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1. 发明申请

US20090304604A1 PULMONARY DELIVERY OF ALPHA-1 PROTEINASE INHIBITOR 审中-公开
标题翻译： ALPHA-1蛋白酶抑制剂的脉冲递送
公开(公告)号：US20090304604A1
公开(公告)日：2009-12-10
申请号：US12278767
申请日：2007-02-08
申请人： Shabtai Bauer , Manfred Keller , Martin Knoch
发明人： Shabtai Bauer , Manfred Keller , Martin Knoch
IPC分类号： A61K9/12 , A61M11/00
CPC分类号： A61K38/57 , A61K9/0078
摘要： The present invention relates to a system that includes a pharmaceutical composition of a purified, stable, active alpha-1 proteinase inhibitor (API) in a form of a ready to use sterile solution and an inhalation nebulizer, and to methods of use thereof for treating pulmonary diseases.
摘要翻译：本发明涉及一种系统，其包括以即用型无菌溶液形式的纯化，稳定的活性α-1蛋白酶抑制剂（API）和吸入式雾化器的药物组合物及其用于治疗肺部疾病

2. 发明授权

US06679251B1 Actuating device for meters and metering aerosol dispensing device with an actuating device for meters 失效
标题翻译：用于仪表和计量气雾剂分配装置的致动装置，具有用于仪表的致动装置
公开(公告)号：US06679251B1
公开(公告)日：2004-01-20
申请号：US09807104
申请日：2001-08-10
申请人： Thomas Gallem , Kevin Stapleton , Martin Knoch
发明人： Thomas Gallem , Kevin Stapleton , Martin Knoch
IPC分类号： A61M1100
CPC分类号： A61M15/009 , A61M15/0068 , A61M15/0075 , A61M15/0081 , G06M1/041 , G06M1/083 , G06M1/16
摘要： Metering aerosol dispensing device comprising an aerosol container (23); a nozzle (31, 32) that is arranged in a nozzle body (30), whereby the aerosol is dispensed via said nozzle when the aerosol container (23) is pushed against the body (30) of the nozzle once the metering aerosol dispensing device is actuated; a meter (1, 2, 4) that counts the number of times that the metering aerosol dispensing device is actuated; and an actuating device (10) that enables the meter (1, 2, 3, 4) to move forward when the metering aerosol dispensing device is actuated. The invention is characterized in that the actuating device (10) is designed and arranged in the metering aerosol dispensing device in such a way that the body (30) of the nozzle is accomodated in the interior of the actuating device (10) and the nozzle (31) is released in order to produce aerosol in an unrestricted manner.
摘要翻译：计量气溶胶分配装置，包括气溶胶容器（23）; 布置在喷嘴主体（30）中的喷嘴（31,32），其中当气雾剂容器（23）被推向喷嘴的主体（30）时，一旦计量气雾剂分配装置被启动对计量气雾剂分配装置的次数进行计数的计量器（1,2,4）; 以及致动装置（10），其使得当计量气雾剂分配装置被致动时，仪表（1,2,3,4）能够向前移动。本发明的特征在于，致动装置（10）被设计和布置在计量气雾剂分配装置中，使得喷嘴的主体（30）容纳在致动装置（10）的内部并且喷嘴（31）被释放以便以无限制的方式产生气溶胶。

