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1. 发明授权

US07404911B2 Heat-transfer media having improved thermal stability and based on higher polyglycols 有权
标题翻译：具有改进的热稳定性和基于较高聚二醇的热转印介质
公开(公告)号：US07404911B2
公开(公告)日：2008-07-29
申请号：US11701773
申请日：2007-02-02
申请人： Markus Hafner , Achim Stankowiak , Johann Schuster , Stefan Mauerberger
发明人： Markus Hafner , Achim Stankowiak , Johann Schuster , Stefan Mauerberger
IPC分类号： C09K5/10 , C09K5/00 , C09K5/08 , C09K3/18
CPC分类号： C09K5/10 , F24S80/20 , Y10S126/91
摘要： The present invention relates to heat-transfer concentrates for solar installations, containing a) from 92 to 99% by weight of at least one polyglycol of the formula R—O—(CH2—CH2—O)n—H, in which n is an integer of from 3 to 500 and R is H, a C1- to C4-alkyl group or an aromatic radical having 6 to 12 carbon atoms, b) from 1 to 8% by weight of at least one corrosion inhibitor, with the proviso that its content of ethylene glycol and 1,2-propylene glycol is less than 0.2% by weight.
摘要翻译：本发明涉及用于太阳能装置的传热浓缩物，其含有a）92-99％（重量）至少一种式RO-（CH 2 -CH 2）2的聚二醇，其中n为3〜500的整数，R为H，C 1〜C 4，具有6至12个碳原子的芳族基团，b）1至8重量％的至少一种腐蚀抑制剂，条件是其乙二醇和1,2-丙二醇的含量小于0.2重量％。

2. 发明申请

US20060033076A1 Silicate-free cooling liquids based on organic acids and carbamates having improved corrosion properties 审中-公开
标题翻译：基于有机酸和具有改善腐蚀性能的氨基甲酸酯的无硅酸盐冷却液
公开(公告)号：US20060033076A1
公开(公告)日：2006-02-16
申请号：US11200950
申请日：2005-08-10
申请人： Markus Hafner , Achim Stankowiak
发明人： Markus Hafner , Achim Stankowiak
IPC分类号： C09K5/00
CPC分类号： C09K5/10 , C09K5/20 , C23F11/10
摘要： The invention relates to coolants or antifreeze concentrates containing: a) from 0.05 to 5% by weight of one or more carbamates of the formula in which X is O or S, R is C1- to C8-alkyl or C6- to C18-aryl, or the ammonium salts thereof, b) from 0.05 to 4% by weight of a tricarboxylic acid and/or of a triazinetriiminocarboxylic acid, c) from 0.05 to 8% by weight of a mono- and/or dicarboxylic acid having 4 to 16 carbon atoms, in the form of their alkali metal or ammonium salts, d) from 0.01 to 2% by weight of a hydrocarbon-triazole or hydrocarbon-thiazole, e) from 0.01 to 2% by weight of a water-soluble alkali metal salt and/or alkaline earth metal salt and f) from 80 to 99% by weight of alkylene glycols, polyglycols or glycerol.
摘要翻译：本发明涉及冷却剂或防冻浓缩物，其含有：a）0.05至5重量％的一种或多种下式的其中X为O或S的氨基甲酸酯，R为C 1〜 C 8 - 烷基或C 6 - 至C 18 - 芳基或其铵盐，b）0.05至4重量％的三羧酸和/或三嗪三亚胺羧酸，c）0.05至8重量％的具有4至16个碳原子的单羧酸和/或二羧酸，其碱金属或铵盐形式，d）0.01 至2重量％的烃 - 三唑或烃 - 噻唑，e）0.01至2重量％的水溶性碱金属盐和/或碱土金属盐和f）80至99重量％的亚烷基二醇，聚二醇或甘油。

