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1. 发明授权

US08911684B2 Microfluidic element for analyzing a liquid sample 有权
标题翻译：用于分析液体样品的微流体元件
公开(公告)号：US08911684B2
公开(公告)日：2014-12-16
申请号：US13487707
申请日：2012-06-04
申请人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
IPC分类号： B01L99/00 , B01F11/00 , B01F1/00 , B01F13/00 , B01L3/00 , B01F15/02 , B01F9/00
CPC分类号： B01F1/0027 , B01F9/0014 , B01F11/0002 , B01F13/0059 , B01F15/0203 , B01F15/0233 , B01L3/502746 , B01L2200/16 , B01L2400/0409 , B01L2400/086
摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.
摘要翻译：提供了用于分析其中包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得液体样品可以流入旋转轴远端试剂室。至少一个试剂室含有与液体样品反应的试剂。

2. 发明申请

US20120301371A1 MICROFLUIDIC ELEMENT FOR ANALYZING A LIQUID SAMPLE 有权
标题翻译：用于分析液体样品的微流体元件
公开(公告)号：US20120301371A1
公开(公告)日：2012-11-29
申请号：US13487707
申请日：2012-06-04
申请人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01F1/0027 , B01F9/0014 , B01F11/0002 , B01F13/0059 , B01F15/0203 , B01F15/0233 , B01L3/502746 , B01L2200/16 , B01L2400/0409 , B01L2400/086
摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.
摘要翻译：提供了用于分析其中包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得液体样品可以流入旋转轴远端试剂室。至少一个试剂室含有与液体样品反应的试剂。

3. 发明申请

US20130236376A1 Microfluidic Test Carrier for Apportioning a Liquid Quantity Into Subquantities 有权
标题翻译：用于将液体数量分配到子品质中的微流体测试载体
公开(公告)号：US20130236376A1
公开(公告)日：2013-09-12
申请号：US13871720
申请日：2013-04-26
申请人： Manfred Augstein , Christoph Boehm , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502723 , B01L3/502738 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2200/141 , B01L2300/0806 , B01L2300/0851 , B01L2300/087 , B01L2400/0409 , B01L2400/0688
摘要： A microfluidic test carrier having a substrate, covering layer, and capillary structure formed in the substrate is provided. The capillary structure is enclosed by the substrate and covering layer and comprises a receiving chamber, sample chamber and connection channel between the receiving and sample chambers. The receiving chamber has two boundary surfaces and a side wall, wherein one boundary surface forms the bottom and the other forms the cover. The receiving chamber has a surrounding venting channel and dam between the receiving chamber and venting channel. The dam and venting channel form a capillary stop configured as a geometric valve, through which air from the receiving chamber can escape into the venting channel. The connecting channel between the venting channel outflow and sample chamber inflow controls fluid transport from the receiving chamber into the sample chamber. The capillary stop is configured to prevent autonomous fluid transport from the receiving chamber.
摘要翻译：提供了一种在基板上形成的具有基板，覆盖层和毛细结构的微流体测试载体。毛细管结构由衬底和覆盖层包围，并包括接收室，样品室和接收室和样品室之间的连接通道。接收室具有两个边界面和侧壁，其中一个边界表面形成底部，另一个形成盖。接收室具有周围的通风通道，并且在接收室和通风通道之间具有阻塞。大坝和排气通道形成一个被设计为几何阀的毛细管阻塞，来自接收室的空气可以通过该几何阀排出到通风通道中。排气通道出口和样品室流入之间的连接通道控制从接收室进入样品室的流体输送。毛细管止动件被构造成防止自主流体从接收室输送。

4. 发明申请

US20110183432A1 TEST ELEMENT FOR ANALYZING AN ANALYTE PRESENT IN A SAMPLE OF A BODY FLUID, ANALYSIS SYSTEM AND METHOD FOR CONTROLLING THE MOVEMENT OF A FLUID CONTAINED IN A CHANNEL OF A TEST ELEMENT 审中-公开
标题翻译：用于分析体液中分析物的分析测试元件，分析系统和控制测试单元的通道中流体运动的方法
公开(公告)号：US20110183432A1
公开(公告)日：2011-07-28
申请号：US13008104
申请日：2011-01-18
申请人： Manfred Augstein , Susanne Wuerl
发明人： Manfred Augstein , Susanne Wuerl
IPC分类号： G01N1/28 , G01N33/48
CPC分类号： F04F3/00 , B01L3/502723 , B01L3/50273 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , B01L2400/0409 , B01L2400/0463 , B01L2400/049 , B01L2400/0688 , F04F5/24 , G01N21/03 , G01N2021/0328 , G01N2021/0346 , Y10T436/25
摘要： Embodiments disclosed herein include an analysis system for the analysis of a body fluid sample for an analyte contained therein, comprising a test element and an evaluation device having a measuring station for measuring a measuring variable on the measuring zone of the test element. Also included is a mounting to hold a test element, the test element having an airflow channel with two expansion sections and a narrow section located between these expansion sections. The expansion sections may have a cross-sectional area that increases in comparison to the narrow section in the direction away therefrom. A connection channel is located between the narrow section and the analysis function channel such that an air exchange connection is formed. The airflow channel is located in such a manner that a partial vacuum, which is generated using an airflow flowing through the airflow channel, acts on the analysis function channel.
摘要翻译：本文公开的实施方案包括用于分析其中包含的分析物的体液样品的分析系统，包括测试元件和具有用于测量测试元件的测量区域上的测量变量的测量站的评估装置。还包括用于保持测试元件的安装件，测试元件具有带有两个膨胀部分的气流通道和位于这些膨胀部分之间的窄部分。膨胀部分可以具有与沿着远离其的方向与窄部分相比增加的横截面面积。连接通道位于狭窄部分和分析功能通道之间，从而形成空气交换连接。气流通道以这样的方式定位，即使用流过气流通道的气流产生的部分真空作用在分析功能通道上。

