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1. 发明授权

US09987488B1 Detecting and treating disordered breathing 有权
公开(公告)号：US09987488B1
公开(公告)日：2018-06-05
申请号：US12163500
申请日：2008-06-27
申请人： Mark Gelfand , Howard Levin , Andrew Halpert , Antonis Panteleon
发明人： Mark Gelfand , Howard Levin , Andrew Halpert , Antonis Panteleon
IPC分类号： A61N1/36 , A61B5/08 , A61N1/365 , A61B5/0205 , A61B5/113 , A61B5/00
CPC分类号： A61N1/3601 , A61B5/0205 , A61B5/0816 , A61B5/0826 , A61B5/113 , A61B5/4818 , A61N1/3605 , A61N1/3611 , A61N1/36514
摘要： Detection and treatment of disordered breathing, with treatment being primarily delivered using electrical stimulation of the diaphragm, either directly or by stimulating appropriate nerves. In some embodiments, the stimulus is applied to still at least one lung upon detection of an apnea-hypopnea of some length or upon the detection of hyperpnea. The stimulation may be initiated during the apnea-hypopnea period or upon detection of a breath of a predetermined intensity near the end of apnea-hypopnea. The stimulation may be initiated in phase with respiration or irrespective of the phase of respiration.

2. 发明申请

US20070118183A1 System and method to modulate phrenic nerve to prevent sleep apnea 有权
标题翻译：调节膈神经的系统和方法，以防止睡眠呼吸暂停
公开(公告)号：US20070118183A1
公开(公告)日：2007-05-24
申请号：US11601150
申请日：2006-11-17
申请人： Mark Gelfand , Howard Levin , Andrew Halpert
发明人： Mark Gelfand , Howard Levin , Andrew Halpert
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36135
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
摘要翻译：一种用于治疗诸如中枢性睡眠呼吸暂停的呼吸障碍的可植入医疗装置，其中刺激从未通过经静脉引导系统提供给膈神经，其中在吸气之后开始刺激以延长呼吸持续时间并且将膈肌保持在收缩状态。

3. 发明申请

US20070123838A1 METHOD AND DEVICE FOR REMOVAL OF RADIOCONTRAST MEDIA FROM BLOOD 有权
标题翻译：从血液中去除放射性核素介质的方法和装置
公开(公告)号：US20070123838A1
公开(公告)日：2007-05-31
申请号：US11620438
申请日：2007-01-05
申请人： Steven Bernard , John O'Mahony , Andrew Halpert , Mark Gelfand , Howard Levin
发明人： Steven Bernard , John O'Mahony , Andrew Halpert , Mark Gelfand , Howard Levin
IPC分类号： A61M31/00
CPC分类号： A61M1/34 , A61M1/341 , A61M1/342 , A61M1/3431 , A61M1/3441 , A61M1/3451 , A61M1/36 , A61M1/3613 , A61M1/3615 , A61M1/3621 , A61M2205/15 , A61M2205/3331 , B01D61/145 , B01D61/22
摘要： An extracorporeal blood circuit including: a withdrawal conduit connectable to a coronary withdrawal catheter; a withdrawal pump connectable to the withdrawal conduit, wherein a pumping rate of the withdrawal pump determines a blood withdrawal rate from the coronary withdrawal catheter; a filter having an input connected to the withdrawal conduit and a blood output connected to an infusion conduit and a filtrate output connected to a filtrate conduit; a filtrate measurement device to determine an amount of filtrate removed from the blood in the filter; a fluid supplementation conduit providing a blood replacement fluid to at least one of the withdrawal conduit, filter and infusion conduit; a supplementation pump connectable to the fluid supplementation conduit, wherein a pumping rate of the supplementation pump determines a rate at which the blood replacement fluid flows into the blood flowing through the blood circuit, and a controller regulating the pumping rate of the supplementation pump such that the rate of the blood replacement fluid provides an amount of blood replacement fluid to the at least one of the withdrawal conduit, filter and infusion conduit so as to substantially match the amount of filtrate removed.
摘要翻译：一种体外血液回路，包括：可连接到冠状动脉取出导管的取出导管; 一个可连接到取出导管的抽吸泵，其中抽吸泵的泵送速率决定了冠状动脉取出导管的血液抽出速率; 过滤器，其具有连接到所述抽出管道的输入件，以及连接到输注管道的血液输出件和连接到滤液管道的滤液输出件; 滤液测量装置，用于确定从过滤器中的血液中除去的滤液量; 流体补充导管，其向至少一个取出导管，过滤器和输注导管提供血液置换流体; 补充泵可连接到流体补充导管，其中补充泵的泵送速率确定血液置换液体流入血液循环中的血液的速率，以及调节补充泵的泵送速率的控制器，使得血液置换液体的速率向抽出管道，过滤器和输注管道中的至少一个提供一定量的血液置换液体，以便基本上匹配除去的滤液量。