3. 发明申请

US20070181849A1 Heat-transfer media having improved thermal stability and based on higher polyglycols 有权
标题翻译：具有改进的热稳定性和基于较高聚二醇的热转印介质
公开(公告)号：US20070181849A1
公开(公告)日：2007-08-09
申请号：US11701773
申请日：2007-02-02
申请人： Markus Hafner , Achim Stankowiak , Johann Schuster , Stefan Mauerberger
发明人： Markus Hafner , Achim Stankowiak , Johann Schuster , Stefan Mauerberger
IPC分类号： C09K3/18 , C09K5/00
CPC分类号： C09K5/10 , F24S80/20 , Y10S126/91
摘要： The present invention relates to heat-transfer concentrates for solar installations, containing a) from 92 to 99% by weight of at least one polyglycol of the formula R—O—(CH2—CH2—O)n—H, in which n is an integer of from 3 to 500 and R is H, a C1- to C4-alkyl group or an aromatic radical having 6 to 12 carbon atoms, b) from 1 to 8% by weight of at least one corrosion inhibitor, with the proviso that its content of ethylene glycol and 1,2-propylene glycol is less than 0.2% by weight.
摘要翻译：本发明涉及用于太阳能装置的传热浓缩物，其含有a）92-99％（重量）至少一种式RO-（CH 2 -CH 2）2的聚二醇，其中n为3〜500的整数，R为H，C 1〜C 4，具有6至12个碳原子的芳族基团，b）1至8重量％的至少一种腐蚀抑制剂，条件是其乙二醇和1,2-丙二醇的含量小于0.2重量％。

4. 发明授权

US06881355B2 Antifreeze 失效
标题翻译：防冻液
公开(公告)号：US06881355B2
公开(公告)日：2005-04-19
申请号：US10627136
申请日：2003-07-25
申请人： Markus Hafner , Gisela Stockbauer , Oliver Pfueller , Achim Stankowiak
发明人： Markus Hafner , Gisela Stockbauer , Oliver Pfueller , Achim Stankowiak
IPC分类号： C23F11/16 , C09K5/20 , C23F11/10 , C23F11/12 , C23F11/14 , C23F11/18 , C09K5/00
CPC分类号： C23F11/10 , C09K5/20
摘要： The present invention relates to antifreeze concentrates comprising a) from 0.05 to 10% by weight of one or more sulfonated or sulfated polyglycols of the formula R—(O)l-(A-O)m—(CH2)k—SO3X in which A is C2- to C4-alkylene, R is H, C1- to C10-alkyl, C2- to C20-alkenyl or C6- to C18-aryl, X is H, an alkali metal or alkaline earth metal, k is a number from 0 to 10, l is 0 or 1, m is a number from 1 to 200, b) from 0.05 to 5% by weight of one or more carbamates of the formula in which X is O or S, R is C1- to C8-alkyl or C6- to C18-aryl, or a corresponding ammonium salt, c) from 0.05 to 5% by weight of an aliphatic or aromatic amine, d) from 0.01 to 1% by weight of a hydrocarbon-triazole, e) alkylene glycols to 100% by weight.
摘要翻译：本发明涉及防冻剂浓缩物，其包含a）0.05至10重量％的一种或多种式（α）的磺化或硫酸化聚二醇，其中：-in-line-formula description =“In-line Formulas”end =“lead” （O）1 - （AO）m - （CH 2）n - 3 其中A是C <2>到C 4 < 亚烷基，R为H，C 1至C 10 - 烷基，C 2 - 至C 20 - 亚烷基或C 6 - 至C 18 - 芳基，X为H，碱金属或碱土金属，k为0至10的数，l 为0或1，m为1至200的数，b）0.05至5重量％的一种或多种下式的其中X为O或S的氨基甲酸酯，R为C 1〜至C 8 - 烷基或C 6 - 至C 18 - 芳基或相应的铵盐，c）0.05至5％的脂族或芳族胺，d）0.01至1重量％的烃 - 三氮唑烯烃，e）亚烷基二醇至100重量％。

5. 发明申请

US20090105286A1 Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors 失效
标题翻译：细胞毒素家族鸟嘌呤核苷酸交换因子的低分子抑制剂
公开(公告)号：US20090105286A1
公开(公告)日：2009-04-23
申请号：US11667046
申请日：2005-11-18
申请人： Michael Famulok , Waldemar Kolanus , Markus Hafner , Imke Grune , Barbara Tappertzhofen , Mirko Theis
发明人： Michael Famulok , Waldemar Kolanus , Markus Hafner , Imke Grune , Barbara Tappertzhofen , Mirko Theis
IPC分类号： A61K31/506 , C07D405/02 , C07D417/06 , C07D409/14 , A61K31/426 , A61K31/36 , A61K31/381 , C07D407/12 , G01N33/566 , A61K31/4196
CPC分类号： A61K31/427 , A61K31/4196 , A61K31/506 , G01N2500/02
摘要： The invention relates to drugs and the use thereof, wherein said drugs contain compounds selected from a group comprising general formulas (1), (2), (3) and (4) and/or enantiomers, diastereomers or the pharmaceutically acceptable salts thereof. Said drugs are used for treating autoimmune and tumoral diseases and/or for immunosuppresion.
摘要翻译：本发明涉及药物及其用途，其中所述药物含有选自由通式（1），（2），（3）和（4）组成的组的化合物和/或其对映体，非对映异构体或其药学上可接受的盐。所述药物用于治疗自身免疫性和肿瘤性疾病和/或用于免疫抑制。

