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1. 发明授权

US4480614A Idling speed control device of an internal combustion engine 失效
标题翻译：内燃机的怠速控制装置
公开(公告)号：US4480614A
公开(公告)日：1984-11-06
申请号：US488820
申请日：1983-04-26
申请人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
发明人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
IPC分类号： F02M3/07 , H02K7/06 , F02M3/00
CPC分类号： F02M3/075 , H02K7/06 , Y10T74/18664
摘要： An idling speed control device of an internal combustion engine comprising a bypass passage which interconnects the intake passage located upstream of the throttle valve to the intake passage located downstream of the throttle valve. A flow control valve is arranged in the bypass passage and actuated by a step motor for controlling the amount of air flowing within the bypass passage to maintain the idling speed of an engine at a predetermined speed. The step motor comprises a screw threaded valve shaft and a rotor rotatably mounted on the valve shaft and having a screw threaded center hole which is in engagement with the screw threads of the valve shaft. A pair of stop pins, each being engageable with the corresponding end face of the rotor, is fixed onto the valve shaft.
摘要翻译：一种内燃机的怠速调速装置，其特征在于，具备将位于所述节流阀上游的进气通路与位于所述节流阀下游的进气通路相互连接的旁路通路。流量控制阀设置在旁路通道中并由步进电机致动，用于控制在旁路通道内流动的空气量，以将发动机的空转速度保持在预定速度。步进电动机包括螺旋阀轴和可旋转地安装在阀轴上并具有与阀轴的螺纹接合的螺纹中心孔的转子。一对可与转子的相应端面接合的止动销固定在阀轴上。

2. 发明授权

US4412517A Idling speed control device of an internal combustion engine 失效
标题翻译：内燃机的怠速控制装置
公开(公告)号：US4412517A
公开(公告)日：1983-11-01
申请号：US256188
申请日：1981-04-21
申请人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
发明人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
IPC分类号： F02M3/07 , H02K7/06 , F02M3/00
CPC分类号： H02K7/06 , F02M3/075 , Y10T74/18664
摘要： An idling speed control device of an internal combustion engine comprising a bypass passage which interconnects the intake passage located upstream of the throttle valve to the intake passage located downstream of the throttle valve. A flow control valve is arranged in the bypass passage and actuated by a step motor for controlling the amount of air flowing within the bypass passage to maintain the idling speed of an engine at a predetermined speed. The step motor comprises a screw threaded valve shaft and a rotor rotatably mounted on the valve shaft and having a screw threaded center hole which is in engagement with the screw threads of the valve shaft. The valve shaft is supported by bearings so that the valve shaft cannot be rotated, but is able to move in the axial direction.
摘要翻译：一种内燃机的怠速调速装置，其特征在于，具备将位于所述节流阀上游的进气通路与位于所述节流阀下游的进气通路相互连接的旁路通路。流量控制阀设置在旁路通道中并由步进电机致动，用于控制在旁路通道内流动的空气量，以将发动机的空转速度保持在预定速度。步进电动机包括螺旋阀轴和可旋转地安装在阀轴上并具有与阀轴的螺纹接合的螺纹中心孔的转子。阀轴由轴承支撑，使得阀轴不能旋转，而是能够沿轴向移动。

