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1. 发明授权

US07242983B2 Channel-selective blanking for a medical device system 有权
标题翻译：用于医疗设备系统的通道选择性消隐
公开(公告)号：US07242983B2
公开(公告)日：2007-07-10
申请号：US10687133
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Mark T. Rise , Jonathon E. Giftakis , Nina M. Graves , David L. Carlson , Randy M. Jensen
发明人： Mark G. Frei , Ivan Osorio , Mark T. Rise , Jonathon E. Giftakis , Nina M. Graves , David L. Carlson , Randy M. Jensen
IPC分类号： A61N1/00
CPC分类号： A61N1/37264 , A61N1/36146 , A61N2/00
摘要： Apparatuses and methods selectively blank a neurological channel of a medical device system in the treatment of a nervous system disorder. A selected signal of a selected channel may be blanked if it is determined that the selected signal may be affected by an artifact when the medical device system delivers a treatment therapy. The selected signal may be blanked by hardware, in which the selected electrode is disconnected from the selected channel (which may include an selected amplifier) and is connected to a fixed voltage in order to avoid saturation of the selected amplifier. The selected channel may be blanked by software, in which a signal processor is instructed not to process neurological data on the selected channel for a determined time duration. Embodiments may combine hardware and software blanking for the selected signal.
摘要翻译：装置和方法选择性地将医疗装置系统的神经通道置于神经系统疾病的治疗中。如果在医疗设备系统递送治疗疗法时确定所选择的信号可能受到伪像的影响，则选定信道的所选信号可能被消隐。所选择的信号可能被硬件消隐，其中所选择的电极与所选择的通道（其可以包括所选择的放大器）断开连接，并且连接到固定电压，以避免所选放大器的饱和。所选择的通道可以被软件置空，其中指示信号处理器不在所选择的通道上处理确定的持续时间的神经学数据。实施例可以组合所选信号的硬件和软件消隐。

2. 发明授权

US07933646B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07933646B2
公开(公告)日：2011-04-26
申请号：US11837987
申请日：2007-08-13
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

3. 发明授权

US07280867B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07280867B2
公开(公告)日：2007-10-09
申请号：US10687571
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

4. 发明授权

US08738136B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US08738136B2
公开(公告)日：2014-05-27
申请号：US11837994
申请日：2007-08-13
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61N1/36
CPC分类号： A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件如癫痫发作相关联的检测簇，以及与治疗疗法相关联的更新治疗参数。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

5. 发明授权

US08579786B2 Screening techniques for management of a nervous system disorder 有权
标题翻译：用于管理神经系统疾病的筛查技术
公开(公告)号：US08579786B2
公开(公告)日：2013-11-12
申请号：US10687344
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
IPC分类号： A61N2/00
CPC分类号： A61N1/08 , A61B5/0476 , A61B5/4094 , A61B5/7275 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/37217
摘要： Apparatus and method support a neurological event screening for a medical device. The medical device assists a user in determining a configuration of the medical device for delivering an effective treatment for a nervous system disorder. The medical device detects a neurological event, such as a seizure, and reports a neurological event focus location and a neurological event spread to the user. The user may use the information to provide a configuration of a therapeutic delivery unit and associated therapy parameters. Therapeutic treatment is delivered to the patient, and the medical device is provided an indication of the patient's acceptance to the treatment. The user may modify the configuration and therapy parameters in order to achieve efficacy and acceptance. Depending upon the patient's acceptance, therapy is applied in either an open loop mode or a closed loop mode. The medical device determines whether the treatment is successful in accordance with a criterion.
摘要翻译：装置和方法支持用于医疗装置的神经事件筛查。医疗装置帮助用户确定医疗装置的配置以递送用于神经系统障碍的有效治疗。医疗装置检测诸如癫痫发作的神经系统事件，并向用户报告神经系统事件焦点位置和神经系统事件。用户可以使用该信息来提供治疗递送单元的配置和相关联的治疗参数。向患者传送治疗性治疗，并且向患者提供患者接受治疗的指示。用户可以修改配置和治疗参数，以达到功效和验收。根据患者的接受程度，治疗以开环模式或闭环模式应用。医疗设备根据标准确定治疗是否成功。

6. 发明授权

US07282030B2 Timed delay for redelivery of treatment therapy for a medical device system 有权
标题翻译：为医疗器械系统重新交付治疗疗法的定时延迟
公开(公告)号：US07282030B2
公开(公告)日：2007-10-16
申请号：US10687567
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Naresh C. Bhavaraju , David L. Carlson , Jonathon E. Giftakis , Nina M. Graves
发明人： Mark G. Frei , Ivan Osorio , Naresh C. Bhavaraju , David L. Carlson , Jonathon E. Giftakis , Nina M. Graves
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method support a repetitive administration of a therapeutic treatment through a delivery unit during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.
摘要翻译：装置和方法支持在神经系统疾病的神经事件（例如癫痫发作）期间通过递送单元重复施用治疗性治疗。医疗设备系统监控来自传感器和放大器的信号数据。通过使用检测算法的医疗装置系统检测到神经系统事件。因此，电刺激脉冲被施加到电极。在递送电刺激脉冲期间，医疗装置系统消除与电极相关联的信号数据。随后，在可能发生信号伪影的时间间隔内提供额外的消隐，并且放大器正在稳定。然后，医疗装置系统收集用于检测算法的信号数据以稳定。随后，医疗设备系统收集附加信号数据，以获得统计上有意义的数据。如果医疗器械系统检测到持续的癫痫发作，则继续治疗。