6. 发明申请

US20110287412A1 Methods for Identifying RNA Segments Bound by RNA-Binding Proteins or Ribonucleoprotein Complexes 有权
标题翻译：识别由RNA结合蛋白或核糖核蛋白复合物结合的RNA片段的方法
公开(公告)号：US20110287412A1
公开(公告)日：2011-11-24
申请号：US13055976
申请日：2009-07-28
申请人： Marcus Landthaler , Manuel Ascano, JR. , Markus Hafner , Thomas Tuschl , Mohsen Khorshid , Lukas Burger , Mihaela Zavolan
发明人： Marcus Landthaler , Manuel Ascano, JR. , Markus Hafner , Thomas Tuschl , Mohsen Khorshid , Lukas Burger , Mihaela Zavolan
IPC分类号： C12Q1/68
CPC分类号： C12N15/1058 , C12Q1/6869 , C12Q2527/125 , C12Q2523/313 , C12Q2523/101
摘要： The present invention relates to a method for identifying a binding site on an RNA transcript, wherein the binding site binds to one or more binding moieties. The method includes, among other things, introducing a photoreactive nucleoside into living cells wherein the living cells incorporate the photoreactive nucleoside into RNA transcripts during transcription thereby producing modified RNA transcripts; reverse transcribing the RNA of isolated cross-linked segments thereby generating cDNA transcripts with one mutation wherein the photoreactive nucleoside is transcribed to a mismatched deoxynucleoside; amplifying the cDNA transcripts thereby generating amplicons; and analyzing the sequences of the amplicons aligned against the reference sequence so as to identify the binding site, wherein the sequences of each amplicon having a mutation resulting from the introduction of the photoreactive nucleoside is considered to be a valid amplicon comprising at least a portion of a binding site on the RNA transcript.
摘要翻译：本发明涉及用于鉴定RNA转录物上的结合位点的方法，其中结合位点结合一个或多个结合部分。该方法包括将光反应性核苷引入活细胞中，其中活细胞在转录过程中将光活性核苷掺入RNA转录物中从而产生修饰的RNA转录物; 反向转录分离的交联链节段的RNA，从而产生具有一个突变的cDNA转录物，其中光活性核苷被转录成错配的脱氧核苷; 扩增cDNA转录物从而产生扩增子; 并分析与参考序列比对的扩增子的序列，以便鉴定结合位点，其中具有由引入光活性核苷产生的突变的每个扩增子的序列被认为是有效的扩增子，其包含至少一部分 RNA转录本上的结合位点。

7. 发明申请

US20100048594A1 USE OF CYTOHESIN INHIBITORS FOR CHEMICALLY INDUCING LONGEVITY 审中-公开
标题翻译： CYTOHESIN抑制剂用于化学诱导长期使用
公开(公告)号：US20100048594A1
公开(公告)日：2010-02-25
申请号：US12514861
申请日：2007-11-14
申请人： Michael Famulok , Markus Hafner , Anton Schmitz , Bernhard Fuss , Ingo Zinke , Michael Hoch
发明人： Michael Famulok , Markus Hafner , Anton Schmitz , Bernhard Fuss , Ingo Zinke , Michael Hoch
IPC分类号： A61K31/4196 , A61K31/505 , A61K31/341 , A61K31/343 , A61P1/16 , A61P3/06 , A61P1/18
CPC分类号： A61K31/4196 , A61K31/343 , A61K31/381 , A61K31/506
摘要： The invention relates to compounds selected from among the group comprising general formulas (1), (2), (3), and/or (4) and/or the enantiomers, diastereomers, and derivatives thereof, and the pharmaceutically acceptable salts thereof for producing a medicament used for therapeutically and/or preventively treating disease and pathological conditions linked to regulation of the insulin and/or insulin-like growth factor (IGF) signalling pathway and/or for chemically inducing longevity.
摘要翻译：本发明涉及选自通式（1），（2），（3）和/或（4）的化合物和/或其对映体，非对映异构体及其衍生物及其药学上可接受的盐，其用于产生用于治疗和/或预防性治疗与调节胰岛素和/或胰岛素样生长因子（IGF）信号传导途径和/或用于化学诱导寿命相关的疾病和病理状况的药物。

