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1. 发明申请

US20080269580A1 System for Non-Invasive Measurement of Bloold Glucose Concentration 审中-公开
标题翻译： Bloold葡萄糖浓度无创测量系统
公开(公告)号：US20080269580A1
公开(公告)日：2008-10-30
申请号：US12158469
申请日：2006-12-12
申请人： Marcello Leonardo Mario Balistreri , Maarten Marinus Johannes Wilhelmus Van Herpen , Antonius Theodorus Martinus Van Gogh
发明人： Marcello Leonardo Mario Balistreri , Maarten Marinus Johannes Wilhelmus Van Herpen , Antonius Theodorus Martinus Van Gogh
IPC分类号： A61B5/01 , A61B5/1468 , A61B8/06
CPC分类号： A61B5/0066 , A61B5/015 , A61B5/14532 , A61B5/1455
摘要： A system and method for non-invasive measurement of glucose concentration in a live subject including a thermal emission spectroscopy (TES) device 10, an optical coherence tomography (OCT) device 20 or near infrared diffuse reflectance (NIDR) device. The TES 10 generates a signal indicative of the absorbtion of glucose, from which the blood glucose concentration is determined and the OCT device 20 generates a signal indicative of the scattering coefficient of a portion of the live subject, from which the blood glucose concentration is determined. The signals generated by the TES and OCT devices along with signals generated by sensors for measuring the body heat and surface temperature of the subject are used in the metabolic heat conformation (MHC) method of determining blood glucose concentration. The system may include a photoacoustic sensor for generating a signal indicative of thermo-elastic skin properties from which the blood glucose concentration is also determined.
摘要翻译：包括热发射光谱（TES）装置10，光学相干断层摄影（OCT）装置20或近红外漫反射（NIDR）装置的活体内的葡萄糖浓度无创测量的系统和方法。 TES10产生指示葡萄糖吸收的信号，从该葡萄糖中测定血糖浓度，并且OCT装置20产生指示活体受试者的一部分的散射系数的信号，从该血糖浓度确定血葡萄糖浓度。在测定血糖浓度的代谢热构象（MHC）方法中使用由TES和OCT装置产生的信号以及由传感器产生的用于测量受试者体温和表面温度的信号。该系统可以包括光声传感器，用于产生指示也确定血糖浓度的热弹性皮肤特性的信号。

2. 发明授权

US08374685B2 System, computer-readable medium, method, and use for combined epithelial early cancer diagnosis and staging 失效
标题翻译：系统，计算机可读介质，方法，并用于联合上皮早期癌症诊断和分期
公开(公告)号：US08374685B2
公开(公告)日：2013-02-12
申请号：US12529552
申请日：2008-03-07
申请人： Antonius Theodorus Martinus Van Gogh , Bernardus Hendrikus Wilhelmus Hendriks , Hans Zou , Maarten Marinus Johannes Wilhelmus Van Herpen
发明人： Antonius Theodorus Martinus Van Gogh , Bernardus Hendrikus Wilhelmus Hendriks , Hans Zou , Maarten Marinus Johannes Wilhelmus Van Herpen
IPC分类号： A61B6/08 , G01J4/00 , G01J3/447 , G01N21/47
CPC分类号： A61B5/0075 , A61B5/0084 , G01N21/4795 , G01N2021/4792
摘要： A system (40) for diagnosis and staging of early stages of cancer in the tissue of a patient is provided. The system—is configured to combine information from a Polarized Light Scattering Spectroscopy measurement (70) having a first probe depth, and a Differential Path Length Spectroscopy measurement (60) having a second probe depth, wherein the second probe depth is set larger than' the first probe depth. By comparing the results of the Polarized Light Scattering Spectroscopy and Differential Path Length Spectroscopy measurements early stages of cancer, such as dysplasia may be detected. Also hyperplasia, carcinoma in situ, and carcinoma may be detected. A computer-readable medium, method and use are also provided.
摘要翻译：提供了一种用于诊断和分期患者组织中癌症早期阶段的系统（40）。该系统被配置为组合来自具有第一探测深度的偏振光散射光谱测量（70）和具有第二探测深度的差分路径长度光谱测量（60）的信息，其中第二探测深度被设置为大于“ 第一探测深度。通过比较极化光散射光谱和差分路径长度光谱测量的结果，可以检测癌症的早期阶段，例如发育异常。也可能检测到增生，原位癌和癌。还提供了计算机可读介质，方法和用途。

