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1. 发明授权

US07122122B2 Molecular imprinting of solute on cellulose/silica composite, and products and uses thereof 有权
标题翻译：溶质在纤维素/二氧化硅复合材料上的分子印迹及其产物及用途
公开(公告)号：US07122122B2
公开(公告)日：2006-10-17
申请号：US10624229
申请日：2003-07-22
申请人： Manuel Marquez-Sanchez , Gustavo Larsen , Ahmad Akashe , David Vu , Rajinder S. Gill
发明人： Manuel Marquez-Sanchez , Gustavo Larsen , Ahmad Akashe , David Vu , Rajinder S. Gill
IPC分类号： C02F9/00 , B01D37/00 , B05D3/00
CPC分类号： B01J20/3293 , B01J20/103 , B01J20/26 , B01J20/28047 , B01J20/3057 , B01J20/3212 , B01J20/3234
摘要： A cellulose/silica composite useful as a filter material is highly selective towards a solute that has been molecularly imprinted upon an inorganic gel coating formed on the cellulose. The filter material provides dual filtering functionality, as both a selective molecular sieve and as a particulate filter. A unique method for making the filter material is also set forth that imparts these attributes and performance capabilities.
摘要翻译：可用作过滤材料的纤维素/二氧化硅复合物对已经分子印迹在形成于纤维素上的无机凝胶涂层上的溶质具有高选择性。过滤材料既提供了选择性分子筛和微粒过滤器两种双重过滤功能。还提出了制作过滤材料的独特方法，赋予这些属性和性能能力。

2. 发明申请

US20050016923A1 Molecular imprinting of solute on cellulose/silica composite, and products and uses thereof 有权
标题翻译：溶质在纤维素/二氧化硅复合材料上的分子印迹及其产物及用途
公开(公告)号：US20050016923A1
公开(公告)日：2005-01-27
申请号：US10624229
申请日：2003-07-22
申请人： Manuel Marquez-Sanchez , Gustavo Larsen , Ahmad Akashe , David Vu , Rajinder Gill
发明人： Manuel Marquez-Sanchez , Gustavo Larsen , Ahmad Akashe , David Vu , Rajinder Gill
IPC分类号： B01D11/00 , B01J20/10 , B01J20/26 , B01J20/32
CPC分类号： B01J20/3293 , B01J20/103 , B01J20/26 , B01J20/28047 , B01J20/3057 , B01J20/3212 , B01J20/3234
摘要： A cellulose/silica composite useful as a filter material is highly selective towards a solute that has been molecularly imprinted upon an inorganic gel coating formed on the cellulose. The filter material provides dual filtering functionality, as both a selective molecular sieve and as a particulate filter. A unique method for making the filter material is also set forth that imparts these attributes and performance capabilities.
摘要翻译：可用作过滤材料的纤维素/二氧化硅复合物对已经分子印迹在形成于纤维素上的无机凝胶涂层上的溶质具有高选择性。过滤材料既提供了选择性分子筛和微粒过滤器两种双重过滤功能。还提出了制作过滤材料的独特方法，赋予这些属性和性能能力。

3. 发明授权

US06814759B2 Stable zeolite/cellulose composite materials and method of preparation 失效
标题翻译：稳定的沸石/纤维素复合材料及其制备方法
公开(公告)号：US06814759B2
公开(公告)日：2004-11-09
申请号：US10212909
申请日：2002-08-06
申请人： Gustavo Larsen , David Vu , Manuel Marquez-Sanchez
发明人： Gustavo Larsen , David Vu , Manuel Marquez-Sanchez
IPC分类号： D06M1138
CPC分类号： D06M11/38 , D06M11/79 , Y10T428/2933 , Y10T428/2965
摘要： Stable cellulosic fiber material for use in forming zeolite/cellulose composites is prepared by suspending loose cellulose fibers in an aqueous solution of sodium hydroxide, potassium hydroxide or sodium silicate, stirring the resulting suspension until it reaches a macroscopically homogenous appearance, heating the resulting mixture at a temperature of 323-423 K until only dry solids remain, contacting the resulting mixture with excess distilled water to remove physically adsorbed or trapped sodium hydroxide, potassium hydroxide or sodium silicate from the fibers, and heating the resulting fiber material at 323-423 K to dry the fiber material. Stable zeolite/cellulose composite material characterized in that leaching of the zeolite phase does not occur upon contact of the composite with water at approximately 373 K comprises a zeolite and a stable cellulosic fiber prepared as described above, the composite material being formed by contacting a zeolite with the stable fiber material.