7. 发明授权

US08187181B2 Scoring of sensed neurological signals for use with a medical device system 有权
标题翻译：感觉神经信号的评分与医疗器械系统一起使用
公开(公告)号：US08187181B2
公开(公告)日：2012-05-29
申请号：US10687389
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
发明人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
IPC分类号： A61B5/00
CPC分类号： A61N1/3702 , A61B5/048 , A61B5/4064 , A61B5/4094 , A61N1/36017 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/37252 , Y10S128/92
摘要： A medical device system capable of scoring a severity of sensed neurological signals relating to a nervous system disorder. The system comprises a monitoring element that receives a neurological signal having at least one event to be scored. The medical device system identifies one or more features of the neurological signal to use in scoring and computes a score of relative severity of the event using the identified feature. Once two or more events have been scored, the events may be ranked by severity relative to each other.
摘要翻译：一种能够评估与神经系统疾病相关的感觉神经信号的严重性的医疗装置系统。该系统包括监测元件，其接收具有至少一个待评分事件的神经信号。医疗设备系统识别用于评分的神经信号的一个或多个特征，并且使用所识别的特征来计算事件的相对严重程度的得分。一旦两次或更多次的事件得分，事件可能会相对于彼此的严重程度进行排名。

8. 发明授权

US08594798B2 Multi-modal operation of a medical device system 有权
标题翻译：医疗器械系统的多模式操作
公开(公告)号：US08594798B2
公开(公告)日：2013-11-26
申请号：US10687289
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Mark T. Rise , Scott F. Schaffner , Nina M. Graves
发明人： Ivan Osorio , Mark G. Frei , Mark T. Rise , Scott F. Schaffner , Nina M. Graves
IPC分类号： A61N1/08
CPC分类号： A61N1/36025 , A61N1/08 , A61N1/36082
摘要： Apparatuses and methods support multi-modal operation of a medical device system for a nervous system disorder. The medical device system comprises an implanted component and an external component and supports a first feature and a second feature that are associated with the treatment therapy. The medical device system supports both features when the implanted component and the external component are coupled. If the external component is decoupled, the implanted component continues to support the first feature. Moreover, the embodiment may support a plurality of features during a treatment interval. Another aspect of the invention allows for modularly expanding a medical device system in order to add a feature that enhances existing functionality or that provides additional functionality. In an embodiment, a module that is associated with an external component of the medical device system supports the added feature.
摘要翻译：装置和方法支持用于神经系统障碍的医疗装置系统的多模式操作。医疗装置系统包括植入部件和外部部件，并且支撑与治疗疗法相关联的第一特征和第二特征。当植入部件和外部部件联接时，医疗装置系统支持两个特征。如果外部组件解耦，则植入组件继续支持第一个特征。此外，该实施例可以在治疗间隔期间支持多个特征。本发明的另一方面允许模块化地扩展医疗设备系统，以便添加增强现有功能或提供附加功能的特征。在一个实施例中，与医疗设备系统的外部部件相关联的模块支持附加的特征。

9. 发明授权

US08543214B2 Configuring and testing treatment therapy parameters for a medical device system 有权
标题翻译：配置和测试医疗器械系统的治疗治疗参数
公开(公告)号：US08543214B2
公开(公告)日：2013-09-24
申请号：US10687135
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Randy M. Jensen
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Randy M. Jensen
IPC分类号： A61N1/00
CPC分类号： A61N1/36132 , A61N1/08
摘要： Apparatus and method support the configuration and testing of therapy parameters for a medical device system in the treatment of nervous system disorders. With the embodiment, the medical device system operates in a manual treatment therapy mode, in which the medical device system evaluates a set of information that is indicative of a system configuration. The medical device system determines if the set of information is acceptable. During the manual treatment therapy mode, the medical device system applies therapeutic treatment to a patient in accordance with the set of information. If the patient cannot tolerate the therapeutic treatment, the user indicates so through a user interface. The medical device system may associate the patient's intolerance to therapeutic treatments that equal or exceed the patient's level of tolerance. Moreover, the medical device system may use this information to prevent a delivery of therapeutic treatment that exceeds the patient's level of tolerance during a run mode.
摘要翻译：装置和方法支持用于治疗神经系统疾病的医疗装置系统的治疗参数的配置和测试。在该实施例中，医疗设备系统以手动治疗治疗模式操作，其中医疗设备系统评估指示系统配置的一组信息。医疗设备系统确定该组信息是否可接受。在手动治疗治疗模式期间，医疗装置系统根据该组信息向患者施加治疗。如果患者不能耐受治疗，则用户通过用户界面来表示。医疗装置系统可以将患者的不耐受性与等于或超过患者的耐受水平的治疗性治疗联系起来。此外，医疗装置系统可以使用该信息来防止在运行模式期间超过患者的容忍度的治疗性治疗的递送。

10. 发明授权

US07174206B2 Signal quality monitoring and control for a medical device system 有权
标题翻译：医疗器械系统的信号质量监测和控制
公开(公告)号：US07174206B2
公开(公告)日：2007-02-06
申请号：US10687557
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Jonathan C. Werder , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61N1/37252 , A61B5/04012 , A61B5/048 , A61B5/4094 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/3702 , A61N1/37229
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

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