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1. 发明授权

US07031771B2 Dual chamber method and apparatus for diagnosis and treatment of arrhythmias 有权
公开(公告)号：US07031771B2
公开(公告)日：2006-04-18
申请号：US10308281
申请日：2002-12-03
申请人： Mark L. Brown , Jeffrey M. Gillberg , Robert W. Stadler
发明人： Mark L. Brown , Jeffrey M. Gillberg , Robert W. Stadler
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61B5/02405 , A61B5/0464 , A61B5/0472 , A61B5/726
摘要： A method and apparatus are provided for improving the detection of certain cardiac rhythms by combining dual chamber interval-related detection methods with electrogram morphology analysis. A prioritized set of rules are defined wherein each rule is directed at identifying a particular arrhythmia or type of arrhythmia. Each rule includes clauses that may be related to sensed event intervals and interval patterns and at least one rule includes at least one clause relating to the EGM morphology.

2. 发明授权

US08972228B2 Assessing intra-cardiac activation patterns 有权
标题翻译：评估心脏内激活模式
公开(公告)号：US08972228B2
公开(公告)日：2015-03-03
申请号：US13462480
申请日：2012-05-02
申请人： Subham Ghosh , Jeffrey M. Gillberg , Robert W. Stadler
发明人： Subham Ghosh , Jeffrey M. Gillberg , Robert W. Stadler
IPC分类号： G06G7/48 , A61B5/0408 , A61B5/0452 , A61B5/05 , A61B5/02 , A61B5/0402 , A61N1/04 , A61N1/362 , A61N1/368
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译：描述了评估心脏电气不同步的技术。在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。

3. 发明申请

US20120284003A1 ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS 有权
标题翻译：评估心脏内膜激活模式
公开(公告)号：US20120284003A1
公开(公告)日：2012-11-08
申请号：US13462480
申请日：2012-05-02
申请人： Subham Gosh , Jeffrey M. Gillberg , Robert W. Stadler
发明人： Subham Gosh , Jeffrey M. Gillberg , Robert W. Stadler
IPC分类号： G06G7/60 , G06F7/60
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译：描述了评估心脏电气不同步的技术。在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。

4. 发明授权

US08301235B2 Method and apparatus for detecting and discriminating tachycardia 有权
标题翻译：用于检测和辨别心动过速的方法和装置
公开(公告)号：US08301235B2
公开(公告)日：2012-10-30
申请号：US12768782
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0472
CPC分类号： A61B5/0464 , A61B5/0245 , A61B5/7203 , A61N1/3621 , A61N1/3956
摘要： A medical device and associated method for discriminating cardiac events sense cardiac signals that includes determining whether a first match score is within one of a first match zone corresponding to a first cardiac event, and a second match zone corresponding to the first cardiac event, and determining whether a second match score is within one of the first match zone, the second match zone, and a third match zone corresponding to a second cardiac event different from the first cardiac event. One of increasing and decreasing an event counter is performed in response to both the determination of whether the first match score is within one of the first match zone and the second match zone and the determination of whether the second match score is within one of the first match zone, the second match zone, and the third match zone.
摘要翻译：用于识别心脏事件的医疗装置和相关联的方法检测心脏信号，所述心脏信号包括确定第一匹配分数是否在对应于第一心脏事件的第一匹配区域之内，以及对应于第一心脏事件的第二匹配区域，以及确定第二匹配得分是否在第一匹配区域，第二匹配区域和对应于不同于第一心脏事件的第二心脏事件的第三匹配区域之一内。响应于第一匹配分数是否在第一匹配区域和第二匹配区域之一的确定以及确定第二匹配分数是否在第一匹配区域之一内的确定来执行增加和减少事件计数器之一匹配区，第二匹配区和第三匹配区。

