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1. 发明授权

US09110079B2 Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS 有权
标题翻译：用于在呈现SIRS的患者身上建立体外预后的方法和试剂盒
公开(公告)号：US09110079B2
公开(公告)日：2015-08-18
申请号：US13242412
申请日：2011-09-23
申请人： Marie-Angélique Cazalis , Alexandre Pachot , Sylvie Tissot , Guillaume Monneret
发明人： Marie-Angélique Cazalis , Alexandre Pachot , Sylvie Tissot , Guillaume Monneret
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： G01N33/6863 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N2333/7158 , G01N2800/52 , G01N2800/7095
摘要： A method and a kit for establishing an in vitro prognosis on a patient exhibiting SIRS, the method comprising: (i) measuring the level of expression of the CX3CR1 gene in vitro from the biological material of a patient sample by bringing into contact said sample with a specific reagent of the CX3CR1 gene; and (ii) comparing the expression level of the CX3CR1 gene of the patient to a predetermined expression threshold; wherein (iii) if the expression level of the CX3CR1 gene of the patient is less than the predetermined expression threshold, the survival prognosis of the patient is poor, and if the expression level of the CX3CR1 gene of the patient is greater than the predetermined expression threshold, the survival prognosis of the patient is good.
摘要翻译：一种用于在显示SIRS的患者身上建立体外预后的方法和试剂盒，所述方法包括：（i）通过使患者样品的生物材料与所述样品接触来测量CX3CR1基因在体外的表达水平， CX3CR1基因的特异性试剂; 和（ii）将患者的CX3CR1基因的表达水平与预定表达阈值进行比较; 其中（iii）如果患者的CX3CR1基因的表达水平低于预定表达阈值，则患者的存活预后差，并且如果患者的CX3CR1基因的表达水平大于预定表达阈值，患者的生存预后良好。

2. 发明申请

US20110250592A1 METHODS FOR DETERMINING A PATIENT'S SUSCEPTIBILITY OF CONTRACTING A NOSOCOMIAL INFECTION AND FOR ESTABLISHING A PROGNOSIS OF THE PROGRESSION OF SEPTIC SYNDROME 审中-公开
标题翻译：确定患者承受感染性感染的可能性和建立SEPIC综合征进展预后的方法
公开(公告)号：US20110250592A1
公开(公告)日：2011-10-13
申请号：US13140678
申请日：2010-01-18
申请人： Marie-Angelique Cazalis , Alain Lepape , Guillaume Monneret , Bruno Mougin , Alexandre Pachot
发明人： Marie-Angelique Cazalis , Alain Lepape , Guillaume Monneret , Bruno Mougin , Alexandre Pachot
IPC分类号： C12Q1/68 , G01N33/566 , G01N33/53
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： A method for determining a patient's susceptibility of contracting a nosocomial infection that includes obtaining a biological sample from the patient and extracting biological material from the biological sample; preparing a specific reagent of an expression product of at least one target gene selected from S100A9 and S100A8 target genes; and determining the expression of at least one of the target genes S100A9 and S100A8, where overexpression relative to a specified threshold value indicates susceptibility of contracting a nosocomial infection.
摘要翻译：一种用于确定患者感染医院感染的易感性的方法，包括从患者获得生物样品并从生物样品中提取生物材料; 制备选自S100A9和S100A8靶基因的至少一种靶基因的表达产物的特异性试剂; 并确定至少一种靶基因S100A9和S100A8的表达，其中相对于指定阈值的过表达指示感染医院感染的易感性。