4. 发明申请

US20130324989A1 Percutaneous Methods and Devices for Carotid Body Ablation 有权
标题翻译：颈动脉身体消融的经皮方法和装置
公开(公告)号：US20130324989A1
公开(公告)日：2013-12-05
申请号：US13908995
申请日：2013-06-03
申请人： Mark Leung , Brett Schleicher , Charles Lennox , Ary Chernomorsky , Zoar Jacob Engelman , Marat Fudim , Martin M. Grasse , Mark Gelfand , Howard Levin
发明人： Mark Leung , Brett Schleicher , Charles Lennox , Ary Chernomorsky , Zoar Jacob Engelman , Marat Fudim , Martin M. Grasse , Mark Gelfand , Howard Levin
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B8/0841 , A61B8/0891 , A61B8/12 , A61B8/145 , A61B8/4227 , A61B8/488 , A61B18/1477 , A61B18/22 , A61B90/11 , A61B2018/00041 , A61B2018/00404 , A61B2018/00791 , A61B2018/0212 , A61B2018/0293 , A61B2090/376 , A61B2090/3762 , A61B2090/378 , A61N7/022 , A61N2007/0026 , F04C2270/0421
摘要： Methods and percutaneous devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via percutaneous carotid body ablation.
摘要翻译：用于评估和治疗患有交感神经介导的疾病的患者的方法和经皮装置，通过经由经皮颈动脉体消融将化学传感器输入减少到神经系统，涉及增加的外周化学反应和增强的交感神经紧张。

5. 发明申请

US20120215272A1 Methods and Apparatus to Increase Secretion of Endogenous Naturetic Hormones 有权
标题翻译：增加内源性自然激素分泌的方法和装置
公开(公告)号：US20120215272A1
公开(公告)日：2012-08-23
申请号：US13426068
申请日：2012-03-21
申请人： Howard Levin , Mark Gelfand
发明人： Howard Levin , Mark Gelfand
IPC分类号： A61N1/362
CPC分类号： A61M25/10181 , A61M25/10 , A61M25/1018 , A61M29/00 , A61M2025/102 , A61N1/36117 , A61N1/3627 , A61N1/368 , A61N1/37235
摘要： A method and apparatus for treatment of heart failure by increasing secretion of endogenous naturetic hormones ANP and BNP such as by stimulation of the heart atria. Heart pacing is done at an atrial contraction rate that is increased and can be higher than the ventricular contraction rate. Pacing may include mechanical distension of the right atrial appendage. An implantable device is used to periodically cyclically stretch the walls of the appendage with an implanted balloon.
摘要翻译：通过增加内源性激素ANP和BNP的分泌来治疗心力衰竭的方法和装置，例如通过刺激心脏心房。心脏起搏是以增加的心房收缩速率完成的，可以高于心室收缩率。起搏可能包括右心耳的机械扩张。使用可植入装置周期性地用植入的气球循环地拉伸附肢的壁。

6. 发明申请

US20110172731A1 METHODS AND APPARATUS TO STIMULATE HEART ATRIA 有权
标题翻译：刺激心脏病的方法和装置
公开(公告)号：US20110172731A1
公开(公告)日：2011-07-14
申请号：US12987498
申请日：2011-01-10
申请人： Howard Levin , Mark Gelfand
发明人： Howard Levin , Mark Gelfand
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/3624 , A61N1/368 , A61N1/3684 , A61N1/37235
摘要： A method and apparatus for treatment of hypertension and heart failure by increasing vagal tone and secretion of endogenous atrial hormones by excitory pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in atrial contraction against closed AV valves, and atrial contraction rate that is higher than the ventricular contraction rate. Pacing results in the increased atrial wall stress. An implantable device is used to monitor ECG and pace the atria in a nonphysiologic manner.
摘要翻译：一种通过增加迷走神经张力和通过心脏心房的兴奋性起搏分泌内源性心房激素来治疗高血压和心力衰竭的方法和装置。心房起搏在心室不应期内完成，导致闭合性AV瓣膜的心房收缩，心房收缩率高于心室收缩率。起搏导致心房壁压力增加。可植入装置用于监测心电图并以非生理学方式对心房进行加速。

7. 发明申请

US20080097273A1 METHOD AND APPARATUS FOR PERIPHERAL VEIN FLUID REMOVAL IN HEART FAILURE 有权
标题翻译：心脏缺血中外周血液去除的方法和装置
公开(公告)号：US20080097273A1
公开(公告)日：2008-04-24
申请号：US11960145
申请日：2007-12-19
申请人： Howard Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
发明人： Howard Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
IPC分类号： A61M1/34 , A61M1/10
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.
摘要翻译：一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质，以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。

