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1. 发明授权

US4929771A Process for the preparation of alkyl-substituted phenols or naphthols 失效
标题翻译：制备烷基取代酚或萘酚的方法
公开(公告)号：US4929771A
公开(公告)日：1990-05-29
申请号：US278396
申请日：1988-12-01
申请人： Martin Clausen , Paul Rys , Wang Junkuan
发明人： Martin Clausen , Paul Rys , Wang Junkuan
IPC分类号： C07B61/00 , B01J31/04 , C07B31/00 , C07B41/02 , C07C27/00 , C07C37/08 , C07C39/06 , C07C39/14 , C07C67/00 , C07C409/08 , C07C409/12
CPC分类号： C07C409/12 , C07C39/06 , C07C39/14 , C07C407/00 , C07C409/08
摘要： Process for the preparation of alkyl-substituted phenols or naphthols by oxidizing the corresponding dialkylbenzenes or dialkylnaphthalenes, respectively, at elevated temperatures of, for example, 70.degree. to 130.degree. C. by means of oxygen or oxygen donors, in the absence of solvents and in the presence of an alkali metal salt or alkaline earth metal salt of an organic carboxylic acid having 5 to 14 carbon atoms, to give the corresponding 2,6-dialkylnaphthalene-or 1,4-dialkylphenyl monohydroperoxides and subsequently hydrolysing the latter in a customary manner.The process results in pure, easily isolatable products in a good yield. The products of the process according to the invention are valuable precursors and intermediates for, inter alia, dyes, plastics or pharmaceuticals.
摘要翻译：通过在不存在溶剂的情况下，通过氧气或氧气供体在高于70℃至130℃的升高的温度下分别氧化相应的二烷基苯或二烷基萘来制备烷基取代的酚或萘酚的方法，以及在具有5至14个碳原子的有机羧酸的碱金属盐或碱土金属盐的存在下，得到相应的2,6-二烷基萘或1,4-二烷基苯基单氢过氧化物，随后在常规的方式。该方法产生纯，易分离的产品，产率良好。根据本发明的方法的产物是用于特别是染料，塑料或药物的有价值的前体和中间体。

2. 发明授权

US4861920A Process for the preparation of 2,6-dihydroxynaphthalene 失效
标题翻译： 2,6-二羟基萘的制备方法
公开(公告)号：US4861920A
公开(公告)日：1989-08-29
申请号：US167807
申请日：1988-03-14
申请人： Martin Clausen , Paul Rys
发明人： Martin Clausen , Paul Rys
IPC分类号： C07C37/08 , B01J31/04 , C07B61/00 , C07C27/00 , C07C39/14 , C07C67/00 , C07C409/12
CPC分类号： C07C39/14 , C07C407/00
摘要： Process for the preparation of 2,6-dihydroxynaphthalene from 2,6-dialkylnaphthalenes, which are dissolved in an inert solvent and are oxidized at temperatures from 50.degree. to 150.degree. C. by means of oxygen or oxygen donors, in the presence of an alkali metal salt or alkaline earth metal salt of an organic carboxylic acid having 5 to 14 carbon atoms, to give the corresponding 2,6-dialkylnaphthalene dihydroperoxides, and the latter are subsequently hydrolysed.The process results in pure, easily isolatable products in a good yield. The process products according to the invention are valuable intermediates for, inter alia, dyes, plastics, synthetic fibres, polymeric liquid crystals or pharmaceuticals.
摘要翻译：从2,6-二烷基萘制备2,6-二羟基萘的方法，它们在惰性溶剂中溶解并在50至150℃的温度下通过氧气或氧气供体氧化，在具有5至14个碳原子的有机羧酸的碱金属盐或碱土金属盐，得到相应的2,6-二烷基萘二氢过氧化物，随后将其水解。该方法产生纯，易分离的产品，产率良好。根据本发明的方法产品是用于尤其是染料，塑料，合成纤维，聚合物液晶或药物的有价值的中间体。