8. 发明授权

US08841073B2 Methods for identifying RNA segments bound by RNA-binding proteins or ribonucleoprotein complexes 有权
标题翻译：用于鉴定由RNA结合蛋白或核糖核蛋白复合物结合的RNA区段的方法
公开(公告)号：US08841073B2
公开(公告)日：2014-09-23
申请号：US13055976
申请日：2009-07-28
申请人： Markus Landthaler , Manuel Ascano, Jr. , Markus Hafner , Thomas Tuschl , Mohsen Khorshid , Lukas Burger , Mihaela Zavolan
发明人： Markus Landthaler , Manuel Ascano, Jr. , Markus Hafner , Thomas Tuschl , Mohsen Khorshid , Lukas Burger , Mihaela Zavolan
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1058 , C12Q1/6869 , C12Q2527/125 , C12Q2523/313 , C12Q2523/101
摘要： The present invention relates to a method for identifying a binding site on an RNA transcript, wherein the binding site binds to one or more binding moieties. The method includes, among other things, introducing a photoreactive nucleoside into living cells wherein the living cells incorporate the photoreactive nucleoside into RNA transcripts during transcription thereby producing modified RNA transcripts; reverse transcribing the RNA of isolated cross-linked segments thereby generating cDNA transcripts with one mutation wherein the photoreactive nucleoside is transcribed to a mismatched deoxynucleoside; amplifying the cDNA transcripts thereby generating amplicons; and analyzing the sequences of the amplicons aligned against the reference sequence so as to identify the binding site, wherein the sequences of each amplicon having a mutation resulting from the introduction of the photoreactive nucleoside is considered to be a valid amplicon comprising at least a portion of a binding site on the RNA transcript.
摘要翻译：本发明涉及用于鉴定RNA转录物上的结合位点的方法，其中结合位点结合一个或多个结合部分。该方法包括将光反应性核苷引入活细胞中，其中活细胞在转录过程中将光活性核苷掺入RNA转录物中从而产生修饰的RNA转录物; 反向转录分离的交联链节段的RNA，从而产生具有一个突变的cDNA转录物，其中光活性核苷被转录成错配的脱氧核苷; 扩增cDNA转录物从而产生扩增子; 并分析与参考序列比对的扩增子的序列，以便鉴定结合位点，其中具有由引入光活性核苷产生的突变的每个扩增子的序列被认为是有效的扩增子，其包含至少一部分 RNA转录本上的结合位点。

9. 发明授权

US08163788B2 Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors 失效
标题翻译：细胞毒素家族鸟嘌呤核苷酸交换因子的低分子抑制剂
公开(公告)号：US08163788B2
公开(公告)日：2012-04-24
申请号：US11667046
申请日：2005-11-18
申请人： Michael Famulok , Waldemar Kolanus , Markus Hafner , Imke Grune , Barbara Tappertzhofen , Mirko Theis
发明人： Michael Famulok , Waldemar Kolanus , Markus Hafner , Imke Grune , Barbara Tappertzhofen , Mirko Theis
IPC分类号： A61K31/4196
CPC分类号： A61K31/427 , A61K31/4196 , A61K31/506 , G01N2500/02
摘要： The invention relates to a pharmaceutical composition and the use thereof, wherein the pharmaceutical composition contains compounds selected from a group of general formulas (5), (6), (7) and (8) and/or enantiomers, diastereomers or the pharmaceutically acceptable salts thereof. The pharmaceutical composition is used for treating autoimmune and tumoral diseases and/or for immunosuppresion.
摘要翻译：本发明涉及药物组合物及其用途，其中药物组合物含有选自通式（5），（6），（7）和（8）的化合物和/或对映异构体，非对映异构体或药学上可接受的的盐。药物组合物用于治疗自身免疫性和肿瘤性疾病和/或用于免疫抑制。

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