专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07399770B2 Thieno-imino acid derivatives for use as matrix metalloproteinase inhibitors 有权
标题翻译：噻吩并亚氨基酸衍生物用作基质金属蛋白酶抑制剂
公开(公告)号：US07399770B2
公开(公告)日：2008-07-15
申请号：US11461189
申请日：2006-07-31
申请人： Manfred Schudok , Hans Matter , Armin Hofmeister , Maxime Lampilas
发明人： Manfred Schudok , Hans Matter , Armin Hofmeister , Maxime Lampilas
IPC分类号： A61K31/4365 , C07D409/02 , C07D495/06
CPC分类号： C07D495/04
摘要： The invention is directed to a compound of the formula I wherein the variables are as defined herein, or a stereoisomeric form thereof, mixture of stereoisomeric forms, in any ratio, or a salt thereof. Another aspect of the present invention is directed to a pharmaceutical composition comprising, a pharmaceutically effective amount of one or more compounds of formula I according to claim 1 in admixture with a pharmaceutically acceptable carrier.The invention is also directed to a method for effecting the prophylaxis and therapy of degenerative joint diseases such as osteoarthroses, spondyloses, cartilage loss following joint trauma or a relatively long period of joint immobilization following meniscus or patella injuries or ligament ruptures, diseases of the connective tissue such as collagenoses, periodontal diseases, wound healing disturbances and chronic diseases of the locomotory apparatus such as inflammatory, immunological or metabolism-associated acute and chronic arthritides, arthropathies, myalgias and disturbances of bone metabolism, for the treatment of ulceration, atheroscleroses and stenoses, and for the treatment of inflammations, cancer diseases, tumor metastasis formation, cachexia, anorexia, cardiac insufficiency and septic shock or for the prophylaxis of myocardial and cerebral infarctions, in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of the compound of formula I according to claim 1, or a pharmaceutically acceptable salt, solvate or prodrug thereof.Furthermore the invention is directed to a method for preparing a compound of formula I.
摘要翻译：本发明涉及式I化合物，其中变量如本文所定义，或其立体异构形式，立体异构体形式的任何比例的混合物或其盐。本发明的另一方面涉及一种药物组合物，其包含药学有效量的一种或多种根据权利要求1的式I化合物与药学上可接受的载体的混合物。本发明还涉及一种用于预防和治疗退行性关节疾病如骨关节炎，椎关节强硬，关节创伤后的软骨损失或半月板或髌骨损伤或韧带断裂后相对较长的关节固定的方法，连接性疾病诸如胶原蛋白，牙周病，伤口愈合障碍和诸如炎症，免疫学或代谢相关的急性和慢性关节炎的关节病，关节病，肌痛和骨骼代谢紊乱的运动器官的组织，用于治疗溃疡，动脉粥样硬化和狭窄，并且用于在有需要的患者中治疗炎症，癌症疾病，肿瘤转移形成，恶病质，厌食症，心脏功能不全和败血性休克或用于预防心肌和脑梗死，包括向患者施用药学有效量的compou 根据权利要求1的式I的或其药学上可接受的盐，溶剂合物或前药。此外，本发明涉及制备式I化合物的方法。

2. 发明授权

US08039481B2 Tetrahydrofuran derivatives for use as inhibitors of matrix metalloproteinases 有权
标题翻译：用作基质金属蛋白酶抑制剂的四氢呋喃衍生物
公开(公告)号：US08039481B2
公开(公告)日：2011-10-18
申请号：US11777324
申请日：2007-07-13
申请人： Manfred Schudok , Hans Matter , Armin Hofmeister
发明人： Manfred Schudok , Hans Matter , Armin Hofmeister
IPC分类号： A61K31/4355 , C07D471/04
CPC分类号： C07D491/04
摘要： The present invention includes novel derivatives of bicyclic tetrahydrofuran imino acids of formula I, processes for their preparation, and uses thereof as medicaments. The compounds are suitable for use in the therapy and prophylaxis of diseases which are associated with an increased matrix metalloproteinase activity.
摘要翻译：本发明包括式I的双环四氢呋喃亚氨基酸的新衍生物，其制备方法及其作为药物的用途。该化合物适合用于治疗和预防与增加的基质金属蛋白酶活性有关的疾病。

