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1. 发明授权

US09333350B2 Psychiatric disorder therapy control 有权
标题翻译：精神障碍治疗控制
公开(公告)号：US09333350B2
公开(公告)日：2016-05-10
申请号：US12425903
申请日：2009-04-17
申请人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
发明人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
IPC分类号： A61N1/00 , A61N1/36 , A61B5/16 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/00
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275 , G06F19/00 , G16H20/70 , G16H40/63
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

2. 发明申请

US20090264956A1 PSYCHIATRIC DISORDER THERAPY CONTROL 有权
标题翻译：心理障碍治疗控制
公开(公告)号：US20090264956A1
公开(公告)日：2009-10-22
申请号：US12425903
申请日：2009-04-17
申请人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
发明人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275 , G06F19/00 , G16H20/70 , G16H40/63
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

3. 发明申请

US20100114237A1 MOOD CIRCUIT MONITORING TO CONTROL THERAPY DELIVERY 审中-公开
标题翻译： MOOD电路监控以控制治疗
公开(公告)号：US20100114237A1
公开(公告)日：2010-05-06
申请号：US12608815
申请日：2009-10-29
申请人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
IPC分类号： A61N1/00
CPC分类号： A61B5/0476 , A61B5/0205 , A61B5/024 , A61B5/0488 , A61B5/16 , A61B5/165 , A61B5/4076 , A61B5/4839 , A61B5/486 , A61M21/00 , A61M2021/0072 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Brain signals may be monitored at different locations of a mood circuit in order to determine a mood state of the patient. A relationship (e.g., a ratio) between frequency band characteristics of the monitored brain signals may be indicative of a particular mood state. In some examples, therapy parameter values that define the therapy delivered to the patient may be selected to maintain a target relationship (e.g., a target ratio) between the frequency band characteristics of the brain signals monitored within the mood circuit. In addition, in some examples, therapy delivery to the patient may be controlled based on the frequency band characteristics of brain signals sensed at different portions of the mood circuit.
摘要翻译：可以在心情电路的不同位置监测脑信号，以便确定患者的情绪状态。所监视的脑信号的频带特性之间的关系（例如，比率）可以指示特定的情绪状态。在一些示例中，可以选择限定递送给患者的治疗的治疗参数值，以在心情电路内监测的脑信号的频带特性之间维持目标关系（例如，目标比率）。此外，在一些示例中，可以基于在心情电路的不同部分感测到的脑信号的频带特性来控制对患者的治疗递送。

4. 发明授权

US09613184B2 Analyzing a washout period characteristic for psychiatric disorder therapy delivery 有权
公开(公告)号：US09613184B2
公开(公告)日：2017-04-04
申请号：US12426065
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/00 , G06F19/00 , A61M5/142 , A61N1/08 , A61N1/36 , A61M5/172 , A61N1/372
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G16H40/40
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.

5. 发明申请

US20090264957A1 ANALYZING A WASHOUT PERIOD CHARACTERISTIC FOR PSYCHIATRIC DISORDER THERAPY DELIVERY 有权
标题翻译：分析精神疾病治疗方法的出院期特征
公开(公告)号：US20090264957A1
公开(公告)日：2009-10-22
申请号：US12426065
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/08 , A61N1/36 , A61M37/00
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G16H40/40
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.
摘要翻译：根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。清洗期包括治疗所产生的结转效应消散的时间。清洗期间特征可以包括例如清洗期间的持续时间，清洗期间的生理信号的幅度或趋势，或者生理信号的功率水平或功率水平的频率比。在一些实施例中，可以使用与多个治疗程序相关联的清除期特征来比较程序。在其他实施例中，清洗周期特征可以用于确定患者的情绪状态，并且在一些情况下可以修改治疗程序。监测清洗期也可能对时间治疗方案试验有用。

