专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5741706A Anti-HIV ribozymes 失效
标题翻译：抗HIV核酶
公开(公告)号：US5741706A
公开(公告)日：1998-04-21
申请号：US719593
申请日：1996-09-25
申请人： Markley C. Leavitt , Richard Tritz , Elizabeth Duarte , Jack Barber , Mang Yu
发明人： Markley C. Leavitt , Richard Tritz , Elizabeth Duarte , Jack Barber , Mang Yu
IPC分类号： A61K38/00 , C12N15/113 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/1132 , A61K38/00 , C12N2310/111 , C12N2310/122
摘要： GUC and GUA ribozymes which cleave HIV RNA are provided. The ribozymes cleave HIV RNA in vitro and in vivo. When the ribozymes are expressed in cells, they inhibit HIV replication in the cells.
摘要翻译：提供了切割HIV RNA的GUC和GUA核酶。核酶在体外和体内切割HIV RNA。当核酶在细胞中表达时，它们抑制细胞中的HIV复制。

2. 发明授权

US5939538A Methods and compositions for inhibiting HIV infection of cells by cleaving HIV co-receptor RNA 失效
标题翻译：通过切割HIV辅助受体RNA来抑制细胞的HIV感染的方法和组合物
公开(公告)号：US5939538A
公开(公告)日：1999-08-17
申请号：US770235
申请日：1996-12-19
申请人： Markley C. Leavitt , Richard Tritz , Yu Feng , Jack Barber , Mang Yu
发明人： Markley C. Leavitt , Richard Tritz , Yu Feng , Jack Barber , Mang Yu
IPC分类号： A61K38/00 , A61K48/00 , C12N15/113 , C07H21/02
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2799/025
摘要： Methods of inhibiting HIV infection by blocking HIV co-receptor RNA expression are provided. Ribozymes which cleave HIV co-receptor RNA and inhibit HIV infection of cells are also provided. Co-receptor targets include fusin and CKR5.
摘要翻译：提供了通过阻断HIV共受体RNA表达来抑制HIV感染的方法。还提供了切割HIV辅助受体RNA并抑制细胞的HIV感染的核酶。辅助受体目标包括fusin和CKR5。

3. 发明授权

US6132962A Retroviral vectors comprising an anti-hiv or other nucleic acid 失效
标题翻译：包含抗-Hiv或其他核酸的逆转录病毒载体
公开(公告)号：US6132962A
公开(公告)日：2000-10-17
申请号：US876996
申请日：1997-06-16
申请人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
发明人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/14 , A61K35/407 , A61K35/44 , A61K35/76 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/18 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/867 , C12R1/92 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/1132 , C12N15/86 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2740/16043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent or a foreign nucleic acid under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
摘要翻译：本发明提供了一种感染性逆转录病毒，其在逆转录病毒的5'和3'长末端重复序列之间插入编码抗-IV型特异性试剂或在pol III启动子控制下的外源核酸的核酸。还提供了含有本发明的逆转录病毒载体的宿主细胞。还提供了干扰或预防感染HIV或可能感染HIV的细胞中HIV病毒复制的方法。

4. 发明授权

US5670361A HIV-specific ribozymes 失效
标题翻译：艾滋病毒特异性核酶
公开(公告)号：US5670361A
公开(公告)日：1997-09-23
申请号：US245742
申请日：1994-05-17
申请人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
发明人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/14 , A61K35/407 , A61K35/44 , A61K35/76 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/18 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/867 , C12R1/92 , C12N15/86 , C12N15/11
CPC分类号： C12N15/1132 , C12N15/86 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2740/16043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
摘要翻译：本发明提供了一种感染性逆转录病毒，其在逆转录病毒的5'和3'长的末端重复序列之间插入编码在pol III启动子控制下的抗HIV型特异性试剂的核酸。还提供了含有本发明的逆转录病毒载体的宿主细胞。还提供了干扰或预防感染HIV或可能感染HIV的细胞中HIV病毒复制的方法。

5. 发明授权

US06043077A Hepatitis C virus ribozymes 失效
标题翻译：丙型肝炎病毒核酶
公开(公告)号：US06043077A
公开(公告)日：2000-03-28
申请号：US954210
申请日：1997-10-20
申请人： Jack R. Barber , Peter J. Welch , Richard Tritz , SoonPin Yei , Mang Yu
发明人： Jack R. Barber , Peter J. Welch , Richard Tritz , SoonPin Yei , Mang Yu
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K48/00 , C07H21/04 , C12N5/10 , C12N7/00 , C12N9/00 , C12N15/113 , C12N15/63 , C12N15/85
CPC分类号： C12N15/1131 , C07H21/04 , A61K38/00 , C12N2310/111 , C12N2310/122 , C12N2799/022 , C12N2799/025 , C12N2799/027
摘要： This invention provides ribozymes useful to treat or prevent Hepatitis C Virus ("HCV") infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes useful in methods of treatment and prevention of HCV infection or disease are also provided.
摘要翻译：本发明提供用于治疗或预防生物体或受试者中的丙型肝炎病毒（“HCV”）感染或疾病的核酶以及治疗HCV感染或疾病的方法。还提供了诸如载体，宿主细胞，编码这些核酶的DNA分子的试剂可用于治疗和预防HCV感染或疾病的方法。

