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1. 发明申请

US20050187198A1 Methods of preparing substituted tetracyclines with transition metal-based chemistries 有权
标题翻译：用过渡金属化学制备取代四环素的方法
公开(公告)号：US20050187198A1
公开(公告)日：2005-08-25
申请号：US11004559
申请日：2004-12-03
申请人： Mark Nelson , Glen Rennie , Darrell Koza
发明人： Mark Nelson , Glen Rennie , Darrell Koza
IPC分类号： C07C231/12 , C07C237/26 , C07D295/185 , C07D295/192 , A61K31/65
CPC分类号： C07D295/185 , C07C231/12 , C07C237/26 , C07C2603/46 , C07D295/192
摘要： The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed. Such compounds may optionally act as intermediates for making other compounds, e.g., hydrogenation of unsaturated groups on the substituent.
摘要翻译：本发明涉及允许迄今为止在四环素反应状态下表现出显着活性的未获得的取代四环素化合物的新化学物质。本文公开的方法在形成被所需有机取代基取代的四环素化合物的条件下使用基于活性四环素的前体化合物，反应性有机取代基前体和过渡金属催化剂。在本发明的一个实施方案中，取代的四环素化合物可以通过将活性四环素类前体化合物如芳族四环素重氮盐和反应性有机取代基前体例如烯烃，取代的烯烃，乙烯基单体，芳族化合物和在过渡金属催化剂如氯化钯存在下，在形成被有机取代基取代的四环素化合物的条件下，进行杂芳族化合物。这样的化合物可以任选地用作制备其它化合物的中间体，例如取代基上不饱和基团的氢化。

2. 发明申请

US20060234988A1 7-N-substituted phenyl tetracycline compounds 审中-公开
公开(公告)号：US20060234988A1
公开(公告)日：2006-10-19
申请号：US11453326
申请日：2006-06-14
申请人： Mark Nelson , Darrell Koza
发明人： Mark Nelson , Darrell Koza
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07C237/26 , C07C2603/46
摘要： 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.

3. 发明申请

US20050119235A1 7-phenyl-substituted tetracycline compounds 审中-公开
标题翻译： 7-苯基取代的四环素化合物
公开(公告)号：US20050119235A1
公开(公告)日：2005-06-02
申请号：US10819343
申请日：2004-04-05
申请人： Mark Nelson , Glen Rennie , Darrell Koza
发明人： Mark Nelson , Glen Rennie , Darrell Koza
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07C237/26 , A61K31/65 , C07C2603/46 , Y02A50/473
摘要： 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
摘要翻译： 7-苯基取代的四环素化合物，治疗四环素应答状态的方法和含有7-苯基取代的四环素化合物的药物组合物。

4. 发明申请

US20050148551A1 7, 8 and 9-substituted tetracycline compounds 失效
标题翻译： 7,8和9-取代四环素化合物
公开(公告)号：US20050148551A1
公开(公告)日：2005-07-07
申请号：US10866220
申请日：2004-06-10
申请人： Mark Nelson , Darrell Koza , Glen Rennie
发明人： Mark Nelson , Darrell Koza , Glen Rennie
IPC分类号： C07C237/26 , A61K31/65 , C07D241/20
CPC分类号： C07C237/26
摘要： 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
摘要翻译： 7,8和9-取代的四环素化合物，治疗四环素应答状态的方法，以及含有7,8和9-取代的四环素化合物的药物组合物。

5. 发明申请

US20070155708A1 7-phenyl-substituted tetracycline compounds 有权
标题翻译： 7-苯基取代的四环素化合物
公开(公告)号：US20070155708A1
公开(公告)日：2007-07-05
申请号：US11706111
申请日：2007-02-13
申请人： Mark Nelson , Glen Rennie , Darrell Koza
发明人： Mark Nelson , Glen Rennie , Darrell Koza
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07C237/26 , A61K31/65 , C07C2603/46 , Y02A50/473
摘要： 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
摘要翻译： 7-苯基取代的四环素化合物，治疗四环素应答状态的方法和含有7-苯基取代的四环素化合物的药物组合物。

6. 发明申请

US20060229282A1 7, 8 And 9-substituted tetracycline compounds 有权
标题翻译： 7,8和9-取代四环素化合物
公开(公告)号：US20060229282A1
公开(公告)日：2006-10-12
申请号：US11454221
申请日：2006-06-16
申请人： Mark Nelson , Darrell Koza , Glen Rennie
发明人： Mark Nelson , Darrell Koza , Glen Rennie
IPC分类号： A61K31/65
CPC分类号： C07C237/26
摘要： 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
摘要翻译： 7,8和9-取代的四环素化合物，治疗四环素应答状态的方法，以及含有7,8和9-取代的四环素化合物的药物组合物。

7. 发明申请

US20060166946A1 Methods of preparing substituted tetracyclines with transition metal-based chemistries 失效
公开(公告)号：US20060166946A1
公开(公告)日：2006-07-27
申请号：US11390902
申请日：2006-03-28
申请人： Mark Nelson , Glen Rennie , Darrell Koza
发明人： Mark Nelson , Glen Rennie , Darrell Koza
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07C237/26 , C07C231/12 , C07C2603/46
摘要： The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed. Such compounds may optionally act as intermediates for making other compounds, e.g., hydrogenation of unsaturated groups on the substituent.

