专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10518090B2 System and method to modulate phrenic nerve to prevent sleep apnea 有权
公开(公告)号：US10518090B2
公开(公告)日：2019-12-31
申请号：US13538713
申请日：2012-06-29
申请人： Mark Gelfand , Howard R. Levin , Andrew Halpert
发明人： Mark Gelfand , Howard R. Levin , Andrew Halpert
IPC分类号： A61N1/36 , A61N1/05 , A61B5/08
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.

2. 发明申请

US20130165989A1 System and Method to Modulate Phrenic Nerve to Prevent Sleep Apnea 审中-公开
标题翻译：调节膈神经以防止睡眠呼吸暂停的系统和方法
公开(公告)号：US20130165989A1
公开(公告)日：2013-06-27
申请号：US13538713
申请日：2012-06-29
申请人： Mark Gelfand , Howard R. Levin , Andrew Halpert
发明人： Mark Gelfand , Howard R. Levin , Andrew Halpert
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36135
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
摘要翻译：一种用于治疗诸如中枢性睡眠呼吸暂停的呼吸障碍的可植入医疗装置，其中刺激从未通过经静脉引导系统提供给膈肌，刺激开始于吸气之后，以延长呼吸持续时间并将隔膜保持在收缩状态。

3. 发明授权

US08244359B2 System and method to modulate phrenic nerve to prevent sleep apnea 有权
标题翻译：调节膈神经的系统和方法，以防止睡眠呼吸暂停
公开(公告)号：US08244359B2
公开(公告)日：2012-08-14
申请号：US11601150
申请日：2006-11-17
申请人： Mark Gelfand , Howard R. Levin , Andrew Halpert
发明人： Mark Gelfand , Howard R. Levin , Andrew Halpert
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36135
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
摘要翻译：一种用于治疗诸如中枢性睡眠呼吸暂停的呼吸障碍的可植入医疗装置，其中刺激从未通过经静脉引导系统提供给膈神经，其中在吸气之后开始刺激以延长呼吸持续时间并且将膈肌保持在收缩状态。

4. 发明申请

US20190000545A1 METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION 审中-公开
公开(公告)号：US20190000545A1
公开(公告)日：2019-01-03
申请号：US16019380
申请日：2018-06-26
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61N7/02 , A61F7/12 , A61M5/142 , A61M5/172 , A61N1/28 , A61N1/32 , A61N1/36 , A61N1/40 , A61N5/04 , A61B18/00 , A61N7/00 , A61N1/362
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

5. 发明申请

US20150282877A1 METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION 审中-公开
标题翻译：用于热诱导的肾脏神经调节的方法和装置
公开(公告)号：US20150282877A1
公开(公告)日：2015-10-08
申请号：US14737254
申请日：2015-06-11
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61N7/02 , A61N1/28
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61F7/123 , A61F2007/126 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/28 , A61N1/32 , A61N1/326 , A61N1/36007 , A61N1/36017 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/403 , A61N5/045 , A61N7/02 , A61N2007/003
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。

6. 发明申请

US20140324016A1 Methods and Devices for Renal Nerve Blocking 审中-公开
标题翻译：肾神经阻滞的方法和装置
公开(公告)号：US20140324016A1
公开(公告)日：2014-10-30
申请号：US14221536
申请日：2014-03-21
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
IPC分类号： A61M5/145 , A61K9/70 , A61K9/00 , A61L29/14
CPC分类号： A61K31/529 , A61K9/0004 , A61K9/0012 , A61K9/7007 , A61K31/135 , A61K31/52 , A61K45/06 , A61L29/146 , A61M5/14276 , A61M5/145 , A61M5/1723 , A61M2005/14513 , A61M2205/05 , A61M2205/50 , A61M2210/1082 , A61N1/0551 , A61N1/326 , A61N1/36007 , A61N1/36114 , A61N1/36117 , A61N1/3627
摘要： A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.
摘要翻译：一种用于通过植入用于阻断肾脏和/或从肾脏的肾神经信号的装置来治疗与交感神经肾神经活动升高相关的心脏和肾脏疾病的方法和装置。该装置可以是药物泵或药物迂回植入物，用于将神经阻断剂靶向递送至肾动脉的动脉周围空间。

7. 发明申请

US20140228739A1 Methods and Apparatus for Renal Neuromodulation 审中-公开
标题翻译：肾脏神经调节的方法和装置
公开(公告)号：US20140228739A1
公开(公告)日：2014-08-14
申请号：US14258802
申请日：2014-04-22
申请人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/12 , A61B18/14 , A61M5/14
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

8. 发明申请

US20140081259A1 METHODS AND APPARATUS FOR RENAL NEUROMODULATION 有权
公开(公告)号：US20140081259A1
公开(公告)日：2014-03-20
申请号：US14056888
申请日：2013-10-17
申请人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/18
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

9. 发明授权

US08603021B2 Method and apparatus for ultrafiltration of blood 有权
标题翻译：超滤血液的方法和装置
公开(公告)号：US08603021B2
公开(公告)日：2013-12-10
申请号：US13098853
申请日：2011-05-02
申请人： Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
发明人： Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译：一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。

10. 发明授权

US08548600B2 Apparatuses for renal neuromodulation and associated systems and methods 有权
标题翻译：肾脏神经调节装置及相关系统及方法
公开(公告)号：US08548600B2
公开(公告)日：2013-10-01
申请号：US13619851
申请日：2012-09-14
申请人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61F2/00 , A61N1/00 , A61N1/30 , A61M31/00 , A61B18/18
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式