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1. 发明授权

US4902620A Novel DNA for expression of delta-aminolevulinic acid synthetase and related method 失效
标题翻译：用于表达δ-氨基乙酰丙酸合成酶的新型DNA及相关方法
公开(公告)号：US4902620A
公开(公告)日：1990-02-20
申请号：US725876
申请日：1985-04-25
申请人： Martin Bard , Thomas D. Ingolia
发明人： Martin Bard , Thomas D. Ingolia
IPC分类号： C12N9/10 , C12N15/64 , C12N15/68 , C12N15/81 , C12P13/00
CPC分类号： C12N9/1029 , C12N15/64 , C12N15/68 , C12N15/81 , C12P13/005 , C12R1/865 , Y10S435/94
摘要： The present invention is a novel method for maintaining and selecting recombinant DNA-containing host cells wherein the DNA encoding a selectable phenotype and the DNA encoding a useful polypeptide are the same. The aforementioned DNA is useful for expressing .delta.-aminolevulinic acid synthetase (ALAS) for the ultimate expression of .delta.-aminolevulinic acid (ALA) in yeast and related organisms. The invention further comprises plasmids pIT300, pIT301, pIT302, pIT304, pIT305, pIT306 and related Saccharomyces ALA deficient transformants. ALA is a five carbon amino acid that is useful as a light dependent herbicide.
摘要翻译：本发明是维持和选择重组含DNA宿主细胞的新方法，其中编码可选表型的DNA和编码有用多肽的DNA相同。上述DNA可用于表达δ-氨基乙酰丙酸合成酶（ALAS），用于在酵母和相关生物体中最终表达δ-氨基乙酰丙酸（ALA）。本发明进一步包括质粒pIT300，pIT301，pIT302，pIT304，pIT305，pIT306和相关的阿拉伯糖酵母缺失型转化体。 ALA是一种五碳氨基酸，可用作光依赖性除草剂。

2. 发明授权

US4806420A Unglazed ceramic tile-shaped article 失效
标题翻译：无釉陶瓷砖形制品
公开(公告)号：US4806420A
公开(公告)日：1989-02-21
申请号：US154147
申请日：1988-02-09
申请人： Martin Bard
发明人： Martin Bard
IPC分类号： E04F13/14 , C04B41/48 , C04B41/83 , E04F15/18 , B32B3/26
CPC分类号： C04B41/009 , C04B41/48 , C04B41/83 , C04B2111/94 , Y10T428/249969 , Y10T428/24997 , Y10T428/249994
摘要： An unglazed ceramic tile-shaped article capable of conducting away electrical potential that reaches it into an electrically conductive substructure consists of a body having open porosity and the pores are filled with an emulsifier which behaves similarly to a metal in terms of its electrical conductivity.
摘要翻译：能够将达到其导电子结构的电势的无釉瓷砖制品由具有开放孔隙率的本体组成，并且在其导电性方面孔中填充有类似于金属的乳化剂。

3. 发明授权

US4790110A Tile-like ceramic element having an electrically conductive surface glaze on the visible side 失效
标题翻译：在可见侧具有导电表面釉的瓷砖状陶瓷元件
公开(公告)号：US4790110A
公开(公告)日：1988-12-13
申请号：US56062
申请日：1987-06-01
申请人： Martin Bard
发明人： Martin Bard
IPC分类号： C04B41/50 , C04B41/86 , E04F15/02 , H05F3/02
CPC分类号： C04B41/009 , C04B41/5022 , C04B41/86 , E04F15/02 , H05F3/025 , C04B2111/94
摘要： For a tile-like ceramic element provided on its visible side with an electrically conductive surface glaze which, when the tile-like ceramic element is laid with a plurality of such elements to form a covering for lining walls or floors, communicates conductively with a substructure which diverts electricity and is to be provided below the covering, its laying to form a flooring can be performed utterly independently, so that a joint material can be selected which completely meets all requirements to be met by such a material in terms of its scuff resistance, its elasticity and hygienic properties, and allows for at least part of the side of the tile-like ceramic element facing away from the visible side to be coated with a material having good electrically conductive properties which communicates with the surface glaze in electrically conductive fashion.
摘要翻译：对于在其可见侧设置有导电表面釉的瓦片状陶瓷元件，当瓷砖状陶瓷元件铺设有多个这样的元件以形成用于衬里墙壁或地板的覆盖物时，与下部结构其可以将电力转移并且被设置在覆盖物下方，其铺设形成地板可以完全独立地进行，使得可以选择完全满足所有这些材料在其抗磨损性方面满足的要求的接合材料，其弹性和卫生性能，并且允许瓦片状陶瓷元件的远离可见侧的至少一部分侧面涂覆有具有良好导电性能的材料，其以导电方式与表面釉质连通。

