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1. 发明授权

US4972834A Pacemaker with improved dynamic rate responsiveness 失效
标题翻译：起搏器具有改善的动态响应速度
公开(公告)号：US4972834A
公开(公告)日：1990-11-27
申请号：US252643
申请日：1988-09-30
申请人： Malcolm J. S. Begemann , Willem Boute , Marijn van Gemert
发明人： Malcolm J. S. Begemann , Willem Boute , Marijn van Gemert
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： A rate adaptive pacemaker system, and method of operation, is provided which has a pacemaker which generates pacing pulses at a controlled pacing rate as a function of at least one monitored patient variable. The correlation of pacing rate with the patient variable is nonlinear, or dynamic, and is adapted to actual patient conditions. The value of the relationship between the pacing rate and the monitoring variable is determined at the lower rate limit and the upper rate limit, and the dynamic characteristic between these limits is automatically adjusted.

2. 发明申请

US20100010832A1 System and Method for The Diagnosis and Alert of A Medical Condition Initiated By Patient Symptoms 审中-公开
标题翻译：由病人症状引起的医疗状况的诊断和警报的系统和方法
公开(公告)号：US20100010832A1
公开(公告)日：2010-01-14
申请号：US12170313
申请日：2008-07-09
申请人： Willem Boute , David Robert Hampton , Wilbert Wesselink , Bernardus Anthony Albers
发明人： Willem Boute , David Robert Hampton , Wilbert Wesselink , Bernardus Anthony Albers
IPC分类号： G06Q50/00
CPC分类号： G06Q50/24 , G06F19/3418 , G16H10/20
摘要： A system and method are provided for diagnosing and generating an alert for a medical condition using procedures initiated by symptoms being experienced by a patient. Diagnostic procedures are initiated in response to the patient entering specific symptoms the patient is experiencing through a patient activator device. The patient activator device may then acquire more information related to the symptoms from the patient, instruct an implantable medical device to perform measurements of certain physiological parameters related to the symptoms, or instruct the patient to perform certain tests. The symptoms and data collected from the patient and medical device are transmitted to a remote diagnostic device for performing clinical decisions based on such information and determining whether the patient is experiencing a particular medical condition. Upon detection of a condition, the remote diagnostic device generates an automated response that may include generating alerts to patients/physicians or instructions for treatment.
摘要翻译：提供了一种系统和方法，用于使用由患者经历的症状引发的过程来诊断和产生用于医疗状况的警报。响应于患者进入患者通过患者激活器装置经历的特定症状而启动诊断程序。患者激活器装置然后可以从患者获得与症状相关的更多信息，指示可植入医疗装置执行与症状相关的某些生理参数的测量，或指示患者执行某些测试。从患者和医疗装置收集的症状和数据被传送到远程诊断装置，用于基于这些信息执行临床决定，并确定患者是否正在经历特定的医疗状况。在检测到状况时，远程诊断装置产生可能包括向患者/医生产生警报或用于治疗的指令的自动响应。

3. 发明申请

US20080183085A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR PHYSIOLOGICAL EVENT MONITORING 有权
标题翻译：可植入医疗设备和生理活动监测方法
公开(公告)号：US20080183085A1
公开(公告)日：2008-07-31
申请号：US11669345
申请日：2007-01-31
申请人： Geeske van Oort , Willem Boute , Gustaaf A.P. Stoop
发明人： Geeske van Oort , Willem Boute , Gustaaf A.P. Stoop
IPC分类号： A61B5/00
CPC分类号： A61N1/3621 , A61N1/3627 , A61N1/3925
摘要： An implantable medical device uses a method for dynamically managing physiological signal monitoring. A physiological signal is sensed for detecting physiological events in response a first threshold. A determination is made whether a second threshold has been met in response to detecting physiological events. If the second threshold has been met, detailed monitoring of the physiological events is enabled.
摘要翻译：可植入医疗装置使用动态管理生理信号监测的方法。感测生理信号以响应于第一阈值检测生理事件。确定响应于检测到生理事件是否满足第二阈值。如果满足第二个阈值，则可以对生理事件进行详细监测。

4. 发明授权

US5534016A Dual chamber pacing system and method utilizing detection of ventricular fusion for adjustment of the atrial-ventricular delay as therapy for hypertrophic obstructive cardiomyopathy 失效
标题翻译：双室起搏系统和方法利用心室融合检测调整心房延迟作为肥大性梗阻性心肌病的治疗
公开(公告)号：US5534016A
公开(公告)日：1996-07-09
申请号：US395372
申请日：1995-02-21
申请人： Willem Boute
发明人： Willem Boute
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A dual chamber pacemaker for providing ventricular pace pulses synchronized with atrial senses or paces, and having specific control for optimizing the AV escape interval and resultant AV delay for purposes of therapy for a patient with hypertrophic obstructive cardiomyopathy (HOCM). The pacemaker has an algorithm for varying the AV escape interval and detecting when the AV delay is lengthened to the point of evoking a fusion beat, thereby providing an accurate indication of a patient's underlying PR interval without significant loss of pacing capture. By monitoring T-wave detection and drop in amplitude of the evoked T-wave, an algorithm is enabled for optimizing the pacemaker AV delay within a range of values just less than the longest value for obtaining pre-excitation by the delivered pace pulse.
摘要翻译：一种双室起搏器，用于提供与心房感觉或步调同步的心室起搏脉搏，并且具有用于优化AV逃逸间隔和由此产生的AV延迟的具体控制，用于治疗肥厚性梗阻性心肌病（HOCM）的患者。起搏器具有用于改变AV逃逸间隔的算法，并且检测AV延迟何时延长到引发融合节点的时间点，从而提供患者的基础PR间期的准确指示，而不会显着地失去起搏捕获。通过监测诱发T波的T波检测和幅度的下降，可以使算法优化起搏器AV延迟的范围，该值仅小于通过传递的起搏脉冲获得预激励的最长值。

