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1. 发明申请

US20060147909A1 Microstructures and use thereof for the directed evolution of biomolecules 审中-公开
标题翻译：微结构及其在生物分子定向进化中的应用
公开(公告)号：US20060147909A1
公开(公告)日：2006-07-06
申请号：US10478809
申请日：2002-05-31
申请人： Markus Rarbach , Ulrich Kettling , Jens Stephan , Andre Koltermann
发明人： Markus Rarbach , Ulrich Kettling , Jens Stephan , Andre Koltermann
IPC分类号： C40B40/08 , C40B40/02
CPC分类号： C12N15/1079 , B01L3/502753 , B01L3/502784 , B01L2200/0673 , B01L2300/0864 , B01L2400/0633 , B01L2400/0661
摘要： The invention relates to microstructures and the use thereof for the directed evolution of biomolecules.
摘要翻译：本发明涉及微结构及其在生物分子定向进化中的应用。

2. 发明申请

US20090233801A1 MICROSTRUCTURES AND USE THEREOF FOR THE DIRECTED EVOLUTION OF BIOMOLECULES 审中-公开
标题翻译：用于生物分子指导性进化的微结构及其用途
公开(公告)号：US20090233801A1
公开(公告)日：2009-09-17
申请号：US12435916
申请日：2009-05-05
申请人： Markus Rarbach , Ulrich Kettling , Jens Stephan , Andre Koltermann
发明人： Markus Rarbach , Ulrich Kettling , Jens Stephan , Andre Koltermann
IPC分类号： C40B10/00 , C40B60/10
CPC分类号： C12N15/1079 , B01L3/502753 , B01L3/502784 , B01L2200/0673 , B01L2300/0864 , B01L2400/0633 , B01L2400/0661
摘要： The invention relates to microstructures and the use thereof for the directed evolution of biomolecules.
摘要翻译：本发明涉及微结构及其在生物分子定向进化中的应用。

3. 发明授权

US08679795B2 Thermostable xylanase for the selective hydrolysis of pentose-containing polysaccharides 有权
标题翻译：用于选择性水解含糖的多糖的热稳定的木聚糖酶
公开(公告)号：US08679795B2
公开(公告)日：2014-03-25
申请号：US13517344
申请日：2010-12-15
申请人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
发明人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
IPC分类号： C12N9/24
CPC分类号： C12N9/248
摘要： The present invention relates to polypeptides having xylanase activity and nucleic acid sequences encoding such polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. One specific application of the xylanase is the selective hydrolysis of pentose sugar components of hemicellulose-containing plant biomass. The nucleotide sequence may be used for the production of the xylanase or optimized mutants thereof.
摘要翻译：本发明涉及具有木聚糖酶活性的多肽和编码此类多肽的核酸序列。本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及用于产生和使用多肽的方法。木聚糖酶的一个具体应用是含有半纤维素的植物生物质的戊糖糖成分的选择性水解。核苷酸序列可用于生产木聚糖酶或其优化的突变体。

4. 发明申请

US20120135475A1 LIQUEFIED BIOMASS 有权
标题翻译：液化生物量
公开(公告)号：US20120135475A1
公开(公告)日：2012-05-31
申请号：US13322395
申请日：2010-05-21
申请人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
发明人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
IPC分类号： C12P19/14 , C07H3/04 , C07H3/02 , C12P1/04 , C12P1/02
CPC分类号： C12P19/02 , C12P19/14 , Y02E50/17
摘要： The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.
摘要翻译：本发明涉及液化甜菜和/或甘蔗生物质材料及其生产方法和用途。液化生物质储存稳定，可用于生产发酵产物。

5. 发明申请

US20090004697A1 Generation of Chemical Building Blocks from Plant Biomass by Selective Depolymerization 有权
标题翻译：通过选择性解聚从植物生物量生成化学构件
公开(公告)号：US20090004697A1
公开(公告)日：2009-01-01
申请号：US12138096
申请日：2008-06-12
申请人： Andre Koltermann , Ulrich Kettling , Thomas Bruck , Markus Rarbach
发明人： Andre Koltermann , Ulrich Kettling , Thomas Bruck , Markus Rarbach
IPC分类号： C12P19/00
CPC分类号： C12N9/2434 , C12N9/0061 , C12P19/02 , C12P19/12 , C12P19/14 , C12P19/16 , C12P19/18 , C12P19/20 , C12P19/22 , C12P19/24 , C13B35/005 , C13K1/02 , C13K1/06 , C13K13/002
摘要： The invention concerns a method for the enzymatic treatment of raw polymeric feedstock comprising the following steps: (a) preferably separation of soluble components from the raw polymeric feedstock, (b) treating the raw polymeric feedstock with an enzyme system in order to liberate defined soluble monomeric or oligomeric building blocks from the insoluble raw polymeric feedstock; and (c) separating the defined monomeric or oligomeric building blocks produced in step b) from the remainder of the raw polymeric feedstock. Preferably, the enzyme system used in step b) contains not more than 50%, preferably not more than 20%, more preferably not more than 10%, more preferably not more than 5%, more preferably not more than 2%, more preferably not more than 1% of other enzyme activities apart from the enzyme activity resulting in liberation of said defined monomeric or oligomeric building blocks from the raw polymeric feedstock according to step b). Further aspects of the invention concern the use of “less pure” and thus less costly enzyme systems in subsequent enzymatic treatment steps and methods for determining the optimum sequence of enzymatic treatment steps by analysis of the raw polymeric feedstock used.
摘要翻译：本发明涉及用于酶处理原料聚合物原料的方法，包括以下步骤：（a）优选将可溶性组分与原料聚合原料分离，（b）用酶体系处理原料聚合物原料，以释放限定的可溶性来自不溶性原料聚合原料的单体或低聚结构单元; 和（c）将步骤b）中制备的限定的单体或低聚结构单元与原始聚合原料的其余部分分离。优选地，步骤b）中使用的酶系统含有不超过50％，优选不超过20％，更优选不超过10％，更优选不超过5％，更优选不超过2％不超过1％的其它酶活性，除了酶活性，导致根据步骤b）从所述原料聚合物原料释放所述限定的单体或低聚结构单元。本发明的另外方面涉及在随后的酶处理步骤中使用“较不纯”且因此较低成本的酶体系，以及通过分析所用原料聚合物原料来确定酶处理步骤的最佳顺序的方法。