3. 发明授权

US4432318A Device of controlling the idling speed of an engine 失效
标题翻译：控制发动机空转速度的装置
公开(公告)号：US4432318A
公开(公告)日：1984-02-21
申请号：US335819
申请日：1981-12-30
申请人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
发明人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
IPC分类号： F02D41/16 , F02D31/00 , F02M69/32 , F02D11/10
CPC分类号： F02D31/003 , F02D31/005 , F02D2011/102
摘要： An engine comprising a main intake passage having a throttle valve therein. A bypass passage is branched off from the main intake passage located upstream of the throttle valve and is connected to the main intake passage located downstream of the throttle valve. A flow control valve, actuated by a step motor, is arranged in the bypass passage. The step motor comprises a rotor and a stator having exciting coils. When the engine is operating in an idling state, the exciting coils are excited for rotating the step motor in a rotating direction wherein the engine speed approaches a desired idling speed. When the engine speed becomes equal to the desired engine speed, the exciting operation of the exciting coils is stopped.
摘要翻译：一种发动机，包括其中具有节流阀的主进气通道。旁通通道从位于节流阀上游的主进气通道分支，并连接到位于节流阀下游的主进气通道。由旁通通道设置由步进电动机驱动的流量控制阀。步进马达包括具有励磁线圈的转子和定子。当发动机工作在怠速状态时，励磁线圈被激励，以使发动机转速接近所需怠速的旋转方向旋转步进电动机。当发动机转速等于期望的发动机转速时，励磁线圈的励磁动作停止。

4. 发明授权

US4391244A Device of controlling the idling speed of an engine 失效
标题翻译：控制发动机空转速度的装置
公开(公告)号：US4391244A
公开(公告)日：1983-07-05
申请号：US387755
申请日：1982-06-11
申请人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
发明人： Mamoru Kobashi , Shinichiro Tanaka , Hideo Saji
IPC分类号： F02D41/16 , F02D41/04 , F02D41/08 , H02P8/00 , F02D11/10
CPC分类号： F02D41/042
摘要： An engine comprising a main intake passage having a throttle valve therein. A bypass passage is branched off from the main intake passage located upstream of the throttle valve and is connected to the main intake passage located downstream of the throttle valve. A flow control valve, actuated by a step motor, is arranged in the bypass passage. When the engine is operating in an idling state, the step motor is rotated at a first speed in a rotating direction wherein the engine speed approaches a desired engine speed. When the ignition switch is turned to the OFF position for stopping the engine, the step motor is rotated at a second speed which is lower than the first speed a little while after the flow control valve fully opens the bypass passage.
摘要翻译：一种发动机，包括其中具有节流阀的主进气通道。旁通通道从位于节流阀上游的主进气通道分支，并连接到位于节流阀下游的主进气通道。由旁通通道设置由步进电动机驱动的流量控制阀。当发动机工作在怠速状态时，步进电动机以其中发动机转速接近期望发动机转速的旋转方向以第一速度旋转。当点火开关转到关闭位置以停止发动机时，步进电动机在流量控制阀完全打开旁通通道之后的一点时间以低于第一速度的第二速度旋转。

5. 发明授权

US4453515A Device for controlling the idling speed of an engine 失效
标题翻译：用于控制发动机空转速度的装置
公开(公告)号：US4453515A
公开(公告)日：1984-06-12
申请号：US391683
申请日：1982-06-24
申请人： Hideo Saji , Yasutaka Yamauchi , Mamoru Kobashi
发明人： Hideo Saji , Yasutaka Yamauchi , Mamoru Kobashi
IPC分类号： F02D41/16 , F02D31/00 , F02M69/32 , F02M23/06
CPC分类号： F02D31/005 , F02D2011/102
摘要： An engine comprising a main intake passage having a throttle valve therein. A bypass passage is branched off from the main intake passage located upstream of the throttle valve and is connected to the main intake passage located downstream of the throttle valve. A flow control valve, actuated by a step motor, is arranged in the bypass passage. The step motor comprises a rotor and a stator having exciting coils. When the engine is operating in an idling state, the exciting coils are excited for rotating the step motor in a rotating direction wherein the engine speed approaches a desired idling speed. When the engine speed becomes equal to the desired engine speed and is higher than a predetermined speed, the exciting coil, which was finally excited immediately before the engine speed becomes equal to the desired idling speed, is intermittently excited in order to maintain the step motor stationary.
摘要翻译：一种发动机，包括其中具有节流阀的主进气通道。旁通通道从位于节流阀上游的主进气通道分支，并连接到位于节流阀下游的主进气通道。由旁通通道设置由步进电动机驱动的流量控制阀。步进马达包括具有励磁线圈的转子和定子。当发动机工作在怠速状态时，励磁线圈被激励，以使发动机转速接近所需怠速的旋转方向旋转步进电动机。当发动机转速等于期望发动机转速并高于预定速度时，在发动机转速变得等于所需空转速度之前立即被激励的励磁线圈被间歇地激励，以便保持步进电动机静止的

