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1. 发明授权

US5849764A Antagonists of gonadotropin releasing hormone 失效
公开(公告)号：US5849764A
公开(公告)日：1998-12-15
申请号：US760817
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
发明人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
IPC分类号： C07D20060101 , C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04 , A61K31/44 , A61K31/40 , C07D209/02 , C07D215/12
CPC分类号： C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

2. 发明授权

US5780437A Antagonists of gonadotropin releasing hormone 失效
标题翻译：促性腺激素释放激素的拮抗剂
公开(公告)号：US5780437A
公开(公告)日：1998-07-14
申请号：US760816
申请日：1996-12-05
申请人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
发明人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Narindar N. Girotra , Peter Lin , Matthew J. Wyvratt
IPC分类号： C07D20060101 , C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08 , A61K38/00 , A61K31/40 , A61K31/54
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗两种男性中各种性激素相关和其他病症和妇女。

3. 发明授权

US06200957B1 Antagonists of gonadotropin releasing hormone 失效
公开(公告)号：US06200957B1
公开(公告)日：2001-03-13
申请号：US09115497
申请日：1998-07-14
申请人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Peter Lin , Mitree M. Ponpipom , Matthew J. Wyvratt , Narindar N. Girotra , Jonathan Young
发明人： Mark Goulet , Wallace T. Ashton , Lin Chu , Michael H. Fisher , Peter Lin , Mitree M. Ponpipom , Matthew J. Wyvratt , Narindar N. Girotra , Jonathan Young
IPC分类号： C07D20910
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

4. 发明授权

US5756507A Antagonists of gonadotropin releasing hormone 失效
公开(公告)号：US5756507A
公开(公告)日：1998-05-26
申请号：US760851
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
发明人： Mark Goulet , Lin Chu , Wallace T. Ashton , Michael H. Fisher , Matthew J. Wyvratt , Roy G. Smith , Robert L. Bugianesi , Mitree M. Ponpipom , Yi Tien Yang , Peter Lin
IPC分类号： C07D209/14 , C07D209/16 , A61K31/405 , A61K31/495 , C07D209/10 , C07D403/06
CPC分类号： C07D209/14 , C07D209/16
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

5. 发明授权

US6156767A Antagonists of gonadotropin releasing hormone 失效
标题翻译：促性腺激素释放激素的拮抗剂
公开(公告)号：US6156767A
公开(公告)日：2000-12-05
申请号：US83477
申请日：1998-05-22
申请人： Mark Goulet , Matthew J. Wyvratt, Jr. , Peter Lin , Lin Chu , Narindar N. Girotra
发明人： Mark Goulet , Matthew J. Wyvratt, Jr. , Peter Lin , Lin Chu , Narindar N. Girotra
IPC分类号： C07D401/12 , C07D401/14 , C07D487/08 , C07D217/00 , A61K31/56 , C07D215/12 , C07D401/00
CPC分类号： C07D401/14 , C07D401/12 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。

6. 发明授权

US5726319A Biphenyl substituted dipeptide analogs promote release of growth hormone 失效
标题翻译：联苯取代的二肽类似物促进生长激素的释放
公开(公告)号：US5726319A
公开(公告)日：1998-03-10
申请号：US510026
申请日：1995-08-01
申请人： Peter Lin , William R. Schoen , Judith M. Pisano , Matthew J. Wyvratt
发明人： Peter Lin , William R. Schoen , Judith M. Pisano , Matthew J. Wyvratt
IPC分类号： A61K38/00 , C07C275/24 , C07D257/04 , C07K5/06 , C07D257/00
CPC分类号： C07D257/04 , C07C275/24 , C07K5/06026 , C07K5/06191 , A61K38/00
摘要： There are disclosed certain compounds identified as substituted dipeptide analogs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such substituted dipeptide analogs as the active ingredient thereof are also disclosed.
摘要翻译：公开了鉴定为取代的二肽类似物的某些化合物，其促进人和动物中生长激素的释放。该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。还公开了含有这种取代的二肽类似物作为其活性成分的生长促进组合物。

