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1. 发明申请

US20080114007A1 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE 审中-公开
标题翻译：作为C-FMS激酶的抑制剂的5-氧代-5,8-二氢吡啶并吡啶
公开(公告)号：US20080114007A1
公开(公告)日：2008-05-15
申请号：US11875294
申请日：2007-10-19
申请人： Mark Player , William Parsons , Hui Huang , Daniel Hutta , Huaping Hu , James Rinker
发明人： Mark Player , William Parsons , Hui Huang , Daniel Hutta , Huaping Hu , James Rinker
IPC分类号： A61K31/519 , C07D471/04 , C07D401/02 , C07D401/14 , A61P35/00 , A61P9/00
CPC分类号： C07D471/04
摘要： The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a salt, stereoisomer, tautomer, crystalline, polymorph, amorphous, solvate, hydrate, ester, prodrug or metabolite form thereof, wherein A, Y, Z, R101 and R200 are described in the specification.
摘要翻译：本发明通过提供c-fms激酶的有效抑制剂来解决当前对选择性和有效的蛋白酪氨酸激酶抑制剂的需要。本发明涉及新的式I化合物：或其盐，立体异构体，互变异构体，结晶，多晶型物，无定形，溶剂合物，水合物，酯，前药或代谢物形式，其中A，Y，Z，R 101 ＆lt; / SUP＆gt;和＆lt; 200＆gt;在本说明书中描述。

2. 发明授权

US10296862B1 Time interval assessment of mission plan quality dynamic asset allocation 有权
公开(公告)号：US10296862B1
公开(公告)日：2019-05-21
申请号：US15152666
申请日：2016-05-12
申请人： Louis Oddo , Devang R. Parekh , William Parsons , Henry H. Fung , Feng Cao , Miteshkumar K. Patel
发明人： Louis Oddo , Devang R. Parekh , William Parsons , Henry H. Fung , Feng Cao , Miteshkumar K. Patel
IPC分类号： G06Q10/06 , G06F3/0484 , G06F16/2457
摘要： A method includes processing one or more mission plan inputs to generate a mission definition file (MDF) that includes mission data that describes one or more plans for one or more manned or unmanned vehicles. The method includes evaluating planned tasks against defined scoring criteria specific to each task type and specific to each task to generate individual task achievement quality scores for each of the planned mission tasks. The method includes processing the MDF, the individual task quality scores, and route costs to generate a mission plan to enable evaluation and comparison of one or more mission plans. The method includes generating graphical output data from the output quality scores where the graphical output data can be configured as a mission plan evaluation chart.

3. 发明授权

US06437165B1 Phosphate derivatives as immunoregulatory agents 失效
标题翻译：磷酸盐衍生物作为免疫调节剂
公开(公告)号：US06437165B1
公开(公告)日：2002-08-20
申请号：US09942411
申请日：2001-08-30
申请人： Suzanne Mandala , James Bergstrom , Richard Hajdu , Hugh Rosen , William Parsons , Deborah J. Card , Malcolm Maccoss , Rupprecht Kathleen
发明人： Suzanne Mandala , James Bergstrom , Richard Hajdu , Hugh Rosen , William Parsons , Deborah J. Card , Malcolm Maccoss , Rupprecht Kathleen
IPC分类号： A61K31662
CPC分类号： C07F9/094 , C07F9/3882
摘要： Immunoregulatory compounds are disclosed of the formula: as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
摘要翻译：公开了具有下式的免疫调节化合物：以及其药学上可接受的盐和水合物。该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥。包括药物组合物和使用方法。

4. 发明申请

US20150151179A1 GOAL APPARATUS 有权
公开(公告)号：US20150151179A1
公开(公告)日：2015-06-04
申请号：US14615334
申请日：2015-02-05
申请人： Allen Keith Holland , William Parsons
发明人： Allen Keith Holland , William Parsons
IPC分类号： A63B63/00
CPC分类号： A63B63/004 , A63B71/0036 , A63B2063/005 , A63B2210/50 , A63B2243/0025
摘要： A goal apparatus for soccer (football) and the like has a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth.