4. 发明申请

US20070296099A1 SYSTEMS FOR PRODUCING MULTILAYERED PARTICLES, FIBERS AND SPRAYS AND METHODS FOR ADMINISTERING THE SAME 失效
标题翻译：用于生产多层颗粒，纤维和喷雾的系统及其管理方法
公开(公告)号：US20070296099A1
公开(公告)日：2007-12-27
申请号：US11743560
申请日：2007-05-02
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
IPC分类号： A61K9/00
CPC分类号： A61K9/5146 , A61K9/5094 , A61K9/5115 , A61K9/5192 , A61K47/551 , A61K47/642 , A61K47/6425 , A61K47/6849 , A61K47/6925 , A61K49/0043 , A61K49/0047 , A61K49/0056 , A61K49/0065 , A61K49/0093 , A61K49/1878 , A61K51/1244 , B01J13/04 , B05B5/0255 , B05B7/061 , B82Y5/00
摘要： Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
摘要翻译：具有至少一种包封和/或包埋的试剂（例如治疗剂，成像剂和其它成分）的胶囊和颗粒可以通过电动力学方法制备。更具体地，封装在载体，胶囊，颗粒，载体或载体中的试剂可以最大限度地减少治疗和/或成像的不利影响，从而最大化恶性癌症的治疗和/或成像。

5. 发明授权

US08297959B2 Systems for producing multilayered particles, fibers and sprays and methods for administering the same 失效
标题翻译：用于生产多层颗粒，纤维和喷雾剂的系统及其施用方法
公开(公告)号：US08297959B2
公开(公告)日：2012-10-30
申请号：US11743560
申请日：2007-05-02
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
IPC分类号： B29B9/10 , A61J3/07
CPC分类号： A61K9/5146 , A61K9/5094 , A61K9/5115 , A61K9/5192 , A61K47/551 , A61K47/642 , A61K47/6425 , A61K47/6849 , A61K47/6925 , A61K49/0043 , A61K49/0047 , A61K49/0056 , A61K49/0065 , A61K49/0093 , A61K49/1878 , A61K51/1244 , B01J13/04 , B05B5/0255 , B05B7/061 , B82Y5/00
摘要： Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
摘要翻译：具有至少一种包封和/或包埋的试剂（例如治疗剂，成像剂和其它成分）的胶囊和颗粒可以通过电动力学方法制备。更具体地，封装在载体，胶囊，颗粒，载体或载体中的试剂可以最大限度地减少治疗和/或成像的不利影响，从而最大化恶性癌症的治疗和/或成像。