7. 发明申请

US20130062495A1 Office Chair Foot Base 审中-公开
标题翻译：办公椅脚座
公开(公告)号：US20130062495A1
公开(公告)日：2013-03-14
申请号：US13230938
申请日：2011-09-13
申请人： Peter Lin
发明人： Peter Lin
IPC分类号： A47C7/62
CPC分类号： A47C7/004
摘要： An office chair foot base providing to support an office chair has a top end disposed towards the office chair, and a bottom end disposed opposite to the top end towards the ground. The office chair foot base comprises a main boy and a plurality of legs. The main boy includes an interior wall formed circularly and a connecting portion connecting to the interior wall at the bottom end. The plurality of legs formed radially extending opposite to the interior wall to a radial extent. Each of the plurality of legs includes a joining portion formed at the bottom end. The joining portion connects with the connecting portion.
摘要翻译：提供用于支撑办公椅的办公椅脚座具有朝向办公椅放置的顶端，以及与顶端朝向地面相对设置的底端。办公椅脚座包括一个主男孩和多个腿。主要男孩包括圆形的内壁和连接到底端的内壁的连接部分。所述多个支腿沿径向延伸形成为径向向内延伸。多个腿中的每一个包括形成在底端的接合部。连接部分与连接部分连接。

8. 发明申请

US20120025575A1 Chair 失效
标题翻译：椅子
公开(公告)号：US20120025575A1
公开(公告)日：2012-02-02
申请号：US12899711
申请日：2010-10-07
申请人： Peter Lin
发明人： Peter Lin
IPC分类号： A47C1/024
CPC分类号： A47C1/026 , A47C3/34 , A47C7/462
摘要： A chair includes a supporting structure, a seat moveably mounted on the supporting structure and being moveable with respect to the supporting structure in a vertical direction, and a backrest including a first frame pivotally connected to the seat and a second frame separate from and pivotally mounted on the first frame so as to connect to the seat. Further, a first control device is mounted and concealed between the first and second frames in order to prevent the user from inadvertently colliding with it. The first control device is adjusted for various relative pivotal positions of first and second frames.
摘要翻译：座椅包括支撑结构，可移动地安装在支撑结构上并且可相对于支撑结构在垂直方向上移动的座椅，以及靠背，其包括枢转地连接到座椅的第一框架和与之枢转地安装的第二框架在第一个框架上，以便连接到座椅。此外，第一控制装置安装并隐藏在第一和第二框架之间，以防止用户与其无意地碰撞。第一控制装置针对第一和第二框架的各种相对枢转位置进行调节。

9. 发明申请

US20100307642A1 Method for Preparing Polycrystalline Structures Having Improved Mechanical and Physical Properties 有权
标题翻译：制备具有改善的机械和物理性能的多晶结构的方法
公开(公告)号：US20100307642A1
公开(公告)日：2010-12-09
申请号：US12808697
申请日：2008-12-18
申请人： Gino Palumbo , Iain Brooks , Klaus Tomantschger , Peter Lin , Karl Aust , Nandakumar Nagarajan , Francisco Gonzalez
发明人： Gino Palumbo , Iain Brooks , Klaus Tomantschger , Peter Lin , Karl Aust , Nandakumar Nagarajan , Francisco Gonzalez
IPC分类号： C25D5/50 , B32B15/01
CPC分类号： C22F1/08 , C21D1/06 , C21D9/0068 , C25D3/12 , C25D3/38 , C25D5/50
摘要： Polycrystalline materials are prepared by electrodeposition of a precursor material that is subsequently heat-treated to induce at least a threefold increase in the grain size of the material to yield a relatively high fraction of ‘special’ low Σ grain boundaries and a randomized crystallographic texture. The precursor metallic material has sufficient purity and a fine-grained microstructure (e.g., an average grain size of 4 nm to 5 μm). The resulting metallic material is suited to the fabrication of articles requiring high mechanical or physical isotropy and/or resistance to grain boundary-mediated deformation or degradation mechanisms.
摘要翻译：多结晶材料通过电沉积前体材料制备，随后进行热处理以诱导材料的晶粒尺寸至少增加三倍，从而产生相对较高的“特殊”低Sgr; 晶界和随机晶体学结构。前体金属材料具有足够的纯度和细粒度的微观结构（例如，平均粒度为4nm至5μm）。所得到的金属材料适于制造需要高机械或物理各向同性的物品和/或对晶界介导的变形或降解机理的抵抗力。

10. 发明申请

US20090137546A1 Anti-Hypercholesterolemic Compounds 审中-公开
标题翻译：抗高胆固醇血症化合物
公开(公告)号：US20090137546A1
公开(公告)日：2009-05-28
申请号：US11992990
申请日：2006-09-29
申请人： Robert J. DeVita , Gregori J. Morriello , Peter Lin
发明人： Robert J. DeVita , Gregori J. Morriello , Peter Lin
IPC分类号： A61K31/397 , C07D205/08
CPC分类号： C07D205/08 , C07D405/10
摘要： This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
摘要翻译：本发明提供式I的胆固醇吸收抑制剂及其药学上可接受的盐和酯。该化合物可用于降低血浆胆固醇水平，特别是低密度脂蛋白胆固醇，以及用于治疗和预防动脉粥样硬化和动脉粥样硬化疾病事件。

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