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1. 发明授权

US09631230B2 Methods and devices for digital PCR 有权
公开(公告)号：US09631230B2
公开(公告)日：2017-04-25
申请号：US12539343
申请日：2009-08-11
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/6851 , B01L3/502784 , B01L7/525 , B01L2300/0838 , B01L2300/0867 , B01L2400/0487 , C12Q2561/101 , C12Q2563/159 , C12Q2565/629
摘要： The invention provides methods of conducting a nucleic acid reaction, including methods for performing digital PCR using a “droplet-in-oil” technology. In the methods, the starting sampled is segmented at least partially into a set of sample droplets each containing on average about one or fewer copies of a target nucleic acid. The droplets are passed in a continuous flow of immiscible carrier fluid through a channel that passes through a thermal cycler, whereby the target is amplified. In one implementation, the droplets are about 350 nl each and the number of positively amplified droplets is counted at the near-saturation point.

2. 发明授权

US09522972B2 Star polymers and compositions thereof 有权
标题翻译：星形聚合物及其组合物
公开(公告)号：US09522972B2
公开(公告)日：2016-12-20
申请号：US11738572
申请日：2007-04-23
申请人： Daniel C. Visger , Mark Davies , David Price , Marina Baum , Barton J. Schober , John R. Johnson
发明人： Daniel C. Visger , Mark Davies , David Price , Marina Baum , Barton J. Schober , John R. Johnson
IPC分类号： B01D19/04 , C08F293/00 , C10M145/14
CPC分类号： C08F293/005 , C08F293/00 , C08F2438/01 , C08F2438/03 , C08F2500/04 , C08G83/005 , C10M145/14 , C10M2205/04 , C10M2209/084 , C10M2217/024 , C10M2217/028 , C10N2220/021 , C10N2220/022 , C10N2220/029 , C10N2230/02 , C10N2230/68 , C10N2240/042
摘要： The invention provides a composition comprising: (a) a star polymer comprising: (i) a core portion comprising a polyvalent (meth)acrylic monomer, oligomer or polymer thereof or a polyvalent divinyl non-acrylic monomer, oligomer or polymer thereof; and (ii) at least two arms of polymerized alkyl(meth)acrylate ester; and (b) an oil of lubricating viscosity, wherein the core portion further comprises a functional group of formula (I): —CH2—C(R1)(C(═O)A)-Y— (I) wherein R1 is hydrogen, a linear or branched alkyl group containing 1 to 5 carbon atoms; A is nitrogen or oxygen; and Y is a free radical leaving group selected from the group consisting of one or more atoms or groups of atoms which may be transferred by a radical mechanism under the polymerization conditions, a halogen, an —O—N═ group and an —S—C(═S)— group. The invention further provides the use of the composition in an oil of lubricating viscosity as a dispersant, a viscosity modifier or a precursor to a dispersant viscosity modifier.
摘要翻译：其中R1是氢，含1至5个碳原子的直链或支链烷基; A是氮或氧; 并且Y是选自一个或多个原子或原子基团的自由基离去基团，其可以在聚合条件下通过自由基机理转移，卤素，-O-N =基团和-S- C（= S） - 组。本发明还提供了组合物在润滑粘度油中作为分散剂，粘度调节剂或分散剂粘度调节剂前体的用途。

3. 发明授权

US08473264B2 Geophysical data processing systems 失效
标题翻译：地球物理数据处理系统
公开(公告)号：US08473264B2
公开(公告)日：2013-06-25
申请号：US12863754
申请日：2008-01-21
申请人： Gary James Barnes , John Morris Lumley , Mark Davies , Joseph Jean Barraud
发明人： Gary James Barnes , John Morris Lumley , Mark Davies , Joseph Jean Barraud
IPC分类号： G06F17/10
CPC分类号： G01V7/16
摘要： A method of processing geophysical data including at least measured potential field data from a potential field survey of a surveyed region of the earth to provide a representation of the geology of said surveyed region, the method comprising generating a first model of said surveyed region by fitting data predicted by said first model to said measured data for a specified frequency range; predicting full range potential field data for all measured frequencies using said generated first model; comparing said full range predicted data to said measured potential field data to provide full range residual data representing a difference between the full range predicted data and the full range measured data, and interpreting said full range residual data to provide a representation of said geology of said surveyed region.
摘要翻译：一种处理地球物理数据的方法，所述方法包括至少测量的来自地球测量区域的潜在现场勘测的势场数据，以提供所述被测区域的地质的表示，所述方法包括通过拟合来生成所述被测区域的第一模型由所述第一模型预测的数据对于指定频率范围的所述测量数据; 使用所述生成的第一模型预测所有测量频率的全范围电势场数据; 将所述全范围预测数据与所述测量的电位场数据进行比较，以提供表示全范围预测数据与全范围测量数据之间的差异的全范围残差数据，以及解释所述全范围残差数据以提供所述全范围预测数据的所述地质学受访地区。

