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1. 发明申请

US20110091493A1 VACCINE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：疫苗组合物及其用途
公开(公告)号：US20110091493A1
公开(公告)日：2011-04-21
申请号：US12906428
申请日：2010-10-18
申请人： Mansour Moahamadzadeh , Todd R. Klaenhammer
发明人： Mansour Moahamadzadeh , Todd R. Klaenhammer
IPC分类号： C12N15/62 , C12N1/21 , A61K39/02
CPC分类号： A61K39/145 , A61K39/0011 , A61K39/07 , A61K39/12 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/545 , A61K2039/55505 , A61K2039/6031 , A61K2039/70 , C07K14/32 , C07K14/4702 , C07K2319/01 , C12N15/62 , C12N2760/16134
摘要： The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems comprising an antigen and a dendritic cell-targeting peptide. Such compositions target vaccines to dendritic cells, resulting in a high level of humoral and acquired immunity, including both mucosal and systemic immunity. Such delivery systems find use in the specific delivery of a wide variety of oral vaccines to subjects.
摘要翻译：本发明涉及疫苗组合物及其应用。本发明的实施方案提供包含抗原和树突状细胞靶向肽的口服细菌（例如，益生菌乳酸菌）疫苗递送系统。这样的组合物将疫苗靶向树突状细胞，导致高水平的体液和获得性免疫，包括粘膜和全身免疫。这种递送系统可用于将各种口服疫苗特异性递送给受试者。

2. 发明授权

US07981651B2 Lactobacillus acidophilus nucleic acids and uses thereof 失效
标题翻译：嗜酸乳杆菌核酸及其用途
公开(公告)号：US07981651B2
公开(公告)日：2011-07-19
申请号：US12253333
申请日：2008-10-17
申请人： Todd R. Klaenhammer , Eric Altermann , Andrea Azcarate-Peril
发明人： Todd R. Klaenhammer , Eric Altermann , Andrea Azcarate-Peril
IPC分类号： C12N9/02 , C12N1/20 , C07H21/04 , C12P21/06
CPC分类号： C12N9/0044 , A23C9/1234 , A23C2220/202 , A23L33/135 , A61K35/747 , A61K38/00 , A61K2035/11 , C07K14/335 , C12N9/0008 , C12N9/1051 , C12N9/13 , C12N9/14 , C12N9/16 , C12N9/18 , C12N9/2471 , C12N9/80 , C12N9/88 , C12N9/90 , C12Q1/689 , C12Y302/01023
摘要： Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells comprising the expression vectors. Methods for producing the polypeptides of the invention and methods for their use are further provided.
摘要翻译：本发明提供了嗜酸乳杆菌NCFM核酸分子，多肽，其片段和变体。此外，还包括融合蛋白，抗原肽和抗体。本发明还提供含有本发明的核酸分子和包含表达载体的细胞的重组表达载体。还提供了制备本发明多肽的方法及其使用方法。

3. 发明申请

US20110081707A1 LACTOBACILLUS ACIDOPHILUS NUCLEIC ACID SEQUENCES ENCODING CARBOHYDRATE UTILIZATION-RELATED PROTEINS AND USES THEREFOR 失效
标题翻译：乳酸杆菌ACIDOPHILUS核酸序列编码碳水化合物利用相关蛋白及其用途
公开(公告)号：US20110081707A1
公开(公告)日：2011-04-07
申请号：US12903346
申请日：2010-10-13
申请人： Todd R. Klaenhammer , Eric Altermann , Rodolphe Barrangou , W. Michael Russell , Tri Duong
发明人： Todd R. Klaenhammer , Eric Altermann , Rodolphe Barrangou , W. Michael Russell , Tri Duong
IPC分类号： C12N1/21 , C07K2/00 , C12N15/63 , C12N1/00 , C07K16/00 , C07H21/00
CPC分类号： C07K14/335
摘要： Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate utilization-related and multidrug transporter fusion proteins, antigenic peptides, and anti-carbohydrate utilization-related and anti-multidrug transporter antibodies are encompassed. The invention also provides vectors containing a nucleic acid of the invention and cells into which the vector has been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.
摘要翻译：碳水化合物利用相关和多药转运蛋白核酸和多肽及其片段和变体在本发明中公开。此外，包括碳水化合物利用相关和多药转运蛋白融合蛋白，抗原肽和抗碳水化合物利用相关和抗多药转运体抗体。本发明还提供了含有本发明的核酸的载体和载体已导入其中的载体。进一步公开了制备多肽的方法和本发明多肽的使用方法。

