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1. 发明申请

US20180346873A1 Artificial micro-gland 审中-公开
公开(公告)号：US20180346873A1
公开(公告)日：2018-12-06
申请号：US16048423
申请日：2018-07-30
申请人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
发明人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
IPC分类号： C12N5/00 , A61K35/39 , A61K35/36 , A61F2/02 , A61L27/38 , A61K35/54 , A61K35/28 , A61L27/60
CPC分类号： C12N5/0062 , A61F2/022 , A61K35/28 , A61K35/36 , A61K35/39 , A61K35/54 , A61L27/3804 , A61L27/60 , A61L2400/12
摘要： A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir. The reservoir is a bio-reactor capable of containing a product of activity of the cells. The reservoir comprises a gas, a liquid, and a gel and preferably also contains nanoparticles, a buffer, a surfactant, and, a gel precursor. The reservoir may also contain cells. Nanoparticles may also surround the artificial gland to form a protective coating. A variety of methods are disclosed for making the artificial gland by directed assembly of cells into the artificial micro-gland by gel, liquid or bubble templating. All involve coating the surface of gel, droplet or bubble with the living cells and the stabilizing the cells on the surface of gels, droplets or bubbles.

2. 发明申请

US20100255059A1 Artificial micro-gland 审中-公开
标题翻译：人造微腺
公开(公告)号：US20100255059A1
公开(公告)日：2010-10-07
申请号：US12726158
申请日：2010-03-17
申请人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
发明人： Manuel Marquez , Samantha M. Marquez , Antonio Garcia
IPC分类号： A61K35/14 , A61K9/00 , A61K35/16 , A61K35/18 , A61K35/12 , A61P5/00 , C12N5/07 , C12N5/0789 , C12N5/073 , C12N5/09 , C12N5/078
CPC分类号： C12N5/0062 , A61F2/022 , A61K35/28 , A61K35/36 , A61K35/39 , A61K35/54 , A61L27/3804 , A61L27/60 , A61L2400/12
摘要： A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir. The reservoir is a bio-reactor capable of containing a product of activity of the cells. The reservoir comprises a gas, a liquid, and a gel and preferably also contains nanoparticles, a buffer, a surfactant, and, a gel precursor. The reservoir may also contain cells. Nanoparticles may also surround the artificial gland to form a protective coating. A variety of methods are disclosed for making the artificial gland by directed assembly of cells into the artificial micro-gland by gel, liquid or bubble templating. All involve coating the surface of gel, droplet or bubble with the living cells and the stabilizing the cells on the surface of gels, droplets or bubbles.
摘要翻译：微生物人工腺体以用于促进生物活性的独立单元的形式被公开。人造腺包括在包围储存器的膜中形成的细胞。储层是能够容纳细胞活性产物的生物反应器。储存器包括气体，液体和凝胶，并且优选地还含有纳米颗粒，缓冲液，表面活性剂和凝胶前体。贮存器还可以含有细胞。纳米颗粒也可以围绕人造腺体形成保护性涂层。公开了通过凝胶，液体或气泡模板将细胞定向组装到人造微腺体中来制备人造腺体的各种方法。所有这些都涉及用活细胞涂覆凝胶表面，液滴或气泡，并将细胞稳定在凝胶，液滴或气泡表面。

3. 发明申请

US20110129903A1 Method of making an artificial micro-gland using taxis 审中-公开
标题翻译：使用出租车制造人造微腺的方法
公开(公告)号：US20110129903A1
公开(公告)日：2011-06-02
申请号：US12860867
申请日：2010-08-21
申请人： Manuel Marquez , Samantha M. Marquez
发明人： Manuel Marquez , Samantha M. Marquez
IPC分类号： C12N1/20 , C12N1/12
CPC分类号： C12N5/0062 , A61K35/74 , A61K35/742 , C12N1/26 , A61K2300/00
摘要： A method is used for making an artificial micro-gland by taxis. A monodisperse multiple emulsion is produced with a first fluid; a second fluid confined within the first fluid; a third fluid within the second fluid. Interfaces between the fluids permit living cells dispersed in the one of the fluids to migrate towards an adjacent fluid having a different concentration of an agent affecting the metabolic activity of the living cells. Waiting, usually about 30 minutes, allows the living cells to migrate to the interface, forming the continuous membrane. Once formed, the artificial micro-gland is removed from the remains of the emulsion. The artificial micro-gland may also be given a second layer of different cells when the emission of the cells of the artificial micro-gland is used as the agent to attract the different cells. The method may also be used to produce an artificial micro-gland within an artificial micro-gland.
摘要翻译：一种用于通过出租车制造人造微腺的方法。用第一种流体制备单分散多重乳液; 限制在第一流体内的第二流体; 第二流体内的第三流体。流体之间的界面允许分散在一种流体中的活细胞迁移到具有不同浓度的影响活细胞的代谢活性的试剂的相邻流体。等待，通常约30分钟，允许活细胞迁移到界面，形成连续膜。一旦形成，人造微腺从乳液的残余物中除去。当将人造微腺细胞的发射用作吸引不同细胞的药剂时，人造微腺体也可以被给予第二层不同的细胞。该方法还可用于在人造微腺体内产生人造微腺体。