3. 发明授权

US5041634A Process for the preparation of carboxylated aromatic hydroxy compounds 失效
标题翻译：羧化芳族羟基化合物的制备方法
公开(公告)号：US5041634A
公开(公告)日：1991-08-20
申请号：US278395
申请日：1988-12-01
申请人： Martin Clausen , Paul Rys , Junkuan Wang
发明人： Martin Clausen , Paul Rys , Junkuan Wang
IPC分类号： B01J27/053 , B01J27/06 , B01J27/08 , B01J27/185 , B01J27/187 , B01J27/232 , B01J31/04 , C07B61/00 , C07C51/265 , C07C51/367 , C07C65/03 , C07C65/11
CPC分类号： C07C51/265
摘要： Process for the preparation of compounds of the formula HO-Ar-COOH in which Ar is a substituted or unsubstituted aromatic ring system, by oxidizing, by means of oxygen or compounds which donate oxygen, compounds of the formula HO-Ar-R.sub.1 in which R.sub.1 is alkyl having 1 to 5 carbon atoms and Ar is as defined above, or the O-acyl derivatives of these compounds, in an organic solvent at 80.degree. to 130.degree. C. and in the presence of an acylating agent, a cobalt and/or manganese compound and a compound which donates bromide, ions, and subsequently hydrolysing the products in a conventional manner. In the presence of the acylating agent, a selective oxidation of the hydroxyl-substituted aromatic compounds to carboxylated hydroxy compounds, which are obtained in a good state of purity and yield, is obtained without the application of pressure.The compounds obtained in accordance with the process are, for example, valuable intermediates for the preparation of dyes, plastics and pharmaceuticals.
摘要翻译：制备式HO-Ar-COOH的化合物的方法，其中Ar是取代或未取代的芳环体系，通过氧气或氧化的化合物，式HO-Ar-R1的化合物，其中 R1是具有1-5个碳原子的烷基，Ar如上所定义，或这些化合物的O-酰基衍生物在有机溶剂中在80-130℃下，在酰化剂，钴和 /或锰化合物和以常规方式提供溴化物，离子和随后水解产物的化合物。在酰化剂的存在下，在没有施加压力的情况下获得羟基取代的芳族化合物选择性氧化成为具有良好的纯度和产率的羧化羟基化合物。根据该方法获得的化合物是例如用于制备染料，塑料和药物的有价值的中间体。

4. 发明授权

US08501967B2 Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols 有权
标题翻译：用于制备对映体纯的1-取代-3-氨基醇的方法
公开(公告)号：US08501967B2
公开(公告)日：2013-08-06
申请号：US13560621
申请日：2012-07-27
申请人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Dominique Michel
发明人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Dominique Michel
IPC分类号： C07D333/22
CPC分类号： C07C303/22 , C07B2200/07 , C07C213/02 , C07C221/00 , C07C309/04 , C07C309/07 , C07C309/30 , C07C215/30 , C07C225/16
摘要： A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (1a), (1b): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues; including a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, said organic solvent which can include water to provide N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and b) asymmetrically hydrogenating.
摘要翻译：制备式（1a），（1b）的N-单取代的β-氨基醇磺酸盐的方法：其中R1是C6-20-芳基或C4-12 - 杂芳基，每个任选被一个或多个卤素原子和/ 或一个或多个C 1-4 - 烷基或C 1-4 - 烷氧基，R 2是C 1-4 - 烷基或C 6-20 - 芳基，每个芳基任选地被一个或多个卤素原子和/或一个或多个C 1〜 4-烷基或C 1-4 - 烷氧基，并且其中R 3选自C 1-18 - 烷基，C 6-20 - 环烷基，C 6-20 - 芳基和C 7-20 - 芳烷基残基; 包括a）使甲基酮，伯胺，甲醛和磺酸在高于1.5巴的压力下，任选地在有机溶剂中反应，所述有机溶剂可包括水以提供式（III）的N-单取代的β-氨基酮磺酸盐 II）：其中R1，R2和R3如上定义，和b）不对称氢化。

5. 发明申请

US20090156833A1 Process for the Preparation of Enantiomerically Pure 1-Substituted-3-Aminoalcohols 有权
标题翻译：对映异构纯的1-取代的3-氨基醇的制备方法
公开(公告)号：US20090156833A1
公开(公告)日：2009-06-18
申请号：US11884542
申请日：2006-02-14
申请人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Colette Mettler , Dominique Michel
发明人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Colette Mettler , Dominique Michel
IPC分类号： C07D333/36
CPC分类号： C07C303/22 , C07B2200/07 , C07C213/02 , C07C221/00 , C07C309/04 , C07C309/07 , C07C309/30 , C07C215/30 , C07C225/16
摘要： A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (Ia), (Ib): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues. The process has the steps of (a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, the organic solvent optionally containing water, to afford N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and (b) asymmetrically hydrogenating. The sulfonates in the presence of a base and a catalyst of a transition metal and a disphosphine ligand, in a polar solvent, optionally in the presence of water.
摘要翻译：制备式（Ia），（Ib）的N-单取代的β-氨基醇磺酸盐的方法：其中R1是C6-20-芳基或C4-12 - 杂芳基，每个任选被一个或多个卤素原子和/ 或一个或多个C 1-4 - 烷基或C 1-4 - 烷氧基，R 2是C 1-4 - 烷基或C 6-20 - 芳基，每个芳基任选地被一个或多个卤素原子和/或一个或多个C 1〜 4-烷基或C 1-4 - 烷氧基，并且其中R 3选自C 1-18 - 烷基，C 6-20 - 环烷基，C 6-20 - 芳基和C 7-20 - 芳烷基残基。该方法具有以下步骤：（a）使甲基酮，伯胺，甲醛和磺酸在高于1.5巴的压力下，任选地在有机溶剂（任选含有水的有机溶剂）中反应，得到N-单取代的β （II）的氨基酮磺酸盐：其中R1，R2和R3如上定义，和（b）不对称氢化。在极性溶剂中，任选地在水存在下，在过渡金属和二膦配体的碱存在下和催化剂存在下的磺酸盐。

