析物的方法，其中将上清液与固相分离，分析物通过装置的盖子离心而结合。本发明还包括使用该装置的方法。

5. 发明申请

US20120088227A1 Devices and Process for Separating Plasma From a Blood Sample 审中-公开
标题翻译：从血液样品中分离血浆的装置和方法
公开(公告)号：US20120088227A1
公开(公告)日：2012-04-12
申请号：US13082646
申请日：2011-04-08
申请人： Tomas Gruebl , Michael Heinrich , Roger Sandoz , Emad Sarofim , Hans-Peter Wahl
发明人： Tomas Gruebl , Michael Heinrich , Roger Sandoz , Emad Sarofim , Hans-Peter Wahl
IPC分类号： B01D43/00 , C12Q1/70
CPC分类号： G01N33/491 , B01L3/5023 , B01L2200/028 , B01L2300/043 , B01L2300/0681 , B01L2300/069 , B01L2400/0406
摘要： The present invention pertains to a device for separating plasma from a blood sample comprising a stacked structure which is provided with a first portion including a separating member having a first surface for applying or receiving the blood sample, wherein the separating member is adapted to permit the passage of plasma but to inhibit the passage of cells, and a second portion including an absorptive member for absorbing the plasma, which has a second surface in contact with the separating member for receiving the plasma, wherein the absorptive member is adapted to generate a capillary pressure so as to draw plasma from the separating member to the absorptive member. The first portion is fixed to the backing member in a manner to be removed without destroying the absorptive member. The absorptive member is fixed to the backing member in a manner to be removed without destroying the absorptive member.
摘要翻译：本发明涉及一种用于从血液样品分离血浆的装置，包括层叠结构，该层叠结构设置有包括具有用于施加或接收血液样本的第一表面的分离构件的第一部分，其中分离构件适于允许等离子体通过，但是抑制细胞通过，第二部分包括用于吸收等离子体的吸收部件，该第二部分具有与用于接收等离子体的分离部件接触的第二表面，其中吸收部件适于产生毛细管压力以将等离子体从分离构件吸入吸收构件。第一部分以不被破坏吸收构件的方式被移除而固定到背衬构件上。吸收构件以不会破坏吸收构件的方式被移除而固定到背衬构件上。

6. 发明申请

US20100120599A1 Lid Separation Device and Methods 有权
标题翻译：盖分离装置及方法
公开(公告)号：US20100120599A1
公开(公告)日：2010-05-13
申请号：US12617611
申请日：2009-11-12
申请人： Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
发明人： Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
IPC分类号： G01N1/34 , B01D21/26 , G01N33/53 , B01L3/00
CPC分类号： G01N35/04 , B01L3/5025 , B01L2200/026 , B01L2300/048 , B01L2300/069 , B01L2300/0829 , B01L2300/0858 , B01L2400/0409 , G01N21/03 , G01N21/07 , G01N21/253 , G01N2021/0328 , G01N2035/0449
摘要： The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.
摘要翻译：本发明包括一种包括盖和容器的装置，其形成允许将废物从净化室转移到废物室的界面和用于净化分析物的方法，其中将上清液与固相分离，分析物通过装置的盖子离心而结合。本发明还包括使用该装置的方法。

7. 发明授权

US08961901B2 Microfluidic system and coating method therefor 有权
标题翻译：微流体系及其涂布方法
公开(公告)号：US08961901B2
公开(公告)日：2015-02-24
申请号：US11828959
申请日：2007-07-26
申请人： Michael Glauser , Hans-Peter Wahl , Irio Giuseppe Calasso , Emad Sarofim
发明人： Michael Glauser , Hans-Peter Wahl , Irio Giuseppe Calasso , Emad Sarofim
IPC分类号： B01L3/00 , A61B5/15 , A61B5/145
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15105 , A61B5/15142 , A61B2562/0295 , B01L3/502707 , B01L2300/0825 , B01L2300/161 , B01L2300/163 , B01L2400/0406 , Y10T436/2575
摘要： A microfluidic system having a microchannel for the capillary transport of a liquid, in particular a body fluid for analytical purposes. The microchannel is provided with a surface coating comprising at least one hydrophilic substance selected from the group consisting of polyacrylic acid, polyacrylate, dextran sulfate and chondroitin sulfate. The invention also concerns a coating method that is suitable for this.
摘要翻译：一种微流体系统，具有用于毛细管理液体的微通道，特别是用于分析目的的体液。微通道设置有包含至少一种选自聚丙烯酸，聚丙烯酸酯，硫酸葡聚糖和硫酸软骨素的亲水性物质的表面涂层。本发明还涉及适合于此的涂布方法。

8. 发明申请

US20100163493A1 Method and Device Employing Centrifugal Force 有权
标题翻译：采用离心力的方法和装置
公开(公告)号：US20100163493A1
公开(公告)日：2010-07-01
申请号：US12617530
申请日：2009-11-12
申请人： Heinz Michael Hein , Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
发明人： Heinz Michael Hein , Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
IPC分类号： B03C1/30
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , Y10T436/111666
摘要： The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.
摘要翻译：本发明包括容器和使用离心力分离一个或多个与磁性颗粒结合的组分的方法。

9. 发明申请

US20080056947A1 MICROFLUIDIC SYSTEM AND COATING METHOD THEREFOR 有权
标题翻译：微流控系统及其涂层方法
公开(公告)号：US20080056947A1
公开(公告)日：2008-03-06
申请号：US11828959
申请日：2007-07-26
申请人： Michael Glauser , Hans-Peter Wahl , Irio Calasso , Emad Sarofim
发明人： Michael Glauser , Hans-Peter Wahl , Irio Calasso , Emad Sarofim
IPC分类号： B01J19/00 , B05D1/02 , B05D3/00 , B05D3/04 , B05D7/22
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15105 , A61B5/15142 , A61B2562/0295 , B01L3/502707 , B01L2300/0825 , B01L2300/161 , B01L2300/163 , B01L2400/0406 , Y10T436/2575
摘要： A microfluidic system having a microchannel for the capillary transport of a liquid, in particular a body fluid for analytical purposes. The microchannel is provided with a surface coating comprising at least one hydrophilic substance selected from the group consisting of polyacrylic acid, polyacrylate, dextran sulfate and chondroitin sulfate. The invention also concerns a coating method that is suitable for this.
摘要翻译：一种微流体系统，具有用于毛细管理液体的微通道，特别是用于分析目的的体液。微通道设置有包含至少一种选自聚丙烯酸，聚丙烯酸酯，硫酸葡聚糖和硫酸软骨素的亲水性物质的表面涂层。本发明还涉及适合于此的涂布方法。

10. 发明授权

US08313652B2 Method and device employing centrifugal force 有权
标题翻译：采用离心力的方法和装置
公开(公告)号：US08313652B2
公开(公告)日：2012-11-20
申请号：US12617530
申请日：2009-11-12
申请人： Heinz Michael Hein , Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
发明人： Heinz Michael Hein , Emad Sarofim , Lotar Schenk , Hans-Peter Wahl
IPC分类号： B03C1/01
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , Y10T436/111666
摘要： The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.
摘要翻译：本发明包括容器和使用离心力分离一个或多个与磁性颗粒结合的组分的方法。

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