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1. 发明授权

US06465193B2 Targeted molecular bar codes and methods for using the same 有权
标题翻译：目标分子条形码及其使用方法
公开(公告)号：US06465193B2
公开(公告)日：2002-10-15
申请号：US09466994
申请日：1999-12-10
申请人： Mark Akeson , David W. Deamer , Wenonah Vercoutere , Hugh E. Olsen , Rebecca Braslau , Bakthan Singaram , Derek Steiner , Frank Cappuccio
发明人： Mark Akeson , David W. Deamer , Wenonah Vercoutere , Hugh E. Olsen , Rebecca Braslau , Bakthan Singaram , Derek Steiner , Frank Cappuccio
IPC分类号： G01N3353
CPC分类号： G01N33/5438 , C12Q1/6823 , G01N33/48721 , G01N33/532 , G01N33/54386 , C12Q2565/607 , C12Q2563/179 , C12Q2523/319
摘要： Targeted molecular bar codes and methods for using the same are provided. The subject targeted molecular bar codes include a molecular bar code and a member of a specific binding pair, where the specific binding pair member is generally bonded to the bar code through a linking group. The subject molecular bar code may be read during translocation through a single nano-meter scale pore. The subject targeted molecular bar codes find use in a variety of different applications involving analyte detection, such as screening and diagnostic applications.
摘要翻译：提供了目标分子条形码及其使用方法。受试者靶向分子条形码包括分子条形码和特异性结合对的成员，其中特异性结合对成员通常通过连接基团键合到条形码。在通过单个纳米尺度孔隙的易位期间可以读取主题分子条形码。主题分子条形码可用于涉及分析物检测的各种不同应用，如筛选和诊断应用。

2. 发明授权

US07060507B2 Targeted molecular bar codes and methods for using the same 有权
公开(公告)号：US07060507B2
公开(公告)日：2006-06-13
申请号：US10219989
申请日：2002-08-13
申请人： Mark Akeson , David W. Deamer , Wenonah Vercoutere , Hugh E. Olsen , Rebecca Braslau , Bakthan Singaram , Derek Steiner , Frank Cappuccio
发明人： Mark Akeson , David W. Deamer , Wenonah Vercoutere , Hugh E. Olsen , Rebecca Braslau , Bakthan Singaram , Derek Steiner , Frank Cappuccio
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , C12Q1/6823 , G01N33/48721 , G01N33/532 , G01N33/54386 , C12Q2565/607 , C12Q2563/179 , C12Q2523/319
摘要： Targeted molecular bar codes and methods for using the same are provided. The subject targeted molecular bar codes include a molecular bar code and a member of a specific binding pair, where the specific binding pair member is generally bonded to the bar code through a linking group. The subject molecular bar code may be read during translocation through a single nano-meter scale pore. The subject targeted molecular bar codes find use in a variety of different applications involving analyte detection, such as screening and diagnostic applications.

3. 发明申请

US20060063196A1 TARGETED MOLECULAR BAR CODES AND METHODS FOR USING THE SAME 有权
公开(公告)号：US20060063196A1
公开(公告)日：2006-03-23
申请号：US10219989
申请日：2002-08-13
申请人： Mark Akeson , David Deamer , Wenonah Vercoutere , Hugh Olsen , Rebecca Braslau , Bakthan Singaram , Derek Steiner , Frank Cappuccio
发明人： Mark Akeson , David Deamer , Wenonah Vercoutere , Hugh Olsen , Rebecca Braslau , Bakthan Singaram , Derek Steiner , Frank Cappuccio
IPC分类号： G01N33/53
CPC分类号： G01N33/5438 , C12Q1/6823 , G01N33/48721 , G01N33/532 , G01N33/54386 , C12Q2565/607 , C12Q2563/179 , C12Q2523/319
摘要： Targeted molecular bar codes and methods for using the same are provided. The subject targeted molecular bar codes include a molecular bar code and a member of a specific binding pair, where the specific binding pair member is generally bonded to the bar code through a linking group. The subject molecular bar code may be read during translocation through a single nano-meter scale pore. The subject targeted molecular bar codes find use in a variety of different applications involving analyte detection, such as screening and diagnostic applications.

