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1. 发明申请

US20050014742A1 Use of inhibitors of the y2 receptor of neuropeptide y in the treatment of alcoholism 审中-公开
标题翻译：使用神经肽Y的y2受体抑制剂治疗酒精中毒
公开(公告)号：US20050014742A1
公开(公告)日：2005-01-20
申请号：US10492785
申请日：2002-10-18
申请人： Markus Heilig , Annika Thorsell , Claes Wahlestedt
发明人： Markus Heilig , Annika Thorsell , Claes Wahlestedt
IPC分类号： A61K31/00 , A61K31/195 , A61K31/4166 , A61K31/4196 , A61K31/495 , A61K31/496 , A61K31/53 , A61K38/22 , A61P25/32 , A61K31/55 , A61K31/40 , A61K31/445 , A61K31/537
CPC分类号： A61K38/2271 , A61K31/00 , A61K31/195 , A61K31/4166 , A61K31/4196 , A61K31/495 , A61K31/496 , A61K31/53
摘要： The present invention relates to the use of a substance that inhibits the Y2 receptor of neuropeptide Y for the preparation of a pharmaceutical composition for treatment of alcoholism. It also relates to a pharmaceutical composition comprising at least one substance with activity against alcohol consumption.
摘要翻译：本发明涉及抑制神经肽Y的Y2受体的物质用于制备用于治疗酒精中毒的药物组合物的用途。它还涉及包含至少一种具有抗酒精消耗活性的物质的药物组合物。

2. 发明申请

US20080191425A1 Planar Seal 审中-公开
标题翻译：平面密封
公开(公告)号：US20080191425A1
公开(公告)日：2008-08-14
申请号：US11909523
申请日：2006-02-02
申请人： Martin Gasch , Markus Heilig , Ralf Flemming
发明人： Martin Gasch , Markus Heilig , Ralf Flemming
IPC分类号： F02F11/00
CPC分类号： F02F11/002 , F16J15/0818 , F16J15/0825 , F16J2015/085 , F16J2015/0862 , F16J2015/0868
摘要： The invention relates to a planar seal, in particular, a cylinder head gasket for an internal combustion engine, comprising several through openings, and several media through openings, whereby a web with at least one bead is formed between individual through openings and at least one stopper element is provided radially adjacent to the bead, for each through opening. A through drilling is provided in the web region, through the bead for the passage of media.
摘要翻译：本发明涉及一种平面密封件，特别是用于内燃机的气缸盖衬垫，其包括多个通孔，以及几个介质通孔，由此在各个通孔和至少一个通孔之间形成有至少一个胎圈的腹板针对每个通孔，止动元件径向地邻近胎圈设置。在纸幅区域中通过珠子提供贯穿钻孔以通过介质。

3. 发明申请

US20060261561A1 Flat gasket, in particular cylinder-head gasket 审中-公开
标题翻译：平垫圈，特别是气缸盖垫片
公开(公告)号：US20060261561A1
公开(公告)日：2006-11-23
申请号：US10549068
申请日：2004-02-26
申请人： Markus Heilig
发明人： Markus Heilig
IPC分类号： F02F11/00
CPC分类号： F02F11/002 , F16J15/0825 , F16J2015/085 , F16J2015/0862
摘要： The invention relates to a flat gasket, in particular a cylinder-head gasket for internal combustion engines, comprising at least one support element, in particular a metallic element, which is provided with at least one passage on the combustion chamber side. According to the invention, the passage is surrounded by a concentric stopper element and at least one concentric elastic half-bead that is inserted into a metallic functional layer. The half-bead lies in a direct force fit against the stopper element, the latter having a greater thickness than that of the support element.
摘要翻译：本发明涉及一种平垫圈，特别是用于内燃机的气缸盖衬垫，其包括至少一个支撑元件，特别是在燃烧室侧设有至少一个通道的金属元件。根据本发明，通道被同心止动元件和插入金属功能层中的至少一个同心弹性半珠包围。半胎圈位于与止动元件的直接力配合中，后者具有比支撑元件的厚度更大的厚度。

