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1. 发明授权

US06403575B1 3-Pyridyl enantiomers and their use as analgesics 有权
标题翻译： 3-吡啶基对映体及其作为止痛剂的用途
公开(公告)号：US06403575B1
公开(公告)日：2002-06-11
申请号：US09619229
申请日：2000-07-19
申请人： Mark W. Holladay , Stephen P. Arneric , Hao Bai , Michael J. Dart , Nan-Horng Lin , John K. Lynch , Yat Sun Or , Keith B. Ryther , James P. Sullivan , James T. Wasicak , Paul P. Ehrlich
发明人： Mark W. Holladay , Stephen P. Arneric , Hao Bai , Michael J. Dart , Nan-Horng Lin , John K. Lynch , Yat Sun Or , Keith B. Ryther , James P. Sullivan , James T. Wasicak , Paul P. Ehrlich
IPC分类号： A61K3144
CPC分类号： A61K31/485 , A61K31/4427 , C07D205/04 , C07D401/12 , A61K2300/00
摘要： The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
摘要翻译：本发明涉及一种控制包括人在内的哺乳动物疼痛的方法，包括向需要治疗的哺乳动物或患者施用选择的式I化合物或其药学上可接受的盐。本发明还涉及上述式（I）的选择的（R）和（S）化合物，其可用作止痛剂以及神经元细胞死亡预防剂和抗炎剂。

2. 发明授权

US6133253A 3-Pyridyl enantiomers and their use as analgesics 失效
标题翻译： 3-吡啶基对映体及其作为止痛剂的用途
公开(公告)号：US6133253A
公开(公告)日：2000-10-17
申请号：US987581
申请日：1997-12-09
申请人： Mark W. Holladay , Stephen P. Arneric , Hao Bai , Michael J. Dart , Nan-Horng Lin , John K. Lynch , Yat Sun Or , Keith B. Ryther , James P. Sullivan , James T. Wasicak , Paul P. Ehrlich
发明人： Mark W. Holladay , Stephen P. Arneric , Hao Bai , Michael J. Dart , Nan-Horng Lin , John K. Lynch , Yat Sun Or , Keith B. Ryther , James P. Sullivan , James T. Wasicak , Paul P. Ehrlich
IPC分类号： A61K31/4427 , A61K31/485 , C07D205/04 , C07D401/12 , A61K31/44
CPC分类号： A61K31/485 , A61K31/4427 , C07D205/04 , C07D401/12
摘要： The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
摘要翻译：本发明涉及一种控制包括人在内的哺乳动物疼痛的方法，包括向需要治疗的哺乳动物或患者施用选择的式I化合物或其药学上可接受的盐。本发明还涉及上述式（I）的选择的（R）和（S）化合物，其可用作止痛剂以及神经元细胞死亡预防剂和抗炎剂。

3. 发明授权

US06645968B2 Potassium channel openers 有权
标题翻译：钾通道开放
公开(公告)号：US06645968B2
公开(公告)日：2003-11-11
申请号：US09777217
申请日：2001-02-05
申请人： Robert J. Altenbach , Hao Bai , Jorge D. Brioni , William A. Carroll , Murali Gopalakrishnan , Robert J. Gregg , Mark W. Holladay , Peggy P. Huang , John F. Kincaid , Michael E. Kort , Philip R. Kym , John K. Lynch , Arturo Perez-Medrano , Henry Q. Zhang
发明人： Robert J. Altenbach , Hao Bai , Jorge D. Brioni , William A. Carroll , Murali Gopalakrishnan , Robert J. Gregg , Mark W. Holladay , Peggy P. Huang , John F. Kincaid , Michael E. Kort , Philip R. Kym , John K. Lynch , Arturo Perez-Medrano , Henry Q. Zhang
IPC分类号： A61K314406
CPC分类号： C07D213/40 , A61K31/17 , A61K31/275 , A61K31/4406 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
摘要翻译：式I化合物可用于治疗用钾通道开放剂预防或改善的疾病。还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。