4. 发明申请

US20110104777A1 Method of making an artificial micro-gland that is anisotropic 审中-公开
标题翻译：制造各向异性的人造微腺的方法
公开(公告)号：US20110104777A1
公开(公告)日：2011-05-05
申请号：US12880113
申请日：2010-09-12
申请人： Manuel Marquez , Samantha M. Marquez
发明人： Manuel Marquez , Samantha M. Marquez
IPC分类号： C12N5/02 , C12N1/00
CPC分类号： A61F2/022
摘要： A method is disclosed for making an artificial micro-gland having a continuous anisotropic membrane of two or more types of living cells. A first step includes forming a carrier fluid in a microchannel in a laminar flow of two distinct fluid flows. Another step includes introducing a template, which may itself be anisotropic, into the microchannel in a manner such that the template straddles the interface between the first fluid-flow and the second fluid-flow. In some embodiments two types of living cells within the template are separately attracted one of the fluid flows by the presence of an agent of taxis. In other embodiments, cells within one or the other of the fluid flows are attracted to agents within the template. Membranes form on the template and join together to form a complete cellular membrane around a reservoir.
摘要翻译：公开了一种用于制造具有两种或更多种类型活细胞的连续各向异性膜的人造微腺的方法。第一步骤包括在两个不同流体流的层流中在微通道中形成载流体。另一步骤包括将模板本身可以是各向异性的，以使模板跨越第一流体流与第二流体流之间的界面的方式引入微通道。在一些实施方案中，模板内的两种类型的活细胞通过出租车的出现分开地吸引流体流中的一种。在其它实施例中，一个或另一个流体流中的细胞被吸引到模板内的试剂上。在模板上形成膜并连接在一起以在储存器周围形成完整的细胞膜。

5. 发明申请

US20170275584A1 Method of making an artificial micro-gland using taxis 审中-公开
公开(公告)号：US20170275584A1
公开(公告)日：2017-09-28
申请号：US15606042
申请日：2017-05-26
申请人： Manuel Marquez , Samantha M. Marquez
发明人： Manuel Marquez , Samantha M. Marquez
IPC分类号： C12N5/00 , C12N1/26 , A61K35/74 , A61K35/742
CPC分类号： C12N5/0062 , A61K35/74 , A61K35/742 , C12N1/26 , A61K2300/00
摘要： A method is used for making an artificial micro-gland by taxis. A monodisperse multiple emulsion is produced with a first fluid; a second fluid confined within the first fluid; a third fluid within the second fluid. Interfaces between the fluids permit living cells dispersed in the one of the fluids to migrate towards an adjacent fluid having a different concentration of an agent affecting the metabolic activity of the living cells. Waiting, usually about 30 minutes, allows the living cells to migrate to the interface, forming the continuous membrane. Once formed, the artificial micro-gland is removed from the remains of the emulsion. The artificial micro-gland may also be given a second layer of different cells when the emission of the cells of the artificial micro-gland is used as the agent to attract the different cells. The method may also be used to produce an artificial micro-gland within an artificial micro-gland.

6. 发明申请

US20180340151A1 Method of making an artificial micro-gland that is anisotropic 审中-公开
公开(公告)号：US20180340151A1
公开(公告)日：2018-11-29
申请号：US15606027
申请日：2017-05-26
申请人： Manuel Marquez , Samantha M. Marquez
发明人： Manuel Marquez , Samantha M. Marquez
IPC分类号： C12N5/071 , C12N13/00
摘要： A method is disclosed for making an artificial micro-gland having a continuous anisotropic membrane of two or more types of living cells. A first step includes forming a carrier fluid in a microchannel in a laminar flow of two distinct fluid flows. Another step includes introducing a template, which may itself be anisotropic, into the microchannel in a manner such that the template straddles the interface between the first fluid-flow and the second fluid-flow. In some embodiments two types of living cells within the template are separately attracted one of the fluid flows by the presence of an agent of taxis. In other embodiments, cells within one or the other of the fluid flows are attracted to agents within the template. Membranes form on the template and join together to form a complete cellular membrane around a reservoir.

7. 发明申请

US20180021140A1 HIGH SPEED 3D PRINTING SYSTEM FOR WOUND AND TISSUE REPLACEMENT 审中-公开
公开(公告)号：US20180021140A1
公开(公告)日：2018-01-25
申请号：US15549083
申请日：2016-02-12
申请人： Samantha M. MARQUEZ , University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation
发明人： Thomas Ettor Angelini , Wallace Gregory Sawyer , Kyle Gene Rowe , Tapomoy Bhattacharjee , Alberto Fernandez-Nieves , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： A61F2/30 , A61L27/18 , A61L27/36 , A61L27/52 , C12N5/071 , A61L27/50 , A61L27/60 , A61L27/54 , C12N5/00 , A61L27/16 , A61L27/26
CPC分类号： A61F2/30942 , A61F2002/30962 , A61F2240/002 , A61K35/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/3604 , A61L27/3625 , A61L27/507 , A61L27/52 , A61L27/54 , A61L27/60 , A61L2300/414 , A61L2300/64 , A61L2430/20 , A61L2430/26 , B29C64/106 , B29L2031/7532 , B33Y70/00 , B33Y80/00 , C12N5/0062 , C12N5/0686 , C12N5/069 , C12N2513/00 , C12N2533/30 , C12N2533/74 , C12N2533/80
摘要： A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

8. 发明授权

US11007705B2 High speed 3D printing system for wound and tissue replacement 有权
公开(公告)号：US11007705B2
公开(公告)日：2021-05-18
申请号：US15549083
申请日：2016-02-12
申请人： University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation , Samantha M. Marquez
发明人： Thomas Ettor Angelini , Wallace Gregory Sawyer , Kyle Gene Rowe , Tapomoy Bhattacharjee , Alberto Fernandez-Nieves , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： A61F2/30 , B29C64/118 , C12N5/00 , B33Y80/00 , B33Y70/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/36 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/60 , C12N5/071 , A61K35/00 , B29L31/00
摘要： A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

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