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1. 发明申请

US20140005603A1 Dispense Interface for Use with a Drug Delivery Device for Delivery of Two or More Drug Agents 审中-公开
标题翻译：用于与两种或多种药剂交付的药物递送装置的分配界面
公开(公告)号：US20140005603A1
公开(公告)日：2014-01-02
申请号：US13984038
申请日：2012-02-14
申请人： Marc Holtwick , Ilona Eggert , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley , Jeffrey Zajac
发明人： Marc Holtwick , Ilona Eggert , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley , Jeffrey Zajac
IPC分类号： A61M5/168 , A61M5/50
CPC分类号： A61M5/16813 , A61M5/19 , A61M5/20 , A61M5/2066 , A61M5/2448 , A61M5/31546 , A61M5/345 , A61M5/50 , A61M2005/2407 , A61M2005/2474 , A61M2005/2496 , A61M2005/3125 , A61M2005/3126 , A61M2005/3128 , A61M2005/31588 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/6072 , A61M2205/8206 , G06F19/00
摘要： A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body and an inner body. The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber. The dispense interface may further comprise a lockout preventing dispense interface reuse.
摘要翻译：用于药物输送装置的分配界面。分配界面包括主外体和内体。内部主体可以被配置为连接到药物输送装置并且限定第一储存器和第二储存器。第一穿刺针与第一容器流体连通，并且定位成用于刺穿药物递送装置的第一药筒。提供第二穿刺针并且与第二容器流体连通并定位成刺穿包含药物输送装置的第二药筒。歧管邻近内体定位并且包括流体槽布置。阀装置定位在内体和歧管之间，并且通过流体槽装置控制容纳在第一盒中的第一流体和容纳在第二盒中的第二流体的流体连通到保持室。分配接口还可以包括防止分配接口重新使用的锁定。

2. 发明授权

US09962500B2 Connection for medical device 有权
公开(公告)号：US09962500B2
公开(公告)日：2018-05-08
申请号：US14113987
申请日：2012-04-26
申请人： Marc Holtwick , Jeffrey Zajac , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley
发明人： Marc Holtwick , Jeffrey Zajac , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley
IPC分类号： A61M5/34 , A61M5/158
CPC分类号： A61M5/349 , A61M5/158 , A61M5/34 , A61M5/343
摘要： The invention faces the technical problem of providing a tight connection between a tube and an dispense interface, while at the same time the biocompatibility of the connection can be improved. The technical problem is solved by an apparatus comprising a tube configured to guide a medium and a dispense interface. The tube comprises a first opening and a second opening, while the dispense interface comprises a recess. The recess has a first opening and a second opening and the tube is at least in part inserted into the recess. The tube is permanently affixed to the dispense interface by a combination of an interference fit and an adhesive, such that the interference fit prevents the adhesive from contaminating the medium.

3. 发明授权

US10039880B2 Dispense interface for use with a drug delivery device for delivery of two or more drug agents 有权
公开(公告)号：US10039880B2
公开(公告)日：2018-08-07
申请号：US13984038
申请日：2012-02-14
申请人： Marc Holtwick , Ilona Eggert , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley , Jeffrey Zajac
发明人： Marc Holtwick , Ilona Eggert , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley , Jeffrey Zajac
IPC分类号： A61M5/168 , A61M5/50 , A61M5/24 , A61M5/19
摘要： A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body and an inner body. The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber. The dispense interface may further comprise a lockout preventing dispense interface reuse.

4. 发明申请

US20140052077A1 Connection for Medical Device 有权
标题翻译：医疗器械连接
公开(公告)号：US20140052077A1
公开(公告)日：2014-02-20
申请号：US14113987
申请日：2012-04-26
申请人： Marc Holtwick , Jeffrey Zajac , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley
发明人： Marc Holtwick , Jeffrey Zajac , James Alexander Davies , Simon Lewis Bilton , David Moore , Steven Wimpenny , Christopher Nigel Langley
IPC分类号： A61M5/34
CPC分类号： A61M5/349 , A61M5/158 , A61M5/34 , A61M5/343
摘要： The invention faces the technical problem of providing a tight connection between a tube and an dispense interface, while at the same time the biocompatibility of the connection can be improved. The technical problem is solved by an apparatus comprising a tube configured to guide a medium and a dispense interface. The tube comprises a first opening and a second opening, while the dispense interface comprises a recess. The recess has a first opening and a second opening and the tube is at least in part inserted into the recess. The tube is permanently affixed to the dispense interface by a combination of an interference fit and an adhesive, such that the interference fit prevents the adhesive from contaminating the medium.
摘要翻译：本发明面临着在管和分配界面之间提供紧密连接的技术问题，同时可以提高连接的生物相容性。该技术问题通过包括配置成引导介质和分配界面的管的装置来解决。管包括第一开口和第二开口，而分配界面包括凹部。凹部具有第一开口和第二开口，并且管至少部分地插入凹部中。通过过盈配合和粘合剂的组合将管永久地固定到分配界面，使得过盈配合防止粘合剂污染介质。

5. 发明申请

US20070117157A1 Parathyroid hormone-like polypeptides 审中-公开
标题翻译：甲状旁腺激素样多肽
公开(公告)号：US20070117157A1
公开(公告)日：2007-05-24
申请号：US10490319
申请日：2003-09-15
申请人： Jeffrey Zajac
发明人： Jeffrey Zajac
IPC分类号： G01N33/567 , C07H21/04 , A61K38/29 , C07K14/635
CPC分类号： C07K16/26 , A61K38/00
摘要： Novel parathyroid hormone polypeptides and biologically active fragments thereof are disclosed along with nucleic acid molecules encoding same. In particular, parathyroid hormone polypeptides and biologically active fragments (and encoding nucleic acid molecules) derived from fish species (eg Japanese pufferfish (Fugu rubripes)) are disclosed. Such polypeptides and fragments may be used for treatment of diseases associated with abnormal calcium homeostasis (eg osteoporosis, osteopenia, Paget's disease, bone cancer, hyperparathyroidism, hypoparathyroidism, hypercalcemia, psoriasis and other skin-related conditions).
摘要翻译：公开了新型甲状旁腺激素多肽及其生物活性片段以及编码相同的核酸分子。特别地，公开了衍生自鱼类的甲状旁腺激素多肽和生物活性片段（和编码核酸分子）（例如日本河豚（Fugu rubripes））。这样的多肽和片段可用于治疗与异常钙稳态相关的疾病（例如骨质疏松症，骨质减少，佩吉特氏病，骨癌，甲状旁腺功能亢进，甲状旁腺功能低下，高钙血症，牛皮癣和其他皮肤相关病症）。

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