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1. 发明授权

US06380203B1 Angiogenesis inhibitors 失效
标题翻译：血管生成抑制剂
公开(公告)号：US06380203B1
公开(公告)日：2002-04-30
申请号：US09424132
申请日：1999-11-18
申请人： Mark T. Bilodeau , Mark E. Fraley , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino
发明人： Mark T. Bilodeau , Mark E. Fraley , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino
IPC分类号： A61K31505
CPC分类号： C07D487/04
摘要： The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tyrosine kinase-dependent diseases/conditions such as angiogenesis, cancer, atherosclerosis, diabetic retinopathy or autoimmune diseases, in mammals.
摘要翻译：本发明涉及抑制酪氨酸激酶的化合物，含有酪氨酸激酶抑制化合物的组合物和使用酪氨酸激酶抑制剂治疗酪氨酸激酶依赖性疾病/病症如血管生成，癌症，动脉粥样硬化，糖尿病性视网膜病变或自身免疫疾病的方法哺乳动物。

2. 发明授权

US06235741B1 Angiogenesis inhibitors 失效
标题翻译：血管生成抑制剂
公开(公告)号：US06235741B1
公开(公告)日：2001-05-22
申请号：US09086152
申请日：1998-05-28
申请人： Mark T. Bilodeau , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino , Mark E. Fraley
发明人： Mark T. Bilodeau , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino , Mark E. Fraley
IPC分类号： A61K31505
CPC分类号： C07D487/04
摘要： The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tyrosine kinase-dependent diseases/conditions such as angiogenenesis, cancer, atherosclerosis, diabetic retinopathy or autoimmune diseases, in mammals.
摘要翻译：本发明涉及抑制酪氨酸激酶的化合物，含有酪氨酸激酶抑制化合物的组合物和使用酪氨酸激酶抑制剂治疗酪氨酸激酶依赖性疾病/病症如血管生成，癌症，动脉粥样硬化，糖尿病性视网膜病变或自身免疫疾病的方法哺乳动物。

3. 发明授权

US07646170B2 Method of selecting replacement indicating voltage for an implantable electrochemical cell 失效
标题翻译：选择可植入电化学电池的替代指示电压的方法
公开(公告)号：US07646170B2
公开(公告)日：2010-01-12
申请号：US11382744
申请日：2006-05-11
申请人： Hong Gan , Robert Rubino , Yuemin Zhang , Esther Takeuchi
发明人： Hong Gan , Robert Rubino , Yuemin Zhang , Esther Takeuchi
IPC分类号： H01M10/44
CPC分类号： H01M10/441 , A61N1/3708 , H01M10/44 , H01M10/48
摘要： A method for providing an elective replacement indicator (ERI) voltage for a first implantable electrochemical cell, comprising the steps of providing a second, substantially identical exemplary electrochemical cell; repeatedly connecting and disconnecting the second cell to a sequence of at least three loads, thereby discharging the second cell from a state of about zero percent to at least about ninety percent depth-of-discharge; generating cell voltage vs. depth-of-discharge plots for the at least three loads repeatedly connected to the second cell; identifying a range of depth-of-discharge for the at least three loads wherein a statistical indicator of the second cell voltage variability with load at the same depth-of-discharge is less than a predetermined value among the at least three loads; and then defining the ERI voltage for the first implantable electrochemical cell as the voltage that occurs at a predetermined load at a specified point within the identified range for the second electrochemical cell.
摘要翻译：一种用于为第一可植入电化学电池提供选择性替代指示剂（ERI）电压的方法，包括以下步骤：提供第二基本相同的示例性电化学电池; 将第二电池重复地连接和断开至至少三个负载的序列，从而将第二电池从大约零百分之一至大约百分之九十的放电深度的状态排出; 产生电池电压与重复连接到第二电池的至少三个负载的放电曲线图; 识别所述至少三个负载的放电深度范围，其中在所述至少三个负载中，具有在相同放电深度处的负载的所述第二电池电压变异性的统计指标小于预定值; 然后将第一可植入电化学电池的ERI电压定义为在第二电化学电池的所识别范围内的特定点处以预定负载发生的电压。

