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1. 发明授权

US09085506B2 Process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine 有权
标题翻译： 3-氨基甲基-3,5,5-三甲基环己胺的制备方法
公开(公告)号：US09085506B2
公开(公告)日：2015-07-21
申请号：US13991718
申请日：2011-11-18
申请人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
发明人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
IPC分类号： C07C209/00 , C07C209/48 , C07C209/26 , C07C253/10 , C07C45/74
CPC分类号： C07C209/48 , C07C45/74 , C07C209/26 , C07C253/10 , C07C2601/14 , Y02P20/127 , Y02P20/582 , C07C211/36 , C07C255/46 , C07C49/603
摘要： The invention relates to an improved process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, referred to hereinafter as isophoronediamine or, in abbreviated form, IPDA, by: I. preparation of isophorone by catalyzed aldol condensations with acetone as reactant; II. reaction of isophorone with HCN to form isophoronenitrile (IPN, 3-cyano-3,5,5-trimethylcyclohexanone); III. catalytic hydrogenation and/or catalytic reductive amination (also referred to as aminative hydrogenation) of 3-cyano-3,5,5-trimethylcyclohexanone, hereinafter called isophoronenitrile or, in abbreviated form, IPN, to give the isophoronediamine.
摘要翻译：本发明涉及一种改进的3-氨基甲基-3,5,5-三甲基环己胺的制备方法，以下称为异佛尔酮二胺或缩写形式为IPDA，通过以下方法：I.通过丙酮作为反应物的催化醛醇缩合制备异佛尔酮; 二，异佛尔酮与HCN的反应形成异佛尔酮腈（IPN，3-氰基-3,5,5-三甲基环己酮）; 三， 3-氰基-3,5,5-三甲基环己酮的催化氢化和/或催化还原胺化（也称为氨基氢化），以下称为异佛尔酮腈或缩写为IPN，得到异佛尔酮二胺。

2. 发明申请

US20130253226A1 PROCESS FOR PREPARING 3-AMINOMETHYL-3,5,5-TRIMETHYLCYCLOHEXYLAMINE 有权
标题翻译：制备3-氨基乙基-3,5,5-三甲基环己基胺的方法
公开(公告)号：US20130253226A1
公开(公告)日：2013-09-26
申请号：US13991718
申请日：2011-11-18
申请人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D. Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
发明人： Markus Galle , Gerda Grund , Axel Hengstermann , Michael D. Hinton , Rolf Hirsch , Robert Jansen , Cord Knoop , Christian Lettmann , Juergen Lippe , Martin Maier , Joerg-Joachim Nitz , Matthias Orschel , Martina Ortelt , Norbert Richter , Armin Rix , Markus Schwarz , Guido Streukens
IPC分类号： C07C209/48
CPC分类号： C07C209/48 , C07C45/74 , C07C209/26 , C07C253/10 , C07C2601/14 , Y02P20/127 , Y02P20/582 , C07C211/36 , C07C255/46 , C07C49/603
摘要： The invention relates to an improved process for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, referred to hereinafter as isophoronediamine or, in abbreviated form, IPDA, by: I. preparation of isophorone by catalyzed aldol condensations with acetone as reactant; II. reaction of isophorone with HCN to form isophoronenitrile (IPN, 3-cyano-3,5,5-trimethylcyclohexanone); III. catalytic hydrogenation and/or catalytic reductive amination (also referred to as aminative hydrogenation) of 3-cyano-3,5,5-trimethylcyclohexanone, hereinafter called isophoronenitrile or, in abbreviated form, IPN, to give the isophoronediamine.
摘要翻译：本发明涉及一种改进的3-氨基甲基-3,5,5-三甲基环己胺的制备方法，以下称为异佛尔酮二胺或缩写形式为IPDA，通过以下方法：I.通过丙酮作为反应物的催化醛醇缩合制备异佛尔酮; 二，异佛尔酮与HCN的反应形成异佛尔酮腈（IPN，3-氰基-3,5,5-三甲基环己酮）; 三， 3-氰基-3,5,5-三甲基环己酮的催化氢化和/或催化还原胺化（也称为氨基氢化），以下称为异佛尔酮腈或缩写为IPN，得到异佛尔酮二胺。

