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1. 发明申请

US20150299168A1 PROCESS FOR ACYLATING AMINES 审中-公开
标题翻译：处理氨基酸的方法
公开(公告)号：US20150299168A1
公开(公告)日：2015-10-22
申请号：US14439336
申请日：2013-10-04
申请人： Martin BINDL , Roland HERRMANN , Günter KNAUP
发明人： Martin Bindl , Roland Hermann , Günter Knaup
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D213/81
摘要： The present invention is concerned with the formation of amide bonds. More specifically, the present invention, relates to processes for the manufacture of organogellant compounds (OG) as depicted below wherein L is selected from C2-C20 alkyl, C6-C20 aryl, C7-C20 alkylaryl, R1 are side chain substituents and one of X1, X2 is nitrogen and the other two are carbon. Processes of the present invention employ reaction mixtures with beneficial flow characteristics allowing sufficient agitation of all parts of these reaction mixtures and thus achieving adequate mixing of reaction partners and/or dissipation of heat. The beneficial flow characteristics are achieved by using suitable activation for coupling the terminal pyridine-carboxylic acid.
摘要翻译：本发明涉及酰胺键的形成。更具体地说，本发明涉及制备如下所述的有机凝胶化合物（OG）的方法，其中L选自C 2 -C 20烷基，C 6 -C 20芳基，C 7 -C 20烷基芳基，R 1是侧链取代基， X1，X2是氮，另外两个是碳。本发明的方法使用具有有利流动特性的反应混合物，允许充分搅拌这些反应混合物的所有部分，从而实现反应伴侣的充分混合和/或散热。通过使用适当的活化偶联末端吡啶羧酸来实现有益的流动特性。

2. 发明授权

US06437145B1 Method of producing oxazolidinones, the use thereof and oxazolidinones 失效
标题翻译：生产恶唑烷酮的方法，其用途和恶唑烷酮
公开(公告)号：US06437145B1
公开(公告)日：2002-08-20
申请号：US09542278
申请日：2000-04-04
申请人： Karlheinz Drauz , Günter Knaup , Stefan Retzow
发明人： Karlheinz Drauz , Günter Knaup , Stefan Retzow
IPC分类号： C07D26308
CPC分类号： C07D263/18 , C07C231/14 , C07C237/22
摘要： The invention concerns a method of producing oxazolidinones of formula (I), wherein R1-R5 have the meanings given in the description, by reacting cyclical anhydrides of formula (II) with carbonyl compounds of general formula (III) at temperatures between ambient temperature and approximately 150° C. The invention also concerns the production of the cyclical anhydrides of formula (II) by reacting N-protected aminodicarboxylic acids of formula (IV) with a dehydrating agent in situ. The invention further concerns the use of oxazolidinones of formula (I) for the &agr;-selective production of esters of formula (V) and amides of general formula (VII).
摘要翻译：本发明涉及一种制备式（I）的恶唑烷酮的方法，其中R1-R5具有本说明书中给出的含义，通式（II）的环状酸酐与通式（III）的羰基化合物在环境温度和本发明还涉及式（II）的环状酸酐通过将式（Ⅳ）的N-保护的氨基二羧酸与脱水剂原位反应来生产。本发明还涉及式（I）的恶唑烷酮在通式（Ⅴ）的酯和通式（Ⅶ）的酰胺的α-选择性生产中的应用。

3. 发明授权

US06281364B1 Process for the preparation of 3-amino-2-oxo-pyrrolidines, novel intermediates and their use 失效
标题翻译： 3-氨基-2-氧代 - 吡咯烷的制备方法，新型中间体及其用途
公开(公告)号：US06281364B1
公开(公告)日：2001-08-28
申请号：US09316150
申请日：1999-05-21
申请人： Karlheinz Drauz , Günter Knaup , Michael Schwarm
发明人： Karlheinz Drauz , Günter Knaup , Michael Schwarm
IPC分类号： C07D20712
CPC分类号： C07D207/273 , C07C229/22 , C07C237/22 , C07C255/60 , C07C271/22 , Y02P20/55
摘要： The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I The invention relates also to novel advantageous intermediates of the general formulae V, IV and II and their salts and their use. The compounds of the general formula I are obtained by cyclising compounds of the general formula II which can be prepared from the intermediate compounds V.
摘要翻译：本发明涉及制备通式的γ-内酰胺的方法本发明还涉及通式V，IV和II及其盐的新型有利的中间体及其用途。获得通式I的化合物通过环化可由中间体化合物V制备的通式II的化合物。

4. 发明申请

US20100010242A1 Process for Preparing beta-Amino-alpha-Hydroxycarboxamides 有权
标题翻译：制备β-氨基-α-羟基甲酰胺的方法
公开(公告)号：US20100010242A1
公开(公告)日：2010-01-14
申请号：US12564497
申请日：2009-09-22
申请人： Günter Knaup
发明人： Günter Knaup
IPC分类号： C07D303/02 , C07C233/12
CPC分类号： C07D303/48 , C07C231/12 , C07C231/20 , C07C237/04 , C07C271/22 , C07C2601/02
摘要： The present invention is directed to a process for preparing β-amino-α-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines.
摘要翻译：本发明涉及一种制备β-氨基-α-羟基甲酰胺的方法。该方法与式2的环氧羧酰胺与氨或其它胺反应。

