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3. 发明授权

US07326696B2 Amino-methyl substituted tetracycline compounds 有权
标题翻译：氨基甲基取代四环素化合物
公开(公告)号：US07326696B2
公开(公告)日：2008-02-05
申请号：US10737361
申请日：2003-12-15
申请人： Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人： Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
IPC分类号： A61K31/65 , C07D50/22
CPC分类号： C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要： Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
摘要翻译：讨论了氨基甲基取代的四环素化合物，药物组合物及其使用方法。

4. 发明申请

US20090299048A1 REACTIVE PYROPHOSPHORIC AND BISPHOSPHONIC ACID DERIVATIVES AND METHODS OF THEIR USE 有权
标题翻译：反应性磷酸和二磷酸衍生物及其使用方法
公开(公告)号：US20090299048A1
公开(公告)日：2009-12-03
申请号：US12374589
申请日：2007-07-23
申请人： Ivan Yanachkov , George E. Wright
发明人： Ivan Yanachkov , George E. Wright
IPC分类号： C12P19/38 , C07F9/6506 , C07F9/58
CPC分类号： C07F9/6506
摘要： This invention features bis-amides of pyrophosphoric acid and bisphosphonic acids, their preparation, and their use in synthesis of P1,P4-dinucleoside tetraphosphates, tetraphosphonates, and related compounds.
摘要翻译：本发明的特征在于焦磷酸和双膦酸的双酰胺，它们的制备及其在合成P1，P4-二核苷四磷酸盐，四磷酸盐和相关化合物中的用途。

5. 发明授权

US06214811B1 Acyclovir diester derivatives 失效
标题翻译：阿昔洛韦二酯衍生物
公开(公告)号：US06214811B1
公开(公告)日：2001-04-10
申请号：US09514552
申请日：2000-02-28
申请人： Arnold Glazier , Milka Yanachkova , Ivan Yanachkov
发明人： Arnold Glazier , Milka Yanachkova , Ivan Yanachkov
IPC分类号： A61K31675
CPC分类号： C07F9/65616
摘要： Disclosed are novel prodrugs represented by the following structural formula; Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.
摘要翻译：公开了由以下结构式表示的新型前药：Z是氧或硫; Y与羟基，阿昔洛韦或阿昔洛韦的类似物一起; A是相对于磷酸酯在邻位或对位具有一个或多个保护的羟基或被保护的胺基的取代苄基，其可在体内转化为羟基或氨基。还公开了一种治疗个体或动物中的病毒感染的方法。该方法包括向个体或动物施用治疗有效量的由上述结构式表示的前药。

6. 发明授权

US06180790B2 Methods of preparing acyclovir prodrugs 失效
标题翻译：制备阿昔洛韦前药的方法
公开(公告)号：US06180790B2
公开(公告)日：2001-01-30
申请号：US09459178
申请日：1999-12-10
申请人： Arnold Glazier , Milka Yanachkova , Ivan Yanachkov
发明人： Arnold Glazier , Milka Yanachkova , Ivan Yanachkov
IPC分类号： C07F96512
CPC分类号： C07F9/65616
摘要： Disclosed are novel prodrugs represented by the following structural formula: Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.
摘要翻译：公开了由以下结构式表示的新型前药：Z是氧或硫; Y与羟基，阿昔洛韦或阿昔洛韦的类似物一起; A是相对于磷酸酯在邻位或对位具有一个或多个保护的羟基或被保护的胺基的取代苄基，其可在体内转化为羟基或氨基。还公开了一种治疗个体或动物中的病毒感染的方法。该方法包括向个体或动物施用治疗有效量的由上述结构式表示的前药。

7. 发明授权

US08288545B2 Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use 有权
标题翻译：反应性焦磷酸和双膦酸衍生物及其使用方法
公开(公告)号：US08288545B2
公开(公告)日：2012-10-16
申请号：US12374589
申请日：2007-07-23
申请人： Ivan Yanachkov , George E. Wright
发明人： Ivan Yanachkov , George E. Wright
IPC分类号： C07F9/572 , C07F9/58
CPC分类号： C07F9/6506
摘要： This invention features bis-amides of pyrophosphoric acid and bisphosphonic acids, their preparation, and their use in synthesis of P1,P4-dinucleoside tetraphosphates, tetraphosphonates, and related compounds.
摘要翻译：本发明的特征在于焦磷酸和双膦酸的双酰胺，它们的制备及其在合成P1，P4-二核苷四磷酸，四磷酸酯和相关化合物中的用途。

8. 发明授权

US6031096A Acyclovir diester derivatives 失效
标题翻译：阿昔洛韦二酯衍生物
公开(公告)号：US6031096A
公开(公告)日：2000-02-29
申请号：US80064
申请日：1998-05-15
申请人： Arnold Glazier , Milka Yanachkova , Ivan Yanachkov
发明人： Arnold Glazier , Milka Yanachkova , Ivan Yanachkov
IPC分类号： A61K31/685 , A61K31/688 , A61P31/12 , A61P31/22 , C07F9/6561 , C07D473/18
CPC分类号： C07F9/65616
摘要： Disclosed are novel prodrugs represented by the following structural formula: ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.
摘要翻译：公开了由以下结构式表示的新型前药：Z是氧或硫; Y与羟基，阿昔洛韦或阿昔洛韦的类似物一起; A是相对于磷酸酯在邻位或对位具有一个或多个保护的羟基或被保护的胺基的取代苄基，其可在体内转化为羟基或氨基。还公开了一种治疗个体或动物中的病毒感染的方法。该方法包括向个体或动物施用治疗有效量的由上述结构式表示的前药。

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