3. 发明授权

US08889914B2 Method for producing isophorone 有权
标题翻译：异佛尔酮的制备方法
公开(公告)号：US08889914B2
公开(公告)日：2014-11-18
申请号：US13990602
申请日：2011-11-17
申请人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
发明人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
IPC分类号： C07C45/00 , C07C45/85 , C07C45/74 , C07C45/82 , C07C45/42
CPC分类号： C07C45/42 , C07C45/74 , C07C45/82 , C07C45/85 , C07C2601/16 , Y02P20/582 , C07C49/603
摘要： The invention relates to a method for producing isophorone by catalyzed aldol condensation of acetone as an educt, reprocessing the reaction product, hydrolyzing the product stream, and separating into an organic and an aqueous fraction, obtaining isophorone from the organic fraction, distillatively reprocessing the aqueous fraction, and feeding the vapors from the head of the distillative reprocessing apparatus into the hydrolysis apparatus.
摘要翻译：本发明涉及通过丙酮作为离子液体的催化醛醇缩合制备异佛尔酮的方法，对反应产物进行后处理，水解产物流，并分离成有机和含水部分，从有机部分获得异佛尔酮，蒸馏再处理含水并将蒸气从蒸馏后处理装置的头部进料到水解装置中。

4. 发明申请

US20130261343A1 METHOD FOR PRODUCING ISOPHORONE 有权
标题翻译：生产异佛尔酮的方法
公开(公告)号：US20130261343A1
公开(公告)日：2013-10-03
申请号：US13990602
申请日：2011-11-17
申请人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
发明人： Matthias Orschel , Robert Jansen , Martin Maier , Gerda Grund , Markus Schwarz , Joerg-Joachim Nitz , Axel Hengstermann
IPC分类号： C07C45/42
CPC分类号： C07C45/42 , C07C45/74 , C07C45/82 , C07C45/85 , C07C2601/16 , Y02P20/582 , C07C49/603
摘要： The invention relates to a method for producing isophorone by catalyzed aldol condensation of acetone as an educt, reprocessing the reaction product, hydrolyzing the product stream, and separating into an organic and an aqueous fraction, obtaining isophorone from the organic fraction, distillatively reprocessing the aqueous fraction, and feeding the vapors from the head of the distillative reprocessing apparatus into the hydrolysis apparatus.
摘要翻译：本发明涉及通过丙酮作为离子液体的催化醛醇缩合制备异佛尔酮的方法，对反应产物进行后处理，水解产物流，并分离成有机和含水部分，从有机部分获得异佛尔酮，蒸馏再处理含水并将蒸气从蒸馏后处理装置的头部进料到水解装置中。

5. 发明授权

US08884066B2 Process for preparing isophorone in the presence of at least one defoamer in the wastewater column in the workup section 有权
标题翻译：在后处理部分的废水柱中存在至少一种消泡剂的情况下制备异佛尔酮的方法
公开(公告)号：US08884066B2
公开(公告)日：2014-11-11
申请号：US14116233
申请日：2012-04-25
申请人： Matthias Orschel , Robert Jansen , Martin Maier , Joerg-Joachim Nitz , Markus Schwarz
发明人： Matthias Orschel , Robert Jansen , Martin Maier , Joerg-Joachim Nitz , Markus Schwarz
IPC分类号： C07C45/00 , C07C45/85 , C07C45/74 , C07C45/82
CPC分类号： C07C45/82 , C07C45/74 , C07C45/85 , Y02P20/127 , Y02P20/582 , C07C49/603
摘要： The invention relates to a process for preparing isophorone (3,5,5-trimethyl-2-cyclohexen-1-one) in the presence of at least one defoamer in the wastewater column in the workup section.
摘要翻译：本发明涉及一种在后处理部分的废水柱中的至少一种消泡剂存在下制备异佛尔酮（3,5,5-三甲基-2-环己烯-1-酮）的方法。