3. 发明授权

US11299768B2 Methods for determining a patient's susceptibility of contracting a nosocomial infection and for establishing a prognosis of the progression of septic syndrome 有权
公开(公告)号：US11299768B2
公开(公告)日：2022-04-12
申请号：US13140678
申请日：2010-01-18
申请人： Marie-Angelique Cazalis , Alain Lepape , Guillaume Monneret , Bruno Mougin , Alexandre Pachot
发明人： Marie-Angelique Cazalis , Alain Lepape , Guillaume Monneret , Bruno Mougin , Alexandre Pachot
IPC分类号： C12Q1/6809 , C12Q1/686 , C12Q1/6886 , C12Q1/6876 , C12Q1/6865 , C12Q1/6813 , C12Q1/6883
摘要： A method for determining a patient's susceptibility of contracting a nosocomial infection that includes obtaining a biological sample from the patient and extracting biological material from the biological sample; preparing a specific reagent of an expression product of at least one target gene selected from S100A9 and S100A8 target genes; and determining the expression of at least one of the target genes S100A9 and S100A8, where overexpression relative to a specified threshold value indicates susceptibility of contracting a nosocomial infection.

4. 发明授权

US11060143B2 Method for diagnosis and/or prognosis of a septic syndrome 有权
公开(公告)号：US11060143B2
公开(公告)日：2021-07-13
申请号：US11794690
申请日：2006-01-30
申请人： Alexandre Pachot , Guillaume Monneret , Alain Lepape
发明人： Alexandre Pachot , Guillaume Monneret , Alain Lepape
IPC分类号： C12Q1/6883 , G01N33/68 , G01N33/569
摘要： The present invention relates to a method for the diagnosis/prognosis of a septic syndrome based on a biological sample from a patient, characterized in that it comprises the following steps: a. biological material is extracted from the biological sample, b. the biological material is brought into contact with at least one specific reagent that is selected from specific reagents for the target genes with a nucleic sequence having any one of SEQ ID Nos 1 to 28; c. the expression of at least one of said target genes is determined.

5. 发明申请

US20090208933A1 Method For Diagnosis And/Or Prognosis Of A Septic Syndrome 审中-公开
标题翻译：脓毒综合征诊断和/或预后的方法
公开(公告)号：US20090208933A1
公开(公告)日：2009-08-20
申请号：US11794690
申请日：2006-01-30
申请人： Alexandre Pachot , Guillaume Monneret , Alain Lepape
发明人： Alexandre Pachot , Guillaume Monneret , Alain Lepape
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/56911 , G01N33/6893 , G01N2800/26
摘要： The present invention relates to a method for the diagnosis/prognosis of a septic syndrome based on a biological sample from a patient, characterized in that it comprises the following steps: a. biological material is extracted from the biological sample, b. the biological material is brought into contact with at least one specific reagent that is selected from specific reagents for the target genes with a nucleic sequence having any one of SEQ ID Nos 1 to 28; c. the expression of at least one of said target genes is determined.
摘要翻译：本发明涉及一种基于来自患者的生物样品的脓毒综合征的诊断/预后的方法，其特征在于其包括以下步骤：a。生物材料从生物样品中提取，b。使生物材料与具有SEQ ID No.2-28中任一项的核酸序列的靶基因的特定试剂的至少一种特异性试剂接触; C。确定至少一个所述靶基因的表达。

6. 发明申请

US20060127912A1 Method for diagnosis and/or prognosis of a septic syndrome 有权
标题翻译：脓毒综合征的诊断和/或预后的方法
公开(公告)号：US20060127912A1
公开(公告)日：2006-06-15
申请号：US10559292
申请日：2004-06-02
申请人： Alexandre Pachot
发明人： Alexandre Pachot
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to a method for diagnosing and/or predicting a septic syndrome, wherein: a. a biological sample from the patient is made available and biological material is extracted from the biological sample b. at least four specific reagents which are selected from the following specific reagents are made available: reagent which is specific for the target gene IL-10, reagent which is specific for the target gene TGFβ, reagent which is specific for the target gene HMG1, reagent which is specific for the target gene T-bet, reagent which is specific for the target gene IL-1β, reagent which is specific for the target gene TNFα and reagent which is specific for the target gene GATA-3 c. the expression of at least four target genes selected from: IL-10, TGFβ, HMG1, T-bet, IL-1β, TNFα and GATA-3 is determined. The present invention also relates to a kit for diagnosing and/or predicting a septic syndrome.
摘要翻译：本发明涉及一种用于诊断和/或预测败血症综合征的方法，其中：a。提供来自患者的生物样品，并从生物样品b中提取生物材料。选自以下特定试剂中的至少四种特异性试剂可用：靶基因IL-10特异性试剂，靶基因TGFbeta特异性试剂，靶基因HMG1特异性试剂特异于目标基因T-bet的靶标基因IL-1β特异性试剂，靶基因TNFα特异的试剂和靶基因GATA-3 c特异的试剂。确定选自IL-10，TGFbeta，HMG1，T-bet，IL-1β，TNFalpha和GATA-3中的至少四种靶基因的表达。本发明还涉及用于诊断和/或预测败血症综合征的试剂盒。