3. 发明申请

US20080275319A1 Non-Invasive System and Method for Measuring Skin Hydration of a Subject 失效
标题翻译：非侵入性系统和测量受试者皮肤水合的方法
公开(公告)号：US20080275319A1
公开(公告)日：2008-11-06
申请号：US12158714
申请日：2006-12-26
申请人： Antonius Theodorus Martinus Van Gogh , Maarten Marinus Johannes Wilhelmus Van Herpen
发明人： Antonius Theodorus Martinus Van Gogh , Maarten Marinus Johannes Wilhelmus Van Herpen
IPC分类号： A61B5/01 , A61B5/1491 , A61B5/1477
CPC分类号： A61B5/0095 , A61B5/01 , A61B5/14532 , A61B5/14546 , A61B5/441 , A61B5/4869
摘要： A non-invasive system and method for measuring skin hydration of a subject comprising a thermistor (7) used in transient mode to obtain a measurement of the thermal conductivity of the skin of the subject and a processor (8) for determining a skin hydration value from the thermal conductivity measurement. The system for measuring skin hydration may be comprised in a non-invasive system for detecting blood analyte concentration, preferably glucose, including a spectroscopic device having e.g. an infrared source (2) which generates infrared beam (3) and detector (6) for detecting transmitted radiation through portion 1 (e.g. finger) of a subject. The system may also include skin hydrator (9) which moisturises the skin connected in a control loop to the system for measuring skin hydration. The system for detecting blood analyte concentration may include a photoacoustic device or a metabolic heat conformation device.
摘要翻译：一种用于测量受试者的皮肤水合的非侵入性系统和方法，包括在瞬态模式中使用的热敏电阻（7）以获得对象皮肤的热导率的测量值和用于确定皮肤水合值的处理器（8）从热导率测量。用于测量皮肤水合的系统可以包含在用于检测血液分析物浓度的非侵入性系统中，优选葡萄糖，包括具有例如血液的分光装置。产生用于检测通过被摄体的部分1（例如手指）的透射辐射的红外光束（3）和检测器（6）的红外源（2）。该系统还可以包括皮肤水分器（9），其将在控制回路中连接的皮肤保湿到用于测量皮肤水合的系统。用于检测血液分析物浓度的系统可以包括光声装置或代谢热构造装置。