5. 发明授权

US4601291A Biomedical system with improved marker channel means and method 失效
标题翻译：具有改进的标记通道手段和方法的生物医学系统
公开(公告)号：US4601291A
公开(公告)日：1986-07-22
申请号：US596916
申请日：1984-04-05
申请人： Willem Boute , Guus Stoop , Gerrit W. van Arragon , Kornelis A. Mensink
发明人： Willem Boute , Guus Stoop , Gerrit W. van Arragon , Kornelis A. Mensink
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/37211
摘要： A biomedical system such as a pacemaker system having an implantable pacemaker and external apparatus, with communications capability for communicating between the implanted device and the external apparatus, characterized by the implanted device having means for cyclically transmitting event and device timing data representative of each prior device interval, the external apparatus having means for receiving and storing the data and for graphically constructing a graphic output representative of the timing and event information over a plurality of device cycles. Graphic output preferably includes a linear timing graph representative of timing functions of the implanted device.
摘要翻译：一种生物医学系统，例如具有可植入起搏器和外部装置的起搏器系统，具有用于在植入装置和外部装置之间通信的通信能力，其特征在于，所述植入装置具有用于循环地传送代表每个现有装置的事件和装置定时数据的装置外部设备具有用于接收和存储数据的装置，以及用于在多个设备周期上图形地构建表示定时和事件信息的图形输出。图形输出优选地包括表示植入装置的定时功能的线性时间图。

6. 发明授权

US4503857A Programmable cardiac pacemaker with microprocessor control of pacer rate 失效
标题翻译：可编程心脏起搏器，微处理器控制起搏器速率
公开(公告)号：US4503857A
公开(公告)日：1985-03-12
申请号：US436411
申请日：1982-10-25
申请人： Willem Boute , Frederik H. M. Wittkampf , Gerrit W. van Arragon , Kornelis A. Mensink
发明人： Willem Boute , Frederik H. M. Wittkampf , Gerrit W. van Arragon , Kornelis A. Mensink
IPC分类号： A61N1/365 , A61N1/37 , A61N1/372 , A61N1/36
CPC分类号： A61N1/37252 , A61N1/365 , A61N1/37
摘要： A programmable pacemaker apparatus having a microprocessor and means for receiving program information from an external source, means for generating and delivering stimulus signals and means for sensing the occurrence of natural heartbeats in a patient, and having a battery source powering the apparatus, said microprocessor being combined with program instructions stored in memory for controlling the operation of said pacemaker, comprising controller circuit means external to said microprocessor and interconnected therewith for controlling the operating state of said microprocessor, said controller means having occurrence means for determining the occurrence of given events. The controller means further comprises means for stopping operation of the microprocessor on command from the microprocessor and for starting operation of the microprocessor upon determination of one of said events, whereby the microprocessor normally is on less than about 25% of the time. The pacemaker provides for at least two modes of pacing rate control, whereby the patient's heartbeat can be overdriven, or abrupt changes in rate are not followed beyond a selected rate change limit. Means are provided for microprocessor control of testing of pacemaker conditions, and for limiting current to the pacemaker output circuit when the battery voltage drops below a predetermined value.
摘要翻译：一种具有微处理器和用于从外部源接收节目信息的装置的可编程起搏器装置，用于生成和递送刺激信号的装置和用于感测患者自然心跳发生的装置，以及具有为装置供电的电池源，所述微处理器为结合存储在存储器中的用于控制所述起搏器的操作的程序指令，包括控制器电路装置，其位于所述微处理器外部并与之互连，用于控制所述微处理器的操作状态，所述控制器装置具有用于确定给定事件发生的发生装置。控制器装置还包括用于根据来自微处理器的命令停止微处理器的操作的装置，以及用于在确定所述事件之一时开始微处理器的操作，由此微处理器通常小于大约25％的时间。起搏器提供至少两种起搏速率控制模式，从而患者的心跳可能过载，或超出所选择的速率变化极限的速率突然变化。提供了用于微处理器控制起搏器状况测试的装置，以及当电池电压降低到预定值以下时将电流限制到起搏器输出电路。