6. 发明申请

US20140107379A1 PROCESS FOR PREPARING ISOPHORONE IN THE PRESENCE OF AT LEAST ONE DEFOAMER IN THE WASTEWATER COLUMN IN THE WORKUP SECTION 有权
标题翻译：在工作部分的废水塔中至少存在一个缺陷剂的情况下制备异辛酮的方法
公开(公告)号：US20140107379A1
公开(公告)日：2014-04-17
申请号：US14116233
申请日：2012-04-25
申请人： Matthias Orschel , Robert Jansen , Martin Maier , Joerg-Joachim Nitz , Markus Schwarz
发明人： Matthias Orschel , Robert Jansen , Martin Maier , Joerg-Joachim Nitz , Markus Schwarz
IPC分类号： C07C45/82
CPC分类号： C07C45/82 , C07C45/74 , C07C45/85 , Y02P20/127 , Y02P20/582 , C07C49/603
摘要： The invention relates to a process for preparing isophorone (3,5,5-trimethyl-2-cyclohexen-1-one) in the presence of at least one defoamer in the wastewater column in the workup section.
摘要翻译：本发明涉及一种在后处理部分的废水柱中的至少一种消泡剂存在下制备异佛尔酮（3,5,5-三甲基-2-环己烯-1-酮）的方法。

7. 发明授权

US09999673B2 PEGylated lipids and their use for drug delivery 有权
公开(公告)号：US09999673B2
公开(公告)日：2018-06-19
申请号：US13979336
申请日：2012-01-11
申请人： Kallanthottathil G. Rajeev , Muthiah Manoharan , Muthusamy Jayaraman , Martin Maier , Jayaprakash K. Nair , David Butler
发明人： Kallanthottathil G. Rajeev , Muthiah Manoharan , Muthusamy Jayaraman , Martin Maier , Jayaprakash K. Nair , David Butler
IPC分类号： A61K47/18 , C07C235/06 , C07C271/16 , C07D207/12 , C07D307/20 , C07D207/14 , C07D307/12 , C08G65/329 , A61K47/48
CPC分类号： A61K47/18 , A61K47/6911 , C07C235/06 , C07C271/16 , C07D207/12 , C07D207/14 , C07D307/12 , C07D307/20 , C08G65/329 , C08L2203/02
摘要： The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.

8. 发明授权

US09810189B2 Fuel distributor 有权
公开(公告)号：US09810189B2
公开(公告)日：2017-11-07
申请号：US13609694
申请日：2012-09-11
申请人： Martin Maier , Martin Goehner , Markus Feigl , Helmut Schneider , Nikolaus Hautmann , Dietmar Uhlenbrock , Holger Uhrig
发明人： Martin Maier , Martin Goehner , Markus Feigl , Helmut Schneider , Nikolaus Hautmann , Dietmar Uhlenbrock , Holger Uhrig
IPC分类号： F02M69/50 , F02M55/02
CPC分类号： F02M69/50 , F02M55/025 , F02M2200/25 , F02M2200/26 , F02M2200/315 , F02M2200/857
摘要： A fuel distributor, which is used, in particular, for fuel injection systems of mixture-compressing, internal combustion engines having externally supplied ignition, includes a distributor pipe, a first holder and at least one second holder. The distributor pipe has a longitudinal axis. In this connection, the first holder and the second holder are situated at the distributor pipe so as to be axially set apart from one another with respect to the longitudinal axis. The distributor pipe is designed to allow axial length compensation. It is also possible for at least one holder to be designed to allow axial length compensation.

