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1. 发明申请

US20050103942A1 Composite seal and window assembly 失效
标题翻译：复合密封和窗组装
公开(公告)号：US20050103942A1
公开(公告)日：2005-05-19
申请号：US10898403
申请日：2004-07-23
申请人： Mark Abrams , Robert Smith
发明人： Mark Abrams , Robert Smith
IPC分类号： B60J1/00 , B60J10/00 , B60J10/02 , B64C1/14 , B65D27/06
CPC分类号： B64C1/1492 , B60J1/006 , B60J10/16 , B60J10/30 , B60J10/70
摘要： A window assembly incorporating a composite seal is provided. The composite seal has a first sealing member and a second member stiffer than the first sealing member.
摘要翻译：提供了一种结合复合密封件的窗组件。复合密封件具有比第一密封构件更硬的第一密封构件和第二构件。

2. 发明申请

US20100302371A1 Vehicle tailgating detection system 审中-公开
标题翻译：车尾检测系统
公开(公告)号：US20100302371A1
公开(公告)日：2010-12-02
申请号：US12454859
申请日：2009-05-27
申请人： Mark Abrams
发明人： Mark Abrams
IPC分类号： H04N7/18
CPC分类号： H04N7/18 , G08G1/0175
摘要： Vehicle tailgating detection system comprising an unmarked police vehicle having a back end, a camera, still or video, installed on the police vehicle facing rearwards for acquiring and recording visual identification information about the tailgating vehicle during the tailgating incident, and a proximity sensor installed on the police vehicle to determine and transmit information about the distance between the unmarked police vehicle and the tailgating vehicle. Also included is a data processing computer for recording and processing identifying information about the tailgating vehicle, information about the distance between the vehicles and the speed of the vehicles, and information about the location, date and time of the tailgating incident. A global positioning navigation device for acquiring and recording information about the location coordinates of the vehicles during the tailgating incident and means to print a report with details about the tailgating incident from which a moving violation citation may be issued are also provided.
摘要翻译：车辆尾随检测系统，包括具有后端的未标记警察车辆，照相机，静止或视频，安装在面向后方的警车上，用于在尾随事件期间获取和记录关于尾随车辆的视觉识别信息，以及安装在警车确定和传送关于未标记的警车与尾车之间的距离的信息。还包括用于记录和处理识别关于尾随车辆的信息的数据处理计算机，关于车辆之间的距离的信息和车辆的速度，以及关于尾随事件的位置，日期和时间的信息。还提供了一种用于在尾随事件期间获取和记录关于车辆的位置坐标的信息的全球定位导航装置，并且还提供了打印具有可从其发出移动违规引用的尾随事件的详细信息的报告的手段。

3. 发明申请

US20050244372A1 Interleukin-3 (IL-3) multiple mutation polypeptides 审中-公开
标题翻译：白细胞介素-3（IL-3）多重突变多肽
公开(公告)号：US20050244372A1
公开(公告)日：2005-11-03
申请号：US10845413
申请日：2004-05-13
申请人： S. Bauer , Mark Abrams , Sarah Braford-Goldberg , Maire Caparon , Alan Easton , Barbara Klein , John McKearn , Peter Olins , Kumnan Paik , John Thomas
发明人： S. Bauer , Mark Abrams , Sarah Braford-Goldberg , Maire Caparon , Alan Easton , Barbara Klein , John McKearn , Peter Olins , Kumnan Paik , John Thomas
IPC分类号： C12N15/09 , A61K38/00 , A61K38/20 , A61K45/00 , A61P7/00 , A61P43/00 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/54 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N15/24 , C12N15/61 , C12P21/02 , C12P21/04 , C12R1/19
CPC分类号： C07K14/5403 , A61K38/00 , C07K2319/00 , C07K2319/02 , Y10S930/141
摘要： The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids 119 to 133 have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide. These hIL-3 multiple mutation polypeptides may have biological activities similar to or better than hIL-3 and, in some cases, may also have an improved side effect profile.
摘要翻译：本发明涉及重组人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。这些hIL-3突变蛋白含有氨基酸取代，并且在N-和C-末端也可具有氨基酸缺失。本发明还涉及含有hIL-3突变蛋白的药物组合物及其使用方法。另外，本发明涉及包含编码hIL-3突变蛋白的核苷酸序列，相关微生物表达系统和使用微生物表达系统制备hIL-3突变蛋白的方法的重组表达载体。本发明包括hIL-3的缺失突变体，其中从N末端缺失1至14个氨基酸，从C末端缺失1至15个氨基酸119至133，其中还含有多肽中的氨基酸取代。这些hIL-3多重突变多肽可具有类似于或优于hIL-3的生物学活性，并且在一些情况下也可具有改善的副作用特征。

4. 发明申请

US20050059149A1 Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins 审中-公开
标题翻译：使用多变量IL-3造血嵌合体蛋白质离体扩增造血细胞的方法
公开(公告)号：US20050059149A1
公开(公告)日：2005-03-17
申请号：US10948576
申请日：2004-09-22
申请人： S. Bauer , Mark Abrams , Sarah Braford-Goldberg , Maire Caparon , Alan Easton , Barbara Klein , John McKearn , Peter Olins , Kumnan Paik , John Thomas
发明人： S. Bauer , Mark Abrams , Sarah Braford-Goldberg , Maire Caparon , Alan Easton , Barbara Klein , John McKearn , Peter Olins , Kumnan Paik , John Thomas
IPC分类号： A61K38/00 , C07K14/54 , C12N5/08
CPC分类号： C07K14/5403 , A61K38/00 , C07K2319/00
摘要： The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a chimera protein which comprises a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
摘要翻译：本发明涉及通过在包含嵌合体蛋白质的生长培养基中培养造血细胞的造血细胞的离体扩增方法，所述嵌合体蛋白质包含含有多个氨基酸取代的人白细胞介素-3（hIL-3）的变体，天然hIL-3分子缺失的部分和造血生长因子。本发明还涉及用于基因治疗的造血细胞的离体扩增。此外，本发明涉及扩大的造血细胞用于治疗造血障碍的患者的用途。

5. 发明授权

US06379662B1 Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production 失效
标题翻译：共同给予白细胞介素-3突变体多肽与CSF用于多系造血细胞生产
公开(公告)号：US06379662B1
公开(公告)日：2002-04-30
申请号：US08468910
申请日：1995-06-06
申请人： John P. McKearn , Peter Olins , John Thomas , Maire Caparon , Alan Easton , Barbara Klein , S. Christopher Bauer , Mark Abrams , Kumnan Paik , Sarah Braford-Goldberg
发明人： John P. McKearn , Peter Olins , John Thomas , Maire Caparon , Alan Easton , Barbara Klein , S. Christopher Bauer , Mark Abrams , Kumnan Paik , Sarah Braford-Goldberg
IPC分类号： A61K4500
CPC分类号： A61K45/00 , A61K38/00 , A61K38/1816 , A61K38/193 , C07K14/5403 , A61K2300/00
摘要： The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
摘要翻译：本发明涉及与其它集落刺激因子（CSF），细胞因子，淋巴因子，白细胞介素，造血生长因子或IL-3变体功能性共同施用的人白细胞介素-3（hIL-3）变体或突变蛋白（突变蛋白）。

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