7. 发明授权

US08639326B2 Implantable medical device with ventricular pacing management of elevated heart rates 有权
标题翻译：具有升高心率的心室起搏管理的可植入医疗器械
公开(公告)号：US08639326B2
公开(公告)日：2014-01-28
申请号：US11039766
申请日：2005-01-21
申请人： Mattias Rouw , Willem Boute , Peter M. Van Dam
发明人： Mattias Rouw , Willem Boute , Peter M. Van Dam
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/3622 , A61N1/368
摘要： An implantable medical device operates to promote intrinsic ventricular depolarization according to a pacing protocol. When a cardiac rate exceeds a predetermined threshold, the implantable medical device modifies the pacing protocol parameters to promote AV synchrony.
摘要翻译：可植入医疗装置用于根据起搏方案促进内在室性去极化。当心率超过预定阈值时，可植入医疗装置修改起搏协议参数以促进AV同步。

8. 发明申请

US20100010358A1 System and Method For The Detection of Acute Myocardial Infarction 有权
标题翻译：用于检测急性心肌梗死的系统和方法
公开(公告)号：US20100010358A1
公开(公告)日：2010-01-14
申请号：US12170379
申请日：2008-07-09
申请人： Willem Boute , Jos van Hove , David Robert Hampton , Wilbert Wesselink
发明人： Willem Boute , Jos van Hove , David Robert Hampton , Wilbert Wesselink
IPC分类号： A61B5/0402 , A61B5/02
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0205 , A61B5/02055 , A61B5/0816 , A61B5/7275 , A61B7/00 , A61N1/3702 , G06F19/00 , G16H10/20 , G16H50/20
摘要： A system and method are provided for the detection of acute myocardial infarction (AMI) using a staged approach for accurate and rapid detection. Physiological signals in a patient's body are sensed and corresponding physiological parameters are derived in a staged approach in order to determine the probability that AMI is occurring in a patient in a first detection stage. If the computed probability from physiological signals indicates the possibility of AMI, then the patient is prompted, such as through a patient-wearable device, to answer specific AMI-related questions to assist in diagnosis of AMI in a second stage. AMI is detected when the computed probability in the second stage exceeds a predefined detection threshold. A patient or physician alert may then be generated, which may further include the transfer of data via a communication link or network, in response to an AMI detection signal.
摘要翻译：提供了一种系统和方法，用于使用分阶段方法检测急性心肌梗死（AMI）以进行准确和快速的检测。检测患者身体中的生理信号，并且在分阶段方法中导出对应的生理参数，以便确定在第一检测阶段中患者发生AMI的可能性。如果来自生理信号的计算概率表明AMI的可能性，则提示患者，例如通过患者穿戴式装置，以回答特定AMI相关问题，以帮助诊断第二阶段的AMI。当计算出的第二级概率超过预定义的检测阈值时，检测到AMI。然后可以生成患者或医生警报，其可以响应于AMI检测信号而进一步包括经由通信链路或网络的数据传输。

9. 发明授权

US07542799B2 Implantable medical device with ventricular pacing protocol 有权
标题翻译：可植入医疗器械与心室起搏方案
公开(公告)号：US07542799B2
公开(公告)日：2009-06-02
申请号：US11039762
申请日：2005-01-21
申请人： Gustaaf A. P. Stoop , Willem Boute , Peter M. Van Dam , Mattias Rouw
发明人： Gustaaf A. P. Stoop , Willem Boute , Peter M. Van Dam , Mattias Rouw
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates to promote intrinsic ventricular depolarization according to a pacing protocol. The medical device determines a course of action based upon the presence or absence of sensed ventricular activity. The device further determines whether that activity is properly conducted or the result of a PVC or nodal rhythm.
摘要翻译：可植入医疗装置用于根据起搏方案促进内在室性去极化。医疗设备基于感测到的心室活动的存在或不存在来确定行动过程。该设备进一步确定该活动是否适当地进行，或者PVC或节点节奏的结果。

10. 发明申请

US20080208007A1 Digital Pen to Capture Data in Ambulatory Monitored Patients 有权
标题翻译：数字笔在动态监测患者中捕获数据
公开(公告)号：US20080208007A1
公开(公告)日：2008-08-28
申请号：US11681864
申请日：2007-03-05
申请人： Jos W. Van Hove , Willem Boute
发明人： Jos W. Van Hove , Willem Boute
IPC分类号： A61B5/00
CPC分类号： G06F3/03545 , A61B5/0006 , A61B5/021 , A61B5/0402 , A61B5/145 , A61B5/4839 , A61N1/37247 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63 , G16H50/20
摘要： A medical device system and method for monitoring a patient include a monitoring device for storing data relating to the patient and a digital pen for digitizing and storing data handwritten by the patient. A control module is configured to aggregate data stored by the monitoring device and handwritten data stored by the digital pen.
摘要翻译：用于监测患者的医疗装置系统和方法包括用于存储与患者有关的数据的监视装置和用于数字化和存储由患者手写的数据的数字笔。控制模块被配置为聚合由监视设备存储的数据和由数字笔存储的手写数据。

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