6. 发明授权

US08168229B2 Methods for making a multicomponent hemostatic dressing 有权
标题翻译：制备多组分止血敷料的方法
公开(公告)号：US08168229B2
公开(公告)日：2012-05-01
申请号：US12299842
申请日：2006-09-27
申请人： Gustavo Larsen , Ruben Spretz
发明人： Gustavo Larsen , Ruben Spretz
IPC分类号： A61K35/16 , A61F13/00
CPC分类号： A61F13/00991 , A61F2013/00463 , A61L15/32 , A61L15/64 , A61L2400/04
摘要： A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredients, initiates and accelerates the biochemical blood clotting cascade processes. The steps of the method include dissolving in an organic solvent one or more soluble bioabsorbable polymers and organic or aqueous-organic media of non-protein constituents to create a homogeneous mixture; forming fibers from the homogeneous mixture; adding to the fibers a molecular-scale first coating of one or more proteins of blood clotting species that minimally react with each other; and optionally adding a second coating of one or more proteins of blood clotting species to the fibers that minimally react with each other and that, together with the one or more proteins of blood clotting species in the molecular-scale first coating, induce blood coagulation in the presence of blood. The fibers may optionally have occluded in them or at their surface other chemicals of abiological or biological origin that aid in the blood clotting process.
摘要翻译：一种制造柔韧的生物吸收性止血敷料的方法，其中所述敷料由具有至少一种分子级涂层的纤维组成，其在首次接触血液并且由于与每单位重量活性成分的血液接触面积大时，起始并加速生化血液凝固级联过程。该方法的步骤包括在有机溶剂中溶解一种或多种可溶性生物可吸收聚合物和非蛋白质组分的有机或水性有机介质以产生均匀混合物; 从均匀混合物形成纤维; 向所述纤维添加一种或多种最小程度地彼此反应的凝血物质的蛋白质的分子级第一次涂层; 并且任选地将一种或多种血液凝固物质的第二涂层添加到彼此最少反应的纤维中，并且与分子级第一涂层中的一种或多种血液凝固物质的蛋白质一起诱导血液凝固血液的存在纤维可以任选地在其中或在其表面上封闭有助于血液凝固过程的生物或生物来源的其它化学物质。

7. 发明授权

US08257778B2 Method of manufacturing fibrous hemostatic bandages 失效
标题翻译：纤维止血绷带的制造方法
公开(公告)号：US08257778B2
公开(公告)日：2012-09-04
申请号：US13414949
申请日：2012-03-08
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
IPC分类号： A61F13/02
CPC分类号： A61K38/363 , A61K38/4833 , A61K38/484 , A61L15/32 , A61L2400/04 , D01D5/0061 , D01D5/0092 , D01D5/18 , D01D10/00 , D01F1/10
摘要： A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.
摘要翻译：通过制造最大限度地暴露每单位重量活性成分的表面积的纤维作为帮助凝块形成过程的手段并且作为使活性成分的浪费最小化的手段来制造坚固和柔韧的纤维止血敷料的方法。该方法使用旋转物体来分离其中心附加的液体生物相容性纤维前体。形成的纤维然后沉积在与旋转物体一定距离处的收集器上，在收集器上产生纤维层。在旋转盘和收集器之间保持电位差。然后，将液体促凝物质引入旋转盘的中心，使其旋转旋转盘并涂覆纤维。

8. 发明申请

US20090203053A1 METHODS AND MATERIALS FOR AMPLIFICATION OF A SIGNAL IN AN IMMUNOASSAY 失效
标题翻译：免疫学信号放大的方法和材料
公开(公告)号：US20090203053A1
公开(公告)日：2009-08-13
申请号：US12244538
申请日：2008-10-02
申请人： Gustavo Larsen , Raffett Velarde Ortiz
发明人： Gustavo Larsen , Raffett Velarde Ortiz
IPC分类号： G01N33/543
CPC分类号： G01N33/542 , B82Y25/00 , G01N33/5434 , G01N33/54346
摘要： Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the signal amplifying molecule within its matrix and may also have antibodies affixed to its surface for molecular recognition. Ultrafine particles are also provided having a matrix component that includes a signal amplifying molecule and at least one antibody specific for the antigen or biomaterial. The ultrafine particles of the present disclosure may be used in assays for the detection, including quantification, of one or more antigens present in a biological sample.
摘要翻译：提供具有核心区域的超细颗粒，其具有信号放大分子和围绕核心区域的壳区域。壳区域具有至少一个附着于其表面的抗体，其对至少一种抗原是特异性的。或者，超细颗粒可以将信号放大分子捕获在其基质内，并且还可以具有附着于其表面的抗体用于分子识别。还提供了具有包含信号放大分子和对抗原或生物材料特异性的至少一种抗体的基质组分的超细颗粒。本公开的超细颗粒可用于生物样品中存在的一种或多种抗原的检测（包括定量）的测定。

