会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • PHARMACEUTICAL FOR USE IN THE TREATMENT OF URETEROLITHIASIS
    • 用于治疗尿毒症的药物
    • US20110230538A1
    • 2011-09-22
    • US13086040
    • 2011-04-13
    • Mamoru KobayashiYoshitaka TomiyamaKumi Kobayashi
    • Mamoru KobayashiYoshitaka TomiyamaKumi Kobayashi
    • A61K31/404A61P13/12A61P25/04
    • C07D209/08A61K31/4045
    • The present invention provides pharmaceutical compositions useful for relieving pain caused by ureteral calculi, facilitating exclusion of ureteral calculi or the like. That is, the present invention provides a pharmaceutical composition for the treatment of ureteral lithiasis, which comprises as an active ingredient an indoline derivative represented by the following general formula (I) or a salt thereof. In the formula, R represents saturated or unsaturated aliphatic acyl which may have a substituent; hydroxyalkyl; aliphatic acyloxyalkyl; lower alkyl which has as a substituent lower alkoxy, carboxy, lower alkoxycarbonyl, aryl-substituted lower alkoxycarbonyl, carbamoyl, mono or di (lower alkyl)-substituted carbamoyl or cyano; optionally substituted aromatic acyl; furoyl or pyridylcarbonyl; R1 represents cyano or carbamoyl; and R2 represents lower alkyl which may have as a substituent halogen, cyano or aryl.
    • 本发明提供了用于缓解由输尿管结石引起的疼痛,有助于排除输尿管结石等的药物组合物。 也就是说,本发明提供了用于治疗输尿管结石的药物组合物,其包含作为活性成分的由以下通式(I)表示的二氢吲哚衍生物或其盐。 在该式中,R表示可具有取代基的饱和或不饱和脂肪族酰基; 羟烷基 脂肪酰氧基烷基; 羧基,低级烷氧基羰基,芳基取代的低级烷氧基羰基,氨基甲酰基,一或二(低级烷基)取代的氨基甲酰基或氰基的低级烷基; 任选取代的芳族酰基; 糠酰基或吡啶基羰基; R1表示氰基或氨基甲酰基; 并且R 2表示可以具有卤素,氰基或芳基的取代基的低级烷基。
    • 2. 发明申请
    • PHARMACEUTICAL FOR USE IN THE TREATMENT OF URETEROLITHIASIS
    • 用于治疗尿毒症的药物
    • US20090163571A1
    • 2009-06-25
    • US12093230
    • 2006-11-22
    • Mamoru KobayashiYoshitaka TomiyamaKumi Kobayashi
    • Mamoru KobayashiYoshitaka TomiyamaKumi Kobayashi
    • A61K31/404A61P13/00
    • C07D209/08A61K31/4045
    • The present invention provides pharmaceutical compositions useful for relieving pain caused by ureteral calculi, facilitating exclusion of ureteral calculi or the like. That is, the present invention provides a pharmaceutical composition for the treatment of ureteral lithiasis, which comprises as an active ingredient an indoline derivative represented by the following general formula (I) or a salt thereof. In the formula, R represents saturated or unsaturated aliphatic acyl which may have a substituent; hydroxyalkyl; aliphatic acyloxyalkyl; lower alkyl which has as a substituent lower alkoxy, carboxy, lower alkoxycarbonyl, aryl-substituted lower alkoxycarbonyl, carbamoyl, mono or di(lower alkyl)-substituted carbamoyl or cyano; optionally substituted aromatic acyl; furoyl or pyridylcarbonyl; R1 represents cyano or carbamoyl; and R2 represents lower alkyl which may have as a substituent halogen, cyano or aryl.
    • 本发明提供了用于缓解由输尿管结石引起的疼痛,有助于排除输尿管结石等的药物组合物。 也就是说,本发明提供了用于治疗输尿管结石的药物组合物,其包含作为活性成分的由以下通式(I)表示的二氢吲哚衍生物或其盐。 在该式中,R表示可具有取代基的饱和或不饱和脂肪族酰基; 羟烷基; 脂肪酰氧基烷基; 羧基,低级烷氧基羰基,芳基取代的低级烷氧基羰基,氨基甲酰基,一或二(低级烷基)取代的氨基甲酰基或氰基的低级烷基; 任选取代的芳族酰基; 糠酰基或吡啶基羰基; R1表示氰基或氨基甲酰基; 并且R 2表示可以具有卤素,氰基或芳基的取代基的低级烷基。