4. 发明授权

US4621001A Tile-shaped composite element 失效
标题翻译：瓦形复合元件
公开(公告)号：US4621001A
公开(公告)日：1986-11-04
申请号：US703873
申请日：1985-02-21
申请人： Martin Bard
发明人： Martin Bard
IPC分类号： B32B3/30 , E04C2/04 , E04C2/52 , E04F13/00
CPC分类号： E04C2/525 , B32B3/30 , E04C2/04 , Y10T428/166 , Y10T428/183 , Y10T428/195 , Y10T428/24322 , Y10T428/24612 , Y10T428/24752 , Y10T428/24777
摘要： A tile-shaped composite element is described in which a ceramic tile serving as the visible tile is glued to a further ceramic tile serving as the base tile. In order to add considerable strength to the two single tiles, thereby substantially improving the sturdiness of the composite element, it is proposed that each tile be provided on the back with a nesting structure and glued together with this nesting structure back-to-back. Since the wall thickness of such a composite element may correspond to the usual wall thickness of shingles or conventional ceramic tiles, extremely thin tiles may be used as the base tile and the visible tile placed thereupon. Because there is a nesting structure on the backside, the tiles may be connected and glued together in such a way that the nesting structures, which generally involve continuous straight grooves and ridges, positively engage to lock into each other, thereby considerably strengthening the firm cohesion of the tiles and, thus of the composite element.
摘要翻译：描述了一种瓦形复合元件，其中用作可见瓦片的瓷砖粘合到用作基底瓦片的另一个瓷砖上。为了增加两个单个瓷砖的相当强度，从而显着提高复合元件的坚固性，建议将每个瓷砖在背面设置有嵌套结构，并且背对背地与该嵌套结构胶合在一起。由于这种复合元件的壁厚可以对应于带状疱板或常规陶瓷砖的通常的壁厚，因此可以使用非常薄的瓷砖作为基底砖，并且可见砖在其上刨切。因为在背面有一个嵌套结构，所以瓦片可以以这样一种方式连接和粘合在一起，使得嵌套结构通常包括连续的直的凹槽和凸脊，从而相互锁定，从而显着地增强了牢固的内聚力的瓦片，因此是复合元件。

5. 发明授权

US4868899A Space heating element comprising a ceramic shaped body provided with an electrically resistive coating, in particular in the form of a ceramic tile 失效
标题翻译：空间加热元件包括设置有电阻涂层的陶瓷成形体，特别是陶瓷砖的形式
公开(公告)号：US4868899A
公开(公告)日：1989-09-19
申请号：US156181
申请日：1988-02-16
申请人： Martin Bard , Gottfried Cremer
发明人： Martin Bard , Gottfried Cremer
IPC分类号： H05B3/20 , F24D13/02 , H05B3/26
CPC分类号： H05B3/265
摘要： A space heating element having a ceramic body, an electrically conductive ceramic glaze provided on the side of the ceramic shaped body opposite the visible side, and a nonconductive ceramic glaze provided over the electrically conductive glaze. The electrically resistive glaze has nonmetallic electrically conductive particles embedded in a carrier substance. The nonconductive glaze has the same carrier substance as the electrically conductive glaze but has kaolin particles embedded therein in place of the nonmetallic electrically conductive particles. The ceramic body, electrically resistive glaze and nonconductive ceramic glaze are heated to a temperature below the quartz transition temperature.
摘要翻译：具有陶瓷体的空间加热元件，设置在与可见侧相对的陶瓷成形体侧的导电陶瓷釉和设置在导电釉上的非导电陶瓷釉。电阻釉具有嵌入载体物质中的非金属导电颗粒。非导电釉具有与导电釉相同的载体物质，但是其中包含高岭土颗粒代替非金属导电颗粒。将陶瓷体，电阻釉和非导电陶瓷釉料加热到低于石英转变温度的温度。

