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1. 发明申请

US20090253634A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 审中-公开
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20090253634A1
公开(公告)日：2009-10-08
申请号：US12064116
申请日：2006-08-21
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , G. Todd Milne , Thea Norman , Shannon Roberts , E. Kelly Sullivan
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , G. Todd Milne , Thea Norman , Shannon Roberts , E. Kelly Sullivan
IPC分类号： A61K38/10 , C07K7/00
CPC分类号： C07K7/08 , C07K14/4705
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastnoesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g. constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（post 手术肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的其它病症和病症。

2. 发明申请

US20090062207A1 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US20090062207A1
公开(公告)日：2009-03-05
申请号：US11054071
申请日：2005-02-08
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10 , C07K7/08 , C07K1/14 , C07H21/00 , A61P1/00 , C12N15/63 , C12N5/00
CPC分类号： C07K5/1016 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/245 , C07K14/705
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

3. 发明授权

US07772188B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US07772188B2
公开(公告)日：2010-08-10
申请号：US11054071
申请日：2005-02-08
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10
CPC分类号： C07K5/1016 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/245 , C07K14/705
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

4. 发明授权

US07910546B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US07910546B2
公开(公告)日：2011-03-22
申请号：US12120023
申请日：2008-05-13
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： C12N1/21
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

5. 发明授权

US07371727B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US07371727B2
公开(公告)日：2008-05-13
申请号：US10899806
申请日：2004-07-27
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

6. 发明申请

US20090191611A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20090191611A1
公开(公告)日：2009-07-30
申请号：US12120023
申请日：2008-05-13
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： C12N1/21 , C12N15/11 , C12N15/00
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

7. 发明授权

US07494979B2 Method for treating congestive heart failure and other disorders 有权
标题翻译：治疗充血性心力衰竭等障碍的方法
公开(公告)号：US07494979B2
公开(公告)日：2009-02-24
申请号：US11054072
申请日：2005-02-08
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun , Caroline Kurtz
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun , Caroline Kurtz
IPC分类号： A61K38/16 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K14/4705
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘描述了其它条件和病症，组合物具有激活鸟苷酸环化酶C（GC-C）受体的肽。

8. 发明申请

US20100234301A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20100234301A1
公开(公告)日：2010-09-16
申请号：US12568107
申请日：2009-09-28
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
IPC分类号： A61K38/10 , C07K7/08 , C07K14/00 , A61P1/10 , A61P1/04 , A61P1/02
CPC分类号： C07K7/08 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘描述了其它条件和病症，组合物具有激活鸟苷酸环化酶C（GC-C）受体的肽。

9. 发明申请

US20130338063A9 Methods and Compositions for the Treatment of Gastrointestinal Disorders 审中-公开
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20130338063A9
公开(公告)日：2013-12-19
申请号：US13427431
申请日：2012-03-22
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
IPC分类号： A61K38/10 , A61P1/00 , C12P21/02 , A61P29/00 , A61P3/04 , C07K7/08 , A61P1/04
CPC分类号： C07K7/08 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘描述了其它条件和病症，组合物具有激活鸟苷酸环化酶C（GC-C）受体的肽。

10. 发明申请

US20120196797A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 审中-公开
公开(公告)号：US20120196797A1
公开(公告)日：2012-08-02
申请号：US13427431
申请日：2012-03-22
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
IPC分类号： A61K38/10 , A61P1/00 , C12P21/02 , A61P29/00 , A61P3/04 , C07K7/08 , A61P1/04
CPC分类号： C07K7/08 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.

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