4. 发明申请

US20100033719A1 METHOD AND DEVICE FOR OPTICAL ANALYSIS OF A TISSUE 有权
标题翻译：用于组织的光学分析的方法和装置
公开(公告)号：US20100033719A1
公开(公告)日：2010-02-11
申请号：US12528088
申请日：2008-02-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Antonius Theodorus Martinus Van Gogh
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Antonius Theodorus Martinus Van Gogh
IPC分类号： G01N21/55 , G01J3/30
CPC分类号： G01N21/49 , A61B5/0068 , G02B21/0064
摘要： The invention relates to a method and device for analyzing a tissue (70), which comprises: —irradiating the tissue (70) with light focused on a focal region (40); —collecting light coming back from the focal region (40) into a first detection device (100A), the first detection device (100A) being arranged to only collect the light coming back from the focal region (40), on a first detection area (140A), by confocal spectroscopy, in order to generate a first signal, containing information on an optical property of the tissue (70); —collecting light, scattered from the focal region (40) to at least a second region (60), coming back from the second region (60), into a second detection device (100B), the second detection device (100B) being arranged to only collect the light coming back from the second region (60), on a second detection area (140B), in order to generate a second signal, —using the first and second signals in order to get information on the scattering and/or absorption coefficients of the tissue (70) in the region between the focal region (40) and the second region (60). Thanks to the invention, information can be gathered on the scattering and/or absorption properties of the tissue.
摘要翻译：本发明涉及一种用于分析组织（70）的方法和装置，其包括：用聚焦在聚焦区域（40）上的光照射组织（70）; - 从聚焦区域（40）返回到第一检测装置（100A）中的收集光，第一检测装置（100A）被布置成仅在第一检测区域收集从焦点区域（40）回来的光（140A），通过共焦光谱法，以产生包含关于组织（70）的光学性质的信息的第一信号; - 从所述焦点区域（40）散射到从所述第二区域（60）返回到至少第二区域（60）的收集光转换成第二检测装置（100B），所述第二检测装置（100B）被布置以仅在第二检测区域（140B）上收集从第二区域（60）返回的光，以便产生第二信号， - 使用第一和第二信号，以获得关于散射和/或在聚焦区域（40）和第二区域（60）之间的区域中的组织（70）的吸收系数。由于本发明，可以收集关于组织的散射和/或吸收性质的信息。

5. 发明授权

US08040495B2 Method and device for optical analysis of a tissue 有权
标题翻译：用于组织光学分析的方法和装置
公开(公告)号：US08040495B2
公开(公告)日：2011-10-18
申请号：US12528088
申请日：2008-02-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Antonius Theodorus Martinus Van Gogh
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Antonius Theodorus Martinus Van Gogh
IPC分类号： G01N21/00
CPC分类号： G01N21/49 , A61B5/0068 , G02B21/0064
摘要： The invention relates to a method and device for analyzing a tissue (70), which comprises: —irradiating the tissue (70) with light focused on a focal region (40); —collecting light coming back from the focal region (40) into a first detection device (100A), the first detection device (100A) being arranged to only collect the light coming back from the focal region (40), on a first detection area (140A), by confocal spectroscopy, in order to generate a first signal, containing information on an optical property of the tissue (70); —collecting light, scattered from the focal region (40) to at least a second region (60), coming back from the second region (60), into a second detection device (100B), the second detection device (100B) being arranged to only collect the light coming back from the second region (60), on a second detection area (140B), in order to generate a second signal, —using the first and second signals in order to get information on the scattering and/or absorption coefficients of the tissue (70) in the region between the focal region (40) and the second region (60). Thanks to the invention, information can be gathered on the scattering and/or absorption properties of the tissue.
摘要翻译：本发明涉及一种用于分析组织（70）的方法和装置，其包括：用聚焦在聚焦区域（40）上的光照射组织（70）; - 从聚焦区域（40）返回到第一检测装置（100A）中的收集光，第一检测装置（100A）被布置成仅在第一检测区域收集从聚焦区域（40）返回的光（140A），通过共焦光谱法，以产生包含关于组织（70）的光学性质的信息的第一信号; - 从所述焦点区域（40）散射到从所述第二区域（60）返回到至少第二区域（60）的收集光转换成第二检测装置（100B），所述第二检测装置（100B）被布置以仅在第二检测区域（140B）上收集从第二区域（60）返回的光，以便产生第二信号， - 使用第一和第二信号，以获得关于散射和/或在聚焦区域（40）和第二区域（60）之间的区域中的组织（70）的吸收系数。由于本发明，可以收集关于组织的散射和/或吸收性质的信息。