4. 发明申请

US20070059599A1 Sandwich Cathode Electrochemical Cell With Wound Electrode Assembly 有权
标题翻译：带有电极组件的三明治阴极电化学电池
公开(公告)号：US20070059599A1
公开(公告)日：2007-03-15
申请号：US11532126
申请日：2006-09-15
申请人： Robert Rubino , Hong Gan , Esther Takeuchi
发明人： Robert Rubino , Hong Gan , Esther Takeuchi
IPC分类号： H01M4/02 , H01M4/58 , H01M4/50 , H01M4/52 , H01M4/66 , H01M4/54 , H01M10/04
CPC分类号： H01M10/0431 , H01M4/136 , H01M4/366 , H01M4/54 , H01M4/5825 , H01M4/661 , H01M4/667 , H01M10/052 , H01M10/0568 , H01M10/0569 , H01M10/0583 , H01M10/0585 , Y10T29/49108
摘要： A new design for a cathode having a configuration of: SVO/first current collector/CFx/second current collector/SVO is described. The two cathode current collectors are vertically aligned one on top of the other in a middle region or zone of the cathode. This coincides to where a winding mandrel will be positioned to form a wound electrode assembly with an anode. The overlapping region of the two current collectors helps balance the expansion forces of the exemplary SVO and CFx active material layers. This, in turn, helps maintain a planar cathode that is more amenable to downstream processing. The use of two current collectors on opposite sides of an intermediate cathode active material also provides for enhanced reliability when cathodes are wound from the center as they lend structural integrity to outer portions of the wind.
摘要翻译：描述了具有以下配置的阴极的新设计：SVO /第一集电器/ CF / /第二集电器/ SVO。在阴极的中间区域或区域中，两个阴极集电体在另一个的顶部垂直对准。这一点与绕组心轴将被定位以形成具有阳极的卷绕电极组件的情况相一致。两个集电器的重叠区域有助于平衡示例性SVO和CF x活性材料层的膨胀力。这又有助于维持更适合于下游处理的平面阴极。在中间阴极活性材料的相对侧上使用两个集电器还提供了当从中心缠绕阴极时提高可靠性，因为它们将结构完整性提供给风的外部部分。

5. 发明申请

US20070072075A1 ANODE-TO-ANODE CAPACITY RATIOS FOR SVO/CFx HYBRID CATHODE ELECTROCHEMICAL CELLS 有权
标题翻译： SVO / CFx混合阴离子电化学细胞的阳极对阳极能力比
公开(公告)号：US20070072075A1
公开(公告)日：2007-03-29
申请号：US11535139
申请日：2006-09-26
申请人： Hong Gan , Robert Rubino , Esther Takeuchi
发明人： Hong Gan , Robert Rubino , Esther Takeuchi
IPC分类号： H01M4/02 , H01M4/54 , H01M4/58 , H01M4/50 , H01M4/48 , H01M4/52 , H01M4/66 , H01M4/72
CPC分类号： H01M4/06 , H01M4/08 , H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/1393 , H01M4/366 , H01M4/38 , H01M4/382 , H01M4/405 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/54 , H01M4/5815 , H01M4/587 , H01M4/661 , H01M4/663 , H01M4/667 , H01M4/669 , H01M4/70 , H01M6/16 , H01M6/5055 , H01M10/052 , H01M2004/021 , H01M2006/5094 , H01M2010/4292
摘要： Improvements in the performance of lithium electrochemical cells comprising a first cathode active material of a relatively high energy density but of a relatively low rate capability, for example CFx, contacted to one side of a current collector and with a second cathode active material having a relatively low energy density but of a relatively high rate capability, for example SVO, contacted to the opposite current collector side are described. An exemplary cathode has the configuration: SVO/first current collector/CFx/second current collector/SVO, and wherein the anodic coulombic capacity does not exceed the total coulombic capacities of the SVO and CFx by greater than 25%. Manganese oxide (MnO2) is another typically used cathode active material in lieu of SVO, and the present invention is applicable to lithium cells of that system as well.
摘要翻译：包括具有相对较高能量密度但具有相对较低速率能力的第一阴极活性材料（例如CF x x）的锂电化学电池的性能的改进与集电器的一侧接触，并与描述了具有相对低的能量密度但具有相对较高速率能力的第二阴极活性材料，例如与反向集流器侧接触的SVO。示例性阴极具有以下结构：SVO /第一集电器/ CF x /第二集电器/ SVO，其中阳极库仑容量不超过SVO和CF < x <大于25％。氧化锰（MnO 2/2）是代替SVO的另一种通常使用的阴极活性材料，本发明也适用于该系统的锂电池。