4. 发明授权

US07897367B2 Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore 有权
标题翻译：因此，编码蛋白酶同源物的嗜酸乳杆菌核酸序列和用途
公开(公告)号：US07897367B2
公开(公告)日：2011-03-01
申请号：US12251501
申请日：2008-10-15
申请人： Todd R. Klaenhammer , Eric Altermann , W. Michael Russell
发明人： Todd R. Klaenhammer , Eric Altermann , W. Michael Russell
IPC分类号： C12P21/06
CPC分类号： C12N9/50 , C07K14/335
摘要： Protease-like nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, protease-like fusion proteins, antigenic peptides, and anti-protease-like antibodies are encompassed. The invention also provides vectors containing a nucleic acid molecule of the invention and cells into which the vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.
摘要翻译：蛋白酶样核酸分子及其多肽及其片段和变体在本发明中公开。此外，还包括蛋白酶样融合蛋白，抗原肽和抗蛋白酶样抗体。本发明还提供了含有本发明的核酸分子的载体和已经引入载体的细胞。进一步公开了制备多肽的方法和本发明多肽的使用方法。

5. 发明授权

US07407787B2 Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof 失效
标题翻译：编码低聚果糖的化合物的嗜酸乳酸乳杆菌核酸及其用途
公开(公告)号：US07407787B2
公开(公告)日：2008-08-05
申请号：US10873467
申请日：2004-06-22
申请人： Rodolphe Barrangou , Todd R. Klaenhammer , Eric Altermann
发明人： Rodolphe Barrangou , Todd R. Klaenhammer , Eric Altermann
IPC分类号： C17H9/24 , C12Q1/68 , C12N15/74 , C07H21/04
CPC分类号： C12N15/52 , C07K14/335 , Y10T436/143333
摘要： Fructooligosaccharide (FOS)-related protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, FOS-related fusion proteins, antigenic peptides, and anti-FOS-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.
摘要翻译：低聚果糖（FOS）相关蛋白核酸分子及其多肽及其片段和变体在本发明中公开。此外，还包括FOS相关融合蛋白，抗原肽和抗FOS相关抗体。本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。本发明的多肽的制备方法及其使用方法进一步公开。