5. 发明授权

US08680098B2 Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators 有权
标题翻译：用作TRPM8受体调节剂的取代的氮杂 - 双环咪唑衍生物
公开(公告)号：US08680098B2
公开(公告)日：2014-03-25
申请号：US13034922
申请日：2011-02-25
申请人： Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
发明人： Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/52 , A61K31/4985 , A61P29/00 , C07D487/04
CPC分类号： C07D471/04 , C07B2200/13 , C07C53/18 , C07C309/04 , C07D473/00 , C07D487/04
摘要： The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
摘要翻译：本发明涉及取代的氮杂 - 双环咪唑衍生物，含有它们的药物组合物及其用于治疗由TRP M8调节的病症和状况的用途，包括例如炎症性疼痛，炎性痛觉过敏，炎症性超敏反应性病症，神经性疼痛，神经性冷异常性疼痛，炎性体痛痛觉过敏，炎性内脏痛觉过敏，由寒冷和肺部疾病加重的心血管疾病加重。

6. 发明授权

US08246496B2 Sports net and goal apparatus 有权
标题翻译：运动网和进球器
公开(公告)号：US08246496B2
公开(公告)日：2012-08-21
申请号：US12599845
申请日：2008-05-15
申请人： Allen Holland , William Parsons
发明人： Allen Holland , William Parsons
IPC分类号： A63B63/00
CPC分类号： A63B63/004 , A63B63/00 , A63B71/0036 , A63B2210/50
摘要： A portable sports goal comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively. A method of providing a goal. A portable football goal.
摘要翻译：一种便携式运动目标，包括框架，第一柔韧门柱构件，第二柔韧门柱构件和柔韧的横杆构件。该框架呈现净连接点，并且被配置为支撑两个网络连接点之间的张力的每个柔韧的目标构件，使得目标装置呈现基本上矩形的目标口。用于目标装置的框架。用于包括第一，第二和第三边缘的目标装置的网，以及分别沿着第一边缘，第二边缘和第三边缘延伸的第一柔性门柱构件，第二柔韧门柱构件和柔韧的横杆构件。提供目标的方法。一个便携式足球目标。

7. 发明申请

US20100093788A1 HETEROCYCLIC BENZIMIDAZOLES AS TRPM8 MODULATORS 有权
标题翻译：作为TRPM8调节剂的杂环苯并咪唑
公开(公告)号：US20100093788A1
公开(公告)日：2010-04-15
申请号：US12576283
申请日：2009-10-09
申请人： Mark R. Player , Daniel J. Parks , William Parsons , Senath K. Meegalla , Carl R. Illig , Shelley K. Ballentine
发明人： Mark R. Player , Daniel J. Parks , William Parsons , Senath K. Meegalla , Carl R. Illig , Shelley K. Ballentine
IPC分类号： A61K31/437 , C07D261/20 , A61K31/42 , C07D498/10 , C07D263/52 , A61K31/421 , C07D471/02 , A61P29/00 , A61P25/24 , A61P9/00
CPC分类号： C07D261/20 , C07D263/52 , C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D498/10
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein W1, W2, W3, R1, R1a, R2, R2a, R3, V, Q, and X are defined herein.
摘要翻译：公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物由式I表示如下：其中W1，W2，W3，R1，R1a，R2，R2a，R3，V，Q和X如本文所定义。

