会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明授权
    • Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
    • 制备药学活性3,1-苯并恶嗪-2-酮的方法
    • US07423146B2
    • 2008-09-09
    • US11586237
    • 2006-10-25
    • Marco SantagostinoWerner RallRainer Soyka
    • Marco SantagostinoWerner RallRainer Soyka
    • C07D265/18
    • C07D265/18Y02P20/55
    • A process for making a compound of formula 1 or a salt thereof, wherein: R1 and R2 are each independently H, halogen, or C1-4-alkyl, or R1 and R2 together are C1-6-alkylene; and R3 is H, halogen, OH, C1-4-alkyl, or O—C1-4-alkyl, the process comprising: (a) reacting a compound of formula 6 wherein R4 is benzyl, diphenylmethyl, or trityl, each optionally substituted at, if available, an aryl group or an aliphatic carbon atom, with a compound of formula 7 or a salt thereof, to obtain a compound of formula 5, or a salt thereof (b) reducing the nitro group of the compound of formula 5 to an amine group and mesylating this amine group and cleaving the protecting group during the reduction step or after the mesylation step to obtain the compound of formula 1.
    • 制备式1化合物或其盐的方法,其中:R 1和R 2各自独立地为H,卤素或C 1-4 R 1,R 2,R 2和R 2一起是C 1-6 - 亚烷基; 且R 3是H,卤素,OH,C 1-4 - 烷基或OC 1-4 - 烷基,所述方法包括: (a)使式6化合物(其中R 4)为苄基,二苯基甲基或三苯甲基,各自任选地在芳基或脂族碳原子上被取代,与式7的化合物 或其盐,得到式5的化合物或其盐(b)将式5的化合物的硝基还原成胺基,并在该还原步骤中或之后在该还原步骤或之后将该胺基甲基化并裂解保护基团 得到式1化合物的甲磺酰化步骤。