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1. 发明申请

US20050261672A1 Systems and methods for selective denervation of heart dysrhythmias 审中-公开
标题翻译：选择性去神经心脏心律失常的系统和方法
公开(公告)号：US20050261672A1
公开(公告)日：2005-11-24
申请号：US11133088
申请日：2005-05-18
申请人： Mark Deem , Hanson Gifford , Denise Demarais
发明人： Mark Deem , Hanson Gifford , Denise Demarais
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00351 , A61B2018/00357 , A61B2018/00613
摘要： Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to selectively denervate heart tissue.
摘要翻译：提供了用于选择性去神经支配心脏传导途径用于治疗心律失常的方法和装置，包括一个或多个消融或电穿孔导管，其具有用于刺激，靶向和消融脂肪垫组织和其它心脏组织以选择性去神经细胞组织的电极。

2. 发明申请

US20070135875A1 Methods and apparatus for thermally-induced renal neuromodulation 审中-公开
标题翻译：热诱导肾神经调节的方法和装置
公开(公告)号：US20070135875A1
公开(公告)日：2007-06-14
申请号：US11599723
申请日：2006-11-14
申请人： Denise Demarais , Andrew Wu , Hanson Gifford , Mark Deem
发明人： Denise Demarais , Andrew Wu , Hanson Gifford , Mark Deem
IPC分类号： A61F7/00
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61F7/123 , A61F2007/126 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/28 , A61N1/32 , A61N1/326 , A61N1/36007 , A61N1/36017 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/403 , A61N5/045 , A61N7/02 , A61N2007/003
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。

3. 发明申请

US20060276852A1 Methods and apparatus for treating hypertension 有权
标题翻译：治疗高血压的方法和装置
公开(公告)号：US20060276852A1
公开(公告)日：2006-12-07
申请号：US11368577
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/0551 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36117 , A61N1/3627 , A61N1/40
摘要： Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗高血压的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和 /或诱导凋亡，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

4. 发明申请

US20060265015A1 Methods and apparatus for monopolar renal neuromodulation 有权
标题翻译：单极肾神经调节的方法和装置
公开(公告)号：US20060265015A1
公开(公告)日：2006-11-23
申请号：US11403329
申请日：2006-04-13
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Howard Levin , Mark Gelfand , US Zadno
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Howard Levin , Mark Gelfand , US Zadno
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/32 , A61N1/327
摘要： Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.
摘要翻译：提供了用于单极神经调节的方法和装置，例如通过脉冲电场。这种单极神经调节可能会导致不可逆的电穿孔或电融合，坏死和/或诱导凋亡，基因表达的改变，动作电位减弱或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，单极神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种单极神经调节是双侧进行的。

5. 发明申请

US20060212076A1 Methods and apparatus for treating end-stage renal disease 有权
标题翻译：治疗终末期肾病的方法和装置
公开(公告)号：US20060212076A1
公开(公告)日：2006-09-21
申请号：US11368949
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于通过脉冲电场经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗终末期肾脏疾病的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和/或诱导凋亡，基因表达改变，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

6. 发明申请

US20070129760A1 Methods and apparatus for intravasculary-induced neuromodulation or denervation 有权
标题翻译：用于血管内诱导的神经调节或去神经支配的方法和装置
公开(公告)号：US20070129760A1
公开(公告)日：2007-06-07
申请号：US11599649
申请日：2006-11-14
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Erik Thai , Benjamin Clark , Nicolas Zadno
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Erik Thai , Benjamin Clark , Nicolas Zadno
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61B18/1492 , A61B2018/00214 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00613 , A61B2018/143 , A61B2018/1432 , A61N1/0529 , A61N1/0539 , A61N1/0551 , A61N1/36007 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/36114 , A61N7/022 , A61N2007/003
摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation or denervation. Neuromodulation may be achieved via direct and/or via indirect application of energy or neuromodulatory agents to target neural matter, or to vascular structures that support the target neural matter. In some embodiments, parameters of the target neural matter, of non-target tissue, or of the apparatus may be monitored via one or more sensors for controlling the neuromodulation or denervation. Such monitoring data optionally may be utilized for feedback control of the neuromodulation or denervation.
摘要翻译：提供了血管内诱导的神经调节或去神经支配的方法和装置。神经调节可以通过直接和/或通过将能量或神经调节剂间接施用于靶神经物质或支持靶神经物质的血管结构来实现。在一些实施例中，可以通过用于控制神经调节或去神经支配的一个或多个传感器监测目标神经物质，非目标组织或装置的参数。这种监测数据可选地用于神经调节或去神经支配的反馈控制。

7. 发明申请

US20070129720A1 Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen 有权
标题翻译：用于进行体腔不连续周边处理的方法和装置
公开(公告)号：US20070129720A1
公开(公告)日：2007-06-07
申请号：US11599890
申请日：2006-11-14
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Nicolas Zadno , Benjamin Clark , Andrew Wu , Kenneth Michlitsch
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Nicolas Zadno , Benjamin Clark , Andrew Wu , Kenneth Michlitsch
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/18 , A61B2018/00023 , A61B2018/00077 , A61B2018/0016 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00648 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1435 , A61B2018/1465 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N7/022
摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.
摘要翻译：提供了用于不间断地周围处理体腔的方法和装置。装置可以定位在患者的体腔内，并且可以在第一纵向和角位置处递送能量，以在第一位置处产生小于整个圆周的处理区域。该装置还可以在体腔内的一个或多个附加的纵向和角度位置处递送能量，以在一个或多个附加位置处创建小于整个圆周处理区域，该一个或多个附加位置从第一处理区域纵向和角度偏移。第一处理区和一个或多个另外的处理区的叠置限定非连续的圆周处理区而不形成连续的周向损伤。提供了用于实现这种非连续圆周处理的方法和装置的各种实施例。

8. 发明申请

US20070265687A1 APPARATUSES FOR RENAL NEUROMODULATION 审中-公开
标题翻译：用于肾神经修复的装置
公开(公告)号：US20070265687A1
公开(公告)日：2007-11-15
申请号：US11782451
申请日：2007-07-24
申请人： Mark Deem , Hanson Gifford , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard Levin
发明人： Mark Deem , Hanson Gifford , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard Levin
IPC分类号： A61N1/04
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

9. 发明申请

US20060206150A1 Methods and apparatus for treating acute myocardial infarction 审中-公开
标题翻译：治疗急性心肌梗死的方法和装置
公开(公告)号：US20060206150A1
公开(公告)日：2006-09-14
申请号：US11368971
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating acute myocardial infarction, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于通过脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗急性心肌梗塞的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，凋亡的坏死和/或诱导，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

10. 发明申请

US20060271111A1 Methods and apparatus for treating contrast nephropathy 有权
公开(公告)号：US20060271111A1
公开(公告)日：2006-11-30
申请号：US11368809
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating contrast nephropathy, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

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