6. 发明申请

US20090264967A1 TIMING THERAPY EVALUATION TRIALS 审中-公开
标题翻译：时间治疗评估试验
公开(公告)号：US20090264967A1
公开(公告)日：2009-10-22
申请号：US12425922
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/0534 , A61N1/36082 , A61N1/37211 , A61N1/37247
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.
摘要翻译：根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。清洗期包括治疗期间遗留结果消失的时间。在治疗评估期间，根据不同的治疗方案，监测清除期可能有助于按时交付治疗。例如，可以监测患者的至少一个生理信号，以便自动确定何时清除期已经结束，例如，当根据第一治疗程序的治疗递送的刺激和携带效应已经基本消散时，为了确定何时治疗可以启动根据第二疗法程序的递送。

7. 发明申请

US20090264955A1 ANALYZING A STIMULATION PERIOD CHARACTERISTIC FOR PSYCHIATRIC DISORDER THERAPY DELIVERY 审中-公开
标题翻译：分析精神疾病治疗方案的刺激期特征
公开(公告)号：US20090264955A1
公开(公告)日：2009-10-22
申请号：US12425859
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/36
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G16H40/40
摘要： A characteristic of a stimulation period, which occurs during the delivery of stimulation therapy to a patient according to a therapy program, may be determined based on a physiological parameter of the patient. The stimulation period characteristic may include, for example, an amplitude or a trend in a physiological signal during the stimulation period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, stimulation period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a stimulation period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program.
摘要翻译：可以基于患者的生理参数来确定在根据治疗程序向患者递送刺激治疗期间发生的刺激期的特征。刺激周期特征可以包括例如刺激期间的生理信号的振幅或趋势，或生理信号的频带中的功率电平或功率电平的比率。在一些实施例中，可以使用与多个治疗程序相关联的刺激周期特征来比较程序。在其他实施例中，刺激周期特征可以用于确定患者的情绪状态，并且在一些情况下可以修改治疗程序。

8. 发明申请

US20100280336A1 ANXIETY DISORDER MONITORING 审中-公开
标题翻译：安静的异常监视
公开(公告)号：US20100280336A1
公开(公告)日：2010-11-04
申请号：US12751537
申请日：2010-03-31
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski
IPC分类号： A61B5/00
CPC分类号： A61B5/0476 , A61B5/1118 , A61B5/165 , A61B5/4803 , A61B5/6846 , A61B5/7267
摘要： An anxiety episode may be identified as being an anxiety event that is attributable to an anxiety disorder of a patient based on the patient activity associated with the anxiety episode. The patient activity may include, for example, patient motion, patient posture or voice activity. Detection of the activity component during an anxiety episode can help distinguish between a general anxiety state and an anxiety event that differs from the general anxiety state. Examples of anxiety events include, for example, an occurrence of a compulsion or a panic attack. The detected anxiety events can be used to evaluate an anxiety disorder of a patient, evaluate therapy programs implemented by a medical device to treat the anxiety disorder, or control therapy delivery. In some examples, a mood state transition is detected based on patient activity information and therapy delivery is controlled based on the detection of the mood state transition.
摘要翻译：基于与焦虑发作相关的患者活动，可能将焦虑事件确定为可归因于患者的焦虑症的焦虑事件。患者活动可以包括例如患者运动，患者姿势或语音活动。在焦虑症状期间检测活动成分可以帮助区分一般焦虑状态和与一般焦虑状态不同的焦虑事件。焦虑事件的例子包括例如强迫或惊恐发作的发生。检测到的焦虑事件可用于评估患者的焦虑症，评估由医疗装置实施的治疗程序以治疗焦虑症或控制治疗递送。在一些示例中，基于患者活动信息检测情绪状态转换，并且基于心情状态转换的检测来控制治疗递送。

9. 发明授权

US07933646B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07933646B2
公开(公告)日：2011-04-26
申请号：US11837987
申请日：2007-08-13
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

10. 发明授权

US07280867B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07280867B2
公开(公告)日：2007-10-09
申请号：US10687571
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

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