4. 发明授权

US08298833B2 Liquid bridge and system 有权
标题翻译：液桥和系统
公开(公告)号：US08298833B2
公开(公告)日：2012-10-30
申请号：US12092261
申请日：2007-02-07
申请人： Mark Davies , Tara Dalton , Kieran Curran
发明人： Mark Davies , Tara Dalton , Kieran Curran
IPC分类号： G01N1/10
CPC分类号： B01L3/502784 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01F2215/0037 , B01L3/5025 , B01L3/502715 , B01L3/502746 , B01L7/525 , B01L2200/0673 , B01L2300/0829 , B01L2300/0838 , B01L2400/0478 , B01L2400/0487 , B01L2400/0633 , B01L2400/082 , C12Q1/686 , F17D1/08 , Y10T137/87676 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： A bridge (30) comprises a first inlet port (31) at the end of a capillary, a narrower second inlet port (32) which is an end of a capillary, an outlet port (33) which is an end of a capillary, and a chamber (34) for silicone oil. The oil is density-matched with the reactor droplets such that a neutrally buoyant environment is created within the chamber (34). The oil within the chamber is continuously replenished by the oil separating the reactor droplets. This causes the droplets to assume a stable capillary-suspended spherical form upon entering the chamber (34). The spherical shape grows until large enough to span the gap between the ports, forming an axisymmetric liquid bridge. The introduction of a second droplet from the second inlet port (32) causes the formation of an unstable funicular bridge that quickly ruptures from the, finer, second inlet port (32), and the droplets combine at the liquid bridge (30). In another embodiment, a droplet (55) segments into smaller droplets which bridge the gap between the inlet and outlet ports.
摘要翻译：桥（30）包括在毛细管端部的第一入口（31），作为毛细管端部的较窄的第二入口（32），作为毛细管的端部的出口（33）和用于硅油的室（34）。油与反应器液滴密度匹配，使得在室（34）内产生中性浮力的环境。室内的油通过分离反应器液滴的油不断补充。这使得液滴在进入室（34）时呈现稳定的毛细管悬浮球形。球形增长直到足够大以跨越端口之间的间隙，形成轴对称液桥。从第二入口端口（32）引入第二液滴导致形成不稳定的索道桥，其从较细的第二入口（32）快速破裂，并且液滴在液体桥（30）处结合。在另一个实施例中，液滴（55）分段成较小的液滴，桥接入口和出口之间的间隙。

5. 发明申请

US20110113596A1 SLIDE FASTENER 有权
标题翻译：滑动紧固件
公开(公告)号：US20110113596A1
公开(公告)日：2011-05-19
申请号：US12949155
申请日：2010-11-18
申请人： Meirion Williams , Mark Davies
发明人： Meirion Williams , Mark Davies
IPC分类号： A44B19/00
CPC分类号： A44B19/36 , A44B19/12 , Y10T24/25 , Y10T24/2514 , Y10T24/2596
摘要： A slide fastener is provided. A pair of coupling elements provided along adjacent edges of a pair of fastener tapes. A slider is configured to engage or separate the pair of coupling elements with or from each other. An end stop is secured to the pair of fastener tapes at an end portion of the pair of coupling elements. The pair of coupling elements are secured to each other at one region of the end portion of the pair of coupling elements. The one region extends between a rear end portion of a diamond of the slider and a base portion of the slider in a state where the base portion of the slider comes in contact with the end stop.
摘要翻译：提供拉链。一对连接元件沿着一对拉链带的相邻边缘设置。滑块被构造成使一对耦合元件彼此接合或分离。端部止动件在一对联接元件的端部处固定到该对拉链带上。一对联接元件在一对联接元件的端部的一个区域处彼此固定。在滑块的基部与端部止挡接触的状态下，一个区域在滑块的金刚石的后端部分与滑块的基部之间延伸。