6. 发明授权

US08094311B2 Spectroscopic method of determining the amount of an analyte in a mixture of analytes 有权
标题翻译：测定分析物混合物中分析物的量的光谱法
公开(公告)号：US08094311B2
公开(公告)日：2012-01-10
申请号：US11912342
申请日：2006-04-26
申请人： Natallia Uzunbajakava , Aleksey Kolesnychenko , Antonius Theodorus Martinus Van Gogh , Gert 'T Hooft , Frank Jeroen Pieter Schuurmans
发明人： Natallia Uzunbajakava , Aleksey Kolesnychenko , Antonius Theodorus Martinus Van Gogh , Gert 'T Hooft , Frank Jeroen Pieter Schuurmans
IPC分类号： G01N21/31
CPC分类号： G01J3/32 , G01J3/02 , G01J3/0213 , G01J3/0229 , G01J3/0264 , G01J3/0272 , G01J3/28 , G01J2003/1282 , G01N21/274
摘要： The invention relates to a multivariate calibration which can be used when the optical system used for that method does not comprise a multi-channel detector such as a CCD sensor or a line array of photodiodes. An optical system without a multi-channel detector doesn't allow to carry out preprocessing steps. Thus there is the need to carry out these preprocessing steps in another way. It is suggested to partially replace the preprocessing step by a measurement of the optical signal, whereby the measurement comprises transmitting or reflecting the optical signal by an optical element, thereby weighing the optical signal by a spectral weighing function. The advantage of the invention is to teach how such an optical system without a bulky and expensive CCD sensor can be used to carry out a multivariate calibration and preprocessing steps.
摘要翻译：本发明涉及当用于该方法的光学系统不包括诸如CCD传感器或光电二极管的线阵列的多通道检测器时可以使用的多变量校准。没有多通道检测器的光学系统不允许执行预处理步骤。因此，需要以另一种方式执行这些预处理步骤。建议通过光信号的测量部分地代替预处理步骤，由此测量包括通过光学元件发送或反射光信号，从而通过光谱称重功能称量光信号。本发明的优点是教导如何不使用庞大且昂贵的CCD传感器的这种光学系统来执行多变量校准和预处理步骤。

7. 发明申请

US20090268203A1 SPECTROSCOPIC METHOD OF DETERMINING THE AMOUNT OF AN ANALYTE IN A MIXTURE OF ANALYTES 有权
标题翻译：分析仪中分析仪的分析仪的分光光度法
公开(公告)号：US20090268203A1
公开(公告)日：2009-10-29
申请号：US11912342
申请日：2006-04-26
申请人： Natallia Uzunbajakava , Aleksey Kolesnychenko , Antonius Theodorus Martinus Van Gogh , Gert 'T Hooft , Frank Jeroen Pieter Schuurmans
发明人： Natallia Uzunbajakava , Aleksey Kolesnychenko , Antonius Theodorus Martinus Van Gogh , Gert 'T Hooft , Frank Jeroen Pieter Schuurmans
IPC分类号： G01N21/31
CPC分类号： G01J3/32 , G01J3/02 , G01J3/0213 , G01J3/0229 , G01J3/0264 , G01J3/0272 , G01J3/28 , G01J2003/1282 , G01N21/274
摘要： The invention relates to a multivariate calibration which can be used when the optical system used for that method does not comprise a multi-channel detector such as a CCD sensor or a line array of photodiodes. An optical system without a multi-channel detector doesn't allow to carry out preprocessing steps. Thus there is the need to carry out these preprocessing steps in another way. It is suggested to partially replace the preprocessing step by a measurement of the optical signal, whereby the measurement comprises transmitting or reflecting the optical signal by an optical element, thereby weighing the optical signal by a spectral weighing function. The advantage of the invention is to teach how such an optical system without a bulky and expensive CCD sensor can be used to carry out a multivariate calibration and preprocessing steps.
摘要翻译：本发明涉及当用于该方法的光学系统不包括诸如CCD传感器或光电二极管的线阵列的多通道检测器时可以使用的多变量校准。没有多通道检测器的光学系统不允许执行预处理步骤。因此，需要以另一种方式执行这些预处理步骤。建议通过光信号的测量部分地代替预处理步骤，由此测量包括通过光学元件发送或反射光信号，从而通过光谱称重功能称量光信号。本发明的优点是教导如何不使用庞大且昂贵的CCD传感器的这种光学系统来执行多变量校准和预处理步骤。

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