5. 发明申请

US20090306404A1 Process for the Preparation of 2-azabicyclo[3.3.0]octane-3-carboxylic Acid Derivatives 有权
标题翻译： 2-氮杂双环[3.3.0]辛烷-3-羧酸衍生物的制备方法
公开(公告)号：US20090306404A1
公开(公告)日：2009-12-10
申请号：US11886420
申请日：2006-03-02
申请人： Günter Knaup , Milan Latinovic
发明人： Günter Knaup , Milan Latinovic
IPC分类号： C07D209/02 , C07C237/18 , C07C69/74
CPC分类号： C07C271/22 , C07C2601/08 , C07D209/52
摘要： The present invention is aimed at a process for the preparation of compounds of the general formula (I). The objective process is in this case based on the Michael reaction of compounds of the general formula (III) with compounds of the general formula (IV), with subsequent hydrogenation and cyclization of the intermediates of the formula (II) obtained.
摘要翻译：本发明的目的在于制备通式（I）化合物的方法。在这种情况下，目的方法是基于通式（III）的化合物与通式（IV）的化合物的迈克尔反应，随后所得式（II）的中间体的氢化和环化。

6. 发明授权

US06492541B2 Process for the preparation of 3-amino-2-oxo-pyrrolidines, novel intermediates and their use 失效
标题翻译： 3-氨基-2-氧代 - 吡咯烷的制备方法，新型中间体及其用途
公开(公告)号：US06492541B2
公开(公告)日：2002-12-10
申请号：US10005817
申请日：2001-12-07
申请人： Karlheinz Drauz , Günter Knaup , Michael Schwarm
发明人： Karlheinz Drauz , Günter Knaup , Michael Schwarm
IPC分类号： C07C30963
CPC分类号： C07D207/273 , C07C229/22 , C07C237/22 , C07C255/60 , C07C271/22 , Y02P20/55
摘要： The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I The invention relates also to novel advantageous intermediates of the general formulae V, IV and II and their salts and their use. The compounds of the general formula I are obtained by cyclising compounds of the general formula II which can be prepared from the intermediate compounds V.
摘要翻译：本发明涉及制备通式的γ-内酰胺的方法本发明还涉及通式V，IV和II及其盐的新型有利的中间体及其用途。获得通式I的化合物通过环化可由中间体化合物V制备的通式II的化合物。

7. 发明授权

US08440862B2 Process for preparing β-amino-α-hydroxycarboxamides 有权
公开(公告)号：US08440862B2
公开(公告)日：2013-05-14
申请号：US12564497
申请日：2009-09-22
申请人： Günter Knaup
发明人： Günter Knaup
IPC分类号： C07C223/06
CPC分类号： C07D303/48 , C07C231/12 , C07C231/20 , C07C237/04 , C07C271/22 , C07C2601/02
摘要： The present invention is directed to a process for preparing β-amino-α-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines.

8. 发明授权

US07935831B2 Process for the preparation of 2-azabicyclo[3.3.0]octane-3-carboxylic Acid Derivatives 有权
标题翻译： 2-氮杂双环[3.3.0]辛烷-3-羧酸衍生物的制备方法
公开(公告)号：US07935831B2
公开(公告)日：2011-05-03
申请号：US11886420
申请日：2006-03-02
申请人： Günter Knaup , Milan Latinovic
发明人： Günter Knaup , Milan Latinovic
IPC分类号： C07D209/52 , C07C271/02 , C07C271/22
CPC分类号： C07C271/22 , C07C2601/08 , C07D209/52
摘要： The present invention is aimed at a process for the preparation of compounds of the general formula (I). The objective process is in this case based on the Michael reaction of compounds of the general formula (III) with compounds of the general formula (IV), with subsequent hydrogenation and cyclization of the intermediates of the formula (II) obtained.
摘要翻译：本发明的目的在于制备通式（I）化合物的方法。在这种情况下，目的方法是基于通式（III）的化合物与通式（IV）的化合物的迈克尔反应，随后所得式（II）的中间体的氢化和环化。

9. 发明授权

US07612237B2 Process for preparing β-amino-α-hydroxycarboxamides 有权
标题翻译：制备β-氨基-α-羟基甲酰胺的方法
公开(公告)号：US07612237B2
公开(公告)日：2009-11-03
申请号：US11819964
申请日：2007-06-29
申请人： Günter Knaup
发明人： Günter Knaup
IPC分类号： C70C231/12
CPC分类号： C07D303/48 , C07C231/12 , C07C231/20 , C07C237/04 , C07C271/22 , C07C2601/02
摘要： The present invention is directed to a process for preparing β-amino-α-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines.
摘要翻译：本发明涉及一种制备β-氨基-α-羟基甲酰胺的方法。该方法与式2的环氧羧酰胺与氨或其它胺反应。

10. 发明授权

US06504047B2 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparation thereof and use thereof 失效
标题翻译： 2,6-二氨基-6-甲基 - 庚酸及其衍生物，其制备方法和用途
公开(公告)号：US06504047B2
公开(公告)日：2003-01-07
申请号：US09840977
申请日：2001-04-25
申请人： Günter Knaup
发明人： Günter Knaup
IPC分类号： C07C23900
CPC分类号： C07C229/08 , C07C229/12 , C07C229/26 , C07C229/30 , C07C233/47 , C07C233/91 , C07C255/24
摘要： The present invention is directed towards compounds of the general formula (I) (I) are important intermediates for the preparation of pharmaceuticals. Further intermediates, process for the preparation of (I) and use thereof.
摘要翻译：本发明涉及通式（I）（I）的化合物是制备药物的重要中间体。其它中间体，（I）的制备方法及其用途。

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