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1. 发明授权

US08852557B2 Aerosols for sinunasal drug delivery 有权
标题翻译：鼻窦药物输送用气溶胶
公开(公告)号：US08852557B2
公开(公告)日：2014-10-07
申请号：US12675257
申请日：2008-08-29
申请人： Manfred Keller , Uwe Schuschnig , Johann Zimmermann , Martin Luber , Andreas Böhm
发明人： Manfred Keller , Uwe Schuschnig , Johann Zimmermann , Martin Luber , Andreas Böhm
IPC分类号： A01N25/02 , A61K9/12 , B05B17/06 , A61M11/00 , A61K9/00 , A61M15/00
CPC分类号： A61M11/005 , A61K9/0043 , A61K9/0078 , A61K9/008 , A61K31/7052 , A61M11/00 , A61M15/0085
摘要： A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterized in that it exhibits a low effective flow rate of less than about 5 liters per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.
摘要翻译：公开了一种适用于将活性化合物递送至鼻粘膜，骨产生复合体或鼻旁窦的药物气溶胶。气溶胶的压力不是恒定的，而是以约10至90Hz的频率脉动。气溶胶的特征还在于它具有小于约5升/分钟的低有效流速。气溶胶尤其适用于预防，治疗或治疗影响鼻子或鼻旁窦的疾病，症状或病症，例如急性和慢性鼻窦炎。

2. 发明申请

US20100316576A1 AEROSOLS FOR SINUNASAL DRUG DELIVERY 有权
标题翻译：航空药物交付使用
公开(公告)号：US20100316576A1
公开(公告)日：2010-12-16
申请号：US12675257
申请日：2008-08-29
申请人： Manfred Keller , Uwe Schuschnig , Johann Zimmermann , Martin Luber , Andreas Böhm
发明人： Manfred Keller , Uwe Schuschnig , Johann Zimmermann , Martin Luber , Andreas Böhm
IPC分类号： A61K9/12 , A61P11/06 , A61P11/02 , A61P11/00 , A61M11/00
CPC分类号： A61M11/005 , A61K9/0043 , A61K9/0078 , A61K9/008 , A61K31/7052 , A61M11/00 , A61M15/0085
摘要： A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterised in that it exhibits a low effective flow rate of less than about 5 litres per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.
摘要翻译：公开了一种适用于将活性化合物递送至鼻粘膜，骨产生复合体或鼻旁窦的药物气溶胶。气溶胶的压力不是恒定的，而是以约10至90Hz的频率脉动。气溶胶的特征还在于它具有小于约5升/分钟的低有效流速。气溶胶尤其适用于预防，治疗或治疗影响鼻子或鼻旁窦的疾病，症状或病症，例如急性和慢性鼻窦炎。

3. 发明授权

US09717867B2 Method for operating an aerosol inhalation device and aerosol inhalation device 有权
公开(公告)号：US09717867B2
公开(公告)日：2017-08-01
申请号：US13203284
申请日：2009-02-27
申请人： Martin Luber , Andreas Boehm , Uwe Schuschnig , Axel Krüner
发明人： Martin Luber , Andreas Boehm , Uwe Schuschnig , Axel Krüner
IPC分类号： A61M11/00 , A61M16/00 , A61M15/00
CPC分类号： A61M15/0085 , A61M2205/3386
摘要： In a first aspect, the invention relates to a method for operating an aerosol inhalation device (10), comprising the steps of transporting a certain amount of an aerosol to a desired location outside said device (10) and vibrating the transported aerosol when it has reached said desired location. In a second aspect, the invention relates to an aerosol inhalation device (10) comprising a pump (1) for flowing a certain amount of an aerosol to a desired location outside the device (10), a vibrator (2) for vibrating the transported aerosol in a vibration mode and a control configured to actuate the vibrator (2) for vibrating the flowed aerosol only when it has reached said desired location.

4. 发明授权

US08347878B2 Aerosol therapy device 失效
标题翻译：气溶胶治疗仪
公开(公告)号：US08347878B2
公开(公告)日：2013-01-08
申请号：US12080843
申请日：2008-04-07
申请人： Uwe Schuschnig , Martin Luber , Wolfgang Achtzehner
发明人： Uwe Schuschnig , Martin Luber , Wolfgang Achtzehner
IPC分类号： A61M11/00
CPC分类号： A61M15/0085 , A61M15/08 , A61M16/0006 , A61M2016/0021 , A61M2016/0027
摘要： Aerosol therapy device comprising a nebuliser (10) for generating an aerosol and forming an aerosol flow, a first nosepiece (11) for introducing the aerosol flow into one of the two nostrils (12) of a user, a pressure fluctuation source for generating a pressure fluctuation (DS), a second nosepiece (14) for introducing the pressure fluctuation into the other of the two nostrils (15) of the user in order to superimpose the pressure fluctuation and the aerosol flow, and a sensor system comprising a first pressure sensor (19) for detecting the signal of the pressure fluctuation that arrives at the first nosepiece (11), and an evaluation means (18) that concludes the degree of closure of the velum of the user based on the signal.
摘要翻译：气溶胶治疗装置，包括用于产生气溶胶并形成气溶胶流的雾化器（10），用于将气溶胶流引入用户的两个鼻孔（12）之一的第一鼻梁（11），用于产生气溶胶流的压力波动源压力波动（DS），用于将压力波动引入用户的两个鼻孔（15）中的另一个中的第二鼻梁（14），以便叠加压力波动和气溶胶流;以及传感器系统，包括第一压力用于检测到达第一鼻梁（11）的压力波动的信号的传感器（19）;以及评估装置（18），其基于该信号来确定用户的绒毛的闭合程度。

