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1. 发明授权

US07482008B1 Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor 失效
标题翻译：人类T细胞反应性猫科动物蛋白（TRFP）从室内灰尘中分离出来，并用于其中
公开(公告)号：US07482008B1
公开(公告)日：2009-01-27
申请号：US09662784
申请日：2000-09-15
申请人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Julian F. Bond , Andrew W. Brauer , Malcolm Morville , Thomas J. Briner , Ze'ev Shaked
发明人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Julian F. Bond , Andrew W. Brauer , Malcolm Morville , Thomas J. Briner , Ze'ev Shaked
IPC分类号： A61K39/35 , A61K39/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K1/00
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/415 , C07K14/47 , C07K14/4705 , C07K16/18 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C12N15/62
摘要： A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.
摘要翻译：从真空袋提取物中分离得到的基本上纯的共价连接的人T细胞反应性猫科蛋白（TRFP），通过亲和纯化从几个家庭用猫收集的房屋灰尘获得; 编码全部或部分TRFP或肽的DNA; 含有这种蛋白质或肽或其部分的组合物; 并且公开了与TRFP或肽反应的抗体。还公开了重组TRFP或肽; 修饰或突变的TRFP肽; 它们用于诊断或治疗目的。

2. 发明授权

US07211408B2 Recombitope peptides 失效
标题翻译：重组单抗肽
公开(公告)号：US07211408B2
公开(公告)日：2007-05-01
申请号：US10463113
申请日：2003-06-16
申请人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-Chang Kuo , Malcolm Morville
发明人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-Chang Kuo , Malcolm Morville
IPC分类号： G01N33/00 , C12N15/09 , C07K1/00
CPC分类号： C07K16/18 , A61K38/00 , C07K14/415 , C07K14/47 , C07K14/4705 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C12N15/62 , G01N33/5091 , Y10S530/806 , Y10S530/858 , Y10S530/868
摘要： The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.
摘要翻译：本发明提供了称为重组竞争肽的具有T细胞刺激活性的肽。本发明的重组匹配肽优选包含至少两种衍生自相同或不同蛋白质抗原的T细胞表位，更优选包含至少两个区域，每个区域优选具有人T细胞刺激活性，每个区域包含至少一个T细胞衍生自蛋白质抗原的表位。本发明的重组蛋白多肽可以衍生自蛋白质过敏原，自身抗原或其他蛋白质抗原。本发明还提供诊断个体中蛋白质变应原或其他蛋白质抗原的敏感性的方法，治疗这种敏感性的方法和包含一种或多种重组蛋白多肽的治疗组合物的方法。本发明还提供了用于设计本发明的重组蛋白肽的方法，其中个体敏感的蛋白质抗原具有未知或不明确的T细胞表位。

3. 发明授权

US5547669A Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I 失效
标题翻译：包含猫过敏原T细胞表位的重组肽，Fel d I
公开(公告)号：US5547669A
公开(公告)日：1996-08-20
申请号：US807529
申请日：1991-12-13
申请人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Malcolm Morville
发明人： Bruce L. Rogers , Jay P. Morgenstern , Julian F. Bond , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Malcolm Morville
IPC分类号： A61K38/00 , C07K14/415 , C07K14/47 , C07K16/18 , C12N15/62 , G01N33/50 , C12N15/12 , A61K38/17 , A61K39/35
CPC分类号： C07K16/18 , C07K14/415 , C07K14/47 , C07K14/4705 , C12N15/62 , G01N33/5091 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , Y10S530/806 , Y10S530/858 , Y10S530/868
摘要： The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.
摘要翻译：本发明提供了称为重组竞争肽的具有T细胞刺激活性的肽。本发明的重组亲和素肽优选包含至少两种衍生自相同或不同蛋白质抗原的T细胞表位，更优选包含至少两个区域，每个区域优选具有人T细胞刺激活性，每个区域包含至少一个T细胞衍生自蛋白质抗原的表位。本发明的重组蛋白多肽可以衍生自蛋白质过敏原，自身抗原或其他蛋白质抗原。本发明还提供诊断个体中蛋白质变应原或其他蛋白质抗原的敏感性的方法，治疗这种敏感性的方法和包含一种或多种重组蛋白多肽的治疗组合物的方法。本发明还提供了用于设计本发明的重组蛋白肽的方法，其中个体敏感的蛋白质抗原具有未知或不明确的T细胞表位。