8. 发明申请

US20170181393A1 ASSEMBLY FOR VERTICAL PLANT ARRAY 审中-公开
公开(公告)号：US20170181393A1
公开(公告)日：2017-06-29
申请号：US15327591
申请日：2015-07-28
申请人： Mark Nelson
发明人： Mark Nelson
IPC分类号： A01G31/06 , A01G27/00 , A01G9/02
CPC分类号： A01G31/06 , A01G9/023 , A01G27/00
摘要： A modular array for growing plants consisting of horizontally extending tubes with plant openings, downspouts for conveying water from an upper tube to a lower tube and means for adjusting the height of water in each tube. Preferably, each downspout is movable within a mounting in the uppertube and the water height is adjusted by altering the height by which the downspout projects into the tube interior.

9. 发明授权

US09612803B2 System and method for use of a virtual assembly builder 有权
公开(公告)号：US09612803B2
公开(公告)日：2017-04-04
申请号：US13448111
申请日：2012-04-16
申请人： Richard P. Mousseau , Mark Nelson , Jon Richards , Troy Schulz , Keith Kelleman , Mark Spotswood , Jeff Berkowitz
发明人： Richard P. Mousseau , Mark Nelson , Jon Richards , Troy Schulz , Keith Kelleman , Mark Spotswood , Jeff Berkowitz
IPC分类号： G06F9/455 , G06F9/44
CPC分类号： G06F8/34 , G06F9/45558 , G06F2009/45562 , G06F2009/4557
摘要： A virtual assembly builder for use in virtualization environments, which can be used as a tool for virtualizing installed components in a reference environment, modifying those components if necessary, and then deploying them into another/target environment. Using the virtual assembly builder, a user (e.g., an administrator) can capture the configuration and product/component binaries of existing software components into software appliance artifacts. Appliances can be grouped, and their relationships defined, into software assembly artifacts. Logical connections between appliances within an assembly can be reconfigured by a process of assembly editing. When a desired assembly configuration has been achieved, the assembly can be prepared for, and deployed into, the target environment.

10. 发明授权

US08986606B2 Chemistry for effective microbe control with reduced gas phase corrosiveness in pulp and paper processing systems 有权
标题翻译：用于在纸浆和纸张处理系统中降低气相腐蚀性的有效微生物控制的化学
公开(公告)号：US08986606B2
公开(公告)日：2015-03-24
申请号：US12472058
申请日：2009-05-26
申请人： Mark Nelson , Marko Kolari , Juhana Ahola
发明人： Mark Nelson , Marko Kolari , Juhana Ahola
IPC分类号： A61L2/18 , D21F1/66 , C02F1/76 , C02F1/50 , C02F103/28
CPC分类号： D21F1/66 , C02F1/50 , C02F1/76 , C02F2103/28 , C02F2303/08 , C02F2303/20
摘要： Processes for biofilm or microorganism growth control in an aqueous system such as a pulp, paper or board manufacturing system are described in which a halogenated hydantoin is added to the aqueous system in combination with haloamine, chlorine dioxide or a combination thereof. The halogenated hydantoin is preferably a fully or partially halogenated dialkyl hydantoin, and more preferably 5,5-dimethyl hydantoin or 5-methyl-5-ethyl hydantoin. The haloamine is preferably a monohaloamine, dihaloamine, trihaloamine, or a combination thereof, and more preferably monochloramine, monobromamine, bromochloroamine or a combination thereof. The halogenated hydantoin is preferably added to the aqueous system in portions of the system susceptible to gas phase corrosion, such as the short loop of the system, and the haloamine and chlorine dioxide are preferably added to other portions of the system. The halogenated hydantoin and haloamine and/or chlorine dioxide maintain good compatibility with each other in the absence of excess free chlorine.
摘要翻译：描述了在水系统如纸浆，纸或板制造系统中的生物膜或微生物生长控制的方法，其中将卤代乙内酰脲与卤胺，二氧化氯或其组合组合加入到水系统中。卤化乙内酰脲优选为完全或部分卤化的二烷基乙内酰脲，更优选为5,5-二甲基乙内酰脲或5-甲基-5-乙基乙内酰脲。卤代胺优选为单卤代胺，二卤代胺，三卤代胺或其组合，更优选一氯胺，一溴胺，溴氯胺或其组合。卤化乙内酰脲优选在易于气相腐蚀的系统的部分系统中加入到水系统中，例如系统的短路，并且卤胺和二氧化氯优选加入系统的其它部分。卤代乙内酰脲和卤代胺和/或二氧化氯在不存在过量游离氯的情况下保持彼此良好的相容性。

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