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1. 发明申请

US20050099634A1 System and method to reduce laser noise for improved interferometric laser ultrasound detection 有权
标题翻译：减少激光噪声的系统和方法，用于改进干涉激光超声检测
公开(公告)号：US20050099634A1
公开(公告)日：2005-05-12
申请号：US10703655
申请日：2003-11-07
申请人： Marc Dubois , Kent Burr , Thomas Drake , Peter Lorraine
发明人： Marc Dubois , Kent Burr , Thomas Drake , Peter Lorraine
IPC分类号： G01B9/02 , G01H9/00
CPC分类号： G01H9/00
摘要： The present invention provides an optical filter assembly that reduces the phase and amplitude noise of a detection laser used to detect ultrasonic displacements. The filtered detection laser is directed to the surface of a remote target. Ultrasonic displacements at the surface scatter the filtered detection laser. Collection optics then gather phase modulated light scattered by the surface and direct the phase modulated light to an optical processor to produce a signal representative of the ultrasonic displacements with an improved SNR. Additional processors may determine the structure of the remote target.
摘要翻译：本发明提供一种滤光器组件，其减少用于检测超声波位移的检测激光器的相位和幅度噪声。滤波的检测激光器被引导到远程目标的表面。表面上的超声波位移散射了滤波的检测激光。收集光学器件然后收集由表面散射的相位调制光，并将相位调制光引导到光学处理器以产生表示具有改善的SNR的超声波位移的信号。附加处理器可以确定远程目标的结构。

2. 发明申请

US20060215174A1 System and method to inspect components having non-parallel surfaces 有权
标题翻译：检查具有不平行表面的部件的系统和方法
公开(公告)号：US20060215174A1
公开(公告)日：2006-09-28
申请号：US11089902
申请日：2005-03-25
申请人： Marc Dubois , Thomas Drake
发明人： Marc Dubois , Thomas Drake
IPC分类号： G01B11/02
CPC分类号： G01N21/1717 , G01H9/00 , G01N29/2418 , G01N2291/0423 , G01N2291/0425 , G01N2291/044
摘要： The present invention provides a method to detect and generate ultrasonic displacements at a remote target for ultrasonic inspection. This method involves generating an ultrasonic wave at a first location on an upper surface of the remote target. This ultrasonic wave is reflected from interior surfaces within the remote target wherein the reflected ultrasonic wave produces ultrasonic displacement at a second location on the upper surface of the remote target. A detection laser beam is generated and directed to the second location on the upper surface of the remote target. Here, the detection laser beam is scattered by the ultrasonic displacements to produce phase-modulated light. This phase-modulated light is collected and processed to obtain data representative of the ultrasonic surface displacements. Further, these ultrasonic displacements, when processed, will yield inspection information associated with the interior of the remote target.
摘要翻译：本发明提供一种在超声波检查的远程目标处检测和产生超声波位移的方法。该方法涉及在远程目标的上表面上的第一位置处产生超声波。该超声波从远程目标内的内表面反射，其中反射的超声波在远程目标的上表面上的第二位置处产生超声波位移。生成检测激光束并将其引导到远程目标的上表面上的第二位置。这里，检测激光束被超声波位移散射以产生相位调制光。收集并处理该相位调制光以获得代表超声表面位移的数据。此外，这些超声波位移在被处理时将产生与远程目标的内部相关联的检查信息。

3. 发明申请

US20060132804A1 System and method to decrease probe size for improved laser ultrasound detection 失效
公开(公告)号：US20060132804A1
公开(公告)日：2006-06-22
申请号：US11018994
申请日：2004-12-21
申请人： Marc Dubois , Thomas Drake , Pavel Fomitchov
发明人： Marc Dubois , Thomas Drake , Pavel Fomitchov
IPC分类号： G01B11/14
CPC分类号： G01N21/474 , G01N21/1702 , G01N29/2418
摘要： The present invention provides a compact optical probe assembly that measures ultrasound in materials. The probe uses angle-terminated optical fiber to direct illumination laser light at the surface of a remote target. Ultrasonic displacements at the surface scatter the illumination laser light. Angle-terminated optical fibers collect phase modulated light and direct the phase modulated light to an optical processor to produce a signal representative of the ultrasonic surface displacements. The probe may also incorporate angle-terminated optical fibers to direct generation laser light to the surface of a remote target to generate ultrasonic surface displacements. Optional shared beam forming element(s) may optically act on the illumination laser and collected phase modulated light.