3. 发明授权

US07205315B2 Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases 有权
标题翻译：双环亚氨基酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US07205315B2
公开(公告)日：2007-04-17
申请号：US10950802
申请日：2004-09-27
申请人： Manfred Schudok , Hans Matter , Armin Hofmeister
发明人： Manfred Schudok , Hans Matter , Armin Hofmeister
IPC分类号： A61K31/4725 , C07D217/22 , C07D217/24
CPC分类号： C07D217/26 , C07D405/12
摘要： The present invention is directed to a compound of formula (I), or a stereoisomer or a mixture of stereoisomer thereof in any ratio, or its physiologically tolerable salt, which is useful as an inhibitor of matrix metalloproteinase. The present invention is also directed to a pharmaceutical preparation comprising a pharmaceutically effective amount of at least one compound of formula (I); processes for their preparation; the use of a compound of formula (I) having activity as an matrix metalloproteinase inhibitor; and for the prophylaxis and therapy of disease states that involve an increase in the activity of matrix metalloproteinase.
摘要翻译：本发明涉及式（I）化合物或其任何比例的立体异构体或其立体异构体的混合物或其生理上可耐受的盐，其可用作基质金属蛋白酶的抑制剂。本发明还涉及包含药学有效量的至少一种式（I）化合物的药物制剂; 其准备过程; 使用具有活性的式（I）化合物作为基质金属蛋白酶抑制剂; 以及用于预防和治疗涉及基质金属蛋白酶活性增加的疾病状态。

4. 发明申请

US20070203118A1 SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS 审中-公开
标题翻译：用于MMP抑制剂形式的取代的四氢喹啉酮，其制备方法及其在药物形式中的用途
公开(公告)号：US20070203118A1
公开(公告)日：2007-08-30
申请号：US11612938
申请日：2006-12-19
申请人： Armin Hofmeister , Manfred Schudok , Hans Matter , Kristin Breitschopf , Antonio Ugolini
发明人： Armin Hofmeister , Manfred Schudok , Hans Matter , Kristin Breitschopf , Antonio Ugolini
IPC分类号： A61K31/55 , A61K31/4704 , A61K31/4035 , C07D217/22 , C07D223/16 , C07D209/44
CPC分类号： C07D217/26 , C07D217/14
摘要： The present invention is directed to a compound of formula (I) wherein R1, R2, R3, R4, A, L and n are as defined herein, or a pharmacologically acceptable salt thereof, its pharmaceutical composition and it use as a MMP inhibitor.
摘要翻译：本发明涉及式（I）的化合物，其中R 1，R 2，R 3，R 4， / SUB，A，L和n如本文所定义，或其药理学上可接受的盐，其药物组合物，并且其用作MMP抑制剂。

5. 发明申请

US20050080127A1 Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases 有权
标题翻译：双环亚氨基酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US20050080127A1
公开(公告)日：2005-04-14
申请号：US10950802
申请日：2004-09-27
申请人： Manfred Schudok , Hans Matter , Armin Hofmeister
发明人： Manfred Schudok , Hans Matter , Armin Hofmeister
IPC分类号： C07D217/26 , C07D405/12 , A61K31/4035 , C07D209/48
CPC分类号： C07D217/26 , C07D405/12
摘要： The present invention is directed to a compound of formula (I), or a stereoisomer or a mixture of stereoisomer thereof in any ratio, or its physiologically tolerable salt, which is useful as an inhibitor of matrix metalloproteinase. The present invention is also directed to a pharmaceutical preparation comprising a pharmaceutically effective amount of at least one compound of formula (I); processes for their preparation; the use of a compound of formula (I) having activity as an matrix metalloproteinase inhibitor; and for the prophylaxis and therapy of disease states that involve an increase in the activity of matrix metalloproteinase.
摘要翻译：本发明涉及式（I）化合物或其任何比例的立体异构体或其立体异构体的混合物或其生理上可耐受的盐，其可用作基质金属蛋白酶的抑制剂。本发明还涉及包含药学有效量的至少一种式（I）化合物的药物制剂; 其准备过程; 使用具有活性的式（I）化合物作为基质金属蛋白酶抑制剂; 以及用于预防和治疗涉及基质金属蛋白酶活性增加的疾病状态。