3. 发明授权

US06606990B2 Mouth piece for inhalation therapy units 有权
标题翻译：用于吸入治疗单元的口腔
公开(公告)号：US06606990B2
公开(公告)日：2003-08-19
申请号：US09223452
申请日：1998-12-30
申请人： Kevin Stapleton , Robert Waldner , Thomas Gallem , Martin Knoch
发明人： Kevin Stapleton , Robert Waldner , Thomas Gallem , Martin Knoch
IPC分类号： A61M1100
CPC分类号： A61M16/208 , A61M15/0018 , A61M16/049
摘要： The invention describes a mouthpiece for an inhalation therapy unit wherein an aerosol for inhalation is prepared for a patient, said mouthpiece comprising a substantially tubular base (1), in the wall of which an orifice (2) is formed, and a flat, elastic valve member (3), which is adapted in dimension and shape to the orifice (2) for the closing thereof and which is secured to the mouthpiece in such a manner that during an inspiration process through the mouthpiece the orifice (2) is closed and during an expiration process directed into the mouthpiece the orifice (2) is opened. According to the invention, at least one enlarged contact surface (6, 8, 11, 13, 15, 16) is provided at the orifice (2) for the accumulation and holding of an amount of liquid by adhesion. This contact surface is established both by an outwardly directed collar (6, 8, 11) surrounding the orifice and by a narrow bar (13, 15, 16) which extends into the orifice (2) for example transversely through the center of the orifice in longitudinal direction of the mouthpiece or transversely across the mouthpiece.
摘要翻译：本发明描述了一种用于吸入治疗单元的吸口，其中为患者制备用于吸入的气雾剂，所述吸嘴包括基本上管状的基部（1），其壁中形成有孔（2），并且具有平坦的弹性阀构件（3），其尺寸和形状适于孔口（2）以关闭，并且以这样的方式固定到接口管，使得在通过接口口的吸气过程中孔口（2）关闭，并且在引导到接口管的呼气过程中，孔（2）打开。根据本发明，在孔口（2）处提供至少一个放大的接触表面（6,8,11,13,15,16），用于通过粘附积聚和保持一定量的液体。该接触表面由围绕孔口的向外指向的环（6,8,11）和延伸到孔（2）中的窄条（13,15,16）构成，例如横向穿过孔的中心在吹嘴的纵向方向上或横向穿过接口管。

4. 发明授权

US5461695A Nebulizing assembly with heating equipment 失效
标题翻译：带加热设备的雾化装配
公开(公告)号：US5461695A
公开(公告)日：1995-10-24
申请号：US97053
申请日：1993-07-27
申请人： Martin Knoch
发明人： Martin Knoch
IPC分类号： A61M13/00 , A61M11/00 , A61M11/04 , A61M11/06 , A61M15/00 , A61M16/10 , A61M16/12 , B05B7/00 , B05B7/16 , H05B3/14 , F24F6/14
CPC分类号： A61M11/06 , A61M11/002 , A61M11/042 , A61M16/1075 , A61M16/125 , B05B7/0012 , B05B7/168 , H05B3/14
摘要： An assembly for nebulizing, distributing and mixing liquid or powdered substances via a flow of compressed air, produces aerosols for inhalation purposes, with a nebulizing nozzle in a nebulizing chamber into which a supply chimney (21) extends so that air can enter. There is a heating assembly (30) in the supply chimney which warms the incoming air. Thus, the cooling effect which occurs during nebulization can be eliminated and an aerosol at a suitable temperature is delivered.
摘要翻译：用于通过压缩空气流雾化，分配和混合液体或粉末物质的组件产生用于吸入目的的气溶胶，雾化喷嘴在雾化室中，供应烟囱（21）延伸进入空气，使得空气能够进入。供应烟囱中有一个加热组件（30），用于加热进入的空气。因此，可以消除在雾化期间发生的冷却效果，并且输送在合适温度下的气溶胶。

5. 外观设计

USD603410S1 Chip card 有权
标题翻译：芯片卡
公开(公告)号：USD603410S1
公开(公告)日：2009-11-03
申请号：US29322452
申请日：2008-08-05
申请人： Martin Knoch
设计人： Martin Knoch

6. 外观设计

USD574384S1 Chip card 有权
标题翻译：芯片卡
公开(公告)号：USD574384S1
公开(公告)日：2008-08-05
申请号：US29267950
申请日：2006-10-26
申请人： Martin Knoch
设计人： Martin Knoch

