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1. 发明申请

US20110257102A1 COMPOSITIONS AND METHODS OF TREATING CANCER 有权
标题翻译：治疗癌症的组合物和方法
公开(公告)号：US20110257102A1
公开(公告)日：2011-10-20
申请号：US13141437
申请日：2009-12-23
申请人： Man-Sun Sy , Wei Xin , Chaoyang Li , Shuiliang Yi , Shaoman Yin
发明人： Man-Sun Sy , Wei Xin , Chaoyang Li , Shuiliang Yi , Shaoman Yin
IPC分类号： A61K38/08 , A61P35/04 , A61P35/00 , A61K38/10 , A61K38/17
CPC分类号： A61K31/7088 , A61K31/00 , A61K38/1709 , A61K38/177
摘要： A method of inhibiting neoplastic, cancer, and/or tumorgenic cell proliferation, cell growth and motility in a subject includes administering to a cancer cell expressing Pro-PrP and FLNa a therapeutically effective amount of a Pro-PrP regulating agent.
摘要翻译：在受试者中抑制肿瘤，癌症和/或肿瘤细胞增殖，细胞生长和运动的方法包括向表达Pro-PrP和FLNa的癌细胞施用治疗有效量的Pro-PrP调节剂。

2. 发明授权

US08158373B2 Method of detecting cancer and evaluating cancer prognosis 有权
标题翻译：检测癌症和评估癌症预后的方法
公开(公告)号：US08158373B2
公开(公告)日：2012-04-17
申请号：US12410867
申请日：2009-03-25
申请人： Man-Sun Sy , Wei Xin
发明人： Man-Sun Sy , Wei Xin
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57438
摘要： A method of detecting cancer in a subject is provided. One step of the method includes obtaining a bodily sample from the subject. Next, the level of pro-prion protein (pro-PrP) in the bodily sample is detected. The level of pro-PrP in the bodily sample is then compared to a control level. An increased level of pro-PrP in the bodily sample as compared to the control level indicates that the subject has cancer or an elevated risk of having cancer.
摘要翻译：提供了一种检测受试者中癌症的方法。该方法的一个步骤包括从受试者获得身体样品。接下来，检测身体样品中的前朊蛋白（pro-PrP）水平。然后将身体样品中的亲PrP水平与对照水平进行比较。与对照水平相比，身体样品中PrP的水平升高表明该受试者患有癌症或具有升高的癌症风险。

3. 发明申请

US20080057523A1 Detection of Protein Aggregates by Homologous Elisa 审中-公开
标题翻译：通过同源Elisa检测蛋白质聚集体
公开(公告)号：US20080057523A1
公开(公告)日：2008-03-06
申请号：US11575230
申请日：2005-09-16
申请人： Man-Sun Sy , Tao Pan , Ruliang Li
发明人： Man-Sun Sy , Tao Pan , Ruliang Li
IPC分类号： G01N33/00 , G01N33/53
CPC分类号： G01N33/53 , G01N33/6896 , G01N2800/2828
摘要： A method of detecting disease related protein aggregate in a sample comprises using a capture monoclonal antibody and detecting-monoclonal antibody. The capture monoclonal antibody and the detecting monoclonal antibody are identical.
摘要翻译：检测样品中疾病相关蛋白聚集体的方法包括使用捕获单克隆抗体和检测单克隆抗体。捕获单克隆抗体和检测单克隆抗体是相同的。

4. 发明授权

US06528269B1 Immunological agents specific for prion protein (PRP) 失效
标题翻译：对朊蛋白（PRP）特异性的免疫学试剂
公开(公告)号：US06528269B1
公开(公告)日：2003-03-04
申请号：US09204816
申请日：1998-12-03
申请人： Man-Sun Sy , Pierluigi Gambetti
发明人： Man-Sun Sy , Pierluigi Gambetti
IPC分类号： G01N3353
CPC分类号： G01N33/6896 , C07K14/47 , C07K16/18 , C07K2317/73 , G01N2800/2828
摘要： The present invention is directed to a panel of monoclonal antibodies (Mabs) specific for murine prion protein PrPc. These Mabs can be applied to immunoblotting, cell surface immunofluorescent staining and immunohistochemistry at light and electron microscopy. Additionally, these Mabs recognize both the normal (PrPc) and protease-resistant (PrPres) isoforms of PrP. Some Mabs are species restricted, while others react with PrP from a broad range of mammals including mice, humans, monkeys, cows, sheep, squirrels and hamsters. Moreover, several of the Mabs selectively recognize different PrP glycoforms as well as the metabolic fragments of PrPc. These newly generated PrPc antibodies are useful for exploring the biology of PrPc and to establish the diagnosis of prion diseases in both humans and animals.
摘要翻译：本发明涉及一种对鼠朊蛋白PrPc特异性的单克隆抗体（Mabs）。这些Mabs可以应用于免疫印迹，细胞表面免疫荧光染色和免疫组织化学在光和电子显微镜。此外，这些Mabs识别PrP的正常（PrPc）和蛋白酶抗性（PrPres）同种型。一些Mab是物种限制的，而其他Mab与来自广泛哺乳动物（包括小鼠，人类，猴子，牛，绵羊，松鼠和仓鼠）的PrP反应。此外，几种Mab选择性地识别不同的PrP糖型以及PrPc的代谢片段。这些新生成的PrPc抗体可用于探索PrPc的生物学和建立人类和动物中朊病毒疾病的诊断。

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