4. 发明授权

US08169812B2 Memory architecture with a current controller and reduced power requirements 有权
标题翻译：具有电流控制器和降低功耗要求的内存架构
公开(公告)号：US08169812B2
公开(公告)日：2012-05-01
申请号：US12706374
申请日：2010-02-16
申请人： John K. Lynch
发明人： John K. Lynch
IPC分类号： G11C7/00
CPC分类号： G11C11/4091 , G11C7/08 , G11C11/404 , G11C11/405 , G11C11/4076 , G11C11/4099 , G11C11/565
摘要： Disclosed is a memory architecture comprising at least one memory bit cell and at least one read bit line whose voltage is controlled and changed by a current from a current controller. Each memory bit cell has a storage mechanism, a controlled current source, and a read switch. The controlled current source in each memory bit cell is electrically connected to the read bit line through the read switch. The current from the current controller that controls and changes the read bit line voltage flows through the controlled current source in the memory bit cell. The value of this current is determined by a function of a difference between the voltage on the storage mechanism in the memory bit cell and a reference voltage from a reference voltage input to the current controller. In some versions an indicator is provided for indicating when to stop the current in the controlled current source that controls a voltage change on one of the read bit lines. The indicator has an on and an off condition and a switch is provided for stopping the current in the controlled current source when the indicator is activated in the on condition. The current in the controlled current source is stopped when the voltage change on the read bit line is greater than a predetermined threshold.
摘要翻译：公开了一种存储器架构，其包括至少一个存储器位单元和至少一个读取位线，其电压由来自电流控制器的电流控制和改变。每个存储器单元具有存储机构，受控电流源和读取开关。每个存储器位单元中的受控电流源通过读开关电连接到读位线。来自控制和改变读位线电压的电流控制器的电流流过存储器位单元中的受控电流源。该电流的值由存储位单元中的存储机构上的电压与输入到电流控制器的参考电压的参考电压之间的差异决定。在一些版本中，提供指示器用于指示何时停止受控电流源中控制读取位线之一上的电压变化的电流。指示灯具有接通和关闭状态，并且当指示器在接通状态下被激活时，提供用于停止受控电流源中的电流的开关。当读取位线上的电压变化大于预定阈值时，受控电流源中的电流停止。

5. 发明授权

US06921821B2 Antagonists of melanin concentrating hormone receptor 失效
标题翻译：黑色素浓缩激素受体的拮抗剂
公开(公告)号：US06921821B2
公开(公告)日：2005-07-26
申请号：US10459682
申请日：2003-06-11
申请人： Christopher Blackburn , Su-Jen Lai , Jennifer L. Che , Martin P. Maguire , Michael A. Patane , Matthew J. LaMarche , Courtney A. Cullis , James Brown , Anil Vasudevan , Jennifer C. Freeman , Mathew M. Mulhern , John K. Lynch , Ju Gao , Dariusz Wodka , Andrew J. Souers , Rajesh Iyengar , Mary Katherin Verzal , Philip R. Kym
发明人： Christopher Blackburn , Su-Jen Lai , Jennifer L. Che , Martin P. Maguire , Michael A. Patane , Matthew J. LaMarche , Courtney A. Cullis , James Brown , Anil Vasudevan , Jennifer C. Freeman , Mathew M. Mulhern , John K. Lynch , Ju Gao , Dariusz Wodka , Andrew J. Souers , Rajesh Iyengar , Mary Katherin Verzal , Philip R. Kym
IPC分类号： C07D403/14 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/517 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P15/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/04 , C07D205/08 , C07D239/02 , C07D401/00
CPC分类号： C07D405/14 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/14
摘要： This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I: where m is zero or one, n is zero to two, Y is oxygen or —N(R9)—, R1, R2, R3, R4, R5, R9 and Ring A are defined in the specification. Coumarin and quinolone compounds where R1 and R2 together form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.
摘要翻译：本发明提供了作为黑色素浓缩激素受体-1（MCH-R1）的拮抗剂的化合物。化合物由式I表示：其中m为0或1，n为0至2，Y为氧或-N（R 9） - ，R 1， R 2，R 3，R 4，R 5，R 9和R 9，和环A在规范中定义。其中R 1和R 2一起形成稠合苯并环的香豆素和喹诺酮化合物是优选的。本发明还提供式VI的化合物，其中香豆素部分被喹唑啉酮环代替。该化合物可用于治疗MCH-R1相关疾病，特别是超重状况，包括肥胖症。