4. 发明授权

US08540999B2 Allergenic proteins and peptides from Japanese cedar pollen 有权
标题翻译：来自日本雪松花粉的过敏蛋白和肽
公开(公告)号：US08540999B2
公开(公告)日：2013-09-24
申请号：US10931260
申请日：2004-08-30
申请人： Irwin J. Griffith , Joanne Pollock , Julian F. Bond , Richard D. Garman , Mei-Chang Kuo , Stephen P. Powers , Mark A. Exley , Xian Chen , Ze'ev Shaked
发明人： Irwin J. Griffith , Joanne Pollock , Julian F. Bond , Richard D. Garman , Mei-Chang Kuo , Stephen P. Powers , Mark A. Exley , Xian Chen , Ze'ev Shaked
IPC分类号： A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00 , C07K16/16
摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.
摘要翻译：本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。本发明还提供了Cryj I和Cryj II的分离的肽。本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

5. 发明授权

US06982326B1 Allergenic proteins and peptides from Japanese cedar pollen 失效
公开(公告)号：US06982326B1
公开(公告)日：2006-01-03
申请号：US09240203
申请日：1999-01-29
申请人： Irwin J. Griffith , Joanne Pollock , Julian F. Bond , Richard D. Garman , Mei-chang Kuo , Stephen P. Powers , Mark A. Exley , Xian Chen , Ze'ev Shaked
发明人： Irwin J. Griffith , Joanne Pollock , Julian F. Bond , Richard D. Garman , Mei-chang Kuo , Stephen P. Powers , Mark A. Exley , Xian Chen , Ze'ev Shaked
IPC分类号： C07H21/04
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00 , C07K16/16
摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

6. 发明授权

US6090386A T cell peptides of the CRX JII allergen 失效
标题翻译： CRX JII变应原的T细胞肽
公开(公告)号：US6090386A
公开(公告)日：2000-07-18
申请号：US467023
申请日：1995-06-06
申请人： Irwin J. Griffith , Joanne Pollock , Julian F. Bond , Richard D. Garman , Mei-chang Kuo , Stephen P. Powers , Mark A. Exley , Xian Chen , Ze'ev Shaked
发明人： Irwin J. Griffith , Joanne Pollock , Julian F. Bond , Richard D. Garman , Mei-chang Kuo , Stephen P. Powers , Mark A. Exley , Xian Chen , Ze'ev Shaked
IPC分类号： A61K39/00 , C07K14/415 , C07K14/725 , A61K38/10 , A61K39/36 , C07K7/08
CPC分类号： C07K14/415 , A61K39/00
摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.
摘要翻译：本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。本发明还提供了Cryj I和Cryj II的分离的肽。本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

7. 发明授权

US6120769A Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor 失效
公开(公告)号：US6120769A
公开(公告)日：2000-09-19
申请号：US431184
申请日：1995-04-28
申请人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Julian F. Bond
发明人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Julian F. Bond
IPC分类号： A61K38/00 , A61P37/08 , C07K14/415 , C07K14/47 , C07K14/725 , C07K16/18 , C12N15/62 , G01N33/50 , A61K39/00 , A61K39/35 , G01N33/53 , G01N33/567
CPC分类号： C07K14/415 , C07K14/47 , C07K14/4705 , C07K16/18 , C12N15/62 , G01N33/5091 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40
摘要： A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.

8. 发明授权

US08338565B2 Macrocyclic compounds for inhibition of tumor necrosis factor alpha 失效
标题翻译：用于抑制肿瘤坏死因子α的大环化合物
公开(公告)号：US08338565B2
公开(公告)日：2012-12-25
申请号：US12544604
申请日：2009-08-20
申请人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
发明人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
IPC分类号： C07K11/02 , A61K38/12
CPC分类号： C07D273/00 , C07D257/02
摘要： Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
摘要翻译：本文公开了大环化合物及其合成和使用的方法。特别地，公开了调节肿瘤坏死因子α的活性和/或可用于治疗诸如类风湿性关节炎，牛皮癣和哮喘等医学病症的大环化合物。

9. 发明申请

US20100152099A1 MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA 失效
标题翻译：用于抑制肿瘤坏死因子ALPHA的大环化合物
公开(公告)号：US20100152099A1
公开(公告)日：2010-06-17
申请号：US12544604
申请日：2009-08-20
申请人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, JR. , Daniel Wang , Timothy F. Briggs , Benjamin A. Seigal , Wei-Chuan Sun , Stephen P. Hale
发明人： Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, JR. , Daniel Wang , Timothy F. Briggs , Benjamin A. Seigal , Wei-Chuan Sun , Stephen P. Hale
IPC分类号： A61K38/12 , C07K5/12 , A61P19/02 , A61P1/00 , A61P35/00 , A61P3/10 , A61P25/28
CPC分类号： C07D273/00 , C07D257/02
摘要： The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
摘要翻译：本发明提供了大环化合物及其合成和使用方法。特别地，本发明提供调节肿瘤坏死因子α活性的大环化合物和/或可用于治疗诸如类风湿性关节炎，牛皮癣和哮喘的医学病症。

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