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1. 发明授权

US07329330B2 Method and device for the distillative processing of 1,6-hexanediol, 1,5-pentanediol and caprolactone 有权
标题翻译： 1,6-己二醇，1,5-戊二醇和己内酯的蒸馏加工方法和装置
公开(公告)号：US07329330B2
公开(公告)日：2008-02-12
申请号：US10451738
申请日：2002-01-08
申请人： Martin Gall , Gerd Kaibel , Thomas Krug , Harald Rust , Frank Stein
发明人： Martin Gall , Gerd Kaibel , Thomas Krug , Harald Rust , Frank Stein
IPC分类号： B01D3/14 , B01D3/42 , C07C29/80
CPC分类号： C07D315/00 , B01D3/14 , B01D3/141 , C07C29/80 , Y10S203/20 , C07C31/26 , C07C31/20
摘要： A process for working up by distillation the crude products obtained in the process according to DE-A 196 07 954 and containing 1,6-hexanediol (HDO), 1,5-pentanediol (PDO) or caprolactone (CLO) in order to obtain the corresponding pure products, the working-up by distillation being carried out in each case in a dividing wall column (TK) in which a dividing wall (T) is arranged in the longitudinal direction of the column with formation of an upper common column region (1), a lower common column region (6), a feed section (2, 4) having a rectification section (2) and stripping section (4), and a take-off section (3, 5) having a stripping section (3) and rectification section (5), with feeding of the respective crude product HDO, PLO or CLO in the middle region of the feed section (2, 4) and removal of the high boiler fraction (C) from the bottom of the column, of the low boiler fraction (A) via the top of the column and of the medium boiler fraction (B) from the middle region of the take-off section (3, 5), or in thermally coupled columns.
摘要翻译：通过蒸馏处理根据DE-A 196 07954的方法获得的含有1,6-己二醇（HDO），1,5-戊二醇（PDO）或己内酯（CLO）的粗产物的方法，以获得相应的纯产品，在各种情况下在分隔壁塔（TK）中进行蒸馏处理，其中分隔壁（T）沿塔的纵向方向排列，形成上共同区域（1），较低的公共列区域（6），具有整流部分（2）和汽提部分（4）的进料部分（2,4）和具有汽提部分的取出部分（3,5）（3）和整流部分（5），在进料部分（2,4）的中间区域供给相应的粗产物HDO，PLO或CLO，并将高沸点馏分（C）从底部通过塔顶和中间锅炉馏分（B）从中间排出低沸点馏分（A）起飞段（3,5）的区域，或热耦合柱。

2. 发明授权

US06288286B1 Method for producing hexanediol-1,6 失效
标题翻译：己二醇-1,6-
公开(公告)号：US06288286B1
公开(公告)日：2001-09-11
申请号：US09700366
申请日：2000-11-15
申请人： Frank Stein , Thomas Krug , Martin Gall , Gabriele Iffland
发明人： Frank Stein , Thomas Krug , Martin Gall , Gabriele Iffland
IPC分类号： C07C2700
CPC分类号： C07C29/149 , C07C2601/14 , C07C31/20 , C07C35/08
摘要： A process for preparing 1,6-hexanediol from a carboxylic acid mixture obtained as by-product in the oxidation of cyclohexane to cyclohexanone/cyclohexanol with oxygen or oxygen-comprising gases and by aqueous extraction of the reaction mixture and comprising adipic acid, 6-hydroxycaproic acid and small amounts of 1,4-cyclohexanediols by esterification of the acids and hydrogenation, by a) reacting the mono- and dicarboxylic acids in the aqueous dicarboxylic acid mixture with a low molecular weight alcohol to form the corresponding carboxylic esters, b) conducting a first distillation to remove excess alcohol and low boilers from the esterification mixture obtained, c) conducting a second distillation to separate the bottom product into an ester fraction which is essentially free from 1,4-cyclohexanediols and a fraction which includes at least the larger proportion of the 1,4-cyclohexanediols, d) subjecting the ester fraction essentially free from 1,4-cyclohexanediols to a catalytic hydrogenation, and e) subjecting the hydrogenation effluent to a distillation to recover 1,6-hexanediol in a conventional manner, comprises using an aqueous dicarboxylic acid mixture comprising more than 20 ppm of cobalt and more than 40 ppm of phosphorus in the form of phosphate and passing this aqueous dicarboxylic acid mixture through a cation exchanger and after the esterification of step (a) through an anion exchanger.
摘要翻译：从环己烷氧化成环己酮/环己醇与氧气或含氧气体的副产物得到的羧酸混合物中制备1,6-己二醇的方法，并通过水提取反应混合物，并包含己二酸，6- 羟基己酸和少量的1,4-环己烷二醇通过酸的酯化和氢化，a）使二羧酸二羧酸混合物与低分子量醇反应形成相应的羧酸酯，b）导电从所得到的酯化混合物中除去多余的醇和低沸点物的第一次蒸馏，c）进行第二次蒸馏以将底部产物分离成基本上不含1,4-环己烷二醇的酯馏分和至少包括较大的 1,4-环己烷二醇的比例，d）将基本上不含1,4-环己烷二醇的酯馏分进行催化水解国家和地区）使氢化流出物以常规方式进行蒸馏以回收1,6-己二醇，包括使用包含大于20ppm钴的多余二羧酸混合物和大于40ppm磷酸盐形式的磷，使该含水二羧酸混合物通过阳离子交换剂，并且在步骤（a）通过阴离子交换剂酯化之后。

