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1. 发明授权

US07329394B2 High throughput incubation devices 有权
标题翻译：高通量孵化装置
公开(公告)号：US07329394B2
公开(公告)日：2008-02-12
申请号：US10200021
申请日：2002-07-18
申请人： Mark R. Weselak , Robert C. Downs
发明人： Mark R. Weselak , Robert C. Downs
IPC分类号： B01L9/00
CPC分类号： B01L1/02 , B01L1/025 , C12M41/14 , G01N35/0099 , G01N35/028 , G01N2035/00356 , G01N2035/00801 , G01N2035/042 , G01N2035/0425 , G01N2035/0455
摘要： The invention provides an efficiently automated incubation device that reduces the number of powered moving parts in the device and the amount of air transfer between environments that are internal and external to the device.
摘要翻译：本发明提供了一种有效的自动化孵化装置，其减少了装置中动力运动部件的数量以及在装置内部和外部的环境之间的空气传送量。

2. 发明授权

US06827113B2 Massively parallel fluid dispensing systems and methods 失效
标题翻译：大规模并行流体分配系统和方法
公开(公告)号：US06827113B2
公开(公告)日：2004-12-07
申请号：US10109582
申请日：2002-03-27
申请人： Robert C. Downs , Mark R. Weselak
发明人： Robert C. Downs , Mark R. Weselak
IPC分类号： B05C100
CPC分类号： B01F13/1055 , B01J19/0046 , B01J2219/00315 , B01J2219/00353 , B01J2219/00355 , B01J2219/0036 , B01J2219/00378 , B01J2219/00412 , B01J2219/00689 , B01J2219/00691 , B01J2219/00756 , B01L3/0293 , B01L3/5085 , B01L9/00 , C30B7/00 , C30B29/58 , C40B60/14 , G01N35/1074
摘要： The present invention provides highly automated fluid delivery systems and related methods with significantly improved throughput relative to preexisting technologies. In particular, the invention relates to a fluid dispensing system that simultaneously produces multiple fluid mixtures on-the-fly in multiple multiwell plates. The invention also includes control system and machine software in addition to various systems and related methods for performing assorted downstream processes.
摘要翻译：本发明提供了高度自动化的流体输送系统和相关方法，其相对于预先存在的技术具有显着提高的产量。特别地，本发明涉及在多个多孔板中同时产生多个流体混合物的流体分配系统。除了用于执行各种下游处理的各种系统和相关方法之外，本发明还包括控制系统和机器软件。

3. 发明授权

US06709872B1 Method and apparatus for dispensing low nanoliter volumes of liquid while minimizing waste 失效
标题翻译：用于分配低纳升体积的液体同时最小化废物的方法和设备
公开(公告)号：US06709872B1
公开(公告)日：2004-03-23
申请号：US09562652
申请日：2000-05-02
申请人： Robert C. Downs , Mark R. Weselak
发明人： Robert C. Downs , Mark R. Weselak
IPC分类号： G01N110
CPC分类号： B01L3/0241 , B01L3/021 , B01L2300/0829 , B01L2400/024 , B01L2400/0487 , Y10T436/2575
摘要： There is provided a method and apparatus for aspirating a volume of liquid into a syringe from a sample of the liquid. A substantial portion of the liquid in the syringe is subsequently dispensed from the syringe and returned to the sample. Accordingly, a small portion of the aspirated liquid is retained in the syringe. One or more nanoliter volumes of the liquid retained in the syringe are then dispensed from the syringe to a container for further use or analysis. It will be understood, therefore, that the volume of the originally aspirated liquid is substantially larger than the volume of liquid dispensed for further use or analysis. The invention also includes a method and apparatus for aspirating and dispensing a plurality of liquids by using a plurality of syringes, and also can be used to dispense liquids onto microplates.
摘要翻译：提供了一种从液体样品中将一定体积的液体吸入注射器的方法和装置。随后将注射器中的大部分液体从注射器分配并返回到样品。因此，吸入的液体的一小部分被保留在注射器中。然后将保持在注射器中的一个或多个纳升体积的液体从注射器分配到用于进一步使用或分析的容器中。因此，应当理解，最初吸入的液体的体积大大地大于分配用于进一步使用或分析的液体的体积。本发明还包括通过使用多个注射器吸取和分配多种液体的方法和装置，并且还可用于将液体分配到微孔板上。

4. 发明授权

US5054186A Clutch assembly method 失效
标题翻译：离合器装配方法
公开(公告)号：US5054186A
公开(公告)日：1991-10-08
申请号：US597920
申请日：1990-10-12
申请人： Mark R. Weselak
发明人： Mark R. Weselak
IPC分类号： B23P19/00 , B23P21/00 , F16D25/0638
CPC分类号： F16D25/0638 , B23P19/001 , B23P21/00 , Y10T29/4984 , Y10T29/49901 , Y10T29/53926
摘要： A clutch structure has a housing in which is slidably disposed a fluid-operated piston, a plurality of inner and outer splined friction plates and a return spring assembly. The friction plates have formed thereon a spline portion such that alternating discs have the splines extending radially outward, engaging the housing, or extending radially inward, away from the housing. The clutch structure is assembled by positioning the clutch housing in a fixture composed of a ring which is sized to accommodate the outer spline of the one set of friction plates. The plates are arranged in two vertical stacks with the inner splined plates in one stack and the outer splined plates in the other. The plates are alternately installed in the housing by descending from the stacks solely by the force of gravity until a desired number of plates have been installed. The piston and a pressure plate can be installed in the housing prior to mounting the housing to the fixture, if desired. The return spring assembly and a backing plate are installed in the housing after the clutch plates have been installed.
摘要翻译：离合器结构具有壳体，其中可滑动地设置流体操作的活塞，多个内花键摩擦片和外花键摩擦片和复位弹簧组件。摩擦片在其上形成有花键部分，使得交替的盘具有径向向外延伸的花键，与壳体接合或径向向内延伸远离壳体。通过将离合器壳体定位在由环组成的固定件中来组装离合器结构，该环的尺寸适于容纳一组摩擦板的外花键。板被布置在两个垂直堆叠中，内部花键板在一个堆叠中，外部花键板在另一个堆叠中。这些板通过仅通过重力直接从堆叠下降而交替地安装在壳体中，直到安装了所需数量的板。如果需要，活塞和压板可以在将外壳安装到固定装置之前安装在外壳中。离合器片安装后，复位弹簧组件和背板安装在外壳中。

5. 发明授权

US07364907B2 Systems and methods for sorting samples 失效
标题翻译：用于分类样品的系统和方法
公开(公告)号：US07364907B2
公开(公告)日：2008-04-29
申请号：US10704335
申请日：2003-11-07
申请人： Mark R. Weselak , Brad Backes , Jared Ek
发明人： Mark R. Weselak , Brad Backes , Jared Ek
IPC分类号： G01N35/00 , B07C5/00
CPC分类号： G01N35/04 , G01N35/00732 , G01N35/028 , G01N35/1067 , G01N2035/00217 , G01N2035/00861 , G01N2035/047 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Methods and systems for sorting compounds and compound holders into batches for subsequent processing are provided.
摘要翻译：提供了用于将化合物和化合物保持剂分批分批以用于后续处理的方法和系统。

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