6. 发明授权

US5538864A Bacteriophage resistant recombinant bacteria 失效
标题翻译：耐噬菌细菌重组菌
公开(公告)号：US5538864A
公开(公告)日：1996-07-23
申请号：US373877
申请日：1995-01-17
申请人： Colin J. Hill , Todd R. Klaenhammer
发明人： Colin J. Hill , Todd R. Klaenhammer
IPC分类号： A23C9/123 , C12N1/04 , C12N1/21 , C12N15/11 , C12N15/34 , C12N15/65 , C12N15/74 , C12N1/20 , A23C9/00 , C12P7/56
CPC分类号： C12N15/65 , A23C9/1236 , C12N1/04 , C12N15/11 , C12N15/746
摘要： Recombinant bacteria containing phage-encoded resistance ("Per") and methods of making and using the same are disclosed. Such bacteria are made by (a) conducting a fermentation of a substrate in a medium containing a defined bacterial culture until bacteriophage are detected in the medium, the bacteriophage being specific to at least one bacteria in the medium; (b) isolating the bacteriophage; (c) digesting DNA of the bacteriophage to produce a library of DNA fragments; (d) transforming the bacteria susceptible to said bacteriophage with the library of DNA fragments to provide transformed bacteria; (e) selecting from among the transformed bacteria, a bacteriophage-resistant transformed bacteria; (f) adding bacteriophage resistant transformed bacteria to the medium; and (g) recommencing step (a). Also disclosed are bacterial cells which contain a first bacteriophage defense mechanism (Per), wherein Per comprises a bacteriophage origin of replication (ori) operatively associated with a DNA sequence incapable of producing live bacteriophage. The bacterial cell is capable of being infected by a bacteriophage, the DNA of which, once injected into the bacterial cell, competes with Per for binding to DNA polymerase.
摘要翻译：公开了含有噬菌体编码抗性（“Per”）的重组细菌及其制备和使用方法。这样的细菌通过以下方法制备：（a）在含有限定的细菌培养基的培养基中进行底物的发酵，直到在培养基中检测到噬菌体，噬菌体对培养基中的至少一种细菌是特异性的; （b）分离噬菌体; （c）消化噬菌体的DNA以产生DNA片段文库; （d）用DNA片段的文库转化对所述噬菌体易感的细菌，以提供转化的细菌; （e）从转化细菌中选择抗噬菌体转化细菌; （f）向培养基中加入抗噬菌体转化细菌; 和（g）重新开始步骤（a）。还公开了含有第一噬菌体防御机制（Per）的细菌细胞，其中Per包含与不能产生活噬菌体的DNA序列可操作地相关的噬菌体复制起点（ori）。细菌细胞能够被噬菌体感染，其噬菌体一旦被注入到细菌细胞中就与Per结合就与DNA聚合酶结合。

7. 发明授权

US09040302B2 Genetically modified Streptococcus thermophilus bacterium 有权
标题翻译：转基因嗜热链球菌
公开(公告)号：US09040302B2
公开(公告)日：2015-05-26
申请号：US13697860
申请日：2011-05-19
申请人： Todd R. Klaenhammer , Richard L. Guerrant , Glynis L. Kolling , Evelyn Durmaz , Michael P. Timko , Cirle Alcantara Warren
发明人： Todd R. Klaenhammer , Richard L. Guerrant , Glynis L. Kolling , Evelyn Durmaz , Michael P. Timko , Cirle Alcantara Warren
IPC分类号： A61K35/74 , A61K38/16 , A23C9/123 , A23L1/30 , C12N1/06 , C12P21/02 , A61K35/00
CPC分类号： A61K38/164 , A23C9/1238 , A23L33/135 , A61K35/74 , A61K2035/11 , C12N1/06 , C12P21/02
摘要： Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by the St. thermophilus bacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject a St. thermophilus bacterium modified to release a biotherapeutic agent following bile exposure. Administration of the St. thermophilus bacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders including C. difficile infection and antibiotic-associated diarrhea.
摘要翻译：提供用于靶向递送生物治疗剂的方法和组合物。组合物包含胆汁敏感的嗜热链球菌，其被修饰以在胆汁暴露后释放生物治疗剂。由本文公开的嗜热链球菌细菌释放的生物治疗剂包括AQ和AQR丰富的肽。本发明的方法包括向受试者施用在胆汁暴露后经修饰以释放生物治疗剂的嗜热链球菌。圣氏嗜热链霉菌的施用促进期望的治疗反应。可以修饰细菌以表达和释放富含AQ或AQR的肽，其随后抑制细胞凋亡或减少粘膜损伤。因此，本发明的方法用于治疗或预防各种胃肠疾病，包括艰难梭菌感染和抗生素相关性腹泻。

