专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07641900B2 Wound treatment utilizing collagenase and a phosphotidylcholine organogel 有权
标题翻译：使用胶原酶和磷脂酰胆碱有机凝胶的伤口治疗
公开(公告)号：US07641900B2
公开(公告)日：2010-01-05
申请号：US11093540
申请日：2005-03-30
申请人： Harry Soroff , Marcia Simon , Thomas Fallon , Peter Fallon , Gabriele Hatch
发明人： Harry Soroff , Marcia Simon , Thomas Fallon , Peter Fallon , Gabriele Hatch
IPC分类号： A61K38/46 , A61K38/48 , A61K38/54 , A01N37/18
CPC分类号： A61K31/375 , A61K31/19 , A61K31/685 , A61K38/4886 , A61K2300/00
摘要： The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e.g., burns or ulcers) is improved by applying collagenase to the wound in combination with an organogel and a phosphatidylcholine, of which lecithin is a readily available source, particularly when the collagenase is first mixed and stored with that choline and an organic solvent and is subsequently mixed with a second individually stored formulation comprising a gel-forming agent and water, the two formulations individually having satisfactory shelf lives and the resultant mixture being applied to the lesion promptly after being formed.
摘要翻译：胶原酶的作用在治疗含有胶原蛋白或混合纤维蛋白凝块（如烧伤或溃疡）的病变中的作用通过将胶原酶与有机凝胶和磷脂酰胆碱组合使用于伤口而得到改善，其中卵磷脂是一种容易获得的来源，特别是当胶原酶首先与该胆碱和有机溶剂混合并随后与包含凝胶形成剂和水的第二单独存储的制剂混合时，两种制剂单独具有令人满意的储存期，并将所得混合物施用于形成后及时发生病变。

2. 发明申请

US20130230494A1 Cellular Preparations For Wound Management 审中-公开
标题翻译：创伤治疗的细胞准备
公开(公告)号：US20130230494A1
公开(公告)日：2013-09-05
申请号：US13699457
申请日：2011-05-25
申请人： Marcia Simon
发明人： Marcia Simon
IPC分类号： C12N5/071 , A61K45/06 , C12N15/85 , A61K35/36
CPC分类号： C12N5/0625 , A61K35/36 , A61K38/1808 , A61K38/1825 , A61K45/06 , A61L15/40 , C12N5/0629 , C12N15/85 , C12N2500/34
摘要： Disclosed herein are methods of preserving or preparing cell-based compositions for use in wound management. The methods can be carried out by steps including: (a) providing skin cells; (b) treating the skin cells with a monosaccharide; (c) treating the skin cells with a disaccharide; and (d) lyophilizing the skin cells.
摘要翻译：本文公开了保存或制备用于伤口管理的基于细胞的组合物的方法。方法可以通过以下步骤进行：（a）提供皮肤细胞; （b）用单糖处理皮肤细胞; （c）用二糖处理皮肤细胞; 和（d）冻干皮肤细胞。

3. 发明申请

US20060222639A1 Wound treatment utilizing collagenase and a phosphotidylcholine organogel 有权
标题翻译：使用胶原酶和磷脂酰胆碱有机凝胶的伤口治疗
公开(公告)号：US20060222639A1
公开(公告)日：2006-10-05
申请号：US11093540
申请日：2005-03-30
申请人： Harry Soroff , Marcia Simon , Thomas Fallon , Peter Fallon , Gabriele Hatch
发明人： Harry Soroff , Marcia Simon , Thomas Fallon , Peter Fallon , Gabriele Hatch
IPC分类号： A61K38/48 , A61K31/685 , A61K31/19 , A61K31/375
CPC分类号： A61K31/375 , A61K31/19 , A61K31/685 , A61K38/4886 , A61K2300/00
摘要： The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e.g., burns or ulcers) is improved by applying collagenase to the wound in combination with an organogel and a phosphotidylcholine, of which lecithin is a readily available source, particularly when the collagenase is first mixed and stored with that choline and an organic solvent and is subsequently mixed with a second individually stored formulation comprising a gel-forming agent and water, the two formulations individually having satisfactory shelf lives and the resultant mixture being applied to the lesion promptly after being formed.
摘要翻译：尤其是胶原酶对胶原蛋白或混合纤维蛋白凝块（例如烧伤或溃疡）的病变的作用可以通过将胶原酶与有机凝胶和磷脂酰胆碱组合使用于伤口，特别是卵磷脂当胶原酶首先与该胆碱和有机溶剂混合并随后与包含凝胶形成剂和水的第二单独存储的制剂混合时，两种制剂单独具有令人满意的储存期，并将所得混合物施用于形成后及时发生病变。

4. 发明授权

US5935850A Model for cell migration and use thereof 失效
标题翻译：细胞迁移模型及其用途
公开(公告)号：US5935850A
公开(公告)日：1999-08-10
申请号：US723789
申请日：1996-09-30
申请人： Richard A. Clark , Marcia Simon
发明人： Richard A. Clark , Marcia Simon
IPC分类号： G01N33/50 , C12N5/00
CPC分类号： G01N33/5029 , G01N33/5008 , G01N33/5044 , G01N33/5055 , G01N33/5064 , G01N2333/49 , G01N2333/75 , G01N2333/78 , G01N2400/40
摘要： The invention provides the development of models for cell migration, including an in vitro model and an in vivo model. The in vitro model for cell migration comprises a first extracellular matrix containing a cell (the cell which will migrate) and a second extracellular matrix in physical contact with the first extracellular matrix. The first extracellular matrix simulates a first natural environment in which the cell naturally resides, and the second extracellular matrix simulates a second natural environment into which the cell naturally migrates from the first natural environment. The in vivo model according to the subject invention comprises an animal model having a naturally occurring first extracellular matrix containing a cell, and a second extracellular matrix in physical contact with the first extracellular matrix. The first and second extracellular matrices are generally as described above for the in vitro model, except that the first extracellular matrix is part of an animal model. The primary uses of the models are for screening substances for their effect on cell migration, and for screening extracellular matrices for their effect on cell migration.
摘要翻译：本发明提供了用于细胞迁移的模型的开发，包括体外模型和体内模型。用于细胞迁移的体外模型包括含有细胞（将迁移的细胞）和与第一细胞外基质物理接触的第二细胞外基质的第一细胞外基质。第一细胞外基质模拟细胞天然存在的第一自然环境，第二细胞外基质模拟细胞从第一自然环境自然迁移到的第二自然环境。根据本发明的体内模型包括具有包含细胞的天然存在的第一细胞外基质的动物模型和与第一细胞外基质物理接触的第二细胞外基质。第一和第二细胞外基质通常如上针对体外模型所述，除了第一细胞外基质是动物模型的一部分。模型的主要用途是筛选物质对细胞迁移的影响，以及筛选细胞外基质对细胞迁移的影响。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式