6. 发明申请

US20080242997A1 METHOD AND APPARATUS FOR CLASSIFYING GASEOUS AND NON-GASEOUS OBJECTS 审中-公开
标题翻译：用于分类气体和非气体物体的方法和装置
公开(公告)号：US20080242997A1
公开(公告)日：2008-10-02
申请号：US12053289
申请日：2008-03-21
申请人： John E. LYNCH , John K. Lynch
发明人： John E. LYNCH , John K. Lynch
IPC分类号： A61B8/06
CPC分类号： G01N29/4445 , G01N29/07 , G01N29/12 , G01N29/4427 , G01N29/449 , G01N2291/011 , G01N2291/014 , G01N2291/02466 , G01N2291/02475 , G01N2291/044
摘要： Ultrasonic pulse echo object classification is described. A broadband ultrasound transducer transmits a broadband ultrasound pulse towards the object and detecting an associated ultra sound echo of that pulse from the object. An ultrasound receiver receives the detected echo signal. A signal processor, coupled to the ultrasound receivers determines and analyzes a time duration parameter and a frequency parameter (and possibly one or more other parameters like amplitude and/or phase) of the detected echo signal and classifies the object as a solid or liquid or as gaseous based on the parameters of the detected echo signal.
摘要翻译：描述超声脉冲回波对象分类。宽带超声换能器向对象发送宽带超声脉冲，并从对象检测该脉冲的相关超声回波。超声波接收器接收检测到的回波信号。耦合到超声接收机的信号处理器确定并分析检测到的回波信号的持续时间参数和频率参数（以及可能的一个或多个其他参数，例如幅度和/或相位），并将该对象分类为固体或液体或基于检测到的回波信号的参数作为气体。

7. 发明授权

US06878700B1 Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds 失效
标题翻译：细胞粘附抑制抗炎和免疫抑制化合物
公开(公告)号：US06878700B1
公开(公告)日：2005-04-12
申请号：US09541795
申请日：2000-03-31
申请人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00 , A61K31/33 , A61K31/415 , C07D221/02 , C07D265/30 , C07D319/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎性和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。

8. 发明授权

US5682562A Digitally controlled quench flash circuit 失效
标题翻译：数字控制淬火闪光电路
公开(公告)号：US5682562A
公开(公告)日：1997-10-28
申请号：US648648
申请日：1996-05-16
申请人： Seiichi Mizukoshi , Masaki Izumi , John K. Lynch , John J. Uebelacker , Kenneth A. Parulski , Clay A. Dunsmore
发明人： Seiichi Mizukoshi , Masaki Izumi , John K. Lynch , John J. Uebelacker , Kenneth A. Parulski , Clay A. Dunsmore
IPC分类号： G03B15/05 , G03B7/16 , G06T1/00 , H04N5/235
CPC分类号： H04N5/2354 , G03B7/16
摘要： A flash quench controller for a camera having a flash unit includes a light detector for producing a signal, an integrator for integrating the signal from the detector and producing an integrated signal, a comparator for comparing the integrated signal to a reference value, and means for quenching the flash unit when the integrated signal reaches the reference value. By using a pulse signal having a variable pulse width to programmably set the reference value, many different quench time values can be easily established. The flash unit may also be quenched by setting a maximum flash time value. The flash is automatically quenched if this flash time value is reached before the integrated signal level reaches the programmed reference value.
摘要翻译：具有闪光单元的相机的闪光淬火控制器包括用于产生信号的光检测器，用于对来自检测器的信号进行积分并产生积分信号的积分器，用于将积分信号与参考值进行比较的比较器，以及用于当集成信号达到参考值时，对闪光单元进行淬火。通过使用具有可变脉冲宽度的脉冲信号可编程地设置参考值，可以容易地建立许多不同的淬灭时间值。闪光单元也可以通过设置最大闪光时间值来淬火。如果在集成信号电平达到编程的参考值之前达到此闪烁时间值，闪光灯将自动淬火。

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