6. 发明申请

US20120288760A1 Flat and High-Density Cathodes for Use in Electrochemical Cells 有权
标题翻译：用于电化学电池的扁平和高密度阴极
公开(公告)号：US20120288760A1
公开(公告)日：2012-11-15
申请号：US13556242
申请日：2012-07-24
申请人： Ashish Shah , Robert Rubino , Hong Gan
发明人： Ashish Shah , Robert Rubino , Hong Gan
IPC分类号： H01M4/64 , H01M4/66
CPC分类号： H01M6/16 , H01M4/043 , H01M4/08 , H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/1393 , H01M4/485 , H01M4/5835 , H01M4/661 , H01M4/663 , H01M4/667 , H01M10/052 , H01M10/058 , Y02E60/122
摘要： The traditional method of pressing CFx, screen and SVO sheet assembly results in an electrode that is cupped and not flat. This results in the reduction of the effective volumetric energy density of the electrode or the addition of a process step of flattening of the cathode if at all possible. The new method of assembly effectively eliminates the cupping behavior and produces a flat electrode. In addition, the physical density of the cathode is also increased.
摘要翻译：按压CFx，屏幕和SVO板组件的传统方法会导致电镀杯而不平坦。这导致电极的有效体积能量密度的降低或者如果可能的话，添加阴极平坦化的工艺步骤。新的装配方法有效地消除了拔罐作用并产生了一个平面电极。此外，阴极的物理密度也增加。

7. 发明申请

US20080038643A1 Lithium/Fluorinated Carbon Cell For High-Rate Pulsatlie Applications 有权
标题翻译：用于高速脉冲应用的锂/氟化碳电池
公开(公告)号：US20080038643A1
公开(公告)日：2008-02-14
申请号：US11668500
申请日：2007-01-30
申请人： Paul Krehl , Steven Davis , Robert Rubino , Hong Gan , Esther Takeuchi
发明人： Paul Krehl , Steven Davis , Robert Rubino , Hong Gan , Esther Takeuchi
IPC分类号： H01M4/02 , H01M4/58 , H01M6/02 , H01M6/18
CPC分类号： H01M10/0569 , H01M4/133 , H01M4/583 , H01M4/5835 , H01M4/622 , H01M4/625 , H01M4/626 , H01M10/052 , H01M10/0568 , H01M2004/028 , Y10T29/49108
摘要： The current invention describes a lithium/carbon monofluoride (Li/CFx) cell capable of delivering sufficient power to supply an ICD or similar demanding device. The cell exhibits the typical excellent long-term stability and predictability of the CFx system, as well as its high energy density (greater than about 300 Ah/cc, greater than about 600 Wh/cc). Additionally, the cell is capable of delivering about 0.5 W/cc of cathode volume for greater than 5 seconds with a voltage above 1.70 V (FIG. 1). The following invention embodiments can be applied individually or in conjunction with each other.
摘要翻译：本发明描述了能够提供足够的电力以供应ICD或类似苛刻装置的锂/碳一氟化物（Li / CF xS）单元。该电池具有典型的优异的长期稳定性和CF x系统的可预测性，以及其高能量密度（大于约300Ah / cc，大于约600Wh / cc）。另外，电池能够以高于1.70V的电压输送大约0.5W / cc的阴极体积大于5秒（图1）。以下发明实施例可以单独地或彼此结合使用。