9. 发明授权

US09325165B2 Device and method for protecting a consumer 有权
标题翻译：用于保护消费者的设备和方法
公开(公告)号：US09325165B2
公开(公告)日：2016-04-26
申请号：US14344985
申请日：2011-09-16
申请人： Klaus Behringer , Martin Maier , Klaus Pfitzner , Bernhard Rösch
发明人： Klaus Behringer , Martin Maier , Klaus Pfitzner , Bernhard Rösch
IPC分类号： H02H5/04 , H02P29/00 , H02P29/02 , G01K7/01 , G01R19/165 , H02H7/085 , H02H3/08
CPC分类号： H02H5/047 , G01K7/01 , G01R19/16571 , H02H3/085 , H02H7/0852 , H02P29/027 , H02P29/68
摘要： A device is disclosed for protecting a consumer, with a first current path having two lines, and a monitoring arrangement for detecting an imminent overload of the electrical consumer. In order to enable the detection of an imminent overload of a consumer, it is proposed that the monitoring arrangement includes a first temperature measuring unit, an evaluation unit and a first measuring element, which establishes an electrically conductive connection between the two lines of the first current path. The first temperature measuring unit is electrically isolated from the first measuring element and includes a first and a second temperature sensor. The first and second temperature sensor of the first temperature measuring unit are configured to simultaneously record a temperature of the first measuring element and the evaluation unit is configured to detect an imminent overload of the consumer based upon the recorded temperatures of the first temperature measuring unit.
摘要翻译：公开了一种用于保护消费者的装置，其中具有两条线路的第一电流路径以及用于检测电消费者即将发生的过载的监视装置。为了能够检测到消费者即将发生的过载，建议监视装置包括第一温度测量单元，评估单元和第一测量元件，该第一测量单元，第一测量单元在第一和第二测量单元的两条线之间建立导电连接当前路径。第一温度测量单元与第一测量元件电隔离并且包括第一和第二温度传感器。第一温度测量单元的第一温度传感器和第二温度传感器被配置为同时记录第一测量元件的温度，并且评估单元被配置为基于第一温度测量单元的记录温度来检测消费者即将发生的过载。

10. 发明授权

US08999351B2 Lipids and compositions for the delivery of therapeutics 有权
标题翻译：用于递送治疗剂的脂质和组合物
公开(公告)号：US08999351B2
公开(公告)日：2015-04-07
申请号：US13128287
申请日：2009-11-10
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu
IPC分类号： A61K39/12 , A61K9/127 , A61K39/00 , C12N15/11
CPC分类号： A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/464
摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.
摘要翻译：本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。特别地，本发明提供具有以下结构（I）的脂质，其中R1和R2各自独立地为任何取代的C 10 -C 30烷基，任选取代的C 10 -C 30烯基，任选取代的C 10 -C 30炔基，任选取代的C 10 -C 30 酰基或 - 连接子 - 配体; R 3为H，任选取代的C 1 -C 10烷基，任选取代的C 2 -C 10烯基，任选取代的C 2 -C 10炔基，烷基硫代烷基磷酸酯，烷基硫代磷酸酯，烷基二硫代磷酸酯，烷基膦酸酯，烷基胺，羟基烷基，ω-氨基烷基，ω-（取代的）氨基烷基， ω-磷酸烷基酯，ω-硫代磷酰基烷基酯，任选取代的聚乙二醇（PEG，mw 100-40K），任选取代的mPEG（mw 120-40K），杂芳基，杂环或连接基 - 配体; E是O，S，N（Q），C（O），N（Q）C（O），C（O）N（Q），（Q）），S（O），NS（O）2N（Q），S（O）2，N（Q）S（O）2，SS，O = N，芳基，杂芳基，环状或杂环; Q为H，烷基，ω-氨基烷基，ω-（取代）氨基烷基，ω-磷酸烷基或ω-硫代磷酰基烷基。

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