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    • 2. 发明申请
    • FREQUENCY ADDRESSABLE MICROACTUATORS
    • 频率可寻址微处理器
    • US20120275079A1
    • 2012-11-01
    • US13415840
    • 2012-03-08
    • Mark BachmanGuann-Pyng LiMinfeng WangYang ZhangBrent Puohan Lin
    • Mark BachmanGuann-Pyng LiMinfeng WangYang ZhangBrent Puohan Lin
    • H01H51/32
    • H01H50/005G02B26/0833H01H2001/0042H01H2001/0084H01H2059/0036
    • Frequency addressable micro-actuators having one or more movable resonating elements actuators, such as cantilevers, can be forced into oscillation by, e.g., electromagnetic actuation. The movable structure is designed to latch at a certain amplitude using one of several latching techniques, such as a near-field magnetic field. In operation, the movable element is driven into resonance, producing a large amplitude, which results in the structure latching. Through resonance, a small force applied in a repeating manner can result in the latching of the actuator, an operation which would normally require a large force. If two or more units, each with different harmonic frequencies, are placed under the same influence, only the one with a harmonic response to the driving force will latch. A single influencing signal may be used to latch more than one device on demand by tuning the frequency to match the natural frequency of the device of interest.
    • 具有一个或多个可移动谐振元件致动器(例如悬臂)的可寻址微型致动器可以通过例如电磁致动而被迫振荡。 可移动结构被设计成使用几种闭锁技术之一(例如近场磁场)以一定幅度锁定。 在操作中,可移动元件被驱动到共振中,产生大的幅度,这导致结构锁定。 通过共振,以重复的方式施加的小的力可导致致动器的锁定,这通常需要大的力。 如果两个或更多个具有不同谐波频率的单元被置于相同的影响下,只有具有对驱动力的谐波响应的单元将被锁定。 可以使用单个影响信号来通过调谐频率来匹配感兴趣的装置的固有频率来按需要锁存多于一个的装置。
    • 7. 发明授权
    • Therapeutic agent delivery systems and devices
    • 治疗剂递送系统和装置
    • US08617143B2
    • 2013-12-31
    • US11952626
    • 2007-12-07
    • Mark BachmanBaruch KuppermannAsheesh DivetiaGuann Pyng Li
    • Mark BachmanBaruch KuppermannAsheesh DivetiaGuann Pyng Li
    • A61K9/22
    • A61K9/0024A61F9/0017A61K9/025
    • Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided. In various embodiments, a device for controlled release of an active ingredient is provided, including a release aperture operably associated with a deflectable member, a base with a porous membrane substrate layer, and at least one chamber juxtaposed between the release aperture and the porous membrane layer. The chamber may contain a matrix including one or more active ingredients and an agent that expands when contacted with an aqueous solution. The device is suitable for implantation in a biological system and can be used for delayed and/or time release of specific drug dosages for various indications.
    • 提供了将预定量的活性成分输送到生物系统的装置,系统和方法。 在各种实施例中,提供了用于控制释放活性成分的装置,包括与可偏转构件可操作地相关联的释放孔,具有多孔膜基底层的基底和并置在释放孔和多孔膜之间的至少一个腔室 层。 该室可以含有包含一种或多种活性成分的基质和当与水溶液接触时膨胀的试剂。 该装置适于植入生物系统中,并且可用于各种适应症的特定药物剂量的延迟和/或时间释放。