3. 发明授权

US07026342B2 Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds 失效
标题翻译：使用噻唑，恶唑和咪唑化合物治疗纤维化疾病或其他适应症的方法
公开(公告)号：US07026342B2
公开(公告)日：2006-04-11
申请号：US10852859
申请日：2004-05-24
申请人： Dilip Wagle , Martin Gall , Stanley C. Bell , Edmond J. LaVoie
发明人： Dilip Wagle , Martin Gall , Stanley C. Bell , Edmond J. LaVoie
IPC分类号： A61K31/425 , A61K31/42
CPC分类号： A61K31/4164 , A61K31/41 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/535 , A61K31/5377 , A61K31/541 , C07D277/46 , C07D277/82 , C07D417/12
摘要： Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.
摘要翻译：本发明提供了一种治疗或改善动物（包括人）中许多适应症的方法，包括施用有效量的式I或IA化合物，其中J为氧，硫或NR d， SUP>。

4. 发明授权

US6078534A Semiconductor memory having redundancy circuit 失效
标题翻译：具有冗余电路的半导体存储器
公开(公告)号：US6078534A
公开(公告)日：2000-06-20
申请号：US937570
申请日：1997-09-25
申请人： Karl-Peter Pfefferl , Martin Gall
发明人： Karl-Peter Pfefferl , Martin Gall
IPC分类号： G11C29/04 , G11C29/00 , G11C7/00
CPC分类号： G11C29/789 , G11C29/80
摘要： A memory having an array of memory cells. The array includes a plurality of normal memory cells and a redundant memory cell. A decoder is provided for selecting an addressed one of the normal memory cells in response to an address and a normal condition signal and adapted address the redundant memory cell in response to the address and a fault condition signal. A redundant decoder is provided having an electronically erasable read-only-memory cell. The redundant decoder is adapted to produce the normal condition signal and to convert the normal condition signal into the fault condition signal when such read-only-memory cell is programmed into a fault condition. Each one of the read-only memory cells include a flash memory cell, a ferroelectric memory cell, or other such type of electronically erasable read-only memory cell which is substantially non-volatile and is able to retain its programmed state for a relatively long period of time. With such an arrangement, because the electronically erasable read-only-memory cell is electronically programmable, a defective normal memory cell may be replaced with a redundant memory cell the memory is packaged.
摘要翻译：具有存储器单元阵列的存储器。阵列包括多个正常存储器单元和冗余存储单元。提供了一种解码器，用于响应于地址和正常条件信号选择正常存储器单元中的寻址的一个，并响应于该地址和故障状态信号对该冗余存储器单元进行了适配地址。提供了具有电可擦除只读存储器单元的冗余解码器。当这种只读存储器单元被编程到故障状态时，冗余解码器适于产生正常条件信号并将正常条件信号转换成故障条件信号。只读存储器单元中的每一个包括快闪存储器单元，铁电存储器单元或其他这种类型的电可擦除只读存储器单元，其基本上是非易失性的并且能够将其编程状态保持相对较长一段的时间。通过这样的布置，由于电子可擦除只读存储器单元是可电子编程的，所以可以用存储器封装的冗余存储器单元替换有缺陷的正常存储单元。

5. 发明授权

US4408049A Substituted piperazinyl-1,2,4-triazoles 失效
标题翻译：取代的哌嗪基-1,2,4-三唑
公开(公告)号：US4408049A
公开(公告)日：1983-10-04
申请号：US362445
申请日：1982-03-26
申请人： Martin Gall
发明人： Martin Gall
IPC分类号： C07D233/54 , C07D249/08 , C07D249/12 , C07D521/00 , C07D401/00 , A61K31/41 , C07D403/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07D249/12
摘要： The present invention provides certain substituted-piperazinyl-1,2,4-triazoles which are useful for the treatment of sensitized humans for allergies and anaphylactic reactions.
摘要翻译：本发明提供某些取代哌嗪基-1,2,4-三唑，其可用于治疗敏化人类的过敏反应和过敏反应。