6. 发明授权

US08258338B2 Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols 有权
标题翻译：用于制备对映体纯的1-取代-3-氨基醇的方法
公开(公告)号：US08258338B2
公开(公告)日：2012-09-04
申请号：US11884542
申请日：2006-02-14
申请人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Colette Mettler, legal representative , Dominique Michel
发明人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Dominique Michel
IPC分类号： C07C33/32 , C07D333/12
CPC分类号： C07C303/22 , C07B2200/07 , C07C213/02 , C07C221/00 , C07C309/04 , C07C309/07 , C07C309/30 , C07C215/30 , C07C225/16
摘要： A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (Ia), (Ib): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues. The process has the steps of (a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, the organic solvent optionally containing water, to afford N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and (b) asymmetrically hydrogenating. The sulfonates in the presence of a base and a catalyst of a transition metal and a disphosphine ligand, in a polar solvent, optionally in the presence of water.
摘要翻译：一种制备式（Ia），（Ib）的N-单取代和（bgr） - 氨基醇磺酸盐的方法：其中R1是C6-20-芳基或C4-12 - 杂芳基，各自任选被一个或多个卤素原子取代， /或一个或多个C 1-4 - 烷基或C 1-4 - 烷氧基，R 2是C 1-4 - 烷基或C 6-20 - 芳基，每个芳基任选被一个或多个卤素原子和/或一个或多个C 1 -4-烷基或C 1-4 - 烷氧基，并且其中R 3选自C 1-18 - 烷基，C 6-20 - 环烷基，C 6-20 - 芳基和C 7-20 - 芳烷基残基。该方法具有以下步骤：（a）使甲基酮，伯胺，甲醛和磺酸在高于1.5巴的压力下，任选地在有机溶剂（任选含有水的有机溶剂）中反应，得到N-单取代的＆bgr （II）的氨基酮磺酸盐：其中R 1，R 2和R 3如上所定义，和（b）不对称氢化。在极性溶剂中，任选地在水存在下，在过渡金属和二膦配体的碱存在下和催化剂存在下的磺酸盐。

7. 发明申请

US20070251753A1 HYDRAULIC STEERING 审中-公开
标题翻译：液压转向
公开(公告)号：US20070251753A1
公开(公告)日：2007-11-01
申请号：US11740370
申请日：2007-04-26
申请人： Martin Clausen
发明人： Martin Clausen
IPC分类号： B62D7/00
CPC分类号： B62D5/075 , B62D5/001 , B62D5/091 , B62D5/30
摘要： The invention concerns a hydraulic steering with a steering motor arrangement, a steering valve arrangement and a pressure supply comprising a first pump and a second pump. It is endeavoured to perform a change between the supplies by the pumps as unperceived as possible. For this purpose, the steering valve arrangement (4) is connected to the first pump (6) through a valve (8) with pressure compensation function and to the second pump (19) through a compensation valve (26).
摘要翻译：本发明涉及一种具有转向马达装置的液压转向装置，转向阀装置和包括第一泵和第二泵的压力源。尽可能地将泵之间的耗材进行更换，这是不容置疑的。为此，转向阀装置（4）通过具有压力补偿功能的阀（8）连接到第一泵（6），并通过补偿阀（26）连接到第二泵（19）。

8. 发明申请

US20120316350A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS 有权
标题翻译：制备纯化1-取代的3-氨基醇的方法
公开(公告)号：US20120316350A1
公开(公告)日：2012-12-13
申请号：US13560621
申请日：2012-07-27
申请人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Dominique Michel
发明人： Walter Brieden , Martin Clausen , John McGarrity , Hanspeter Mettler , Dominique Michel
IPC分类号： C07D333/22 , C07C309/04
CPC分类号： C07C303/22 , C07B2200/07 , C07C213/02 , C07C221/00 , C07C309/04 , C07C309/07 , C07C309/30 , C07C215/30 , C07C225/16
摘要： A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (1a), (1b): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues; including a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, said organic solvent which can include water to provide N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and b) asymmetrically hydrogenating.
摘要翻译：一种制备式（1a），（1b）的N-单取代的 - 氨基醇磺酸盐的方法：其中R1是C6-20-芳基或C4-12 - 杂芳基，每个任选被一个或多个卤素原子取代， /或一个或多个C 1-4 - 烷基或C 1-4 - 烷氧基，R 2是C 1-4 - 烷基或C 6-20 - 芳基，每个芳基任选被一个或多个卤素原子和/或一个或多个C 1 4-烷基或C 1-4 - 烷氧基，其中R 3选自C 1-18 - 烷基，C 6-20 - 环烷基，C 6-20 - 芳基和C 7-20 - 芳烷基残基; 包括a）使甲基酮，伯胺，甲醛和磺酸在高于1.5巴的压力下，任选地在有机溶剂中反应，所述有机溶剂可以包括水以提供具有式（I）的N-单取代和重量的氨基酮磺酸盐（II）：其中R1，R2和R3如上定义，和b）不对称氢化。