6. 发明申请

US20130123115A1 OPTIMIZED CELLULASE ENZYMES 有权
标题翻译：优化的纤维素酶
公开(公告)号：US20130123115A1
公开(公告)日：2013-05-16
申请号：US13578291
申请日：2011-02-11
申请人： Ulrich Kettling , Christoph Reisinger , Thomas Brück , Andre Koltermann , Jochen Gerlach , Isabel Unterstrasser , Lutz Röcher , Markus Rarbach , Jörg Claren , Andreas Kohl , Jan Carsten Pieck , Dominik Schlosser
发明人： Ulrich Kettling , Christoph Reisinger , Thomas Brück , Andre Koltermann , Jochen Gerlach , Isabel Unterstrasser , Lutz Röcher , Markus Rarbach , Jörg Claren , Andreas Kohl , Jan Carsten Pieck , Dominik Schlosser
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/24 , C12Y302/01091
摘要： The invention discloses cellulase enzymes with optimized properties for processing of cellulose- and lignocellulose-containing substrates. In particular, cellobiohydrolase enzymes with preferred characteristics are disclosed. The present invention provides fusion, insertion, deletion and/or substitution variants of such enzymes. Enzyme variants have enhanced thermostability, proteolytic stability, specific activity and/or stability at extreme pH. Nucleic acid molecules encoding said enzymes, a composition comprising said enzymes, a method for preparation, and the use for cellulose processing and/or for the production of biofuels are disclosed.
摘要翻译：本发明公开了具有优化的用于加工含纤维素和木质素纤维素的底物的纤维素酶。特别地，公开了具有优选特性的纤维二糖水解酶。本发明提供了这种酶的融合，插入，缺失和/或取代变体。酶变体在极端pH下具有增强的热稳定性，蛋白水解稳定性，比活度和/或稳定性。公开了编码所述酶的核酸分子，包含所述酶的组合物，制备方法以及用于纤维素加工和/或生产生物燃料的用途。

7. 发明授权

US09458443B2 Optimized cellulase enzymes 有权
标题翻译：优化的纤维素酶
公开(公告)号：US09458443B2
公开(公告)日：2016-10-04
申请号：US13578291
申请日：2011-02-11
申请人： Ulrich Kettling , Christoph Reisinger , Thomas Brück , Andre Koltermann , Jochen Gerlach , Isabel Unterstrasser , Lutz Röcher , Markus Rarbach , Jörg Claren , Andreas Kohl , Jan Carsten Pieck , Dominik Schlosser
发明人： Ulrich Kettling , Christoph Reisinger , Thomas Brück , Andre Koltermann , Jochen Gerlach , Isabel Unterstrasser , Lutz Röcher , Markus Rarbach , Jörg Claren , Andreas Kohl , Jan Carsten Pieck , Dominik Schlosser
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/24 , C12Y302/01091
摘要： The invention discloses cellulase enzymes with optimized properties for processing of cellulose- and lignocellulose-containing substrates. In particular, cellobiohydrolase enzymes with preferred characteristics are disclosed. The present invention provides fusion, insertion, deletion and/or substitution variants of such enzymes. Enzyme variants have enhanced thermostability, proteolytic stability, specific activity and/or stability at extreme pH. Nucleic acid molecules encoding said enzymes, a composition comprising said enzymes, a method for preparation, and the use for cellulose processing and/or for the production of biofuels are disclosed.
摘要翻译：本发明公开了具有优化的用于加工含纤维素和木质素纤维素的底物的纤维素酶。特别地，公开了具有优选特性的纤维二糖水解酶。本发明提供了这种酶的融合，插入，缺失和/或取代变体。酶变体在极端pH下具有增强的热稳定性，蛋白水解稳定性，比活性和/或稳定性。公开了编码所述酶的核酸分子，包含所述酶的组合物，制备方法以及用于纤维素加工和/或生产生物燃料的用途。

