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1. 发明授权

US08050384B2 Delivery system for radiation therapy 有权
标题翻译：辐射治疗放疗系统
公开(公告)号：US08050384B2
公开(公告)日：2011-11-01
申请号：US12251298
申请日：2008-10-14
申请人： Mark Philip Carol , Joseph A. Heanue
发明人： Mark Philip Carol , Joseph A. Heanue
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/10 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1084 , A61N2005/1059 , A61N2005/1091 , A61N2005/1098
摘要： A small tabletop stationary five-degree of freedom device such as a “robot” is used to define the treatment region by tracing the region under direct visualization and then to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other in a predetermined parallel or similar geometry, each source equipped with blocking and attenuation mechanisms, at a plurality of positions in a planar fashion across or through a selected treatment field, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue and can be used to treat regions on or below the surface of tissue, in a cavity and underlying region created following a surgical resection, on or below the surface of an internal cavity, hollow viscus, or lumen, or deep in tissue adjacent to an inserted probe or conduit or catheter. By generating a plurality of overlapping beams indexed on a millimeter or submillimeter grid that converge on a target volume loaded with gold nanoparticles, a tumorcidal dose of radiation can be delivered in as little as a single session to tumor cells but not to normal cells within or outside the treatment volume. This approach also makes it possible to deliver serial radiosurgical treatments.
摘要翻译：使用诸如“机器人”的小桌面固定式五自由度装置通过在直接可视化下跟踪该区域来定义治疗区域，然后通过定位单个低能量来精确地传递由自动规划系统创建的治疗计划辐射源或多个以预定的平行或相似几何形状彼此连接的低能量源，每个源在平面形式的多个位置处配备有阻挡和衰减机制，跨越或通过选定的治疗区域，由此递送多个平行的重叠光束在毫米或亚毫米格栅上分度，使得在组织中相对于辐射首先进入组织的剂量可变深度处实现剂量浓度，并可用于治疗表面上或表面下方的区域的组织，在腔内和在手术切除后创建的下面的区域，在int的表面上或下方内腔，中空粘液或内腔，或与插入的探针或导管或导管相邻的组织深部。通过产生在毫米或亚毫米网格上分度的多个重叠波束，其聚集在装载有金纳米颗粒的靶体上，可将肿瘤剂量的辐射以少量单次递送至肿瘤细胞，但不能递送至肿瘤细胞内的正常细胞，治疗量以外。这种方法也可以提供串联放射治疗。

2. 发明申请

US20090154646A1 DELIVERY SYSTEM FOR RADIATION THERAPY 有权
标题翻译：用于辐射治疗的输送系统
公开(公告)号：US20090154646A1
公开(公告)日：2009-06-18
申请号：US12251298
申请日：2008-10-14
申请人： Mark Philip Carol , Joseph A. Heanue
发明人： Mark Philip Carol , Joseph A. Heanue
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/10 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1084 , A61N2005/1059 , A61N2005/1091 , A61N2005/1098
摘要： A small tabletop stationary five-degree of freedom device such as a “robot” is used to define the treatment region by tracing the region under direct visualization and then to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other in a predetermined parallel or similar geometry, each source equipped with blocking and attenuation mechanisms, at a plurality of positions in a planar fashion across or through a selected treatment field, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue and can be used to treat regions on or below the surface of tissue, in a cavity and underlying region created following a surgical resection, on or below the surface of an internal cavity, hollow viscus, or lumen, or deep in tissue adjacent to an inserted probe or conduit or catheter. By generating a plurality of overlapping beams indexed on a millimeter or submillimeter grid that converge on a target volume loaded with gold nanoparticles, a tumorcidal dose of radiation can be delivered in as little as a single session to tumor cells but not to normal cells within or outside the treatment volume. This approach also makes it possible to deliver serial radiosurgical treatments.
摘要翻译：使用诸如“机器人”的小桌面固定式五自由度装置通过在直接可视化下跟踪该区域来定义治疗区域，然后通过定位单个低能量来精确地传递由自动规划系统创建的治疗计划辐射源或多个以预定的平行或相似几何形状彼此连接的低能量源，每个源在平面形式的多个位置处配备有阻挡和衰减机制，跨越或通过选定的治疗区域，由此递送多个平行的重叠光束在毫米或亚毫米格栅上分度，使得在组织中相对于辐射首先进入组织的剂量可变深度处实现剂量浓度，并可用于治疗表面上或表面下方的区域的组织，在手术切除后创建的腔和下面的区域中，在内表面上或下面 l腔，中空粘液或内腔，或与插入的探针或导管或导管相邻的组织深部。通过产生在毫米或亚毫米网格上分度的多个重叠波束，其聚集在装载有金纳米颗粒的靶体上，可将肿瘤剂量的辐射以少量单次递送至肿瘤细胞，但不能递送至肿瘤细胞内的正常细胞，治疗量以外。这种方法也可以提供串联放射治疗。