4. 发明授权

US06722662B2 Metallic cylinder head gasket 有权
标题翻译：金属气缸盖垫片
公开(公告)号：US06722662B2
公开(公告)日：2004-04-20
申请号：US10046664
申请日：2002-01-16
申请人： Markus Heilig , Christoph Hilgert , Fabrice Audibert
发明人： Markus Heilig , Christoph Hilgert , Fabrice Audibert
IPC分类号： F02F1100
CPC分类号： F16J15/0825 , F16J2015/085 , F16J2015/0862 , F16J2015/0875
摘要： A metal cylinder head gasket includes a spacer plate; a sealing layer superposed on the spacer plate; an opening in the spacer plate and the sealing layer for surrounding a combustion chamber of an internal-combustion engine and a full bead provided in the sealing layer and surrounding the opening. The full bead has a crest, and first and second bead feet situated radially inward and, respectively, radially outward of the crest. An annular overlay surrounds the opening and is positioned between the spacer plate and the sealing layer and is in engagement with the full bead. The annular overlay has a radially inner edge face in alignment with the opening edges; and a radially outer edge face situated between the crest and the second bead foot. The sealing layer further has a half bead surrounding the full bead and being spaced radially outward from the second bead foot.
摘要翻译：金属气缸盖垫片包括间隔板; 重叠在间隔板上的密封层; 间隔板中的开口和用于包围设置在密封层中并围绕开口的内燃机和燃烧室的燃烧室的密封层。整个胎圈具有顶部，以及分别径向向内并且分别在顶部径向向外的第一和第二胎圈支脚。环形覆盖物围绕开口并且定位在间隔板和密封层之间并且与整个胎圈接合。环形覆盖层具有与开口边缘对准的径向内边缘面; 以及位于顶部和第二胎圈脚之间的径向外边缘面。密封层还具有围绕整个焊道并与第二焊道脚径向向外间隔开的半焊道。

5. 发明申请

US20080185790A1 Planar Seal 审中-公开
标题翻译：平面密封
公开(公告)号：US20080185790A1
公开(公告)日：2008-08-07
申请号：US11909561
申请日：2006-02-02
申请人： Martin Gasch , Markus Heilig , Ralf Flemming
发明人： Martin Gasch , Markus Heilig , Ralf Flemming
IPC分类号： F16J15/08
CPC分类号： F02F11/002 , F16J15/0818 , F16J15/0825 , F16J2015/0868
摘要： A planar seal, in particular, a cylinder head gasket for an internal combustion engine, is provided with several through openings forming a web between the same, several screw and media through openings, at least one bead in the region of each through opening and each web which are contiguous, whereby at least one through drilling is provided on the web side and embodied such that the beads on the through opening side pass to both sides of the through drilling in the direction of the web and are connected to the beads running through the web in the region of the web.
摘要翻译：平面密封件，特别是用于内燃机的气缸盖衬垫，设置有几个通孔，该通孔在相同的几个螺杆和介质通过开口之间形成腹板，每个通孔的区域中的至少一个胎圈纤维网是连续的，由此至少一个贯通钻孔设置在幅材侧上并且被实施为使得通孔开口侧上的珠粒沿着网状物的方向通过贯通钻孔的两侧，并且连接到穿过的珠粒网络在网络的区域。

6. 发明授权

US06180167B2 Method of providing a wear-resistant overlay on a metal sealing gasket 失效
标题翻译：在金属密封垫上提供耐磨覆盖层的方法
公开(公告)号：US06180167B2
公开(公告)日：2001-01-30
申请号：US08880436
申请日：1997-06-23
申请人： Klaus-Peter Majewski , Klaus Schmitt , Markus Heilig , Matthias Heike , Klaus Lönne
发明人： Klaus-Peter Majewski , Klaus Schmitt , Markus Heilig , Matthias Heike , Klaus Lönne
IPC分类号： B05D302
CPC分类号： F02F11/002 , F16J15/0825 , F16J2015/085 , F16J2015/0856
摘要： A flat metal sealing gasket is made as follows: on an unhardened spring steel plate having an aperture and a bead surrounding the aperture, a sinterable powder is deposited along the bead in a desired shape and thickness. Thereafter a sufficiently high temperature is applied to the deposited sinterable powder to effect sintering or melting of the powder to provide a pressure-resistant overlay on the plate and to simultaneously effect a hardening of the plate.
摘要翻译：平面金属密封垫片如下制成：在具有孔和未围绕孔的未硬化弹簧钢板上，沿着焊道以可以期望的形状和厚度沉积可烧结粉末。然后将足够高的温度施加到沉积的可烧结粉末上以实现粉末的烧结或熔化，以在板上提供耐压覆盖层并同时实现板的硬化。

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