6. 发明授权

US06458567B1 Hepatitis C Virus ribozymes 失效
标题翻译：丙型肝炎病毒核酶
公开(公告)号：US06458567B1
公开(公告)日：2002-10-01
申请号：US09431419
申请日：1999-11-01
申请人： Jack R. Barber , Peter J. Welch , Richard Tritz , SoonPin Yei , Mang Yu
发明人： Jack R. Barber , Peter J. Welch , Richard Tritz , SoonPin Yei , Mang Yu
IPC分类号： C07H2104
CPC分类号： C12N15/1131 , A61K38/00 , C07H21/04 , C12N2310/111 , C12N2310/122 , C12N2799/022 , C12N2799/025 , C12N2799/027
摘要： This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (“HCV”) infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes usefull in methods of treatment and prevention of HCV infection or disease are also provided.
摘要翻译：本发明提供用于治疗或预防生物体或受试者中的丙型肝炎病毒（“HCV”）感染或疾病的核酶以及治疗HCV感染或疾病的方法。还提供了诸如载体，宿主细胞，编码这些核酶的DNA分子的试剂在治疗和预防HCV感染或疾病的方法中有用。

7. 发明申请

US20050004020A1 Broad spectrum anti-viral therapeutics and prophylaxis 有权
标题翻译：广谱抗病毒治疗和预防
公开(公告)号：US20050004020A1
公开(公告)日：2005-01-06
申请号：US10718986
申请日：2003-11-21
申请人： Mang Yu , Fang Fang
发明人： Mang Yu , Fang Fang
IPC分类号： A61K20060101 , A61K38/16 , A61K38/17 , A61K38/47 , A61K38/48 , A61K38/55 , A61K38/56 , A61K38/57 , A61K39/00 , A61K47/48
CPC分类号： B82Y5/00 , A61K38/47 , A61K38/57
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。优选的靶细胞是上皮细胞。本发明提供了用于预防病毒性疾病（例如流行性感冒）的组合物和方法，使用具有锚定结构域的化合物，所述化合物具有可结合与细胞外作用以干扰靶细胞的病毒感染的酶活性连接的靶细胞。本发明还提供了用于使用具有锚定结构域的化合物来预防病毒性疾病例如流感的组合物和方法，所述化合物具有可以结合与蛋白酶抑制剂连接的靶细胞，其可以在细胞外作用以干扰靶细胞的病毒感染。

8. 发明申请

US20080075708A1 Broad specturm anti-viral therapeutics and prophylaxis 审中-公开
标题翻译：广谱抗病毒治疗和预防
公开(公告)号：US20080075708A1
公开(公告)日：2008-03-27
申请号：US11893621
申请日：2007-08-15
申请人： Mang Yu , Fang Fang
发明人： Mang Yu , Fang Fang
IPC分类号： A61K38/46 , A61P31/16 , C12N9/14
CPC分类号： B82Y5/00 , A61K38/47 , A61K38/57
摘要： Provided are new compositions and methods for preventing and treating pathogen infection. In particular, provided are compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. Also provided are compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. Also provided are compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.
摘要翻译：提供了预防和治疗病原体感染的新的组合物和方法。特别地，提供了具有将化合物锚定到靶细胞表面的锚定结构域的化合物和可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。优选的靶细胞是上皮细胞。还提供了用于预防病毒性疾病例如流行性感冒的组合物和方法，使用具有锚定结构域的化合物，所述化合物具有可结合与细胞外作用以干扰靶细胞的病毒感染的酶活性连接的靶细胞。还提供了用于使用具有锚定结构域的化合物来预防病毒性疾病例如流感的组合物和方法，该锚定结构域可以结合可与细胞外作用以干扰靶细胞的病毒感染的蛋白酶抑制剂连接的靶细胞。

9. 发明授权

US5646034A Increasing rAAV titer 失效
标题翻译：增加rAAV滴度
公开(公告)号：US5646034A
公开(公告)日：1997-07-08
申请号：US487080
申请日：1995-06-07
申请人： Michael Mamounas , Flossie Wong-Staal , Mark Leavitt , Mang Yu
发明人： Michael Mamounas , Flossie Wong-Staal , Mark Leavitt , Mang Yu
IPC分类号： A61K47/48 , A61K48/00 , C12N5/22 , C12N7/01 , C12N15/864 , C12N15/87 , C12N15/86
CPC分类号： C12N15/86 , A61K47/48315 , A61K47/48776 , C12N15/87 , A61K48/00 , C12N2750/14143
摘要： Methods, kits and compositions for increasing the titer of rAAV vectors are provided.
摘要翻译：提供了用于增加rAAV载体滴度的方法，试剂盒和组合物。

10. 发明授权

US5811275A HIV-specific ribozymes 失效
标题翻译：艾滋病毒特异性核酶
公开(公告)号：US5811275A
公开(公告)日：1998-09-22
申请号：US465483
申请日：1995-06-05
申请人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Mark Leavitt , Anthony Ho
发明人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Mark Leavitt , Anthony Ho
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/14 , A61K35/407 , A61K35/44 , A61K35/76 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/18 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/867 , C12R1/92 , C12N15/86
CPC分类号： C12N15/1132 , C12N15/86 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2740/16043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
摘要翻译：本发明提供了一种感染性逆转录病毒，其在逆转录病毒的5'和3'长的末端重复序列之间插入编码在pol III启动子控制下的抗HIV型特异性试剂的核酸。还提供了含有本发明的逆转录病毒载体的宿主细胞。还提供了干扰或预防感染HIV或可能感染HIV的细胞中HIV病毒复制的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式