5. 发明授权

US08301233B2 Detecting a condition of a patient using a probability-correlation based model 有权
标题翻译：使用基于概率相关的模型检测患者的状况
公开(公告)号：US08301233B2
公开(公告)日：2012-10-30
申请号：US12415445
申请日：2009-03-31
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/0452 , A61B5/7203 , A61N1/3621 , A61N1/3702 , A61N1/3962
摘要： Techniques are described for detecting a condition of a patient using a probability-correlation based model that integrates a plurality of parameters associated with the condition. A medical device that operates in accordance with the techniques obtains a plurality of parameters associated with the condition of the patient. The medical device obtains probabilities that the condition of the patient exists based on each single parameter separately and correlations between each of the parameters and the other ones of the parameters. After obtaining the probabilities and correlations associated with each of the parameters, the medical device determines whether the condition of the patient exists based on the determined probabilities and correlations. Such techniques may be particularly effective for use in distinguishing whether a rhythm of a patient is treatable, e.g., VT or VF, or non-treatable, e.g., SVT.
摘要翻译：描述了用于使用集成了与条件相关联的多个参数的基于概率相关的模型来检测患者的状况的技术。根据技术操作的医疗装置获得与患者状况相关联的多个参数。医疗设备根据每个单独的参数获得病人的状况存在的概率，以及每个参数与其他参数之间的相关性。在获得与每个参数相关联的概率和相关性之后，医疗设备基于所确定的概率和相关性来确定患者的状况是否存在。这种技术可能特别有效地用于区分患者的节律是否可治疗，例如VT或VF，或不可治疗的，例如SVT。

6. 发明申请

US20110270108A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 有权
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：US20110270108A1
公开(公告)日：2011-11-03
申请号：US12768850
申请日：2010-04-28
申请人： Robert W. Stadler , Xusheng Zhang , Jeffrey M. Gillberg
发明人： Robert W. Stadler , Xusheng Zhang , Jeffrey M. Gillberg
IPC分类号： A61B5/0464 , A61B5/0452
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/04011 , A61B5/0464 , A61B5/0468 , A61B5/686 , A61B5/6869 , A61B5/7203 , A61N1/3622 , A61N1/36507 , A61N1/37264
摘要： A medical device and associated method for monitoring a patient's heart rhythm sense cardiac events and detect a sudden change in the heart rhythm in response to the sensed cardiac events. Detecting the sudden change includes determining a variability of intervals between the sensed cardiac events and switching between a low variability mode of operation and a high variability mode of operation in response to the variability of intervals. During the low variability mode, detecting the sudden change includes detecting an increase in the rate of cardiac events. During the high variability mode, detecting the sudden change includes detecting a sudden decrease in the variability of the cardiac event intervals. A concerning cardiac rhythm is detected in response to detecting the sudden change.
摘要翻译：用于监测患者心律的医疗装置和相关联的方法感测心脏事件并且响应于感测到的心脏事件来检测心律的突然变化。检测突然变化包括响应于间隔的可变性来确定所感测的心脏事件之间的间隔的可变性和低变异性操作模式与高变异性操作模式之间的切换。在低变异性模式期间，检测突然变化包括检测心脏事件发生率的增加。在高可变性模式期间，检测突然变化包括检测心脏事件间隔的变异性的突然降低。响应于检测到突然变化而检测到关于心律的A。

7. 发明申请

US20100249627A1 Detecting A Condition Of A Patient Using A Probability-Correlation Based Model 有权
标题翻译：使用概率相关模型检测患者的病情
公开(公告)号：US20100249627A1
公开(公告)日：2010-09-30
申请号：US12415445
申请日：2009-03-31
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0464
CPC分类号： A61B5/0452 , A61B5/7203 , A61N1/3621 , A61N1/3702 , A61N1/3962
摘要： Techniques are described for detecting a condition of a patient using a probability-correlation based model that integrates a plurality of parameters associated with the condition. A medical device that operates in accordance with the techniques obtains a plurality of parameters associated with the condition of the patient. The medical device obtains probabilities that the condition of the patient exists based on each single parameter separately and correlations between each of the parameters and the other ones of the parameters. After obtaining the probabilities and correlations associated with each of the parameters, the medical device determines whether the condition of the patient exists based on the determined probabilities and correlations. Such techniques may be particularly effective for use in distinguishing whether a rhythm of a patient is treatable, e.g., VT or VF, or non-treatable, e.g., SVT.
摘要翻译：描述了用于使用集成了与条件相关联的多个参数的基于概率相关的模型来检测患者的状况的技术。根据技术操作的医疗装置获得与患者状况相关联的多个参数。医疗设备根据每个单独的参数获得病人的状况存在的概率，以及每个参数与其他参数之间的相关性。在获得与每个参数相关联的概率和相关性之后，医疗设备基于所确定的概率和相关性来确定患者的状况是否存在。这种技术可能特别有效地用于区分患者的节律是否可治疗，例如VT或VF，或不可治疗的，例如SVT。