8. 发明授权

US09005936B2 Liquefied biomass 有权
标题翻译：液化生物质
公开(公告)号：US09005936B2
公开(公告)日：2015-04-14
申请号：US13322395
申请日：2010-05-21
申请人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
发明人： Andre Koltermann , Markus Rarbach , Thomas Bruck , Jochen Gerlach , Isabel Unterstrasser , Andreas Kohl , Zdravko Dragovic , Ulrich Kettling
IPC分类号： C12P19/14 , C12P19/02 , C12P1/04 , C12P1/02 , C07H3/02
CPC分类号： C12P19/02 , C12P19/14 , Y02E50/17
摘要： The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.
摘要翻译：本发明涉及液化甜菜和/或甘蔗生物质材料及其生产方法和用途。液化生物质储存稳定，可用于生产发酵产物。

9. 发明授权

US08524471B2 Generation of chemical building blocks from plant biomass by selective depolymerization 有权
标题翻译：通过选择性解聚从植物生物量生成化学积木
公开(公告)号：US08524471B2
公开(公告)日：2013-09-03
申请号：US12138096
申请日：2008-06-12
申请人： Andre Koltermann , Ulrich Kettling , Thomas Bruck , Markus Rarbach
发明人： Andre Koltermann , Ulrich Kettling , Thomas Bruck , Markus Rarbach
IPC分类号： C12P19/02 , C12P21/04 , C12Q1/00
CPC分类号： C12N9/2434 , C12N9/0061 , C12P19/02 , C12P19/12 , C12P19/14 , C12P19/16 , C12P19/18 , C12P19/20 , C12P19/22 , C12P19/24 , C13B35/005 , C13K1/02 , C13K1/06 , C13K13/002
摘要： The invention concerns a method for the enzymatic treatment of raw polymeric feedstock comprising the following steps: (a) preferably separation of soluble components from the raw polymeric feedstock, (b) treating the raw polymeric feedstock with an enzyme system in order to liberate defined soluble monomeric or oligomeric building blocks from the insoluble raw polymeric feedstock; and (c) separating the defined monomeric or oligomeric building blocks produced in step b) from the remainder of the raw polymeric feedstock. Preferably, the enzyme system used in step b) contains not more than 50%, preferably not more than 20%, more preferably not more than 10%, more preferably not more than 5%, more preferably not more than 2%, more preferably not more than 1% of other enzyme activities apart from the enzyme activity resulting in liberation of said defined monomeric or oligomeric building blocks from the raw polymeric feedstock according to step b). Further aspects of the invention concern the use of “less pure” and thus less costly enzyme systems in subsequent enzymatic treatment steps and methods for determining the optimum sequence of enzymatic treatment steps by analysis of the raw polymeric feedstock used.
摘要翻译：本发明涉及用于酶处理原料聚合物原料的方法，包括以下步骤：（a）优选将可溶性组分与原料聚合原料分离，（b）用酶体系处理原料聚合物原料，以释放限定的可溶性来自不溶性原料聚合原料的单体或低聚结构单元; 和（c）将步骤b）中制备的限定的单体或低聚结构单元与原始聚合原料的其余部分分离。优选地，步骤b）中使用的酶系统含有不超过50％，优选不超过20％，更优选不超过10％，更优选不超过5％，更优选不超过2％不超过1％的其它酶活性，除了酶活性，导致根据步骤b）从所述原料聚合物原料释放所述限定的单体或低聚结构单元。本发明的另外方面涉及在随后的酶处理步骤中使用“较不纯”且因此较低成本的酶体系，以及通过分析所用原料聚合物原料来确定酶处理步骤的最佳顺序的方法。

10. 发明申请

US20130109062A1 THERMOSTABLE XYLANASE FOR THE SELECTIVE HYDROLYSIS OF PENTOSE-CONTAINING POLYSACCHARIDES 有权
标题翻译：用于选择性水解含PENTOSE的多糖的热稳定性XYLANASE
公开(公告)号：US20130109062A1
公开(公告)日：2013-05-02
申请号：US13517344
申请日：2010-12-15
申请人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
发明人： Andreas Kohl , Isabel Unterstrasser , Markus Rarbach , Andre Koltermann , Christoph Reisinger , Thomas Brück , Ulrich Kettling , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson
IPC分类号： C12N9/24
CPC分类号： C12N9/248
摘要： The present invention relates to polypeptides having xylanase activity and nucleic acid sequences encoding such polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. One specific application of the xylanase is the selective hydrolysis of pentose sugar components of hemicellulose-containing plant biomass. The nucleotide sequence may be used for the production of the xylanase or optimized mutants thereof.
摘要翻译：本发明涉及具有木聚糖酶活性的多肽和编码此类多肽的核酸序列。本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及用于产生和使用多肽的方法。木聚糖酶的一个具体应用是含有半纤维素的植物生物质的戊糖糖成分的选择性水解。核苷酸序列可用于生产木聚糖酶或其优化的突变体。

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