4. 发明申请

US20090149656A1 OPTICAL DETERMINATION OF GLUCOSE UTILIZING BORONIC ACID ADDUCTS 有权
标题翻译：使用硼酸添加剂的葡萄糖的光学测定
公开(公告)号：US20090149656A1
公开(公告)日：2009-06-11
申请号：US12189089
申请日：2008-08-08
申请人： Bakthan Singaram , Ritchie A. Wessling
发明人： Bakthan Singaram , Ritchie A. Wessling
IPC分类号： C07D401/00 , C07C69/52
CPC分类号： A61K49/0019 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C07D213/82 , C07F5/025 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , G01N33/542 , G01N33/543 , G01N33/582 , G01N33/66 , Y10T436/144444
摘要： The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
摘要翻译：本发明涉及一种改进的光学方法和光学感测装置，用于确定水性介质中体外和/或体内多羟基取代的有机分子的水平。检测范围在约400和800nm之间。特别地，在哺乳动物中实施感官设计以确定糖水平。具体地说，在糖如果糖或葡萄糖的存在下，将染料与共轭含氮杂环芳族硼酸取代的双鎓化合物组合。紫罗兰是优选的芳族共轭含氮硼酸取代的化合物。该方法对于测定人的糖含量是有用的。

5. 发明申请

US20150119580A1 SYNTHESIS OF BORONIC ESTERS AND BORONIC ACIDS USING GRIGNARD REAGENTS 有权
标题翻译：使用格兰杰试剂合成硼酸和硼酸
公开(公告)号：US20150119580A1
公开(公告)日：2015-04-30
申请号：US14234382
申请日：2012-07-20
申请人： Jacob W. Clary , Bakthan Singaram
发明人： Jacob W. Clary , Bakthan Singaram
IPC分类号： C07F5/04 , C07F5/02
CPC分类号： C07F5/04 , C07F5/025
摘要： Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg0. When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.
摘要翻译：通过Grignard试剂与含硼底物的反应，在环境温度下在醚溶剂中合成硼酸酯和硼酸。含硼底物可以是硼酸酯，例如频哪醇硼烷，新戊基乙二醇硼烷，或二异丙基氨基硼烷等二烷基氨基硼烷化合物。格氏试剂可以由烷基，烯基，芳基，芳基烷基，杂芳基，乙烯基或烯丙基卤化合物和MgO预先形成或生成。当含硼底物是硼酸酯时，反应通常在室温下进行，而不在约1至3小时内加入碱以形成硼酸酯化合物。当含硼底物是二烷基氨基硼烷化合物时，反应通常在0℃下在约1小时内完成以形成硼酸化合物。

6. 发明授权

US07968714B2 Optical determination of glucose utilizing boronic acid adducts 有权
标题翻译：使用硼酸加合物光学测定葡萄糖
公开(公告)号：US07968714B2
公开(公告)日：2011-06-28
申请号：US12189089
申请日：2008-08-08
申请人： Bakthan Singaram , Ritchie A. Wessling
发明人： Bakthan Singaram , Ritchie A. Wessling
IPC分类号： C07F5/02 , C07D401/04
CPC分类号： A61K49/0019 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C07D213/82 , C07F5/025 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , G01N33/542 , G01N33/543 , G01N33/582 , G01N33/66 , Y10T436/144444
摘要： The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
摘要翻译：本发明涉及一种改进的光学方法和光学感测装置，用于确定水性介质中体外和/或体内多羟基取代的有机分子的水平。检测范围在约400和800nm之间。特别地，在哺乳动物中实施感官设计以确定糖水平。具体地说，在糖如果糖或葡萄糖的存在下，将染料与共轭含氮杂环芳族硼酸取代的双鎓化合物组合。紫罗兰是优选的芳族共轭含氮硼酸取代的化合物。该方法对于测定人的糖含量是有用的。

7. 发明授权

US06362373B1 Chiral amino alcohols and process for preparation of same 失效
标题翻译：手性氨基醇及其制备方法
公开(公告)号：US06362373B1
公开(公告)日：2002-03-26
申请号：US09661421
申请日：2000-09-13
申请人： Christian T. Goralski , Bakthan Singaram , William Chrisman
发明人： Christian T. Goralski , Bakthan Singaram , William Chrisman
IPC分类号： C07C20922
CPC分类号： C07D295/096 , C07B2200/07 , C07C213/04 , C07C215/44 , C07C2601/14 , C07C2603/74 , C07D209/44 , C07D211/14 , C07D211/62 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/205
摘要： The disclosed invention comprises a compound having the formula: in which R1 and R2 independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the disclosed chiral amino alcohols from a starting amine compound and a limonene oxide.
摘要翻译：所公开的发明包括具有下式的化合物：其中R 1和R 2独立地表示氢或4个或更多个碳原子的烷基。进一步公开的是从起始胺化合物和柠檬烯氧化物制备公开的手性氨基醇的方法。