4. 发明申请

US20100056524A1 Compound 审中-公开
标题翻译：复合
公开(公告)号：US20100056524A1
公开(公告)日：2010-03-04
申请号：US12384477
申请日：2009-04-02
申请人： Edward Giles Mciver , Justin Stephen Bryans , Ela Smiljanic , Stephen John Lewis , Joanne Hough , Thomas Drake
发明人： Edward Giles Mciver , Justin Stephen Bryans , Ela Smiljanic , Stephen John Lewis , Joanne Hough , Thomas Drake
IPC分类号： A61K31/5377 , C07D239/02 , C07D403/12 , C07D413/12 , A61K31/505 , A61K31/506
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04
摘要： A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein: R1 is C3-8-cycloalkyl; X is O, NR7 or C3-6-heterocycloalkyl; R2 is aryl, heteroaryl, fused or unfused aryl-C3-6-heterocycloalkyl or fused or unfused heteroaryl-C3-6-heterocycloalkyl, each of which is optionally substituted by one or more substitutents selected from aryl, heteroaryl, C1-6-alkyl, C3-7-cycloalkyl and a group A, wherein said C1-6-alkyl group is optionally substituted by one or more substituents selected from aryl, heteroaryl, R10 and a group A, said heteroaryl group is optionally substituted by one or more R10 groups; and wherein said C3-6-heterocycloalkyl group optionally contains one or more groups selected from oxygen, sulfur, nitrogen and CO; R3 is C1-6-alkyl optionally substituted by one or more substituents selected from aryl, heteroaryl, —NR4R5, —OR6, —NR7(CO)R6, —NR7(CO)NR4R5, —NR7SO2R6, —NR7COOR7, —CONR4R5, C3-6-heterocycloalkyl and wherein R4-7 and A are as defined in the claims.Further aspects relate to the use of said compounds in the treatment of various therapeutic disorders, and more particularly as inhibitors of one or more kinases.
摘要翻译：本发明的第一方面涉及式（I）化合物或其药学上可接受的盐或酯，其中：R 1为C 3-8 - 环烷基; X是O，NR 7或C 3-6 - 杂环烷基; R 2是芳基，杂芳基，稠合或未稠合的芳基-C 3-6 - 杂环烷基或稠合或未稠合的杂芳基-C 3-6 - 杂环烷基，其各自任选被一个或多个选自芳基，杂芳基，C 1-6 - 烷基 C 3-7 - 环烷基和基团A，其中所述C 1-6 - 烷基任选被一个或多个选自芳基，杂芳基，R 10和A基团的取代基取代，所述杂芳基任选地被一个或多个R 10 团体并且其中所述C 3-6杂环烷基任选地含有一个或多个选自氧，硫，氮和CO的基团; R 3是任选被一个或多个选自芳基，杂芳基，-NR 4 R 5，-OR 6，-NR 7（CO）R 6，-NR 7（CO）NR 4 R 5，-NR 7 SO 2 R 6，-NR 7 COOR 7，-CONR 4 R 5，C 3 -6-杂环烷基，其中R 4-7和A如权利要求中所定义。其它方面涉及所述化合物在治疗各种治疗性疾病中的用途，更具体地涉及一种或多种激酶的抑制剂。

5. 发明申请

US20050231735A1 System and method to enable eye-safe laser ultrasound detection 有权
标题翻译：系统和方法，实现眼睛安全的激光超声检测
公开(公告)号：US20050231735A1
公开(公告)日：2005-10-20
申请号：US10828068
申请日：2004-04-20
申请人： Mark Dubois , John Deaton , Thomas Drake
发明人： Mark Dubois , John Deaton , Thomas Drake
IPC分类号： G01N29/24 , G01N29/34 , G01B11/14
CPC分类号： G01N29/2418 , G01N29/348 , G01N2291/0421
摘要： A system and method that replaces safety requirements of a laser detection system by shifting the wavelength of a detection laser. An optical wavelength converter that shifts the optical wavelength of a detection laser from a first wavelength within the Infrared “A” portion of the spectrum to a more eye-safe wavelength. The detection laser is directed to the surface of a remote target. Ultrasonic displacements at the surface scatter the filtered detection laser. Collection optics then gather phase modulated light scattered by the surface and direct the phase modulated light to an optical processor that produces a signal representative of the ultrasonic displacements. Signal processors then determine the internal structure of the remote target based on the signal.
摘要翻译：通过移动检测激光器的波长来代替激光检测系统的安全要求的系统和方法。一种光学波长转换器，其将检测激光器的光波长从光谱的红外“A”部分内的第一波长移位到更安全的波长。检测激光器被引导到远程目标的表面。表面上的超声波位移散射了滤波的检测激光。收集光学器件然后收集由表面散射的相位调制光，并将相位调制光引导到产生表示超声波位移的信号的光学处理器。然后，信号处理器根据信号确定远程目标的内部结构。

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