8. 发明授权

US08178337B2 Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor 失效
标题翻译：编码碳水化合物利用相关蛋白质的嗜酸乳酸乳杆菌核酸序列及其用途
公开(公告)号：US08178337B2
公开(公告)日：2012-05-15
申请号：US12903346
申请日：2010-10-13
申请人： Todd R. Klaenhammer , Eric R. Altermann , Rodolphe Barrangou , W. Michael Russell , Tri Duong
发明人： Todd R. Klaenhammer , Eric R. Altermann , Rodolphe Barrangou , W. Michael Russell , Tri Duong
IPC分类号： C12N1/20 , C12N1/00 , C12N15/00 , C12N9/40 , C12P21/06 , C12P19/34 , A61K38/00 , C07H21/04
CPC分类号： C07K14/335
摘要： Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate utilization-related and multidrug transporter fusion proteins, antigenic peptides, and anti-carbohydrate utilization-related and anti-multidrug transporter antibodies are encompassed. The invention also provides vectors containing a nucleic acid of the invention and cells into which the vector has been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.
摘要翻译：碳水化合物利用相关和多药转运蛋白核酸和多肽及其片段和变体在本发明中公开。此外，包括碳水化合物利用相关和多药转运蛋白融合蛋白，抗原肽和抗碳水化合物利用相关和抗多药转运体抗体。本发明还提供了含有本发明的核酸的载体和载体已导入其中的载体。进一步公开了制备多肽的方法和本发明多肽的使用方法。

9. 发明申请

US20110020900A1 LACTOBACILLUS ACIDOPHILUS NUCLEIC ACID SEQUENCES ENCODING PROTEASE HOMOLOGUES AND USES THEREFORE 有权
标题翻译： Lactobacillus ACIDOPHILUS核酸序列编码蛋白质HOMOLOGE及其用途
公开(公告)号：US20110020900A1
公开(公告)日：2011-01-27
申请号：US12251501
申请日：2008-10-15
申请人： Todd R. Klaenhammer , Eric Altermann , W. Michael Russell
发明人： Todd R. Klaenhammer , Eric Altermann , W. Michael Russell
IPC分类号： C12N9/48 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C12N9/50 , C07K14/335
摘要： Protease-like nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, protease-like fusion proteins, antigenic peptides, and anti-protease-like antibodies are encompassed. The invention also provides vectors containing a nucleic acid molecule of the invention and cells into which the vectors have been introduced. Methods for producing the polypeptides and methods of use for the polypeptides of the invention are further disclosed.
摘要翻译：蛋白酶样核酸分子及其多肽及其片段和变体在本发明中公开。此外，还包括蛋白酶样融合蛋白，抗原肽和抗蛋白酶样抗体。本发明还提供了含有本发明的核酸分子的载体和已经引入载体的细胞。进一步公开了制备多肽的方法和本发明多肽的使用方法。

10. 发明授权

US07538209B2 Lactobacillus acidophillus nucleic acid sequences encoding cell surface protein homologues and uses therefore 失效
标题翻译：因此，编码细胞表面蛋白质同源物的酸乳酸乳杆菌核酸序列
公开(公告)号：US07538209B2
公开(公告)日：2009-05-26
申请号：US11701335
申请日：2007-02-01
申请人： Todd R. Klaenhammer , W. Michael Russell , Eric Altermann , B. Logan Buck
发明人： Todd R. Klaenhammer , W. Michael Russell , Eric Altermann , B. Logan Buck
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： A23L3/3526 , A23C9/123 , A23C19/0323 , A23L33/18 , A61K38/00 , C07K14/335
摘要： Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface and secreted fusion proteins, antigenic peptides, and anti-cell wall, cell surface and secreted antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the expression vectors have been introduced. Methods for producing the polypeptides of the invention and methods for their use are further disclosed.
摘要翻译：细胞壁，细胞表面和分泌的蛋白质核酸分子及其多肽及其片段和变体在本发明中公开。此外，还包括细胞壁，细胞表面和分泌的融合蛋白，抗原肽和抗细胞壁，细胞表面和分泌的抗体。本发明还提供了含有本发明的核酸分子的重组表达载体和已经引入表达载体的宿主细胞。本发明的多肽的制备方法及其使用方法进一步公开。

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