7. 发明申请

US20060054166A1 Inhalation nebulizer 审中-公开
标题翻译：吸入雾化器
公开(公告)号：US20060054166A1
公开(公告)日：2006-03-16
申请号：US11269783
申请日：2005-11-07
申请人： Martin Knoch , Manfred Keller , Roland Stangl , Thomas Gallem , Rainer Liening-Ewert , Markus Urich
发明人： Martin Knoch , Manfred Keller , Roland Stangl , Thomas Gallem , Rainer Liening-Ewert , Markus Urich
IPC分类号： A61M11/00 , B05B17/06
CPC分类号： B05B17/0646 , A61M15/0015 , A61M15/0018 , A61M15/0085
摘要： An inhalation nebulizer includes an aerosol generator that has a diaphragm vibrated by a vibration generator. The inhalation nebulizer includes a liquid storage container that is in fluid contact with the diaphragm. A liquid contained in the storage container is atomized into a mixing chamber through openings in the diaphragm and can subsequently be inhaled by a patient.
摘要翻译：吸入雾化器包括具有由振动发生器振动的隔膜的气溶胶发生器。吸入雾化器包括与隔膜流体接触的液体储存容器。容纳在储存容器中的液体通过隔膜中的开口被雾化成混合室，并且可随后被患者吸入。

8. 发明授权

US06481438B1 Meter 失效
标题翻译：仪表
公开(公告)号：US06481438B1
公开(公告)日：2002-11-19
申请号：US09807091
申请日：2001-10-22
申请人： Thomas Gallem , Kevin Stapleton , Martin Knoch
发明人： Thomas Gallem , Kevin Stapleton , Martin Knoch
IPC分类号： A62B700
CPC分类号： A61M15/009 , A61M15/0068 , A61M15/0075 , A61M15/0081 , G06M1/041 , G06M1/083 , G06M1/16
摘要： The present invention relates to a meter, especially a meter for metering aerosol devices, basically consisting of four disk units that are arranged in a parallel position and located on the same axis.
摘要翻译：本发明涉及一种计量器，特别是一种用于测量气溶胶装置的仪表，其基本上由布置在平行位置并位于同一轴线上的四个圆盘单元组成。

9. 外观设计

USD483860S1 Electronic inhaler and control unit 失效
标题翻译：电子吸入器和控制单元
公开(公告)号：USD483860S1
公开(公告)日：2003-12-16
申请号：US29170808
申请日：2002-11-12
申请人： Martin Knoch
设计人： Martin Knoch

10. 发明授权

US06228346B1 Propellant mixtures and aerosols for micronizing medicaments with compressed gas 失效
标题翻译：用于将压缩气体微粒化的推进剂混合物和气溶胶
公开(公告)号：US06228346B1
公开(公告)日：2001-05-08
申请号：US09171695
申请日：1998-12-09
申请人： Zhengfeng Zhang , Martin Knoch
发明人： Zhengfeng Zhang , Martin Knoch
IPC分类号： A61L904
CPC分类号： A61K9/008 , A61K9/124
摘要： Propellant mixtures and medicament aerosols which contain them are described for micronizing medicaments for pulmonary use. The propellant mixture is in a subcritical state and contains at least one component from a first class of propellant gasses and at least one component from a second class of propellant gasses. The first class includes propellant gasses with an evaporation enthalpy of 200 kJ/kg or less at 25° C. and a vapor pressure of 20 bars or more at 25° C., and the second class includes propellant gasses with an evaporation enthalpy of 300 kJ/kg or more at 25° C. and a vapor pressure of 10 bars or less at 25° C. By using this propellant mixture in a medicament aerosol, micronized medicaments are obtained in which approximately 80% by weight of the generated particles have less than 8 &mgr;m diameter.
摘要翻译：描述含有它们的推进剂混合物和药物气溶胶用于微粉化用于肺部使用的药物。推进剂混合物处于亚临界状态，并且包含来自第一类推进剂气体的至少一种组分和来自第二类推进剂气体的至少一种组分。第一类包括在25℃下蒸发焓为200kJ / kg或更低的推进剂气体，在25℃下蒸气压为20巴或更高，第二类包括蒸发焓为300的推进剂气体 25℃下的kJ / kg以上，25℃下10巴以下的蒸汽压。通过在药物气溶胶中使用该推进剂混合物，可获得微粉化药物，其中约80重量％的所产生的颗粒具有小于8毫米直径。

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