9. 发明授权

US08042568B2 Fluid controller and a method of detecting an error in a fluid controller 有权
标题翻译：流体控制器和检测流体控制器中的误差的方法
公开(公告)号：US08042568B2
公开(公告)日：2011-10-25
申请号：US11766279
申请日：2007-06-21
申请人： Martin Clausen
发明人： Martin Clausen
IPC分类号： F16K37/00
CPC分类号： F15B13/0402 , F15B11/006 , F15B13/0433 , F15B19/005 , F15B21/08 , F15B2211/30575 , F15B2211/328 , F15B2211/329 , F15B2211/527 , F15B2211/634 , G05B11/42 , Y10T137/8242 , Y10T137/86622 , Y10T137/8663
摘要： The invention provides a fluid controller for controlling a machine, e.g. for steering a vehicle. The controller comprises a housing defining an inlet port connected to the source and an outlet port connected to the pressure operated device. The flow rate is controlled by movement of a valve member within the housing, and a processor provides a reference which is indicative of a desired position of the valve member relative to the housing. The fluid controller comprises a fault detection system based on an observer. The observer calculates a theoretically correct position of the valve member relative to the housing for a given reference, and compares this position to an obtained position of the valve member relative to the housing. The difference between the positions is compared with a threshold value. In order to dynamically change the sensitivity of the system, the threshold value is scaled based on a gradient of the reference.
摘要翻译：本发明提供一种用于控制机器的流体控制器，用于转向车辆。控制器包括限定连接到源的入口的壳体和连接到压力操作装置的出口。流量由壳体内的阀构件的运动控制，并且处理器提供指示阀构件相对于壳体的期望位置的参考。流体控制器包括基于观察者的故障检测系统。对于给定的参考，观察者计算阀构件相对于壳体的理论上正确的位置，并将该位置与获得的阀构件相对于壳体的位置进行比较。将位置之间的差异与阈值进行比较。为了动态地改变系统的灵敏度，基于参考的梯度来缩放阈值。

10. 发明申请

US20070295924A1 FLUID CONTROLLER AND A METHOD OF DETECTING AN ERROR IN A FLUID CONTROLLER 有权
标题翻译：流体控制器和检测流体控制器中的错误的方法
公开(公告)号：US20070295924A1
公开(公告)日：2007-12-27
申请号：US11766279
申请日：2007-06-21
申请人： Martin Clausen
发明人： Martin Clausen
IPC分类号： F16K31/02
CPC分类号： F15B13/0402 , F15B11/006 , F15B13/0433 , F15B19/005 , F15B21/08 , F15B2211/30575 , F15B2211/328 , F15B2211/329 , F15B2211/527 , F15B2211/634 , G05B11/42 , Y10T137/8242 , Y10T137/86622 , Y10T137/8663
摘要： The invention provides a fluid controller for controlling a machine, e.g. for steering a vehicle. The controller comprises a housing defining an inlet port connected to the source and an outlet port connected to the pressure operated device. The flow rate is controlled by movement of a valve member within the housing, and a processor provides a reference which is indicative of a desired position of the valve member relative to the housing. The fluid controller comprises a fault detection system based on an observer. The observer calculates a theoretically correct position of the valve member relative to the housing for a given reference, and compares this position to an obtained position of the valve member relative to the housing. The difference between the positions is compared with a threshold value. In order to dynamically change the sensitivity of the system, the threshold value is scaled based on a gradient of the reference.
摘要翻译：本发明提供一种用于控制机器的流体控制器，用于转向车辆。控制器包括限定连接到源的入口的壳体和连接到压力操作装置的出口。流量由壳体内的阀构件的运动控制，并且处理器提供指示阀构件相对于壳体的期望位置的参考。流体控制器包括基于观察者的故障检测系统。对于给定的参考，观察者计算阀构件相对于壳体的理论上正确的位置，并将该位置与获得的阀构件相对于壳体的位置进行比较。将位置之间的差异与阈值进行比较。为了动态地改变系统的灵敏度，基于参考的梯度来缩放阈值。

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