8. 发明申请

US20060183755A1 Tyrosine kinase inhibitors 失效
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20060183755A1
公开(公告)日：2006-08-17
申请号：US10537758
申请日：2003-12-05
申请人： Mark Fraley , Scott Hambaugh , Robert Rubino , Randall Hungate
发明人： Mark Fraley , Scott Hambaugh , Robert Rubino , Randall Hungate
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , A61K45/06
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, macular edema, retinal ischemia, inflammatory diseases, and the like in mammals.
摘要翻译：本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的化合物，含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤生长，动脉粥样硬化的方法，年龄相关性黄斑变性，糖尿病性视网膜病变，黄斑水肿，视网膜缺血，炎症性疾病等。

9. 发明申请

US20060037190A1 METHOD FOR PROVIDING A HERMETICALLY SEALED COIN CELL 有权
标题翻译：提供密封密封蛋白细胞的方法
公开(公告)号：US20060037190A1
公开(公告)日：2006-02-23
申请号：US11163826
申请日：2005-11-01
申请人： Robert Rubino , Hong Gan , Joseph Prinzbach , Esther Takeuchi
发明人： Robert Rubino , Hong Gan , Joseph Prinzbach , Esther Takeuchi
IPC分类号： H01M10/04
CPC分类号： H01M2/023 , H01M2/0426 , H01M2/065 , H01M2/08 , Y10T29/4911 , Y10T29/49114
摘要： A hermetically sealed coin cell is described. The coin cell has the opposite polarity terminals isolated from one another by a glass-to-metal seal. Glassing a conductive disc inside a ring of greater diameter and height forms this seal. The height of the ring is equivalent to the desired height of the cell. The disc acts as one cell terminal, which can be positive or negative, and the ring serves as the other terminal. In plan view, both terminals are on the same side of the cell. This allows for easy mounting and connection to an electronic circuit board, and the like.
摘要翻译：描述了密封的纽扣电池。纽扣电池具有相反的极性端子，通过玻璃对金属密封件相互隔离。在更大直径和高度的环内玻璃导电盘形成这种密封。环的高度等于电池的所需高度。盘作为一个单元端子，其可以是正的或负的，并且该环用作另一个端子。在平面图中，两个终端位于单元的同一侧。这允许容易地安装和连接到电子电路板等。

10. 发明授权

US06919141B2 Phosphate additives for nonaqueous electrolyte rechargeable electrochemical cells 有权
标题翻译：磷酸添加剂用于非水电解质可充电电化学电池
公开(公告)号：US06919141B2
公开(公告)日：2005-07-19
申请号：US10251137
申请日：2002-09-20
申请人： Hong Gan , Esther S. Takeuchi , Robert Rubino
发明人： Hong Gan , Esther S. Takeuchi , Robert Rubino
IPC分类号： H01M4/485 , H01M4/505 , H01M4/525 , H01M4/58 , H01M4/587 , H01M4/60 , H01M6/04 , H01M10/0525 , H01M10/0567 , H01M10/0568 , H01M10/0569
CPC分类号： H01M10/0525 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/581 , H01M4/587 , H01M4/623 , H01M4/625 , H01M10/0567 , H01M10/0568 , H01M10/0569 , H01M2300/004 , H01M2300/0042
摘要： A lithium ion electrochemical cell having high charge/discharge capacity, long cycle life and exhibiting a reduced first cycle irreversible capacity, is described. The stated benefits are realized by the addition of at least one phosphate additive having the formula: (R1O)P(═O) (OR2) (OR3) and wherein R1, R2 and R3 are the same or different, wherein at least one, but not all three, of the R groups is hydrogen, or at least one of the R groups has at least 3 carbon atoms and contains an sp or sp2 hybridized carbon atom bonded to an sp3 hybridized carbon atom bonded to the oxygen atom bonded to the phosphorous atom.
摘要翻译：描述了具有高充电/放电容量，长循环寿命并且显示出降低的第一周期不可逆容量的锂离子电化学电池。所述优点通过加入至少一种具有下式的磷酸酯添加剂来实现：（R 1）O（O）（OR 2）（OR 2） > 3），并且其中R 1，R 2和R 3相同或不同，其中至少一个，但是不是所有三个R基团都是氢，或者至少一个R基团具有至少3个碳原子并且含有与sp 3连接的sp或sp2-2杂交的碳原子与键合到磷原子的氧原子键合的杂原子碳原子。

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