6. 发明授权

US4833300A Space heating element having a ceramic body with an electrically resistive coating thereon 失效
标题翻译：空间加热元件，其上具有电阻涂层的陶瓷体
公开(公告)号：US4833300A
公开(公告)日：1989-05-23
申请号：US131856
申请日：1987-12-11
申请人： Martin Bard , Gottfried Cremer
发明人： Martin Bard , Gottfried Cremer
IPC分类号： F24D13/02 , H05B3/28
CPC分类号： H05B3/283 , F24D13/022 , H05B3/286 , Y02B30/26
摘要： An electrical space heating element having a ceramic body which is provided on the side facing away from the space to be heated with an electrically resistive coating. The space heating element provides a high thermal yield while consuming little electrical power and may be used as an element of design for the periphery of a room. The space heating element may be installed in such a way so that no channels are formed which might force air currents to circulate in the room to be heated. The electrically resistive coating is a layer of a carrier impregnated with nonmetallic particles which have a large specific area, are electrically conductive, and do not substantially vary the electrical conductivity at higher temperatures. The carrier in which the nonmetallic particles are embedded has no greater than poor electrical conductivity. The electrically resistive coating is applied in such a way that it has uniform electrical and thermal conductivity.
摘要翻译：一种电气空间加热元件，其具有陶瓷体，该陶瓷体设置在背离待加热空间的一侧，并具有电阻涂层。空间加热元件提供高的热收率，同时消耗很少的电力，并且可以用作室内外围设计的元件。空间加热元件可以以这样的方式安装，使得不形成可能迫使气流在要加热的房间中循环的通道。电阻涂层是浸渍有非金属颗粒的载体层，其具有大比表面积，导电性，并且在较高温度下基本上不改变导电性。其中嵌入非金属颗粒的载体不大于差的导电性。以这样的方式施加电阻涂层，使得其具有均匀的导电和导热性。

7. 发明授权

US4821478A Large-format ceramic tile with holding elements provided on the side facing away from its visible side 失效
标题翻译：大面积瓷砖，其保持元件设置在远离其可见侧的一侧
公开(公告)号：US4821478A
公开(公告)日：1989-04-18
申请号：US56644
申请日：1987-06-01
申请人： Gottfried Cremer , Martin Bard
发明人： Gottfried Cremer , Martin Bard
IPC分类号： B32B18/00 , B28B11/04 , B28B23/00 , C04B37/00 , C04B37/02 , E04C2/52 , E04F13/14 , E04F13/21 , E04F13/08
CPC分类号： C04B37/005 , B28B11/044 , B28B23/005 , C04B37/025 , E04C2/526 , E04F13/142 , C04B2235/661 , C04B2237/10 , C04B2237/32 , C04B2237/40 , C04B2237/595 , C04B2237/62 , C04B2237/64 , C04B2237/704 , C04B2237/76 , C04B2237/80 , C04B2237/86
摘要： The present invention is an improvement for large-format ceramic tiles, each of which has holding elements provided on their non-visible sides. The improvement includes attaching the holding elements to joining points determined according to static requirements by means of a ceramic glaze, whose thermal expansion coefficient is at least approximately equal to that of the ceramic tile.
摘要翻译：本发明是对大型瓷砖的改进，每个瓷砖都具有设置在其不可见侧的保持元件。改进包括将保持元件连接到通过陶瓷釉确定的根据静态要求确定的接合点，陶瓷釉的热膨胀系数至少近似等于陶瓷砖的热膨胀系数。