5. 发明申请

US20080251068A1 Aerosol therapy device 失效
标题翻译：气溶胶治疗仪
公开(公告)号：US20080251068A1
公开(公告)日：2008-10-16
申请号：US12080843
申请日：2008-04-07
申请人： Uwe Schuschnig , Martin Luber , Wolfgang Achtzehner
发明人： Uwe Schuschnig , Martin Luber , Wolfgang Achtzehner
IPC分类号： A61M11/00
CPC分类号： A61M15/0085 , A61M15/08 , A61M16/0006 , A61M2016/0021 , A61M2016/0027
摘要： Aerosol therapy device comprising a nebuliser (10) for generating an aerosol and forming an aerosol flow, a first nosepiece (11) for introducing the aerosol flow into one of the two nostrils (12) of a user, a pressure fluctuation source for generating a pressure fluctuation (DS), a second nosepiece (14) for introducing the pressure fluctuation into the other of the two nostrils (15) of the user in order to superimpose the pressure fluctuation and the aerosol flow, and a sensor system comprising a first pressure sensor (19) for detecting the signal of the pressure fluctuation that arrives at the first nosepiece (11), and an evaluation means (18) that concludes the degree of closure of the velum of the user based on the signal.
摘要翻译：气溶胶治疗装置，包括用于产生气溶胶并形成气溶胶流的雾化器（10），用于将气溶胶流引入用户的两个鼻孔（12）之一的第一鼻梁（11），用于产生气溶胶流的压力波动源压力波动（DS），用于将压力波动引入用户的两个鼻孔（15）中的另一个中的第二鼻梁（14），以便叠加压力波动和气溶胶流;以及传感器系统，包括第一压力用于检测到达第一鼻梁（11）的压力波动的信号的传感器（19）;以及评估装置（18），其基于该信号来确定用户的绒毛的闭合程度。

6. 发明申请

US20070202051A1 Aerosols for sinunasal drug delivery 审中-公开
标题翻译：鼻窦药物输送用气溶胶
公开(公告)号：US20070202051A1
公开(公告)日：2007-08-30
申请号：US11704659
申请日：2007-02-09
申请人： Uwe Schuschnig
发明人： Uwe Schuschnig
IPC分类号： A61K9/12 , A61K31/573 , A61K38/00 , A61K31/724 , A61K31/717 , A61K9/127
CPC分类号： A61K9/0043
摘要： A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nasal cavity or of the paranasal sinuses. The aerosol is characterised in that its pressure is not constant, but pulsates at a frequency of about 10 to 90 Hz. The mass median diameter of the dispersed phase is from about 2 to 6 μm, and the volume of about 5 mL or less of the dispersed phase comprises a unit dose of an active compound. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.
摘要翻译：公开了适于将活性化合物递送至鼻腔或鼻旁窦粘膜的药物气溶胶。气溶胶的特征在于其压力不是恒定的，而是在约10至90Hz的频率下脉动。分散相的质量中值粒径为约2〜6μm，分散相约5mL以下的体积为单位剂量的活性化合物。气溶胶尤其适用于预防，治疗或治疗影响鼻子或鼻旁窦的疾病，症状或病症，例如急性和慢性鼻窦炎。

7. 发明申请

US20130112197A1 OPERATING METHOD FOR AN AEROSOL DELIVERY DEVICE AND AEROSOL DELIVERY DEVICE 审中-公开
标题翻译：航空运输装置和航空运输装置的操作方法
公开(公告)号：US20130112197A1
公开(公告)日：2013-05-09
申请号：US13643585
申请日：2011-04-26
申请人： Axel Krüner , Elisabeth Klopfer , Uwe Schuschnig , René Seifert
发明人： Axel Krüner , Elisabeth Klopfer , Uwe Schuschnig , René Seifert
IPC分类号： A61M16/14
CPC分类号： A61M16/14 , A61M11/005 , A61M15/0085 , A61M15/08 , A61M16/0006 , A61M16/0063 , A61M2209/02 , A61M2210/0681
摘要： The invention relates to a method for operating an aerosol delivery device (10), comprising the steps of generating a predetermined amount of an aerosol in the device (10) and inducing a transport flow in the device (10) for transporting at least a portion of the predetermined amount of the aerosol outside the device (10). During the aerosol generating step, the transport flow is first induced, then stopped after a predetermined first period of time and then induced again after a predetermined second period of time. Further, the invention relates to an aerosol delivery device (10) comprising an aerosol generator (3) for generating an aerosol in the device (10), a gas conveying element (1} for inducing a transport flow in the device (10) for transporting at least a portion of the generated aerosol outside the device (10), and a control configured, during the aerosol generating step, to first activate the gas conveying element (1), then deactivate the gas conveying element (1) after a predetermined first period of time and then activate the gas conveying element (1) again after a predetermined second period of time, so that the transport flow is first induced, then stopped after the first period of time and then induced again after the second period of time.
摘要翻译：本发明涉及一种用于操作气溶胶输送装置（10）的方法，包括以下步骤：在所述装置（10）中产生预定量的气溶胶并且在所述装置（10）中引起运输流，用于输送至少一部分在装置（10）外部的预定量的气溶胶。在气溶胶生成步骤期间，首先感应输送流，然后在预定的第一时间段之后停止，然后在预定的第二时间段之后再次诱导。此外，本发明涉及一种气溶胶输送装置（10），其包括用于在装置（10）中产生气溶胶的气溶胶发生器（3），用于在装置（10）中诱导运输流动的气体输送元件（1），用于将产生的气溶胶的至少一部分运送到装置（10）外部;以及控制装置，其在烟雾发生步骤期间首先启动气体输送元件（1），然后在预定的气体输送元件第一时间段，然后在预定的第二时间段之后再次启动气体输送元件（1），使得首先感应输送流，然后在第一时间段之后停止，然后在第二时间段之后再次诱导。

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