8. 发明授权

US06980860B2 Detection of supraventricular tachycardia with 1:1 atrial to ventricular conduction 有权
标题翻译：检测室性心律不齐与1：1心房与心室传导
公开(公告)号：US06980860B2
公开(公告)日：2005-12-27
申请号：US10284874
申请日：2002-10-31
申请人： Robert W. Stadler , Jeffrey M. Gillberg
发明人： Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： The invention is directed to method and process for discriminating supraventricular tachycardia (SVT) with 1:1 atrial to ventricular conduction (AV conduction). Upon detection of a rapid heart rate, an implanted medical device may determine whether the rhythm exhibits insufficient evidence of sinus tachycardia, whether the rhythm exhibits 1:1 conduction, and whether an electrical signal corresponding to the rhythm exhibits a normal morphology. When these tests have been satisfied, the device determines that an SVT with 1:1 AV conduction has been detected.
摘要翻译：本发明涉及用1：1心房至室性传导（AV传导）鉴别室上性心动过速（SVT）的方法和过程。在检测到快速心率时，植入的医疗装置可以确定节律是否表现出窦性心动过速的证据不足，节律是否表现出1:1的传导以及对应于节律的电信号是否呈现正常的形态。当满足这些测试时，该装置确定检测到具有1：1 AV导通的SVT。

9. 发明申请

US20120283587A1 ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS AND ELECTRICAL DYSSYNCHRONY 有权
标题翻译：评估心脏内皮细胞活化模式和电学性质
公开(公告)号：US20120283587A1
公开(公告)日：2012-11-08
申请号：US13462404
申请日：2012-05-02
申请人： Subham Gosh , Jeffrey M. Gillberg , Robert W. Stadler
发明人： Subham Gosh , Jeffrey M. Gillberg , Robert W. Stadler
IPC分类号： A61B5/044 , A61B5/0402
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译：描述了评估心脏电气不同步的技术。在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。

10. 发明申请

US20110270106A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 有权
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：US20110270106A1
公开(公告)日：2011-11-03
申请号：US12768782
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0402
CPC分类号： A61B5/0464 , A61B5/0245 , A61B5/7203 , A61N1/3621 , A61N1/3956
摘要： A medical device and associated method for discriminating cardiac events sense cardiac signals that includes determining whether a first match score is within one of a first match zone corresponding to a first cardiac event, and a second match zone corresponding to the first cardiac event, and determining whether a second match score is within one of the first match zone, the second match zone, and a third match zone corresponding to a second cardiac event different from the first cardiac event. One of increasing and decreasing an event counter is performed in response to both the determination of whether the first match score is within one of the first match zone and the second match zone and the determination of whether the second match score is within one of the first match zone, the second match zone, and the third match zone.
摘要翻译：用于识别心脏事件的医疗装置和相关联的方法检测心脏信号，所述心脏信号包括确定第一匹配分数是否在对应于第一心脏事件的第一匹配区域之内，以及对应于第一心脏事件的第二匹配区域，以及确定第二匹配得分是否在第一匹配区域，第二匹配区域和对应于不同于第一心脏事件的第二心脏事件的第三匹配区域之一内。响应于第一匹配分数是否在第一匹配区域和第二匹配区域之一的确定以及确定第二匹配分数是否在第一匹配区域之一内的确定来执行增加和减少事件计数器之一匹配区，第二匹配区和第三匹配区。

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