6. 发明申请

US20100092987A1 MICROFLUIDIC ANALYSIS SYSTEM 审中-公开
标题翻译：微流感分析系统
公开(公告)号：US20100092987A1
公开(公告)日：2010-04-15
申请号：US12617286
申请日：2009-11-12
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/686 , B01F5/0057 , B01F13/0059 , B01L3/50273 , B01L3/502776 , B01L3/502784 , B01L7/525 , B01L2200/0636 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/185 , B01L2400/0409 , B01L2400/0487 , G01N35/08 , G01N35/1095 , G01N2035/00514
摘要： A microfluidic analysis system (1) performs polymerase chain reaction (PCR) analysis on a bio sample. In a centrifuge (6) the sample is separated into DNA and RNA constituents. The vortex is created by opposing flow of a silicon oil primary carrier fluid effecting circulation by viscous drag. The bio sample exits the centrifuge enveloped in the primary carrier fluid. This is pumped by a flow controller (7) to a thermal stage (9). The thermal stage (9) has a number of microfluidic devices (70) each having thermal zones (71, 72, 73) in which the bio sample is heated or cooled by heat conduction to/from a thermal carrier fluid and the primary carrier fluid. Thus, the carrier fluids envelope the sample, control its flowrate, and control its temperature without need for moving parts at the micro scale.
摘要翻译：微流体分析系统（1）对生物样品进行聚合酶链反应（PCR）分析。在离心机（6）中，将样品分离成DNA和RNA成分。涡流通过由粘性阻力影响循环的硅油主载流体的相反流动而产生。生物样品离开包围在主载体流体中的离心机。这被流量控制器（7）泵送到热级（9）。热级（9）具有多个微流体装置（70），每个微流体装置（70）各自具有热区（71,72,73），其中生物样品通过向热载体流体和主载体流体的热传导而被加热或冷却。因此，载体流体包裹样品，控制其流速，并控制其温度，而不需要微量级的移动部件。

7. 发明申请

US20100041055A1 NOVEL GENE NORMALIZATION METHODS 审中-公开
标题翻译：新基因正常化方法
公开(公告)号：US20100041055A1
公开(公告)日：2010-02-18
申请号：US12539773
申请日：2009-08-12
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6809 , C12Q1/6886 , C12Q2545/101
摘要： Measurement of gene expression relative to an endogenous control gene is prone to excessive variability between samples and even replicates. The disclosure provides methods for normalizing expression levels of a gene by scaling gene expression levels to that of the most highly expressed gene in the set of genes whose expression levels are measured, rather than a house-keeping gene.
摘要翻译：相对于内源性对照基因的基因表达的测量在样品之间容易发生过度的变异，甚至复制。本公开提供了通过将基因表达水平与表达水平测定的基因组中最高表达基因的基因表达水平相比较而不是保存基因来使基因表达水平正常化的方法。

8. 发明申请

US20090211760A1 Well servicing tool storage system for subsea well intervention 失效
标题翻译：井下维护工具存储系统
公开(公告)号：US20090211760A1
公开(公告)日：2009-08-27
申请号：US11631087
申请日：2005-06-03
申请人： Andrew Richards , Mark Davies
发明人： Andrew Richards , Mark Davies
IPC分类号： E21B23/14 , E21B23/00 , E21B19/22 , E21B33/076
CPC分类号： E21B33/076 , E21B7/124 , E21B17/023 , E21B17/028 , E21B19/146 , H01R13/533 , H01R13/6277
摘要： A well servicing tool storage system for subsea well intervention is disclosed which provides a tool storage means as part of the intervention system and which has a plurality of tool storage arms deployed around the tool storage means. Each arm has a clamp capable of clamping a tool, and moving the clamped tool between a stored position near the perimeter of the tool storage means, and a deployed position in the centre of the tool storage means where the tool can be made up into a wireline connection.
摘要翻译：公开了用于海底井介入的井维修工具存储系统，其提供作为干预系统的一部分的工具存储装置，并且具有围绕工具存储装置展开的多个工具存储臂。每个臂具有能够夹紧工具的夹具，并且将夹持的工具移动到靠近工具存储装置的周边的存储位置与工具存储装置的中心的展开位置之间，其中工具可以构成有线连接。