6. 发明授权

US07858619B2 Substituted tetrahydroisochinolines as MMP inhibitors, related production method and use as medicine 有权
标题翻译：取代的四氢异噻唑啉作为MMP抑制剂，相关制备方法和用作药物
公开(公告)号：US07858619B2
公开(公告)日：2010-12-28
申请号：US11862818
申请日：2007-09-27
申请人： Armin Hofmeister , Manfred Schudok , Hans Matter , Kristin Breitschopf , Antonio Ugolini
发明人： Armin Hofmeister , Manfred Schudok , Hans Matter , Kristin Breitschopf , Antonio Ugolini
IPC分类号： C07D401/02 , A61K31/47
CPC分类号： C07D217/26 , C07D403/12
摘要： The present invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, A, L and n are as defined herein, its pharmaceutical composition, preparation and uses as a MMP inhibitor.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，A，L和n如本文所定义，其药物组合物，制剂和用作MMP抑制剂。

7. 发明申请

US20070155778A1 4-Trifluoromethoxyphenoxybenzol-4-Sulfonic Acids, Method For The Production And Use Thereof In Medicaments 审中-公开
标题翻译： 4-三氟甲氧基苯氧基苯酚-4-磺酸，药物的生产和使用方法
公开(公告)号：US20070155778A1
公开(公告)日：2007-07-05
申请号：US11611199
申请日：2006-12-15
申请人： Manfred Schudok , Armin Hofmeister
发明人： Manfred Schudok , Armin Hofmeister
IPC分类号： A61K31/4741 , A61K31/4704 , C07D217/22 , C07D491/02
CPC分类号： C07D217/26 , C07D223/16 , C07D493/04
摘要： The present invention is directed to a compound of fomula I, wherein R1, R2, R3 X, A, m and n are as herein defined, the process for its preparation and its use thereof as a medicament.
摘要翻译：本发明涉及式I化合物，其中R1，R2，R3X，A，m和n如本文所定义，其制备方法及其作为药物的用途。

8. 发明授权

US08748614B2 Substituted isoquinoline and isoquinolinone derivatives 有权
标题翻译：取代的异喹啉和异喹啉酮衍生物
公开(公告)号：US08748614B2
公开(公告)日：2014-06-10
申请号：US12487455
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Jochen Goerlitzer , Matthias Löhn
发明人： Oliver Plettenburg , Armin Hofmeister , Jochen Goerlitzer , Matthias Löhn
IPC分类号： A61K31/535 , C07D217/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物，化合物。

9. 发明授权

US08710228B2 Cycloalkylamine substituted isoquinoline derivatives 有权
标题翻译：环烷基胺取代的异喹啉衍生物
公开(公告)号：US08710228B2
公开(公告)日：2014-04-29
申请号：US12487386
申请日：2009-06-18
申请人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Stefan Peukert , Sven Ruf , Matthias Löhn , Peter Monecke , Alexander Schiffer , Aimo Kannt , Markus Kohlmann
发明人： Oliver Plettenburg , Armin Hofmeister , Dieter Kadereit , Stefan Peukert , Sven Ruf , Matthias Löhn , Peter Monecke , Alexander Schiffer , Aimo Kannt , Markus Kohlmann
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24 , C07D401/04 , C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹啉衍生物和含有这些化合物的组合物。

10. 发明授权

US08067614B2 N-substituted (benzoimidazol-2-yl)phenylamines, processes for their preparation, their use as a medicament or diagnostic aid, and a medicament comprising them 失效
标题翻译： N-取代的（苯并咪唑-2-基）苯胺，其制备方法，它们作为药物或诊断助剂的用途，以及包含它们的药物
公开(公告)号：US08067614B2
公开(公告)日：2011-11-29
申请号：US12722634
申请日：2010-03-12
申请人： Uwe Heinelt , Hans-Jochen Lang , Armin Hofmeister , Klaus Wirth , Martin Hug
发明人： Uwe Heinelt , Hans-Jochen Lang , Armin Hofmeister , Klaus Wirth , Martin Hug
IPC分类号： A61K31/4184 , C07D235/30
CPC分类号： C07D235/30
摘要： This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke.
摘要翻译：本发明涉及式（I）化合物，含有抑制亚型3（NHE3）的钠 - 质子交换剂的所述化合物的组合物，其可用于预防或治疗患有疾病状态的患者中的各种疾病，例如包括急性或慢性肾衰竭，胆汁功能障碍和呼吸系统疾病如打鼾或睡眠呼吸暂停或中风的肾脏疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式