6. 发明授权

US4020085A 1-(.alpha.-Amino-.alpha.-phenyl-o-tolyl)imidazoles 失效
标题翻译： 1 - （{60-氨基 - {60-苯基 - 邻甲苯基）咪唑
公开(公告)号：US4020085A
公开(公告)日：1977-04-26
申请号：US681184
申请日：1976-04-28
申请人： Martin Gall
发明人： Martin Gall
IPC分类号： C07D233/56 , C07D233/64 , C07D249/08 , C07D233/58
CPC分类号： C07D233/56 , C07D233/64 , C07D249/08
摘要： 3-Substituted 4-(.alpha.-amino-.alpha.-phenyl-o-tolyl)-4H-1,2,4-triazoles, 2-substituted 1-(.alpha.amino-.alpha.-phenyl-o-tolyl)imidazoles, pharmacologically acceptable acid addition salts thereof and processes for their production. The compounds of this invention and the pharmacologically acceptable acid addition salts thereof are useful as sedatives, hypnotics, anticonvulsants, tranquilizers, and muscle relaxants. They are also useful as feed additives for increasing growth rate and feed efficiency of livestock and poultry.
摘要翻译： 3-取代的4-（α-氨基-α-苯基 - 邻甲苯基）-4H-1,2,4-三唑，2-取代的1-（α氨基-α-苯基 - 邻 - 甲苯基）咪唑，药理学上可接受的其酸加成盐及其制备方法。本发明的化合物及其药理学上可接受的酸加成盐可用作镇静剂，催眠药，抗惊厥药，镇静剂和肌肉松弛剂。它们也可用作增加牲畜和家禽生长速度和饲料效率的饲料添加剂。

7. 发明授权

US4010177A [3-Substituted-5-[(di-methylamino)methyl]-4H-1,2,4-triazol- 4-yl]benzophenones and process 失效
标题翻译： {8,3-取代的5- {8（二甲基氨基）甲基{9 -4 H-1,2,4-三唑-4-基} {9二苯甲酮和方法
公开(公告)号：US4010177A
公开(公告)日：1977-03-01
申请号：US584616
申请日：1975-06-06
申请人： Martin Gall
发明人： Martin Gall
IPC分类号： C07D243/20 , C07D249/08 , C07D487/04 , C07D401/06 , C07D403/06 , C07D413/06
CPC分类号： C07D249/08 , C07D243/20 , C07D487/04
摘要： Compounds of the formula I: ##STR1## wherein R.sub.1 is hydroxymethyl, or -CH.sub.2 NR.sub.6 R.sub.7, in which R.sub.6 is -CH.sub.2 -C.tbd.CH, -CH.sub.2 -CH=CH.sub.2, ##STR2## or alkyl of 1 to 3 carbon atoms, inclusive; R.sub.7 is hydrogen or alkyl of 1 to 3 carbon atoms, or together ##STR3## is pyrrolidino, piperidino or morpholino; wherein R.sub.2 is hydrogen, chlorine or fluorine; wherein R.sub.3 is hydrogen, or fluorine if R.sub.2 is fluorine; wherein R.sub.4 is hydrogen, fluorine, chlorine, bromine, nitro, or trifluoromethyl; and wherein R.sub.5 is hydrogen, methyl or ethyl. These compounds, except those in which R.sub.7 is hydrogen, are produced by heating a compound of formula II: ##STR4## wherein R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are defined as hereinabove, and wherein R'.sub.1 is the same as R.sub.1 except that in defining R'.sub.1,R.sub.7 may not be hydrogen, with aqueous formaldehyde in formic acid solution at reflux temperature (about 100.degree. C.).Compounds in which R.sub.7 are hydrogen require steps further shown in the specification.The compounds of formula I and their pharmacologically acceptable acid addition salts thereof have tranquilizing, anti-anxiety and anti-convulsant activity useful for the treatment of animals and man.
摘要翻译：式I的化合物：其中R 1是羟甲基或-CH 2 NR 6 R 7，其中R 6是-CH 2 -C 3 CH 3，CH 2 -CH = CH 2，或者具有1至3个碳原子的烷基，包括 ; R 7是氢或1至3个碳原子的烷基，或者一起是吡咯烷子基，哌啶子基或吗啉代; 其中R2是氢，氯或氟; 其中R 3为氢，或如果R 2为氟，则为氟; 其中R4是氢，氟，氯，溴，硝基或三氟甲基; 并且其中R 5是氢，甲基或乙基。这些化合物除了R7是氢的化合物之外，是通过加热式II化合物制备的：其中R2，R3，R4和R5如上所定义，并且其中R'1与R1相同，除了在定义R'1时，R7可能不是氢，甲醛水溶液在甲酸溶液中在回流温度（约100℃）下。