7. 发明申请

US20080293047A1 Method for the Diagnosis of Aspirin Intolerance 审中-公开
标题翻译：阿司匹林不耐症诊断方法
公开(公告)号：US20080293047A1
公开(公告)日：2008-11-27
申请号：US11663211
申请日：2005-10-17
申请人： Alexandre Pachot , Yves Pacheco , Gilles Devouassoux , Eric Van Ganse
发明人： Alexandre Pachot , Yves Pacheco , Gilles Devouassoux , Eric Van Ganse
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The present invention relates to a method for the diagnosis of aspirin intolerance based on a biological sample from a patient, characterized in that it comprises the following steps: a. biological material is extracted from the biological sample, b. the biological material is brought into contact with at least one specific reagent chosen from the reagents specific for the target genes exhibiting a nucleic sequence having any one of SEQ ID Nos. 1 to 25; c. the expression of at least one of said target genes is determined.
摘要翻译：本发明涉及一种基于来自患者的生物样品诊断阿司匹林不耐症的方法，其特征在于其包括以下步骤：a。生物材料从生物样品中提取，b。使生物材料与选自对具有SEQ ID No.1至25中任一个的核酸序列的靶基因特异性的试剂中的至少一种特异性试剂接触; C。确定至少一个所述靶基因的表达。

8. 发明授权

US07622249B2 Method for diagnosing and/or predicting of a septic syndrome 有权
标题翻译：诊断和/或预测败血症综合征的方法
公开(公告)号：US07622249B2
公开(公告)日：2009-11-24
申请号：US10559292
申请日：2004-06-02
申请人： Alexandre Pachot
发明人： Alexandre Pachot
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/53 , C07H21/04 , C07K14/00
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to a method for diagnosing and/or predicting a septic syndrome, wherein: a. a biological sample from the patient is made available and biological material is extracted from the biological sample b. at least four specific reagents which are selected from the following specific reagents are made available: reagent which is specific for the target gene IL-10, reagent which is specific for the target gene TGFβ, reagent which is specific for the target gene HMG1, reagent which is specific for the target gene T-bet, reagent which is specific for the target gene IL-1β, reagent which is specific for the target gene TNFα and reagent which is specific for the target gene GATA-3 c. the expression of at least four target genes selected from: IL-10, TGFβ, HMG1, T-bet, IL-1β, TNFα and GATA-3 is determined. The present invention also relates to a kit for diagnosing and/or predicting a septic syndrome.
摘要翻译：本发明涉及一种用于诊断和/或预测败血症综合征的方法，其中：a。提供来自患者的生物样品，并从生物样品b中提取生物材料。选自以下特定试剂中的至少四种特异性试剂可用：靶基因IL-10特异性试剂，靶基因TGFbeta特异性试剂，靶基因HMG1特异性试剂特异于目标基因T-bet的靶标基因IL-1β特异性试剂，靶基因TNFα特异的试剂和靶基因GATA-3 c特异的试剂。确定选自IL-10，TGFbeta，HMG1，T-bet，IL-1β，TNFalpha和GATA-3中的至少四种靶基因的表达。本发明还涉及用于诊断和/或预测败血症综合征的试剂盒。

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