5. 发明授权

US08790932B2 Method for providing a dried reagent in a microfluidic system and microfluidic system 有权
标题翻译：在微流体系统和微流体系统中提供干燥试剂的方法
公开(公告)号：US08790932B2
公开(公告)日：2014-07-29
申请号：US12573472
申请日：2009-10-05
申请人： Manfred Augstein , Romi Roedl , Susanne Wuerl , Valerie Winckler-Desprez
发明人： Manfred Augstein , Romi Roedl , Susanne Wuerl , Valerie Winckler-Desprez
IPC分类号： G01N1/42 , B05D1/26 , B01J19/00
CPC分类号： B01L3/502707 , B01L7/00 , B01L2200/12 , B01L2200/16 , F26B5/06
摘要： A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization.
摘要翻译：提供了一种在微流体系统中提供干燥试剂的方法，该方法包括以下步骤：提供具有微流体结构的微流体系统，将含有试剂的可流动载体介质引入微流体结构中，并干燥微流体中的试剂冻结结构。

6. 发明申请

US20100112717A1 Method for Providing a Dried Reagent in a Microfluidic System and Microfluidic System 有权
标题翻译：在微流体系统和微流体系统中提供干试剂的方法
公开(公告)号：US20100112717A1
公开(公告)日：2010-05-06
申请号：US12573472
申请日：2009-10-05
申请人： Manfred Augstein , Romi Roedl , Susanne Wuerl , Valerie Winckler-Desprez
发明人： Manfred Augstein , Romi Roedl , Susanne Wuerl , Valerie Winckler-Desprez
IPC分类号： G01N1/00 , B01J19/00
CPC分类号： B01L3/502707 , B01L7/00 , B01L2200/12 , B01L2200/16 , F26B5/06
摘要： A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization.
摘要翻译：提供了一种在微流体系统中提供干燥试剂的方法，该方法包括以下步骤：提供具有微流体结构的微流体系统，将含有试剂的可流动载体介质引入微流体结构中，并干燥微流体中的试剂冻结结构。

7. 发明授权

US08545774B2 Electrical connection system for an electrochemical analysis system 有权
标题翻译：电化学分析系统的电气连接系统
公开(公告)号：US08545774B2
公开(公告)日：2013-10-01
申请号：US12791500
申请日：2010-06-01
申请人： Stefan Riebel , Bruno Robert Thoes , Manfred Augstein , Herbert Wieder , Gregor Bainczyk
发明人： Stefan Riebel , Bruno Robert Thoes , Manfred Augstein , Herbert Wieder , Gregor Bainczyk
IPC分类号： B01L99/00 , G01N15/06 , G01N27/00
CPC分类号： G01N33/4875 , Y10T29/49002
摘要： An electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system are disclosed. The analysis system provides an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and an electrical contact element which makes electrical contact with an electrical contact surface of an analytical test element to produce an electrical connection between the contact surface and the evaluation appliance. The contact element is moved by means such that contact with the electrical contact surface of the test element is made when the test element holder is in the measurement position.
摘要翻译：公开了一种用于分析系统的电连接系统和使用所述分析系统分析测试元件上的液体样品的方法。分析系统提供用于评估电信号的评估装置，用于在测量位置保持和定位分析测试元件的测试元件保持器，以及与分析测试元件的电接触表面电接触的电接触元件以在接触表面和评估设备之间产生电连接。接触元件通过使得当测试元件保持器处于测量位置时与测试元件的电接触表面的接触而移动。

8. 发明申请

US20110182774A1 Plastic Injection-Moulded Part With Embedded Component 有权
标题翻译：带嵌入式部件的注塑成型件
公开(公告)号：US20110182774A1
公开(公告)日：2011-07-28
申请号：US13081724
申请日：2011-04-07
申请人： Manfred Augstein
发明人： Manfred Augstein
IPC分类号： G01N33/00
CPC分类号： A61B5/1491 , A61B5/14532 , A61B2562/12 , B29C45/14434 , B29K2709/08
摘要： A method for producing a plastic injection-moulded part having an insert made of a material different from the plastic material is provided, the method comprising the steps of: (a) introducing and positioning the insert in a cavity of an injection mould; (b) setting the clamping force of the injection mould on a clamping mechanism to a maximum force predetermined by the material of the insert; and (c) seamlessly encapsulating the insert with the plastic material of the plastic injection-moulded part inside the injection mould, wherein the encapsulating is seamless or complete.
摘要翻译：提供了一种用于制造具有由与塑料材料不同的材料制成的嵌件的塑料注模部件的方法，该方法包括以下步骤：（a）将插入件引入并定位在注射模具的空腔中; （b）将注射模具的夹持力设定在夹持机构上至由插入件的材料预定的最大力; 以及（c）将所述插入物与塑料注射成型部件的塑料材料无缝地包封在注射模具内，其中封装是无缝的或完整的。