8. 发明授权

US07166625B2 Method for treating fibrotic diseases and other indications 失效
标题翻译：治疗纤维化疾病及其他适应症的方法
公开(公告)号：US07166625B2
公开(公告)日：2007-01-23
申请号：US10037447
申请日：2001-12-31
申请人： John J. Egan , Dilip Wagle , Sara Vasan , Martin Gall , Stanley Bell , Edmond J. LaVoie
发明人： John J. Egan , Dilip Wagle , Sara Vasan , Martin Gall , Stanley Bell , Edmond J. LaVoie
IPC分类号： A61K31/42 , C07D263/00 , C07D263/30
CPC分类号： C07D233/54 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/541 , C07D277/22 , C07D277/60 , C07D277/62
摘要： Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:
摘要翻译：本发明提供了一种在动物（包括人）中治疗或改善或预防本发明的指征的方法，包括给予有效量的式I化合物：

9. 发明授权

US06516537B1 Method for drying and producing microporous particles 有权
标题翻译：干燥和生产微孔颗粒的方法
公开(公告)号：US06516537B1
公开(公告)日：2003-02-11
申请号：US09623856
申请日：2000-09-11
申请人： Friedhelm Teich , Heiner Schelling , Herbert Köster , Horst Kratzer , Wolfgang Reichert , Martin Gall , Bernd Ziegler
发明人： Friedhelm Teich , Heiner Schelling , Herbert Köster , Horst Kratzer , Wolfgang Reichert , Martin Gall , Bernd Ziegler
IPC分类号： F26B300
CPC分类号： F26B17/14 , B01D12/00 , B01J13/0091 , C01B33/158 , C01B33/1585 , F26B7/00 , F26B21/14 , Y02P20/544
摘要： In a process for drying microporous, fluid-containing particles, the fluid-containing particles to be dried are fed as a moving bed countercurrently to a drying fluid, the interfacial tension of the fluid being reduced in comparison with the interfacial tension of the fluid at room temperature, at near-critical to supercritical pressure of the fluid, preferably to a value in the range from 0 to {fraction (1/10)}, in particular from 0 to {fraction (1/20)}, of the interfacial tension at room temperature. Furthermore, microporous, three-dimensionally networked particles are prepared by a process comprising preparation of microporous particles containing pore liquid, exchange of the pore liquid in the particles for a fluid and drying of the fluid-containing particles, the exchange and drying being carried out in the moving bed by the countercurrent method.
摘要翻译：在微孔，含流体颗粒的干燥过程中，要干燥的含流体颗粒作为移动床与干燥流体逆流进料，与流体的界面张力相比，流体的界面张力相对于在室温附近，液体的临界压力接近临界压，优选为室温下界面张力的0至1/10，特别是0至1/20的值。此外，通过包括制备包含孔隙液体的微孔颗粒，交换颗粒中的孔隙液体用于流体并干燥含流体的颗粒，进行交换和干燥的方法制备微孔，三维网状颗粒在移动床上采用逆流法。

10. 发明授权

US06438867B1 Method for drying and producing microporous particles and a drying device 有权
标题翻译：干燥和生产微孔颗粒的方法和干燥装置
公开(公告)号：US06438867B1
公开(公告)日：2002-08-27
申请号：US09623873
申请日：2000-09-11
申请人： Friedhelm Teich , Heiner Schelling , Herbert Köster , Horst Kratzer , Wolfgang Reichert , Martin Gall , Bernd Ziegler
发明人： Friedhelm Teich , Heiner Schelling , Herbert Köster , Horst Kratzer , Wolfgang Reichert , Martin Gall , Bernd Ziegler
IPC分类号： F26B300
CPC分类号： F26B7/00
摘要： In a process for drying microporous, fluid-containing particles, the heat required for increasing the temperature is supplied by convection by reducing the interfacial tension of the fluid, preferably to 0 to 1/10, in particular to 0 to 1/20, of the interfacial tension of the fluid at room temperature, by appropriately increasing the temperature at from close to the critical pressure to supercritical pressure of the fluid. Furthermore, microporous, three-dimensionally networked particles are prepared by a process in which the drying process is used. In addition, an apparatus is used for carrying out the drying process, the apparatus comprising a pressure container having an inner container and pressure-withstanding outer container and suitable measuring and control apparatuses and pump apparatuses and heat exchangers, the inner container being provided for holding the particles to be dried and a gap being provided between the inner container and the outer container.
摘要翻译：在微孔，含流体颗粒的干燥过程中，通过降低流体的界面张力，优选为0至1/10，特别是0至1/20，通过对流来提供增加温度所需的热量流体在室温下的界面张力，通过将接近临界压力的温度适当地提高到流体的超临界压力。此外，通过使用干燥方法的方法制备微孔，三维网状颗粒。此外，使用装置进行干燥处理，该装置包括具有内部容器和耐压外部容器的压力容器以及合适的测量和控制装置以及泵装置和热交换器，所述内部容器设置用于保持待干燥的颗粒和在内部容器和外部容器之间设置的间隙。

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