8. 发明授权

US5466798A Synthesis of lithium aminoborohydrides and reactions thereof 失效
标题翻译：氨基硼氢化锂的合成及其反应
公开(公告)号：US5466798A
公开(公告)日：1995-11-14
申请号：US138612
申请日：1993-10-15
申请人： Bakthan Singaram , Gary B. Fisher , Joseph C. Fuller , John Harrison , Christian T. Goralski
发明人： Bakthan Singaram , Gary B. Fisher , Joseph C. Fuller , John Harrison , Christian T. Goralski
IPC分类号： C07C213/00 , C07C215/08 , C07D295/084 , C07D295/088 , C07D295/096 , C07D223/02 , C07D207/00 , C07F5/02
CPC分类号： C07D295/096 , C07C213/00 , C07C215/08 , C07D295/084 , C07D295/088 , C07D295/092
摘要： The present invention relates to novel, powerful reducing agents, lithium aminoborohydrides which are prepared by addition of BH.sub.3 .cndot.THF to the corresponding dialkylamine at 25.degree. C. to give the intermediate amineborane complex. Subsequent deprotonation by strong base, e.g. n-BuLi, yields the aminoborohydride quantitatively. Lithium aminoborohydrides are powerful reducing agents, comparable in strength to lithium aluminum hydride. The activity is determined by the dialkylamine. Lithium pyrrolidinoborohydride has unique activity and selectivity in its reducing properties. Esters, lactones and anhydrides are reduced cleanly at 25.degree. C. to give the corresponding alcohols, while carboxylic acids are not reduced. Test reductions show that lithium pyrrolidinoborohydride is also capable of reducing a wide range of functional groups including amides, epoxides, oximes, nitriles and halides.
摘要翻译：本发明涉及通过在25℃下向相应的二烷基胺中加入BH3.THF而制得的新的强大的还原剂氨基硼酸锂，得到中间体胺硼烷络合物。随后通过强碱去质子化，例如 n-BuLi，定量产生氨基硼氢化钠。氨基硼氢化锂是强大的还原剂，其强度与氢化铝锂相当。活性由二烷基胺决定。吡咯烷基硼氢化锂在还原性能方面具有独特的活性和选择性。酯，内酯和酸酐在25℃下干净地还原，得到相应的醇，而羧酸不被还原。测试减少表明，吡咯烷基硼氢化锂还能够减少宽范围的官能团，包括酰胺，环氧化物，肟，腈和卤化物。

9. 发明授权

US09243004B2 Synthesis of boronic esters and boronic acids using grignard reagents 有权
标题翻译：使用格氏试剂合成硼酸酯和硼酸
公开(公告)号：US09243004B2
公开(公告)日：2016-01-26
申请号：US14234382
申请日：2012-07-20
申请人： Jacob W. Clary , Bakthan Singaram
发明人： Jacob W. Clary , Bakthan Singaram
IPC分类号： C07F5/04 , C07F5/02
CPC分类号： C07F5/04 , C07F5/025
摘要： Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg0. When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.
摘要翻译：通过Grignard试剂与含硼底物的反应，在环境温度下在醚溶剂中合成硼酸酯和硼酸。含硼底物可以是硼酸酯，例如频哪醇硼烷，新戊基乙二醇硼烷，或二异丙基氨基硼烷等二烷基氨基硼烷化合物。格氏试剂可以由烷基，烯基，芳基，芳基烷基，杂芳基，乙烯基或烯丙基卤化合物和MgO预先形成或生成。当含硼底物是硼酸酯时，反应通常在室温下进行，而不在约1至3小时内加入碱以形成硼酸酯化合物。当含硼底物是二烷基氨基硼烷化合物时，反应通常在0℃下在约1小时内完成以形成硼酸化合物。

10. 发明申请

US20060083688A1 Optical determination of glucose utilizing boronic acid adducts 有权
公开(公告)号：US20060083688A1
公开(公告)日：2006-04-20
申请号：US11296898
申请日：2005-12-07
申请人： Bakthan Singaram , Ritchie Wessling
发明人： Bakthan Singaram , Ritchie Wessling
IPC分类号： A61K49/00 , C07F5/02 , C07D401/14
CPC分类号： A61K49/0019 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C07D213/82 , C07F5/025 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , G01N33/542 , G01N33/543 , G01N33/582 , G01N33/66 , Y10T436/144444
摘要： The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

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