9. 发明申请

US20090181072A1 Methods for Making a Multicomponent Hemostatic Dressing 有权
标题翻译：制造多组分止血敷料的方法
公开(公告)号：US20090181072A1
公开(公告)日：2009-07-16
申请号：US12299842
申请日：2006-09-27
申请人： Gustavo Larsen , Ruben Spretz
发明人： Gustavo Larsen , Ruben Spretz
IPC分类号： A61L15/00
CPC分类号： A61F13/00991 , A61F2013/00463 , A61L15/32 , A61L15/64 , A61L2400/04
摘要： A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredients, initiates and accelerates the biochemical blood clotting cascade processes. The steps of the method include dissolving in an organic solvent one or more soluble bioabsorbable polymers and organic or aqueous-organic media of non-protein constituents to create a homogeneous mixture; forming fibers from the homogeneous mixture; adding to the fibers a molecular-scale first coating of one or more proteins of blood clotting species that minimally react with each other; and optionally adding a second coating of one or more proteins of blood clotting species to the fibers that minimally react with each other and that, together with the one or more proteins of blood clotting species in the molecular-scale first coating, induce blood coagulation in the presence of blood. The fibers may optionally have occluded in them or at their surface other chemicals of abiological or biological origin that aid in the blood clotting process.
摘要翻译：一种制造柔韧的生物吸收性止血敷料的方法，其中所述敷料由具有至少一种分子级涂层的纤维组成，其在首次接触血液并且由于与每单位重量活性成分的血液接触面积大时，起始并加速生化血液凝固级联过程。该方法的步骤包括在有机溶剂中溶解一种或多种可溶性生物可吸收聚合物和非蛋白质组分的有机或水性有机介质以产生均匀混合物; 从均匀混合物形成纤维; 向所述纤维添加一种或多种最小程度地彼此反应的凝血物质的蛋白质的分子级第一次涂层; 并且任选地将一种或多种血液凝固物质的第二涂层添加到彼此最少反应的纤维中，并且与分子级第一涂层中的一种或多种血液凝固物质的蛋白质一起诱导血液凝固血液的存在纤维可以任选地在其中或在其表面上封闭有助于血液凝固过程的生物或生物来源的其它化学物质。

10. 发明授权

US08530244B2 Methods and materials for amplification of a signal in an immunoassay 失效
标题翻译：用于在免疫测定中扩增信号的方法和材料
公开(公告)号：US08530244B2
公开(公告)日：2013-09-10
申请号：US12244538
申请日：2008-10-02
申请人： Gustavo Larsen , Raffett Velarde Ortiz
发明人： Gustavo Larsen , Raffett Velarde Ortiz
IPC分类号： G01N21/76
CPC分类号： G01N33/542 , B82Y25/00 , G01N33/5434 , G01N33/54346
摘要： Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the signal amplifying molecule within its matrix and may also have antibodies affixed to its surface for molecular recognition. Ultrafine particles are also provided having a matrix component that includes a signal amplifying molecule and at least one antibody specific for the antigen or biomaterial. The ultrafine particles of the present disclosure may be used in assays for the detection, including quantification, of one or more antigens present in a biological sample.
摘要翻译：提供具有核心区域的超细颗粒，其具有信号放大分子和围绕核心区域的壳区域。壳区域具有至少一个附着于其表面的抗体，其对至少一种抗原是特异性的。或者，超细颗粒可以将信号放大分子捕获在其基质内，并且还可以具有附着于其表面的抗体用于分子识别。还提供了具有包含信号放大分子和对抗原或生物材料特异性的至少一种抗体的基质组分的超细颗粒。本公开的超细颗粒可用于生物样品中存在的一种或多种抗原的检测（包括定量）的测定。

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