9. 发明申请

US20090118150A1 Process for Preparing Polymers and Compositions Thereof 有权
标题翻译：制备聚合物及其组合物的方法
公开(公告)号：US20090118150A1
公开(公告)日：2009-05-07
申请号：US11577769
申请日：2005-10-21
申请人： Marina Baum , Barton J. Schober , Mark Davies , Daniel C. Visger , John R. Johnson
发明人： Marina Baum , Barton J. Schober , Mark Davies , Daniel C. Visger , John R. Johnson
IPC分类号： C10M149/10 , C10M169/04 , C08F290/14 , C10M145/14 , C10M149/06
CPC分类号： C10M145/14 , C08F2/38 , C08F293/005 , C08F2438/03 , C08L53/00 , C10M177/00 , C10M2209/084 , C10M2217/023 , C10M2217/024 , C10M2217/028 , C10N2220/021 , C10N2220/029 , C10N2230/02 , C10N2230/04 , C10N2230/08 , C10N2230/68 , C10N2240/04 , C10N2240/042 , C10N2240/044 , C10N2240/08 , C10N2240/10 , C10N2270/00 , C08L2666/02 , C08L2666/04
摘要： The present invention provides a process for preparing a polymer, employing the steps of: (1) contacting a free radical initiator; a chain transfer agent containing a thiocarbonyl thio group and a free radical leaving group; and a radically polymerisable monomer, to form a polymer chain; and (2) contacting the polymer chain of step (1) with at least one of a polyvalent coupling agent, a polymerisation inhibitor, a grafting acylating agent, an amine and an oil of lubricating viscosity. The invention further provides compositions and uses for the polymer.
摘要翻译：本发明提供一种制备聚合物的方法，采用以下步骤：（1）使自由基引发剂接触; 含有硫代羰基硫基和自由基离去基团的链转移剂; 和可自由基聚合的单体，以形成聚合物链; 和（2）使步骤（1）的聚合物链与多价偶联剂，聚合抑制剂，接枝酰化剂，胺和具有润滑粘度的油中的至少一种接触。本发明还提供了聚合物的组合物和用途。

10. 发明申请

US20080306314A1 Hydrocarbyl- and Hydroxy-Substituted Aromatic Condensate 审中-公开
标题翻译：烃基和羟基取代的芳族冷凝物
公开(公告)号：US20080306314A1
公开(公告)日：2008-12-11
申请号：US11914961
申请日：2006-05-17
申请人： David J. Moreton , Mark F. Wilkes , Mark Davies
发明人： David J. Moreton , Mark F. Wilkes , Mark Davies
IPC分类号： C07C13/00
CPC分类号： C10L1/1835 , C10L1/1981 , C10L10/14 , C10M129/14 , C10M145/20 , C10M2207/024 , C10M2209/101 , C10N2230/08
摘要： This invention relates to a composition containing: (a) a hydrocarbon fluid; and (b) a hydrocarbyl- and hydroxy-substituted aromatic condensate comprising the reaction product of: (1) at least 75 mole percent based on the total amount of (b)(1) and (b)(2) of a hydrocarbyl- and hydroxy-substituted aromatic compound wherein the hydrocarbyl substituent is a linear substituent containing 8 to 36 carbon atoms; (2) 0.001 to 25 mole percent based on the total amount of (b)(1) and (b)(2) of a hydrocarbyl- and hydroxy-substituted aromatic compound wherein the hydrocarbyl substituent is a branched substituent containing 8 to 20 carbon atoms; and (3) an amount of an aldehyde, ketone, or reactive equivalent thereof effective to condense (1) and (2) to form the hydro-carbyl- and hydroxy-substituted aromatic condensate. The invention further relates to method of preparing the condensate and its use as an additive in a crude oil, a liquid fuel or an oil of lubricating viscosity.
摘要翻译：本发明涉及一种组合物，其含有：（a）烃类流体; 和（b）烃基和羟基取代的芳族缩合物，其包含以下物质的反应产物：（1）基于（b）（1）和（b）（2）的烃基 - 和羟基取代的芳族化合物，其中烃基取代基是含有8至36个碳原子的直链取代基; （2）基于烃基和羟基取代的芳族化合物的（b）（1）和（b）（2）的总量的0.001-25摩尔％，其中烃基取代基是含有8至20个碳的支链取代基原子和（3）一定量的醛，酮或其活性当量有效地冷凝（1）和（2）以形成氢 - 羰基和羟基取代的芳族缩合物。本发明还涉及制备冷凝物及其在原油，液体燃料或润滑粘度油中作为添加剂的用途的方法。

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