8. 发明申请

US20060135912A1 Biodegradable pericardia constraint system and method 审中-公开
标题翻译：可生物降解的心包约束系统及方法
公开(公告)号：US20060135912A1
公开(公告)日：2006-06-22
申请号：US11282694
申请日：2005-11-21
申请人： Ary Chernomorsky , Mark Gelfand , Howard Levin
发明人： Ary Chernomorsky , Mark Gelfand , Howard Levin
IPC分类号： A61M1/00
CPC分类号： A61M25/0084 , A61B17/00491 , A61B2017/00247 , A61B2018/00392
摘要： A system has been developed for injecting a biodegradable pericardial constraint including: a biodegradable viscoelastic substance (BES); an external injection container for the BES; a cannula having a distal section adapted to be inserted into a pericardial sac of a mammalian heart and a proximal section connectable to the external injection container; wherein BES from the injection container is injected into the pericardial sac through the cannula.
摘要翻译：已经开发了用于注射可生物降解的心包约束的系统，包括：生物可降解粘弹性物质（BES）; 用于BES的外部注射容器; 套管，其具有适于插入哺乳动物心脏的心包囊中的远端部分和可连接到外部注射容器的近端部分; 其中来自注射容器的BES通过套管被注射到心包囊中。

9. 发明申请

US20120259309A1 Kidney protection method 审中-公开
标题翻译：肾脏保护方法
公开(公告)号：US20120259309A1
公开(公告)日：2012-10-11
申请号：US13507234
申请日：2012-06-14
申请人： Mark Gelfand , Howard Levin
发明人： Mark Gelfand , Howard Levin
IPC分类号： A61M5/142 , A61M5/14
CPC分类号： A61M5/142 , A61B5/201 , A61B5/208 , A61B5/4839 , A61M5/007 , A61M5/16895 , A61M5/1723 , A61M5/365 , A61M2205/18 , A61M2205/3355 , A61M2205/3393 , G01G17/04
摘要： A method of driving a toxin through a patient's kidneys, the method includes administering a diuretic to the patient to induce increased urine flow and collecting urine expelled by the patient. The amount of urine expelled by the patient is determined based on the collected urine. The patient is infused with fluid from a fluid source. Diuresis is induced by automatically adjusting the amount of fluid infused into the patient from the fluid source based on the determined amount of urine expelled by the patient to at least balance the amount of urine expelled by the patient with the amount of fluid infused into the patient to drive the toxin out of the patient's kidneys.
摘要翻译：一种通过患者的肾脏驱动毒素的方法，所述方法包括向患者施用利尿剂以诱导增加的尿流量并收集患者排出的尿液。基于收集的尿确定患者排出的尿量。患者从流体源注入流体。基于由患者排出的尿液的确定量至少平衡患者排出的尿量与注入患者的液体量而自动调节从流体源输入到患者体内的液体的量引起的利尿将毒素从病人的肾脏驱赶出去。

10. 发明申请

US20120259308A1 Goal-directed fluid therapy 审中-公开
标题翻译：目标导向流体治疗
公开(公告)号：US20120259308A1
公开(公告)日：2012-10-11
申请号：US13507233
申请日：2012-06-14
申请人： Mark Gelfand , Howard Levin
发明人： Mark Gelfand , Howard Levin
IPC分类号： A61M5/142 , A61M5/14
CPC分类号： A61M5/142 , A61B5/201 , A61B5/208 , A61B5/4839 , A61M5/007 , A61M5/16895 , A61M5/1723 , A61M5/365 , A61M2205/18 , A61M2205/3355 , A61M2205/3393 , G01G17/04
摘要： A method includes setting a hydration goal and administering a diuretic to the patient to induce increased urine flow and collecting urine expelled by the patient. The amount of urine expelled by the patient is determined based on the collected urine. The patient is infused with fluid from a fluid source. The amount of fluid infused into the patient is determined. Diuresis is induced by automatically and continuously adjusting the amount of fluid infused into the patient from the fluid source to meet the hydration goal based on the set hydration goal, the determined amount of urine expelled by the patient and the fluid infused.
摘要翻译：一种方法包括设定水化目标并向患者施用利尿剂以诱导增加的尿液流动并收集由患者排出的尿液。基于收集的尿确定患者排出的尿量。患者从流体源注入流体。确定输入患者体内的液体量。通过基于设定的水化目标，由患者排出的尿液和输注的液体自动和连续地调节从流体源输入到患者体内的液体量以达到水化目标而诱发利尿。

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