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1. 发明申请

US20160005581A1 MULTIPLE ION GATE METHOD AND APPARATUS 审中-公开
标题翻译：多个门控方法和装置
公开(公告)号：US20160005581A1
公开(公告)日：2016-01-07
申请号：US14742653
申请日：2015-06-17
申请人： Adam Michael Graichen , Robert H. Jackson , Mark A. Osgood , Ching Wu , Jianglin Wu
发明人： Adam Michael Graichen , Robert H. Jackson , Mark A. Osgood , Ching Wu , Jianglin Wu
IPC分类号： H01J49/06 , H01J49/00 , G01N27/62
CPC分类号： H01J49/0031 , G01N27/622 , G01N30/7233 , H01J49/004
摘要： A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.
摘要翻译：离子移动光谱仪中的第二个门用于选择或阻止离子迁移谱的不同时间窗。离子迁移质谱仪中的第二个栅极用于调制IMS光谱中的峰值强度，允许IMS光谱中的每个峰与其随后的MS-MS质谱中的碎片离子组明确匹配。

2. 发明申请

US20150303043A1 INTELLIGENTLY CONTROLLED SPECTROMETER METHODS AND APPARATUS 审中-公开
标题翻译：智能控制光谱仪的方法和设备
公开(公告)号：US20150303043A1
公开(公告)日：2015-10-22
申请号：US14703868
申请日：2015-05-04
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
IPC分类号： H01J49/00 , H01J49/04
CPC分类号： H01J49/004 , C07B63/00 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0495 , H01J49/067
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
摘要翻译：本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。可以将快速切换机制用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。

3. 发明申请

US20100200745A1 ION GATE METHOD AND APPARATUS 有权
标题翻译：离子孔方法和装置
公开(公告)号：US20100200745A1
公开(公告)日：2010-08-12
申请号：US12763092
申请日：2010-04-19
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
IPC分类号： H01J49/04 , H01J49/26 , H01B19/00
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , Y10T29/49227
摘要： The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.
摘要翻译：本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。

4. 发明申请

US20180067078A1 APPARATUS AND METHOD FOR ION MOBILITY SPECTROMETRY AND SAMPLE INTRODUCTION 审中-公开
公开(公告)号：US20180067078A1
公开(公告)日：2018-03-08
申请号：US15713684
申请日：2017-09-24
申请人： Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
发明人： Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.

5. 发明授权

US09177770B2 Ion gate method and apparatus 有权
标题翻译：离子浇口法和装置
公开(公告)号：US09177770B2
公开(公告)日：2015-11-03
申请号：US12763092
申请日：2010-04-19
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
IPC分类号： H01J49/06 , G01N27/62 , C07B63/00
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , Y10T29/49227
摘要： The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.
摘要翻译：本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。

6. 发明授权

US09024255B2 Intelligently controlled spectrometer methods and apparatus 有权
标题翻译：智能控制光谱仪的方法和设备
公开(公告)号：US09024255B2
公开(公告)日：2015-05-05
申请号：US12764808
申请日：2010-04-21
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
IPC分类号： H01J49/00 , C07B63/00 , G01N27/62
CPC分类号： H01J49/004 , C07B63/00 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0495 , H01J49/067
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching machenism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
摘要翻译：本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。快速切换宏观主义可以用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。

7. 发明授权

US11024497B2 Chemically modified ion mobility separation apparatus and method 有权
公开(公告)号：US11024497B2
公开(公告)日：2021-06-01
申请号：US16808353
申请日：2020-03-03
申请人： Ching Wu , Mark A. Osgood
发明人： Ching Wu , Mark A. Osgood
IPC分类号： H01J49/06 , H01J49/00 , C07B63/00 , G01N27/622
摘要： An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.

8. 发明申请

US20190285583A1 APPARATUS AND METHOD FOR ION MOBILITY SPECTROMETRY AND SAMPLE INTRODUCTION 审中-公开
公开(公告)号：US20190285583A1
公开(公告)日：2019-09-19
申请号：US16430309
申请日：2019-06-03
申请人： Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
发明人： Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
IPC分类号： G01N27/62 , H01J49/16 , H01J49/06
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. In addition, automation of the direct spray needle can be achieved by setting up array of the spray needles that are loaded in a manner that rotates and/or moves to the next spray needle in the ESI source region.

9. 发明申请

US20190259595A1 CHEMICALLY MODIFIED ION MOBILITY SEPARATION APPARATUS AND METHOD 审中-公开
公开(公告)号：US20190259595A1
公开(公告)日：2019-08-22
申请号：US16396715
申请日：2019-04-28
申请人： Ching Wu , Mark A. Osgood
发明人： Ching Wu , Mark A. Osgood
IPC分类号： H01J49/06 , G01N27/62 , C07B63/00 , H01J49/00
摘要： An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.

10. 发明申请

US20160196964A1 AC GATE ION FILTER METHOD AND APPARATUS 审中-公开
标题翻译： AC GATE离子过滤器方法和装置
公开(公告)号：US20160196964A1
公开(公告)日：2016-07-07
申请号：US14992053
申请日：2016-01-11
申请人： Ching Wu , Mark A. Osgood
发明人： Ching Wu , Mark A. Osgood
IPC分类号： H01J49/06 , G01N27/62 , H01J49/00
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , H01J49/0027
摘要： The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.
摘要翻译：本发明在离子浇口上使用交流电压而不是直流电压来过滤/选择性地通过离子。通过AC离子浇口的离子可以在光谱仪器中进一步分离。使用AC离子浇口的离子迁移谱仪可以获得更好的门控性能。对于具有AC离子浇口的飞行时间离子迁移谱仪，选择的离子的窄脉冲可以被传送到漂移管中，基于它们的低场离子迁移率，它们被分离。此外，当AC离子浇口处的AC电压具有用于差示离子迁移率光谱法的波形时，将飞行时间离子迁移谱仪转换成二维分离光谱仪，其中离子首先基于它们的高场离子迁移率而被分离然后基于它们的低场离子迁移率进一步分离。

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