9. 发明申请

US20080217407A1 Host Apparatus and Method Providing Calibration and Reagent Information to a Measurement Apparatus with Makes Use of a Consumable Reagent in a Measuring Process 有权
标题翻译：主机装置和方法向测量装置提供校准和试剂信息，在测量过程中使用消耗性试剂
公开(公告)号：US20080217407A1
公开(公告)日：2008-09-11
申请号：US11914405
申请日：2006-05-16
申请人： Friedrich Karl Ackermann , Manfred Augstein , Timothy L. Beck , Markus Stephan Fuerst , Robert Lawrence Meek , Phillip Edgar Pash , Blaine Edward Ramey , Robert Paul Sabo , Matthew Carlyle Sauers , Joerg Schreiber , Wolfgang Walter , Seeth Faulkner Williams , Frederick Leland Wittekind
发明人： Friedrich Karl Ackermann , Manfred Augstein , Timothy L. Beck , Markus Stephan Fuerst , Robert Lawrence Meek , Phillip Edgar Pash , Blaine Edward Ramey , Robert Paul Sabo , Matthew Carlyle Sauers , Joerg Schreiber , Wolfgang Walter , Seeth Faulkner Williams , Frederick Leland Wittekind
IPC分类号： G06K7/01
CPC分类号： G16H40/40 , A61B5/14532 , A61B2560/0223 , A61B2560/0271 , G06F19/00
摘要： Apparatuses and methods providing data such as, for example, calibration and reagent information (30) over a network (6) to a measurement apparatus (4) which makes use of a consumable reagent (18) in a measuring process are disclosed. The present invention permits a measurement apparatus (4) to download the necessary code assignment (24) and calibration data (32) of the consumable reagent (18) by means of an electronic communication protocol from a host (33). The host (33) can be a software application running on a host computer (34), another measurement apparatus (50, 58) with or without a code-key slot used to read a memory device providing the above mentioned information (30), a dedicated connectivity device, such as a docking station (44), a portable memory reader (48), a remote computer (54), and combinations thereof.
摘要翻译：公开了一种在测量过程中通过网络（6）提供诸如校准和试剂信息（30）等数据的设备和方法，该测量设备利用消耗试剂（18）测量设备（4）。本发明允许测量装置（4）借助于来自主机（33）的电子通信协议下载可消耗试剂（18）的必要代码分配（24）和校准数据（32）。主机（33）可以是在主计算机（34）上运行的软件应用程序，具有或不具有用于读取提供上述信息（30）的存储器件的代码键槽的另一测量装置（50,58）专用连接装置，例如对接站（44），便携式存储器读取器（48），远程计算机（54）及其组合。

10. 发明申请

US20060152207A1 Electrical connection system for an electrochemical analysis system 失效
标题翻译：电化学分析系统的电气连接系统
公开(公告)号：US20060152207A1
公开(公告)日：2006-07-13
申请号：US11295187
申请日：2005-12-06
申请人： Stefan Riebel , Bruno Thoes , Manfred Augstein , Herbert Wieder , Gregor Bainczyk
发明人： Stefan Riebel , Bruno Thoes , Manfred Augstein , Herbert Wieder , Gregor Bainczyk
IPC分类号： G01N27/00
CPC分类号： G01N33/4875 , Y10T29/49002
摘要： The invention relates to an electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system. The analysis system comprises an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and at least one electrical contact element configured to make electrical contact with at least one electrical contact surface of an analytical test element, and to produce an electrical connection between the contact surface and the evaluation appliance. The at least one contact element is arranged to move to contact the contact surface of a test element held either in a fixed test element holder or a moveable test element holder, such as a slide. Furthermore, the analysis system has a means for moving the electrical contact element to the electrical contact surface of an analytical test element when the test element holder is in the measurement position.
摘要翻译：本发明涉及用于分析系统的电连接系统和使用所述分析系统分析测试元件上的液体样品的方法。分析系统包括用于评估电信号的评估装置，用于在测量位置保持和定位分析测试元件的测试元件保持器，以及配置成与至少一个电接触表面进行电接触的至少一个电接触元件的分析测试元件，并且在接触表面和评估设备之间产生电连接。所述至少一个接触元件布置成移动以接触保持在固定测试元件保持器或可移动测试元件保持器（例如滑块）中的测试元件的接触表面。此外，分析系统具有当测试元件保持器处于测量位置时将电接触元件移动到分析测试元件的电接触表面的装置。

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