6. 发明授权

US09370589B2 Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same 有权
标题翻译：开关荧光纳米粒子探针和荧光颗粒成像方法使用相同
公开(公告)号：US09370589B2
公开(公告)日：2016-06-21
申请号：US13818392
申请日：2011-08-08
申请人： Isao Hara , Eiichi Ozeki , Hideo Saji , Shunsaku Kimura , Masahiro Ono , Takashi Temma
发明人： Isao Hara , Eiichi Ozeki , Hideo Saji , Shunsaku Kimura , Masahiro Ono , Takashi Temma
IPC分类号： A61K9/14 , A61K49/00
CPC分类号： A61K49/0089 , A61K49/0032 , A61K49/0093 , Y10S977/773 , Y10S977/927
摘要： The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
摘要翻译：本发明提供了具有开关功能（在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能）的新型荧光纳米颗粒成像探针。一种开关荧光纳米颗粒探针，包括：由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含：必需的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是由式（I）表示的花青化合物：和荧光染料被封装在单分子组装中。

7. 发明授权

US08642008B2 Molecular probe for imaging of pancreatic islets and use of the same 有权
标题翻译：胰岛成像用分子探针及其用途
公开(公告)号：US08642008B2
公开(公告)日：2014-02-04
申请号：US12872837
申请日：2010-08-31
申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： A61K51/08
CPC分类号： A61K51/088
摘要： To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides: Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (5) B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (9) where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring, wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R1 represents a substituent that contains radioactive iodine, R2 represents either a hydrogen atom or a substituent different from that represented by R1, and R3 represents any one of a bond, a methylene group, and an oxymethylene group.
摘要翻译：为胰岛成像提供分子探针。提供了一种用于胰岛成像的分子探针。分子探针包括以下多肽之一：由下式（1），（5）和（9）表示的多肽。和与前述多肽具有同源性的多肽：Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（1）Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2（5）B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（9）其中式（1）和（5）中的X和式（9）表示氨基用具有芳环的下式（I）表示的基团标记，其中A表示芳香族烃基或芳香族杂环基，R 1表示含有放射性碘的取代基， R2表示氢原子或与R1表示的不同的取代基，R3表示键，亚甲基和氧亚甲基中的任一个。

8. 发明申请

US20120029209A1 METHOD FOR SYNTHESIZING [18F]SFB USING MICROSYNTHESIS TECHNIQUE 审中-公开
标题翻译：使用微结构技术合成[18 F] SFB的方法
公开(公告)号：US20120029209A1
公开(公告)日：2012-02-02
申请号：US13254152
申请日：2010-03-01
申请人： Hiroaki Nakanishi , Hidekazu Saiki , Hideo Saji , Hiroyuki Kimura , Hidekazu Kawashima , Kenji Tomatsu , Yuji Kuge
发明人： Hiroaki Nakanishi , Hidekazu Saiki , Hideo Saji , Hiroyuki Kimura , Hidekazu Kawashima , Kenji Tomatsu , Yuji Kuge
IPC分类号： C07D207/46
CPC分类号： C07D207/404 , A61K51/00 , C07B59/001 , C07B59/002
摘要： A method for synthesizing [18F]SFB is disclosed, which comprises using a microreactor including a substrate having one channel formed therein so as to have a cross-sectional width of 1 mm or less and a cross-sectional depth of 1 mm or less, the channel being connected to a raw material injection port and a first reagent injection port at one end thereof, and connected to a second reagent injection port at a position far from the one end thereof, and connected to a third reagent injection port at a position far from the second reagent injection port in a direction toward another end thereof, and connected to a liquid discharge port at the other end thereof; and continuously performing a three-step reaction by allowing a reaction solution to flow through the channel serving as a reaction channel from the one end to the other end thereof without taking out the reaction solution from anywhere between the one end and the other end of the channel.
摘要翻译：公开了一种合成[18F] SFB的方法，其包括使用包括其中形成有一个通道的基板的微反应器，以使其横截面宽度为1mm以下，横截面深度为1mm以下，所述通道在其一端连接到原料注入口和第一试剂注入口，并且在远离其一端的位置处连接到第二试剂注入口，并且连接到位于其的一端的第三试剂注入口远离第二试剂注入口朝向其另一端的方向，并且在另一端连接到液体排出口; 并且通过使反应溶液从一端到另一端流过作为反应通道的通道而不从其一端到另一端的任何位置取出反应溶液，从而连续进行三步反应渠道。