8. 发明授权

US06225075B1 DNA encoding sterol methyltransferase 失效
标题翻译：编码固醇甲基转移酶的DNA
公开(公告)号：US06225075B1
公开(公告)日：2001-05-01
申请号：US09041718
申请日：1998-03-13
申请人： Martin Bard
发明人： Martin Bard
IPC分类号： C12Q148
CPC分类号： C12N9/1007 , G01N2333/40 , G01N2333/91011 , G01N2500/00
摘要： The invention provides an isolated and purified nucleic acid molecule encoding a Candida albicans sterol methyltransferase (ERG6). Also provided is a C. albicans strain or isolate that has reduced levels of sterol methyltransferase as a result of the disruption of at least one sterol methyltransferase gene. Preferred isolates are more susceptible to a number of sterol synthesis and metabolic inhibitors relative to wild type isolates. Further provided are methods to identify sterol methyltransferase inhibitors and methods to screen for antifungals or metabolic inhibitors which are not normally permeable to the fungal cell.
摘要翻译：本发明提供了分离和纯化的编码白色念珠菌甾醇甲基转移酶（ERG6）的核酸分子。还提供了由于至少一种甾醇甲基转移酶基因的破坏的结果，具有降低的固醇甲基转移酶水平的白色念珠菌菌株或分离物。优选的分离物相对于野生型分离物更易受许多甾醇合成和代谢抑制剂的影响。进一步提供了确定甾醇甲基转移酶抑制剂的方法和筛选通常不可渗透真菌细胞的抗真菌剂或代谢抑制剂的方法。

9. 发明授权

US5512472A DNA sequence encoding sterol .DELTA.14 reductase 失效
标题翻译：编码固醇DELTA14还原酶的DNA序列
公开(公告)号：US5512472A
公开(公告)日：1996-04-30
申请号：US439131
申请日：1995-05-11
申请人： Margaret H. K. Lai , Donald R. Kirsch , Martin Bard
发明人： Margaret H. K. Lai , Donald R. Kirsch , Martin Bard
IPC分类号： C12N9/02 , C12N15/53 , C12N15/09 , C12N15/81
CPC分类号： C12N9/001
摘要： A gene encoding Saccharomyces cerevisiae sterol .DELTA.14 reductase of the ergosterol biosynthetic pathway is isolated and cloned by selecting strains carrying sequences on a 2.mu. based vector for resistance to a morpholine fungicide such as fenpropimorph. Four distinct plasmid inserts which produce morpholine resistance are obtained, and one of these is characterized and sequenced. The purified and isolated DNA sequence encoding sterol .DELTA.14 reductase encodes a polypeptide exhibiting homology to the S. cerevisiae sterol C-24(28) reductase enzyme in the ergosterol biosynthetic pathway.
摘要翻译：通过选择在2基于载体上携带序列的菌株来分离和克隆麦角甾醇生物合成途径的酿酒酵母甾醇DELTA 14还原酶的基因，以抵抗吗啉杀真菌剂例如茴香霉素。获得产生吗啉抗性的四种不同的质粒插入片段，其中之一被表征和测序。编码固醇DELTA14还原酶的纯化和分离的DNA序列编码与麦角甾醇生物合成途径中的酿酒酵母甾醇C-24（28）还原酶具有同源性的多肽。

10. 发明授权

US4976082A Natural stone plate having holding elements provided on the side facing away from the visible side 失效
标题翻译：具有设置在远离可见侧的一侧的保持元件的天然石板
公开(公告)号：US4976082A
公开(公告)日：1990-12-11
申请号：US342485
申请日：1989-04-24
申请人： Martin Bard
发明人： Martin Bard
IPC分类号： E04F13/21 , E04F13/08 , E04F13/14
CPC分类号： E04F13/0835 , E04F13/144
摘要： In a natural stone plate having holding elements provided on the side facing away from the visible side, said holding elements are attached to the stone plate by means of a glass solder. The coefficient of thermal expansion of the glass solder is approximately equal to that of the stone plate. Further, the holding elements are disposed on the stone plate at points of attachment determined according to static requirements.
摘要翻译：在具有设置在远离可见侧的一侧的保持元件的天然石板中，所述保持元件通过玻璃焊料附接到石板。玻璃焊料的热膨胀系数近似等于石板的热膨胀系数。此外，保持元件在根据静态要求确定的附接点处设置在石板上。

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