3. 发明申请

US20120093293A1 DELIVERY SYSTEM FOR RADIATION THERAPY 有权
标题翻译：用于辐射治疗的输送系统
公开(公告)号：US20120093293A1
公开(公告)日：2012-04-19
申请号：US13279208
申请日：2011-10-21
申请人： Mark Philip Carol , Joseph Anthony Heanue
发明人： Mark Philip Carol , Joseph Anthony Heanue
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/10 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1084 , A61N2005/1059 , A61N2005/1091 , A61N2005/1098
摘要： A device is used to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other, in a predetermined parallel, planar, or similar geometry, each source equipped with blocking and attenuation mechanisms, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue. A plurality of overlapping beams indexed on a millimeter or submillimeter grid can converge on a target volume loaded with gold nanoparticles to deliver a tumorcidal dose of radiation in as little as a single session to tumor cells but not to normal cells or to deliver serial radiosurgical treatments.
摘要翻译：通过将预定的平行，平面或相似的几何形状中的单个低能量辐射源或彼此连接的多个低能源定位在一起，用于通过将自动规划系统创建的治疗计划精确地传递给设备，每个源配备阻塞和衰减机制，从而输送索引在毫米或亚毫米格栅上的多个平行的重叠光束，使得在组织中相对于辐射首先进入组织的剂量的可变深度处获得剂量浓度。在毫米或亚毫米格栅上分度的多个重叠光束可以收敛于装载有金纳米颗粒的靶体上，以仅在单个时间段内向肿瘤细胞递送杀肿瘤剂量的辐射，但不能传播到正常细胞或递送连续放射外科治疗。

4. 发明申请

US20140205067A1 DELIVERY SYSTEM FOR RADIATION THERAPY 有权
标题翻译：用于辐射治疗的输送系统
公开(公告)号：US20140205067A1
公开(公告)日：2014-07-24
申请号：US14170478
申请日：2014-01-31
申请人： Mark Philip Carol , Triple Ring Technologies, Inc.
发明人： Mark Philip Carol , Joseph Anthony Heanue
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/10 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1084 , A61N2005/1059 , A61N2005/1091 , A61N2005/1098
摘要： A device is used to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other, in a predetermined parallel, planar, or similar geometry, each source equipped with blocking and attenuation mechanisms, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue. A plurality of overlapping beams indexed on a millimeter or submillimeter grid can converge on a target volume loaded with gold nanoparticles to deliver a tumorcidal dose of radiation in as little as a single session to tumor cells but not to normal cells or to deliver serial radiosurgical treatments.
摘要翻译：通过将预定的平行，平面或相似的几何形状中的单个低能量辐射源或彼此连接的多个低能源定位在一起，用于通过将自动规划系统创建的治疗计划精确地传递给设备，每个源配备阻塞和衰减机制，从而输送索引在毫米或亚毫米格栅上的多个平行的重叠光束，使得在组织中相对于辐射首先进入组织的剂量的可变深度处获得剂量浓度。在毫米或亚毫米格栅上分度的多个重叠光束可以收敛于装载有金纳米颗粒的靶体上，以仅在单个时间段内向肿瘤细胞递送杀肿瘤剂量的辐射，但不能传播到正常细胞或递送连续放射外科治疗。

5. 发明授权

US08644452B2 Delivery system for radiation therapy 有权
标题翻译：辐射治疗放疗系统
公开(公告)号：US08644452B2
公开(公告)日：2014-02-04
申请号：US13279208
申请日：2011-10-21
申请人： Mark Philip Carol , Joseph Anthony Heanue
发明人： Mark Philip Carol , Joseph Anthony Heanue
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/10 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1084 , A61N2005/1059 , A61N2005/1091 , A61N2005/1098
摘要： A device is used to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other, in a predetermined parallel, planar, or similar geometry, each source equipped with blocking and attenuation mechanisms, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue. A plurality of overlapping beams indexed on a millimeter or submillimeter grid can converge on a target volume loaded with gold nanoparticles to deliver a tumorcidal dose of radiation in as little as a single session to tumor cells but not to normal cells or to deliver serial radiosurgical treatments.
摘要翻译：通过将预定的平行，平面或相似的几何形状中的单个低能量辐射源或彼此连接的多个低能源定位在一起，用于通过将自动规划系统创建的治疗计划精确地传递给设备，每个源配备阻塞和衰减机制，从而输送索引在毫米或亚毫米格栅上的多个平行的重叠光束，使得在组织中相对于辐射首先进入组织的剂量的可变深度处获得剂量浓度。在毫米或亚毫米格栅上分度的多个重叠光束可以收敛于装载有金纳米颗粒的靶体上，以仅在单个时间段内向肿瘤细胞递送杀肿瘤剂量的辐射，但不能传播到正常细胞或递送连续放射外科治疗。

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