9. 发明申请

US20110081663A1 Molecular Probe for Imaging of Pancreatic Islets and Use of the Same 有权
标题翻译：胰岛成像用分子探针及其用途
公开(公告)号：US20110081663A1
公开(公告)日：2011-04-07
申请号：US12893896
申请日：2010-09-29
申请人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： A61K51/08
摘要： A molecular probe for imaging of pancreatic islets is provided. The molecular probe includes a polypeptide represented by the following formula (1), or a polypeptide that has a homology with the foregoing polypeptide. (SEQ ID NO. 1) Z-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSX-NH2 (1) Wherein “X” represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a group represented by the following chemical formula (I), wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a substituent that contains 11C, 13N, 15O, 18F, 64Cu, 67Ga, 68Ga, 75Br, 76Br, 77Br, 99mTc, 111In, 123I, 124I, 125I, or 131I; R2 represents either a hydrogen atom, or a substituent different from that represented by R1; and R3 represents any one of a bond, an alkylene group having 1 to 6 carbon atoms, and an oxyalkylene group having 1 to 6 carbon atoms.
摘要翻译：提供了用于胰岛成像的分子探针。分子探针包括由下式（1）表示的多肽，或与前述多肽具有同源性的多肽。（SEQ ID NO.1）Z-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSX-NH2（1）其中，“X”表示赖氨酸残基，赖氨酸残基的侧链的氨基用下述化学式（I）表示的基团标记，其中A表示芳族烃基或芳族杂环基; R1表示含有11C，13N，150C，18F，64Cu，67Ga，68Ga，75Br，76Br，77Br，99mTc，111In，123I，124I，125I或131I的取代基; R2表示氢原子或与R1表示的取代基不同的取代基; R3表示碳原子数1〜6的亚烷基，碳原子数1〜6的氧亚烷基。

10. 发明申请

US20110033381A1 MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND THE PRECURSOR, AND USE OF THE SAME 审中-公开
标题翻译：用于成像胰腺和前列腺的分子探针及其用途
公开(公告)号：US20110033381A1
公开(公告)日：2011-02-10
申请号：US12854007
申请日：2010-08-10
申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： A61K51/08 , C07K14/00 , A61K49/00
CPC分类号： A61K51/08 , C07K14/435 , C07K14/57563 , Y02P20/55
摘要： A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide. *-DLSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(1) *-LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(2) *-SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(3) *-K* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2,(4) wherein *- indicates that an α-amino group at an N-terminus is protected by a protecting group or modified with a modifying group having no electric charge; K* indicates that an amino group of a side chain of a lysine is protected by a protecting group; and —NH2 indicates that a carboxyl group at a C-terminus is amidated.
摘要翻译：提供了用于胰岛成像的分子探针的前体。由下式（1）至（4）中任一项表示的多肽或与前述多肽具有同源性的多肽。 * -DLSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（1）* -LSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（2）* -SK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（3）* -K * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2，（4）其中 *表示N-末端的α-氨基被保护基保护或用不带电的修饰基团修饰; K *表示赖氨酸的侧链的氨基被保护基保护; 并且-NH 2表示C末端的羧基被酰胺化。

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