8. 发明申请

US20070060584A1 Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers 审中-公开
标题翻译：二芳基取代的噻唑，恶唑和咪唑作为钠通道阻断剂
公开(公告)号：US20070060584A1
公开(公告)日：2007-03-15
申请号：US10553554
申请日：2004-04-14
申请人： Prasun Chakravarty , Michael Fisher , William Parsons , Sriram Tyagarajan , Bishan Zhou , Jeffrey Fisher
发明人： Prasun Chakravarty , Michael Fisher , William Parsons , Sriram Tyagarajan , Bishan Zhou , Jeffrey Fisher
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , C07D413/02 , C07D417/02 , C07D403/02
CPC分类号： C07D233/64 , C07D233/68 , C07D233/90 , C07D233/96 , C07D263/32 , C07D263/34 , C07D263/48 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/56 , C07D403/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Biaryl substituted thiazole, oxazole and imidazole compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treatment or prevention of conditions, including acute pain, chronic pain, visceral pain, inflammatory pain, and neuropathic pain comprise administering an effective amount of the present compounds, either alone, or in combination with one or more therapeutically active compounds.
摘要翻译：双芳基取代的噻唑，恶唑和咪唑化合物是可用于治疗疼痛的钠通道阻滞剂。药物组合物包含单独的或与一种或多种治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗或预防包括急性疼痛，慢性疼痛，内脏痛，炎性疼痛和神经性疼痛的病症的方法包括单独施用有效量的本发明化合物或与一种或多种治疗活性化合物组合施用。

9. 发明申请

US20050175331A1 Localized surface volatilization 有权
标题翻译：局部表面挥发
公开(公告)号：US20050175331A1
公开(公告)日：2005-08-11
申请号：US10984013
申请日：2004-11-08
申请人： Kelvin Tam , Zi Zeng , William Parsons , David Mather
发明人： Kelvin Tam , Zi Zeng , William Parsons , David Mather
IPC分类号： A01M1/20 , A61L9/03 , A61H33/12
CPC分类号： A61L9/037 , A01M1/2072 , A01M1/2077 , A01M2200/012 , A61L9/127 , F24F2003/1689
摘要： An apparatus including a replacement refill assembly for dispersing a volatile active into air. The replacement refill assembly includes a reservoir for containing a composition having a volatile active and a wick having an emanating surface from which the active may be volatized. A retainer is included in the apparatus for receiving and retaining the replacement refill assembly. A wire heating element is resiliently supported by opposing spring members so that when the refill assembly is received within the retainer, the spring members bias the heating element against the emanating surface of the wick while yielding an amount sufficient to prevent the heating element from breaking. In one embodiment, the apparatus also includes an air regulator, such as a baffle, for minimizing the flow of air across the heater element. A method and apparatus for controlling the source of power in the apparatus to periodically heat and clean the heating element is further described.
摘要翻译：一种装置，包括用于将挥发性活性物质分散到空气中的替换填充组件。替换补充组件包括用于容纳具有挥发性活性物的组合物和具有发射表面的芯的储存器，活性物质可以从其中挥发。用于接收和保持更换填充组件的装置中包括保持器。电线加热元件由相对的弹簧构件弹性地支撑，使得当再填充组件被容纳在保持器内时，弹簧构件将加热元件偏置在芯的发散表面上，同时产生足以防止加热元件断裂的量。在一个实施例中，该装置还包括用于使穿过加热器元件的空气流最小化的空气调节器，例如挡板。进一步描述用于控制装置中的功率源以周期性地加热和清洁加热元件的方法和装置。

10. 发明授权

US10261652B1 4D interactive mission analytics for visualization of unmanned vehicle performance indicators 有权
公开(公告)号：US10261652B1
公开(公告)日：2019-04-16
申请号：US15204690
申请日：2016-07-07
申请人： Miteshkumar K. Patel , Louis Oddo , William Parsons , Feng Cao , Henry H. Fung , Devang R. Parekh
发明人： Miteshkumar K. Patel , Louis Oddo , William Parsons , Feng Cao , Henry H. Fung , Devang R. Parekh
IPC分类号： G06F3/00 , G06T11/20 , G06F3/0481 , G06F3/16 , G06F3/01
摘要： A system includes an analytics collector that receives world state data to provide status relating to a plurality of mission analytics of an unmanned vehicle or an unmanned vehicle mission planner. An asset filter filters the status from the analytics collector with respect to mission analytics of a subset of selected assets. An analytic aggregator collects the filtered status from the asset filter and generates a visual analytics file based on one or more selected analytics for the subset of selected assets. A rendering pipeline processes the visual analytics file from the analytic aggregator and generates a formatted output file describing a visualization of the plurality of mission analytics from the visual analytics file.

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