专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060041277A1 Methods and apparatus for renal neuromodulation 有权
标题翻译：肾脏神经调节的方法和装置
公开(公告)号：US20060041277A1
公开(公告)日：2006-02-23
申请号：US11189563
申请日：2005-07-25
申请人： Mark Deem , Denise Demarais , Douglas Sutton , Hanson Gifford , Howard Levin , Mark Gelfand , Benjamin Clark
发明人： Mark Deem , Denise Demarais , Douglas Sutton , Hanson Gifford , Howard Levin , Mark Gelfand , Benjamin Clark
IPC分类号： A61N1/32 , H03C3/09
CPC分类号： A61N1/36117 , A61B18/1492 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/00982 , A61B2018/1435 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N1/36017 , A61N1/36128 , A61N5/00
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置为用于实现这种神经调节的脉冲电场的血管外递送。

2. 发明申请

US20060276852A1 Methods and apparatus for treating hypertension 有权
标题翻译：治疗高血压的方法和装置
公开(公告)号：US20060276852A1
公开(公告)日：2006-12-07
申请号：US11368577
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/0551 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36117 , A61N1/3627 , A61N1/40
摘要： Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗高血压的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和 /或诱导凋亡，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

3. 发明申请

US20060212076A1 Methods and apparatus for treating end-stage renal disease 有权
标题翻译：治疗终末期肾病的方法和装置
公开(公告)号：US20060212076A1
公开(公告)日：2006-09-21
申请号：US11368949
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于通过脉冲电场经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗终末期肾脏疾病的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和/或诱导凋亡，基因表达改变，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

4. 发明申请

US20070265687A1 APPARATUSES FOR RENAL NEUROMODULATION 审中-公开
标题翻译：用于肾神经修复的装置
公开(公告)号：US20070265687A1
公开(公告)日：2007-11-15
申请号：US11782451
申请日：2007-07-24
申请人： Mark Deem , Hanson Gifford , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard Levin
发明人： Mark Deem , Hanson Gifford , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard Levin
IPC分类号： A61N1/04
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

5. 发明申请

US20060206150A1 Methods and apparatus for treating acute myocardial infarction 审中-公开
标题翻译：治疗急性心肌梗死的方法和装置
公开(公告)号：US20060206150A1
公开(公告)日：2006-09-14
申请号：US11368971
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating acute myocardial infarction, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于通过脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗急性心肌梗塞的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，凋亡的坏死和/或诱导，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

6. 发明申请

US20060265014A1 Methods and apparatus for bilateral renal neuromodulation 有权
标题翻译：双侧肾神经调节的方法和装置
公开(公告)号：US20060265014A1
公开(公告)日：2006-11-23
申请号：US11368836
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61B18/12 , A61B18/14 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61M5/1408 , A61M5/14276 , A61M2210/1082 , A61N1/0412 , A61N1/05 , A61N1/327 , A61N1/36007 , A61N1/36017 , A61N7/00
摘要： Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了双侧肾神经调节的方法和装置，例如通过脉冲电场，通过刺激电场，经由局部药物递送，经由高频超声波，通过热技术等。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，改变基因表达，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

7. 发明申请

US20060212078A1 Methods and apparatus for treating congestive heart failure 有权
标题翻译：治疗充血性心力衰竭的方法和装置
公开(公告)号：US20060212078A1
公开(公告)日：2006-09-21
申请号：US11368553
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/40 , A61N1/18
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等治疗充血性心力衰竭的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，凋亡的坏死和/或诱导，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

8. 发明申请

US20050288730A1 Methods and apparatus for renal neuromodulation 有权
标题翻译：肾脏神经调节的方法和装置
公开(公告)号：US20050288730A1
公开(公告)日：2005-12-29
申请号：US11129765
申请日：2005-05-13
申请人： Mark Deem , Hanson Gifford , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard Levin
发明人： Mark Deem , Hanson Gifford , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard Levin
IPC分类号： A61F2/958 , A61N1/05 , A61N1/08 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

9. 发明申请

US20130116685A1 APPARATUSES FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于肾神经调节和相关系统和方法的装置
公开(公告)号：US20130116685A1
公开(公告)日：2013-05-09
申请号：US13619950
申请日：2012-09-14
申请人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

10. 发明授权

US08548600B2 Apparatuses for renal neuromodulation and associated systems and methods 有权
标题翻译：肾脏神经调节装置及相关系统及方法
公开(公告)号：US08548600B2
公开(公告)日：2013-10-01
申请号：US13619851
申请日：2012-09-14
申请人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61F2/00 , A61N1/00 , A61N1/30 , A61M31/00 , A61B18/18
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式